The influence of maternal vitamin D supplementation on infant vitamin D status: A systematic review and meta-analyses

Zhong X 1 , Xiong Y 2 , Wei D 1 , Wang S 1 , Xiao Z 3 , Liu M 4 Show all authors , Tan SC 5 , Low TY 5 , Khani V 6 , Wang J 7

Affiliations 

  • 1 Department of Obstetrical, Penglai People's Hospital, Penglai, Shandong, 265600, China
  • 2 Department of Gynecologic, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China
  • 3 Department of Obstetrical, Guicheng Hospital, Nanhai District, Foshan City, Guangdong Province, 528200, China
  • 4 Department of Obstetrical, Jinan Maternal and Child Healthcare Hospital, Jinan, Shandong, 250001, China
  • 5 UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 6 Department of Radiology, Taleghani Hospital, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 7 Department of Obstetrics, Dongying People's Hospital of Shandon, Dongying, Shandong, 257091, China. Electronic address: 15505462288wjr@sina.com
Complement Ther Med, 2020 Aug;52:102491.
PMID: 32951740 DOI: 10.1016/j.ctim.2020.102491

Abstract

BACKGROUND: Inconsistencies exist with regard to effect of maternal vitamin D supplementation on infant vitamin D status. The inconsistencies could be attributed to numerous factors, such as duration of intervention and dosage, among others. In this work, we conducted a systematic review and meta-analysis to determine the influence of maternal vitamin D supplementation on infant vitamin D status.

METHODS: A comprehensive systematic search was performed in Scopus, EMBASE, Web of Science, and PubMed/MEDLINE, by investigators, from database inception until November 2019, without using any restrictions. Weighted mean difference (WMD) with the 95 % CI was used for assessing the effects of maternal vitamin D supplementation on 25(OH) D levels in infants.

RESULTS: Overall results from 14 studies revealed a non-significant effect of maternal vitamin D administration on the level of 25(OH) D in breastfeeding infants (WMD: -0.464 ng/mL, 95 % CI: -6.68 to 5.75, p = 0.884, I2 = 98 %). Subgroup analyses demonstrated that vitamin D supplementation dosage ≥2000 IU/day (WMD: 9 ng/mL, 95 % CI: 8.19, 9.82, I2 = 99 %) and intervention duration ≥20 weeks (WMD: 16.20 ng/mL, 95 % CI: 14.89, 17.50, I2 = 99 %) significantly increased 25(OH) D.

CONCLUSIONS: The main results indicate a non-significant increase in infant vitamin D following maternal vitamin D supplementation. Additionally, vitamin D supplementation dosage ≥2000 IU/day and intervention duration ≥20 weeks significantly increased infant 25(OH) D.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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