Affiliations 

  • 1 Department of Chemistry, School of Basic Sciences, VELS Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India
  • 2 Department of Inorganic Chemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India
  • 3 Institute of Nanoelectronic Engineering, Universiti Malaysia Perlis (UniMAP), Perlis, Malaysia
Crit Rev Anal Chem, 2021 Feb 23.
PMID: 33622098 DOI: 10.1080/10408347.2021.1882834

Abstract

Paracetamol (PAR) is an effective antipyretic and analgesic drug utilized worldwide, safer at therapeutic levels but over-dosing and the chronic usage of PAR results in accumulation of toxic metabolites, which leads to kidney and liver damages. Hence, a simple, rapid, cost-effective, and sensitive analytical technique is needed for the accurate determination of PAR in pharmaceutical and biological samples. Though numerous techniques have been reported for PAR detection, electrochemical methods are being receiving more interest due to their advantages. Moreover, in the past few decades, room temperature ionic liquids (RTILs) have been utilized in electrochemical sensors due to their attractive properties. In this present review, authors gathered research findings available for the determination of PAR using RTIL-based electrochemical sensors and discussed. The advantages and limitations in these systems as well as the future research directions are summarized.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.