Displaying publications 1 - 20 of 190 in total

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  1. Mousavi SM, Low FW, Hashemi SA, Lai CW, Ghasemi Y, Soroshnia S, et al.
    Artif Cells Nanomed Biotechnol, 2020 Dec;48(1):1189-1205.
    PMID: 32930615 DOI: 10.1080/21691401.2020.1817052
    Graphene and its derivative materials present high potential towards medical and biological applications, including drug delivery and bioimaging, due to their exceptional properties such as thermal conductivity and high specific surface area. The main focus of this work is to review the current development of graphene materials and the derivatives for biocompatible, bioimaging and drug delivery applications. Also, the synthesis methods with variation of graphene nanocomposites and the functionalisation will be further explained. For the graphene approaches, chemical vapour deposition (CVD) is the best-known technique to make high-quality graphene sheet by growth route with mass production. By considering the organic graphene nanocomposites, the biocompatibility and cytotoxic effects against graphene nanocomposites were evaluated for biomedical employments such as high quality bioimaging and effective drug delivery for cancer treatments. For example, graphene oxide incorporated with PEG and loaded with SN 38 for camptothecin analolgue as anticancer drug and revealed high cytotoxicity has an effect of 1000 times better effect than CPT in HCT-116 cells. Their drug delivery ability for both in-vivo and in-vitro applications compared to the controlled drugs such as doxorubicin (DOX) will be discussed accordingly. The graphene and its deriavatives possess some intriguing properties, which will lead to drug delivery due to strong biocompatibility and cyctotoxic effect towards biomedicine applications.
  2. Isahak M, Loh MY, Susilowati IH, Kaewboonchoo O, Harncharoen K, Mohd Amin N, et al.
    Asia Pac J Public Health, 2017 May;29(4):315-327.
    PMID: 28569111 DOI: 10.1177/1010539517699060
    Quality of life is associated with several factors, including personal living styles and working conditions. This article aims to investigate the factors associated with quality of life among small and medium enterprises (SME) workers in 4 countries of the Association of Southeast Asian Nations (ASEAN), namely Malaysia, Indonesia, Thailand, and Vietnam. A total of 2014 workers from food and textile industries were asked to answer a questionnaire about their sociodemographic characteristics, working environment and conditions, and quality of life. Results from showed that lifestyle (ie, alcohol intake and exercising), working characteristics (ie, shift work, working hours, and working days) and workplace conditions were associated with SME workers' quality of life (ie, physical, psychological, social, and environmental domain). Among the 16 types of workplace conditions, "sitting on the chair" and "slippery floor" most affect their quality of life . It is important for these variables to be taken into account in promoting workers' well-being and quality of life.
  3. Alsemiry RD, Sarifuddin, Mandal PK, Sayed HM, Amin N
    Biomed Res Int, 2020;2020:7609562.
    PMID: 32090110 DOI: 10.1155/2020/7609562
    The simultaneous effect of flexible wall and multiple stenoses on the flow and mass transfer of blood is investigated through numerical computation and simulations. The solution is obtained using the Marker and Cell technique on an axisymmetric model of Newtonian blood flow. The results compare favorably with physical observations where the pulsatile boundary condition and double stenoses result in a higher pressure drop across the stenoses. The streamlines, the iso-concentration lines, the Sherwood number, and the mass concentration variations along the entire wall segment provide a comprehensive analysis of the mass transport characteristics. The double stenoses and pulsatile inlet conditions increase the number of recirculation regions and effect a higher mass transfer rate at the throat, whereby more mass is expected to accumulate and cause further stenosis.
  4. Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Alshaer W, Hasan H, Albakri KA, et al.
    Biomedicines, 2022 May 24;10(6).
    PMID: 35740242 DOI: 10.3390/biomedicines10061219
    Infants who are exclusively breastfed in the first six months of age receive adequate nutrients, achieving optimal immune protection and growth. In addition to the known nutritional components of human breast milk (HBM), i.e., water, carbohydrates, fats and proteins, it is also a rich source of microRNAs, which impact epigenetic mechanisms. This comprehensive work presents an up-to-date overview of the immunomodulatory constituents of HBM, highlighting its content of circulating microRNAs. The epigenetic effects of HBM are discussed, especially those regulated by miRNAs. HBM contains more than 1400 microRNAs. The majority of these microRNAs originate from the lactating gland and are based on the remodeling of cells in the gland during breastfeeding. These miRNAs can affect epigenetic patterns by several mechanisms, including DNA methylation, histone modifications and RNA regulation, which could ultimately result in alterations in gene expressions. Therefore, the unique microRNA profile of HBM, including exosomal microRNAs, is implicated in the regulation of the genes responsible for a variety of immunological and physiological functions, such as FTO, INS, IGF1, NRF2, GLUT1 and FOXP3 genes. Hence, studying the HBM miRNA composition is important for improving the nutritional approaches for pregnancy and infant's early life and preventing diseases that could occur in the future. Interestingly, the composition of miRNAs in HBM is affected by multiple factors, including diet, environmental and genetic factors.
  5. Chowdhury TH, Islam A, Mahmud Hasan AK, Terdi MA, Arunakumari M, Prakash Singh S, et al.
    Chem Rec, 2016 Apr;16(2):614-32.
    PMID: 26816190 DOI: 10.1002/tcr.201500206
    Third-generation solar cells are understood to be the pathway to overcoming the issues and drawbacks of the existing solar cell technologies. Since the introduction of graphene in solar cells, it has been providing attractive properties for the next generation of solar cells. Currently, there are more theoretical predictions rather than practical recognitions in third-generation solar cells. Some of the potential of graphene has been explored in organic photovoltaics (OPVs) and dye-sensitized solar cells (DSSCs), but it has yet to be fully comprehended in the recent third-generation inorganic-organic hybrid perovskite solar cells. In this review, the diverse role of graphene in third-generation OPVs and DSSCs will be deliberated to provide an insight on the prospects and challenges of graphene in inorganic-organic hybrid perovskite solar cells.
  6. Mustapha N, Amin N, Chakravarty S, Mandal PK
    Comput Biol Med, 2009 Oct;39(10):896-906.
    PMID: 19665698 DOI: 10.1016/j.compbiomed.2009.07.004
    Flow of an electrically conducting fluid characterizing blood through the arteries having irregular shaped multi-stenoses in the environment of a uniform transverse magnetic-field is analysed. The flow is considered to be axisymmetric with an outline of the irregular stenoses obtained from a three-dimensional casting of a mild stenosed artery, so that the physical problem becomes more realistic from the physiological point of view. The marker and cell (MAC) and successive-over-relaxation (SOR) methods are respectively used to solve the governing unsteady magnetohydrodynamic (MHD) equations and pressure-Poisson equation quantitatively and to observe the flow separation. The results obtained show that the flow separates mostly towards the downstream of the multi-stenoses. However, the flow separation region keeps on shrinking with the increasing intensity of the magnetic-field which completely disappears with sufficiently large value of the Hartmann number. The present observations certainly have some clinical implications relating to magnetotherapy which help reducing the complex flow separation zones causing flow disorder leading to the formation and progression of the arterial diseases.
  7. Sirunyan AM, Tumasyan A, Adam W, Ambrogi F, Bergauer T, Dragicevic M, et al.
    Comput Softw Big Sci, 2020;4(1):10.
    PMID: 33196702 DOI: 10.1007/s41781-020-00041-z
    We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ¯ .
  8. Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Ahmad S, Hasan H, Ahmad Suhaimi NA, et al.
    Emerg Microbes Infect, 2022 Dec;11(1):2600-2631.
    PMID: 36263798 DOI: 10.1080/22221751.2022.2132882
    The current outbreak of monkeypox (MPX) infection has emerged as a global matter of concern in the last few months. MPX is a zoonosis caused by the MPX virus (MPXV), which is one of the Orthopoxvirus species. Thus, it is similar to smallpox caused by the variola virus, and smallpox vaccines and drugs have been shown to be protective against MPX. Although MPX is not a new disease and is rarely fatal, the current multi-country MPX outbreak is unusual because it is occurring in countries that are not endemic for MPXV. In this work, we reviewed the extensive literature available on MPXV to summarize the available data on the major biological, clinical and epidemiological aspects of the virus and the important scientific findings. This review may be helpful in raising awareness of MPXV transmission, symptoms and signs, prevention and protective measures. It may also be of interest as a basis for performance of studies to further understand MPXV, with the goal of combating the current outbreak and boosting healthcare services and hygiene practices.Trial registration: ClinicalTrials.gov identifier: NCT02977715..Trial registration: ClinicalTrials.gov identifier: NCT03745131..Trial registration: ClinicalTrials.gov identifier: NCT00728689..Trial registration: ClinicalTrials.gov identifier: NCT02080767..
  9. Wong SL, Ngadi N, Amin NA, Abdullah TA, Inuwa IM
    Environ Technol, 2016;37(2):245-54.
    PMID: 26150081 DOI: 10.1080/09593330.2015.1068376
    Pyrolysis of low density polyethylene (LDPE) waste from local waste separation company in subcritical water was conducted to investigate the effect of reaction time, temperature, as well as the mass ratio of water to polymer on the liquid yield. The data obtained from the study were used to optimize the liquid yield using response surface methodology. The range of reaction temperature used was 162-338°C, while the reaction time ranged from 37 min to 143 min, and the ratio of water to polymer ranged from 1.9 to 7.1. It was found that pyrolysis of LDPE waste in subcritical water produced hydrogen, methane, carbon monoxide and carbon dioxide, while the liquid product contained alkanes and alkenes with 10-50 carbons atoms, as well as heptadecanone, dichloroacetic acid and heptadecyl ester. The optimized conditions were 152.3°C, reaction time of 1.2 min and ratio of water solution to polymer of 32.7, with the optimum liquid yield of 13.6 wt% and gases yield of 2.6 wt%.
  10. Redzuan RA, Abu Bakar N, Rozano L, Badrun R, Mat Amin N, Mohd Raih MF
    Genome Announc, 2014;2(3).
    PMID: 24812220 DOI: 10.1128/genomeA.00375-14
    Erwinia mallotivora was isolated from papaya trees infected with dieback disease, which were planted at the Malaysian Agricultural Research and Development Institute (MARDI), Malaysia. Here, we report a draft genome sequence of E. mallotivora BT-MARDI, which offers an important source of information for understanding pathogen and host interaction during papaya dieback development.
  11. Emon EI, Islam AM, Sobayel MK, Islam S, Akhtaruzzaman M, Amin N, et al.
    Heliyon, 2023 Mar;9(3):e14438.
    PMID: 36950573 DOI: 10.1016/j.heliyon.2023.e14438
    Transition metal di-chalcogenides (TMCDs)-Tungsten disulfide (WS2) exhibit excellent optoelectronic properties such as suitable bandgap, high absorption coefficient, good conductivity, high carrier mobility, etc. to be used as a photovoltaic material for thin-film solar cells. In the present work, we have replaced the traditional buffer CdS and ITO/ZnO window layer in CdTe solar cells with the non-toxic, earth-abundant WS2 buffer and SnO2 window layer, respectively. The SCAPS-1D solar simulator is used to investigate the potentiality of WS2 as buffer material in CdTe solar cells. This numerical study provides a comparison of the performances between the proposed structure: SnO2/WS2/CdTe/Au and the baseline structure: ITO/ZnO/CdS/CdTe/Au. The impacts of the charge carrier generation rate, spectral response, current-voltage characteristics, bulk defect density, defect density at buffer/absorber interface, operating temperature, and capacitance-voltage characteristics on the solar cell performance parameters have also been analyzed. The tolerance level of defect density in WS2 bulk and WS2/CdTe interface are found to be 1017 cm-3 and 1012 cm-3, respectively. The temperature study reveals the poor structural robustness and thermal stability of the proposed cell. The conversion efficiency of the proposed cell has found to be 20.55% at the optimized device structure. Nevertheles, these findings may provide an insight to fabricate viable, environment friendly, and inexpensive CdTe thin-film solar cells.
  12. Ahmad NI, Kar YB, Doroody C, Kiong TS, Rahman KS, Harif MN, et al.
    Heliyon, 2023 Nov;9(11):e21622.
    PMID: 38027707 DOI: 10.1016/j.heliyon.2023.e21622
    Recent advancements in CdTe solar cell technology have introduced the integration of flexible substrates, providing lightweight and adaptable energy solutions for various applications. Some of the notable applications of flexible solar photovoltaic technology include building integrated photovoltaic systems (BIPV), transportation, aerospace, satellites, etc. However, despite this advancement, certain issues regarding metal and p-CdTe remained unresolved. Besides, the fabrication of a full-working device on flexible glass is challenging and requires special consideration due to the unstable morphology and structural properties of deposited film on ultra-thin glass substrates. The existing gap in knowledge about the vast potential of flexible CdTe solar cells on UTG substrates and their possible applications blocks their full capacity utilization. Hence, this comprehensive review paper exclusively concentrates on the obstacles associated with the implementation of CdTe solar cells on UTG substrates with a potential back surface field (BSF) layer. The significance of this study lies in its meticulous identification and analysis of the substantial challenges associated with integrating flexible CdTe onto UTG substrates and leveraging Cu-doped ZnTe as a potential BSF layer to enhance the performance of flexible CdTe solar cells.
  13. Wong LP, Lee HY, Khor CS, Abdul-Jamil J, Alias H, Abu-Amin N, et al.
    PMID: 33879981 DOI: 10.1007/s12288-021-01428-7
    Throughout the world, there has been growing concern over the risk of hepatitis E virus (HEV) transmission via blood transfusion. The present study screened blood donor samples for anti-HEV immunoglobulin M (IgM) and immunoglobulin G (IgG). The prevalence of HEV infection was assessed on a total of 1,003 archived serum samples obtained from the National Blood Centre, Malaysia. The samples were collected from healthy blood donor from Klang Valley between 2017 and 2018. All samples were tested for IgM and IgG antibodies to HEV using enzyme-linked immunosorbent assays (ELISA). HEV-specific IgG antibodies were detected in 31/1003 (3.1%; 95% confidence interval [CI] 2.1%-4.4%) and IgM in 9/1003 (0.9%; 95% CI 0.4%-1.7%) samples. In bivariate analysis, there was no significant difference in the prevalence of anti-HEV IgG with respect to gender and district of origin. Although not statistically significant, males had higher odds of having anti-HEV IgG than females (odds ratio [OR] = 2.86; 95% CI 0.95-8.64). All anti-HEV IgG positive individuals were people of Chinese descent. Anti-HEV IgG increased significantly with age, from 0.6% (95% CI 0.1%-2.6%) of 18-30-year-old donors to 7.4% (95% CI 2.7%-17.0%) of donors older than 50 years and was highest among non-professional workers (5.3%; 95% CI 2.5%-10.5%). Increasing age and a non-professional occupation remained significant predictors for anti-HEV IgG in the multivariable analysis. Screening of blood donations for HEV in Malaysia is important to safeguard the health of transfusion recipients. The higher rates of HEV infection in blood from older donors and donors who are non-professional workers may provide insights into targeted groups for blood screening.
  14. Al-Hatamleh MAI, Hatmal MM, Mustafa SHF, Alzu'bi M, AlSou'b AF, Abughanam SNS, et al.
    Infect Dis Poverty, 2022 Dec 13;11(1):123.
    PMID: 36510264 DOI: 10.1186/s40249-022-01047-y
    BACKGROUND: During the COVID-19 vaccination, the access to vaccines has been unequal among countries and individuals, for example low-income countries displayed significant low levels of vaccination. Furthermore, most refugees are living in developing low-income countries which struggling to access the essential health-care services including vaccination. Thus, the objective of this study was to assess the experiences and perceptions of COVID-19 infection and vaccination among Palestine refugees in Jerash camp compared to resident Jordanian citizens.

    METHODS: A face-to-face interview-based comparative cross-sectional study was carried out among Palestine refugees in Jerash camp located in northern Jordan and Jordanian citizens from different cities in Jordan from October, 2021 to March, 2022. A Chi-square test was used to determine the differences in the experiences and perceptions of COVID-19 infection and vaccination between Palestinian refugees and resident Jordanian citizens. Logistic regression analysis was performed to predict factors associated with the beliefs, barriers and hesitancy towards COVID-19 vaccines.

    RESULTS: The total number of participants was 992, with 501 (50.5%) Palestinian refugees and 491 (49.5%) Jordanian citizens. Most participants (64.1%) who have never been tested for COVID-19 were from the refugees (P n = 303) were from the refugees (P 

  15. Abdul Razak, S. Z., Abd. Rahman, N. A., Baharuddin, A. S., Mohd Amin, N. A., Mat Johari, A., Mohammad Parid, D.
    MyJurnal
    The present work aimed at obtaining the optimum combination of stabilisers used in an
    instant ice cream formulation. Instant ice cream mixes were formulated using milk protein,
    fat, sucrose, stabilisers, emulsifiers and water. A basic formulation for ice cream mix was
    prepared according to the process flow of instant ice cream. Three different stabilisers
    mixtures, which were carboxymethyl cellulose (CMC), carrageenan, and sodium alginate
    used in 14 formulations were studied using mixture design methodology. Physical analyses on
    meltdown rate, hardness, melted ice cream viscosity, and overrun were performed. The results
    were compared with those of commercial instant ice cream to determine the acceptability and
    quality of the final products. From the optimisation study, the recommended combination of
    stabilisers was found to be 0.151% CMC and 0.149% sodium alginate. The optimised sample
    had a higher viscosity of 0.17 Pa.s than the commercial one (0.16 Pa.s), which corresponded to
    higher hardness thus indicating slower melting rate, which is a good texture for ice cream. The
    overrun of the optimised sample was 108.33%, which is considered high. The high amount of
    air, viscosity, and hardness resulted in a low melting rate of 0.22 g/min, which is desirable for
    ice cream consumption. Based on sensory evaluation, the optimised instant ice cream was the
    most preferred by panellists as compared to commercial sample.
  16. Yusoff NM, Van Rostenberghe H, Shirakawa T, Nishiyama K, Amin N, Darus Z, et al.
    J Hum Genet, 2003;48(12):650-653.
    PMID: 14618420 DOI: 10.1007/s10038-003-0095-2
    Southeast Asian ovalocytosis (SAO) is a red blood cell abnormality common in malaria-endemic regions and caused by a 27 nt deletion of the band 3 protein gene. Since band 3 protein, also known as anion exchanger 1, is expressed in renal distal tubules, the incidence of SAO was examined in distal renal tubular acidosis (dRTA) in Malays in Kelantan, Malaysia. Twenty-two patients with dRTA and 50 healthy volunteers were examined for complication of SAO by both morphological and genetic analyses. SAO was identified in 18 of the 22 dRTA patients (81.8%), but only two of the 50 controls (4%). The incidence of SAO was significantly high in those with dRTA (p<0.001), indicating a dysfunctional role for band 3 protein/anion exchanger 1 in the development of dRTA.
  17. Lai CW, Samsudin NA, Low FW, Abd Samad NA, Lau KS, Chou PM, et al.
    Materials (Basel), 2020 Jun 03;13(11).
    PMID: 32503128 DOI: 10.3390/ma13112533
    In this present work, we report the deposition of cadmium selenide (CdSe) particles on titanium dioxide (TiO2) nanotube thin films, using the chemical bath deposition (CBD) method at low deposition temperatures ranging from 20 to 60 °C. The deposition temperature had an influence on the overall CdSe-TiO2 nanotube thin film morphologies, chemical composition, phase transition, and optical properties, which, in turn, influenced the photoelectrochemical performance of the samples that were investigated. All samples showed the presence of CdSe particles in the TiO2 nanotube thin film lattice structures with the cubic phase CdSe compound. The amount of CdSe loading on the TiO2 nanotube thin films were increased and tended to form agglomerates as a function of deposition temperature. Interestingly, a significant enhancement in photocurrent density was observed for the CdSe-TiO2 nanotube thin films deposited at 20 °C with a photocurrent density of 1.70 mA cm-2, which was 17% higher than the bare TiO2 nanotube thin films. This sample showed a clear surface morphology without any clogged nanotubes, leading to better ion diffusion, and, thus, an enhanced photocurrent density. Despite having the least CdSe loading on the TiO2 nanotube thin films, the CdSe-TiO2 nanotube thin films deposited at 20 °C showed the highest photocurrent density, which confirmed that a small amount of CdSe is enough to enhance the photoelectrochemical performance of the sample.
  18. Hasan AAQ, Alkahtani AA, Islam MA, Alsariera YA, Sathiswary S, Kassim NM, et al.
    Materials (Basel), 2022 Nov 15;15(22).
    PMID: 36431542 DOI: 10.3390/ma15228056
    Extensive research on fault diagnosis is essential to detect various faults that occur to different photovoltaic (PV) panels to keep PV systems operating at peak performance. Here, we present an impact analysis of potential induced degradation (PID) on the current-voltage (I-V) characteristics of crystalline silicon (c-Si) solar cells. The impact of parasitic resistances on solar cell performance is highlighted and linked to fault and degradation. Furthermore, a Simulink model for a single solar cell is proposed and used to estimate the I-V characteristics of a PID-affected PV cell based on experimental results attributes. The measured data show that the fill factor (FF) drops by approximately 13.7% from its initial value due to a decrease in shunt resistance (Rsh). Similarly, the simulation results find that the fill factor degraded by approximately 12% from its initial value. The slight increase in measured data could be due to series resistance effects which were assumed to be zero in the simulated data. This study links simulation and experimental work to confirm the I-V curve behavior of PID-affected PV cells, which could help to improve fault diagnosis methods.
  19. Mohamad IS, Doroody C, Alkharasani WM, Norizan MN, Chelvanathan P, Shahahmadi SA, et al.
    Materials (Basel), 2023 May 31;16(11).
    PMID: 37297240 DOI: 10.3390/ma16114106
    In this study, we investigated the pathways for integration of perovskite and silicon solar cells through variation of the properties of the interconnecting layer (ICL). The user-friendly computer simulation software wxAMPS was used to conduct the investigation. The simulation started with numerical inspection of the individual single junction sub-cell, and this was followed by performing an electrical and optical evaluation of monolithic 2T tandem PSC/Si, with variation of the thickness and bandgap of the interconnecting layer. The electrical performance of the monolithic crystalline silicon and CH3NH3PbI3 perovskite tandem configuration was observed to be the best with the insertion of a 50 nm thick (Eg ≥ 2.25 eV) interconnecting layer, which directly contributed to the optimum optical absorption coverage. These design parameters improved the optical absorption and current matching, while also enhancing the electrical performance of the tandem solar cell, which benefited the photovoltaic aspects through lowering the parasitic loss.
  20. Nisham Rosly H, Doroody C, Harif MN, Mohamad IS, Isah M, Amin N
    Materials (Basel), 2023 May 31;16(11).
    PMID: 37297242 DOI: 10.3390/ma16114108
    The effect of a nontoxic chloride treatment on the crystallinity and optoelectrical characteristics of a CdSe thin film was studied. A detailed comparative analysis was conducted utilizing four molarities (0.01 M, 0.10 M, 0.15 M, and 0.20 M) of indium (III) chloride (InCl3), where the results showed a notable improvement in CdSe properties. The crystallite size of treated CdSe samples increased from 31.845 nm to 38.819 nm, and the strain in treated films dropped from 4.9 × 10-3 to 4.0 × 10-3, according to XRD measurements. The highest crystallinity resulted from the 0.10 M InCl3-treated CdSe films. The In contents in the prepared samples were verified by compositional analysis, and FESEM images from treated CdSe thin films demonstrated compact and optimal grain arrangements with passivated grain boundaries, which are required for the development of a robust operational solar cell. The UV-Vis plot, similarly, showed that the samples were darkened after treatment and the band gap of 1.7 eV for the as-grown samples fell to roughly 1.5 eV. Furthermore, the Hall effect results suggested that the carrier concentration increased by one order of magnitude for samples treated with 0.10 M of InCl3, but the resistivity remained in the order of 103 ohm/cm2, suggesting that the indium treatment had no considerable effect on resistivity. Hence, despite the deficit in the optical results, samples treated at 0.10 M InCl3 showed promising characteristics as well as the viability of treatment with 0.10 M InCl3 as an alternative to standard CdCl2 treatment.
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