METHODS: A 5-year retrospective chart review was carried out at 2 university hospitals. All patients with acute blunt traumatic spinal or spinal cord injuries transported directly from the injury site to the hospital were entered. None of the 120 patients seen at the University of Malaya had spinal immobilization during transport, whereas all 334 patients seen at the University of New Mexico did. The 2 hospitals were comparable in physician training and clinical resources. Neurologic injuries were assigned to 2 categories, disabling or not disabling, by 2 physicians acting independently and blinded to the hospital of origin. Data were analyzed using multivariate logistic regression, with hospital location, patient age, gender, anatomic level of injury, and injury mechanism serving as explanatory variables.
RESULTS: There was less neurologic disability in the unimmobilized Malaysian patients (OR 2.03; 95% CI 1.03-3.99; p = 0.04). This corresponds to a <2% chance that immobilization has any beneficial effect. Results were similar when the analysis was limited to patients with cervical injuries (OR 1.52; 95% CI 0.64-3.62; p = 0.34).
CONCLUSION: Out-of-hospital immobilization has little or no effect on neurologic outcome in patients with blunt spinal injuries.
METHODS: The governing equations of fluid flow have been transformed in the form of ordinary differential equations. These equations have been solved by two methods namely, shooting method and three-stage Lobatto IIIa formula.
RESULTS: The effects of different parameters on temperature, velocity, concentration profiles, skin friction coefficient, Sherwood number, and reduced Nusselt number were obtained and presented graphically. It was noticed that four solutions existed at definite ranges of the parameters for high suction over both surfaces for the first time. The results of the stability analysis revealed that only the first solution is more stable and possess physical reliability compared to the remaining solutions.
CONCLUSION: The graphs also indicated that the fluid velocity decreases as the thermophoresis parameter increases but the opposite behavior observed for both temperature and concentration profiles in the first solution. Furthermore, it was detected that the concentration profile declined at the higher values of the Brownian motion parameter.
OBJECTIVE: This paper presents a machine learning-based approach for the automatic classification of regular and irregular capnogram segments.
METHODS: Herein, we proposed four time- and two frequency-domain features experimented with the support vector machine classifier through ten-fold cross-validation. MATLAB simulation was conducted on 100 regular and 100 irregular 15 s capnogram segments. Analysis of variance was performed to investigate the significance of the proposed features. Pearson's correlation was utilized to select the relatively most substantial ones, namely variance and the area under normalized magnitude spectrum. Classification performance, using these features, was evaluated against two feature sets in which either time- or frequency-domain features only were employed.
RESULTS: Results showed a classification accuracy of 86.5%, which outperformed the other cases by an average of 5.5%. The achieved specificity, sensitivity, and precision were 84%, 89% and 86.51%, respectively. The average execution time for feature extraction and classification per segment is only 36 ms.
CONCLUSION: The proposed approach can be integrated with capnography devices for real-time capnogram-based respiratory assessment. However, further research is recommended to enhance the classification performance.
METHODS: A ratio of 25:37:38 of POEs: external phase: surfactants (Tween 80:Span 20, in a ratio 80:20), respectively was selected as the basic composition for the production of a nanocream with ideal properties. Various nanocreams were prepared using phosphate-buffered saline as the external phase at three different pH values. The abilities of these formulae to deliver piroxicam were assessed in vitro using a Franz diffusion cell fitted with a cellulose acetate membrane and full thickness rat skin. These formulae were also evaluated in vivo by comparing their anti-inflammatory and analgesic activities with those of the currently marketed gel.
RESULTS: After eight hours, nearly 100% of drug was transferred through the artificial membrane from the prepared formula F3 (phosphate-buffered saline at pH 7.4 as the external phase) and the marketed gel. The steady-state flux through rat skin of all formulae tested was higher than that of the marketed gel. Pharmacodynamically, nanocream formula F3 exhibited the highest anti- inflammatory and analgesic effects as compared with the other formulae.
CONCLUSION: The nanocream containing the newly synthesized POEs was successful for trans-dermal delivery of piroxicam.