MyMedR

Fulltext Psychological Distress Among Infertile Women: Exploring Biopsychosocial Response To Infertility

Zuraida, A.S.

Malaysian Journal of Psychiatry, 2010;19(2):1-11.

MyJurnal

Previous studies have shown that the experience of infertility is linked with psychological responses such as depression, anxiety, guilt, social isolation, and decreased self-esteem in both men and women. The prevalence of depression among infertile women ranges from 8% to 54%. Treating gynecologists and healthcare professionals seldom recognized the psychosocial distress in women undergoing fertility treatment. Therefore this paper reviewed the bio-psychosocial response towards infertility among women with infertility.

Matched MeSH terms: Infertility, Female

Expression of ADR-α1, 2 and ADR-β2 in cumulus cell culture of infertile women with polycystic ovary syndrome and poor responder who are a candidate for IVF: the novel strategic role of clonidine in this expression

Zangeneh FZ, Bagheri M, Shoushtari MS, Naghizadeh MM

J Recept Signal Transduct Res, 2021 Jun;41(3):263-272.

PMID: 32878560 DOI: 10.1080/10799893.2020.1806320

OBJECTIVE: Alpha and beta-adrenoceptors (ADR-α1, 2, and β2) play a regulatory role in the folliculogenesis and steroidogenesis in the ovarian follicles. This study aimed to measure these adrenoceptors mRNA and its protein levels in cumulus cells (CCs) culture of poor ovarian reserve (POR) and polycystic ovarian syndrome (PCOS) infertile women (IVF candidate) and the effect of clonidine treatment at CCs culture.

METHODS: This case/control study was conducted in 2017 includes a control (donation oocytes) and two studies (PCO and POR) groups. The ovulation induction drugs were prescribed in all groups. After the oocyte puncture, the follicular fluid was collected and CCs were isolated were cultured. RNA was extracted and cDNA was synthesized and designed the primer for the ADR-α1, 2 and ADR-β2 gene expression. The protein levels were investigated by Western Blot.

RESULTS: The results showed a high level of three adrenergic expressions in PCO women compared to the control group (p-value

Matched MeSH terms: Infertility, Female

A pilot study to determine whether progestogen supplementation using dydrogesterone during the first trimester will reduce the incidence of gestational hypertension in primigravidae

Zainul Rashid MR, Lim JF, Nawawi NH, Luqman M, Zolkeplai MF, Rangkuty HS, et al.

Gynecol Endocrinol, 2014 Mar;30(3):217-20.

PMID: 24552449 DOI: 10.3109/09513590.2013.860960

Gestational hypertension (GH) remains one of the main causes of high maternal and perinatal morbidity and mortality worldwide with the highest incidence among primigravidae of about 10%-15%. However, it was noted that the incidence of GH in primigravidae who conceived following assisted reproductive technique (ART) or intrauterine insemination (IUI) supplemented with dydrogesterone during the first trimester was low.

Study site: Obstetrics and Gynecology
Department, Pusat Perubatan Universiti Kebangsaan Malaysia PPUKM

Matched MeSH terms: Infertility, Female/therapy

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial

Zain MM, Jamaluddin R, Ibrahim A, Norman RJ

Fertil. Steril., 2009 Feb;91(2):514-21.

PMID: 18321486 DOI: 10.1016/j.fertnstert.2007.12.002

To determine the first-line medication to be used in anovulatory patients with polycystic ovary syndrome (PCOS) for ovulation induction and pregnancy achievement.

Matched MeSH terms: Infertility, Female/ethnology; Infertility, Female/etiology; Infertility, Female/physiopathology; Infertility, Female/therapy*

Treatment of tubal occlusion by hydrotubation

Thambu JA

Med J Malaysia, 1978 Sep;33(1):4-6.

PMID: 750894

Matched MeSH terms: Infertility, Female/drug therapy

Fulltext Inhibition of progesterone secretion by oestradiol administered in the luteal phase of assisted conception cycles

Tay PYS, Lenton EA

Med J Malaysia, 2003 Jun;58(2):187-95.

PMID: 14569738

A prospective randomised study was done to assess the effect of supplemental oestradiol in addition to progesterone on the luteal steroid profiles and pregnancy outcome in stimulated cycles with and without pituitary down regulation. Women undergoing stimulated cycle IVF with GnRH-a and FSH (Group A, n = 63) or stimulated intrauterine insemination using CC and FSH (Group B, n = 55) were studied. These subjects were randomly allocated to receive either 400 mg daily of vaginally administrated Cyclogest (progesterone) alone or in combination with 2 mg daily of oral Oestradiol Valerate (E2V) during the luteal phase. Significant lower concentrations of plasma progesterone were observed in those subjects supplemented with both E2V and progesterone compared to those in whom progesterone only was given during the luteal phase (P < 0.05). Exogenous E2V had a minimal impact on plasma oestradiol concentrations and did not disguise the characterised mid luteal decline in oestradiol secretion. The suppressive effect of E2V on plasma progesterone was lost if implantation occurred normally because any small change in steroid concentrations was reversed by the rapidly increasing concentrations of HCG. Similar pregnancy rates were observed among subjects supplemented with or without oestradiol. The addition of oestradiol to the luteal supplement suppresses endogenous corpus luteum progesterone secretion irrespective of the type of assisted conception cycle and that its use is unlikely to be beneficial to the process of implantation.

Matched MeSH terms: Infertility, Female/blood; Infertility, Female/drug therapy*

Pelvic tuberculosis: an uncommon gynaecological problem in Malaysia

Sivanesaratnam V, Lim BH, Sivanesan S, Menon A

J Trop Med Hyg, 1986 Aug;89(4):167-9.

PMID: 3783810

Tuberculosis of the genital tract was diagnosed in only 12 patients during the 17 year period from March 1968 to February 1985 at the University Hospital, Kuala Lumpur, which serves as a major referral centre in Malaysia. The incidence was 0.31 per 1000 gynaecological admissions and the peak age incidence was in the age group 26 to 35 years. The surgical management was mainly conservative as infertility was the most frequent mode of presentation (50%). Evidence of previous pulmonary tuberculosis was present in only five cases. Adnexal adhesions were the commonest pelvic finding; the fallopian tubes and endometrium were affected with equal frequency. Positive cultures for Mycobacterium tuberculosis were obtained in only five of the 12 patients. All patients received combination anti-tuberculosis drugs with satisfactory response.

Matched MeSH terms: Infertility, Female/etiology

Fulltext Reproduction research and health: part III: fertility health

Sinnathuray TA

Med J Malaysia, 1980 Mar;34(3):307-13.

PMID: 7412671

The tremendous research advances in recent decades in the three widely used methods of fertility regulation (family planning), namely hormonal steroidal contraception, sterilisation and legal abortion, have been presented and discussed. The considerable health benefits accruing to the woman, in particular, and to the society, in general, from the practice of these fertility regulation methods. especially in the context of developing countries, have been reviewed. Recent research advances in the area of fertility augmentation (infertility management) have been presented and discussed. The manner in which some of the future trends in fertility regulation are likely to develop has been briefly stated.

Matched MeSH terms: Infertility, Female

Phases of female sexual response cycle among Malaysian women with infertility: a factor analysis study

Seen Heng Y, Sidi H, Nik Jaafar NR, Razali R, Ram H

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:50-4.

PMID: 23857837 DOI: 10.1111/appy.12044

This cross-sectional study aimed to determine the construct of the phases of the female sexual response cycle (SRC) among women attending an infertility clinic in a Malaysian tertiary center.

Matched MeSH terms: Infertility, Female/psychology*

Fulltext Salpingitis isthmica nodosa: review of four cases from the General Hospital, Kota Bharu

Sathyamoorthy P

Singapore Med J, 1994 Feb;35(1):65-6.

PMID: 8009284

Four cases of salpingitis isthmica nodosa diagnosed from a total of 82 hysterosalpingograms, over a period of three years at the General Hospital, Kota Bharu, were reviewed. The diagnosis was made based on the radiographic appearance of globules of contrast medium in the periluminal tissues which were in continuity with the lumen of the fallopian tubes. Three of these patients had ectopic pregnancy. Diagnosis of salpingitis isthmica nodosa which is readily demonstrated by hysterosalpingogram, is extremely important because of its impact on ectopic pregnancy rates. Hysterosalpingography is indicated following ectopic pregnancy to show whether there is diverticulosis of the contralateral tube. By such knowledge, optimal treatment can be offered to patients wishing to attempt further conception. As the disease is relatively localised it is amenable to resection with reimplantation of the distal portion of the tube.

Matched MeSH terms: Infertility, Female/radiography; Infertility, Female/surgery

Fulltext Chlamydial infection in asymptomatic infertile women

Rachagan SP, Ngeow YF

Med J Malaysia, 1990 Dec;45(4):298-303.

PMID: 2152050

Thirty-six asymptomatic infertile women undergoing laparoscopic examination as part of their infertility investigations, were included in this study on chlamydial infection. Patients were tested for chlamydial antigen in the cervix and peritoneal fluid. The serum of twenty-five of these patients was titrated for evidence of chlamydial antibodies. Fifty women attending a family planning clinic were used as a control group. The study showed a strong relationship between chlamydial infection and infertility due to tubal pathology. The incidence of chlamydial infection in asymptomatic infertile women was 33.3%. The results indicate that Chlamydia trachomatis should be sought in patients presenting with infertility and, if detected, appropriate medical treatment be given.

Matched MeSH terms: Infertility, Female/microbiology*

Certain aspects of hystero-salpingography

Peng LT, Fong TN

Med J Malaysia, 1975 Dec;30(2):121-6.

PMID: 1228377

Matched MeSH terms: Infertility, Female/diagnosis

Pyruvate reduces in vitro the embryotoxic effect of peritoneal fluid from infertile women with endometriosis

Noordin L, San GT, Singh HJ, Othman MS, Hafizah W

Eur J Obstet Gynecol Reprod Biol, 2008 Jan;136(1):67-73.

PMID: 18079036

To ascertain the embryotoxicity of peritoneal fluid from infertile women with endometriosis (PF-E), on mouse embryos in culture and to examine the effect of pyruvate in the culture medium on PF-E induced embryotoxicity.

Matched MeSH terms: Infertility, Female/etiology; Infertility, Female/physiopathology*

Genital tuberculosis: a new challenge in an old disease

Nissapatorn V

South. Med. J., 2008 Dec;101(12):1201.

PMID: 19005453 DOI: 10.1097/SMJ.0b013e318185a090

Matched MeSH terms: Infertility, Female/etiology*

Fulltext Clomid induced combined extrauterine and intrauterine pregnancy--a case report

Ng YT, Wong WP, Puraviappan AP

Med J Malaysia, 1983 Jun;38(2):150-2.

PMID: 6621446

A 23 year old Indian lady, gravida 1 para 0, with Clomid induced pregnancy was admitted to the University Hospital on 29 August 1981 with signs and symptoms of pregnancy and intraperitoneal bleed. Period ofamenorrhoea at time of admission was eight weeks. Emergency laparotomy revealed a right leaking ectopic pregnancy and an enlarged gravid uterus. Ultrasound done on the 7th post operative day confirmed concurrent intrauterine pregnancy which progressed normally to term, ending with a normal healthy baby at 39 weeks through an assisted breech delivery.

Matched MeSH terms: Infertility, Female/drug therapy

Fulltext The empty follicle syndrome

Ng SP, Jamil MA, Nurshaireen A, Zainul MR

Med J Malaysia, 2006 Oct;61(4):499-500.

PMID: 17243533 MyJurnal

The empty follicle syndrome (EFS) is a rare complication of in vitro fertilization (IVF) treatment, leading to cycle cancellation. Low human chorionic gonadotropin (hCG) bioavailability and ovarian dysfunction have been implicated with this condition. This case report illustrates a typical case of EFS and several strategies suggested to overcome this problem.

Matched MeSH terms: Infertility, Female/complications; Infertility, Female/therapy*

Fulltext Bromocriptine-induced pregnancies in the amenorrhoea-galactorrhoea syndrome

Mustaffa BE, Khalid BAK, Satgunasingam N, Adeeb N, Tan PL, Chandran S

Med J Malaysia, 1983 Sep;38(3):237-43.

PMID: 6672568

13 patients with the amenorrhoea-galactorrhoea syndrome who conceived during treatment with bromocriptine were reported. Mean period of amenorrhoea was 3.0 years. In ten patients galactorrhoea was noted for a mean period of 4.2 years while in three it was discovered during examination. Seven patients presented with primary infertility. Menses returned in all cases after a mean duration of 2 months of treatment with bromocriptine at an average dose of 5. 86 mg daily. Mean serum prolactin was 4344 mUll (range 750 mU/l to 23,000 mU/l) before treatment and this declined to 186 mU/l with treatment. Seven patients became pregnant 5 to 25 months of treatment while six conceived after first menses. 21 pregnancies resulted from the thirteen patients. There was one spontaneous abortion and one premature delivery in which the baby died. Of the 16 live- births, there were twelve girls and four boys and their mean birth-weight was 2932 g. All were normal at birth and during subsequent developments except one with congenital dislocation of hip. It is concluded that bromocriptine is effective in restoring menstrual cycles and fertility by lowering serum prolactin in patients with the amenorrhoea-galactorrhoea syndrome. Bromocriptine may be safe for use during pregnancy, but it is suggested that the medication should be stopped immediately after conception unless tumour growth is apparent.

Matched MeSH terms: Infertility, Female/drug therapy

Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients

Mustafa KB, Keane KN, Walz NL, Mitrovic KI, Hinchliffe PM, Yovich JL

Reprod Biol, 2017 Mar;17(1):34-41.

PMID: 27964842 DOI: 10.1016/j.repbio.2016.11.004

This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, ≤4 follicles (group E), the LBR was the lowest at 10.7%. The pregnancy loss rate (PLR) significantly increased with poorer AFC categories, from 21.8% in AFC group A (≥20 follicles), to 54.4% in AFC group E (p<0.0001). This trend was repeated with advancing age, from 21.6% for younger women (<35years), to 32.9, 48.5 and 100% for ages 35-39, 40-44 and ≥45 years, respectively (p<0.0001). However, LBR within the specific AFC group E cohort was also age-dependent and decreased significantly from 30.0% for <35 years old, to 13.3, 3.9 and 0% for patients aged 35-39, 40-44 and ≥45 years, respectively. Most, importantly, LBR rates within these age groups were not dependent on the number of IVF attempts (1st, 2nd, 3rd or ≥4 cycles), which indicated that cycle number should not be the primary deciding factor for cessation of IVF treatment in responding women <45years old.

Matched MeSH terms: Infertility, Female/diagnosis; Infertility, Female/therapy*

Fulltext Electrophoretic Techniques for the Detection of Human Microsatellite D19S884

Mansor F, Zamri L, Hamzah SS

Malays J Med Sci, 2015 Mar-Apr;22(2):18-24.

PMID: 26023291 MyJurnal

The detection and analysis of microsatellites is very important for the mapping of genetic diseases because they are commonly used as genetic markers. Microsatellite marker D19S884 has been associated with polycystic ovary syndrome (PCOS), the most common reproductive endocrine disease of women in their childbearing years. It is responsible for an estimated 70% of cases of anovulatory infertility. In this work, we detected microsatellites in DNA extracted from the blood of PCOS patients.

Matched MeSH terms: Infertility, Female

Review: Ajwa date (Phoenix dactylifera)- an emerging plant in pharmacological research

Mallhi TH, Qadir MI, Ali M, Ahmad B, Khan YH, Rehman A

Pak J Pharm Sci, 2014 May;27(3):607-16.

PMID: 24811825

Date Fruits are consumed in Arab areas for a long time as a part of essential diet. Phoenix dactylifera belongs to family Arecaceae and its leaves, barks, pits, fruits and pollens have anticancer, antioxidant, hepatoprotective, antidiabetic, antihypertensive, antiulcertavie, anti-inflammatory, antiproliferative, antimutagenic, antidiarheal, antibacterial, antifungal and antiviral potential. Besides these, Dates also increase level of estrogen, testosterone, RBCs, Hb, PCV, reticulocytes and platelet counts. It can also cure lead induced heamotoxicity, side effects of methylprednisolon, male and female infertility. It has also cerebroprotective, neuroprotective and haemopoietic activity. Phoenix dactylifera can be used for number of complications if further evaluated and isolated. The present paper is an overview of pharmacological properties of Phoenix dactylifera reported in literature.

Matched MeSH terms: Infertility, Female/drug therapy

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