MyMedR

A case of Stein-Leventhal syndrome complicated by large multiple fibromyomas

Fook CW

Med J Malaya, 1970 Jun;24(4):314-6.

PMID: 4248357

Matched MeSH terms: Leiomyoma/complications*

Fulltext A case report of pyomyoma: radiological diagnosis of a potentially fatal complication of uterine leiomyoma.

Mubarak, M.Y., Noordini, M.D.

International Medical Journal Malaysia, 2008;7(2):63-65.

MyJurnal

Pyomyoma (suppurative leiomyoma) is a rare complication of uterine leiomyoma. It results from infarction and infection of a leiomyoma. It may lead to diagnostic and therapeutic difficulties with potential complications such as bacteraemia, uterine rupture, compressive effect to adjacent structures and even death. We report a case of pyomyoma based on the Ultrasound (US) and Computed Tomography (CT) findings and literature review on the subject.

Matched MeSH terms: Leiomyoma

An oncological curiosity of a male patient with a huge leiomyoma of the terminal ileum

Zainudin S, Rajanthran SK, Azizan N, Hayati F, Ginawoi J, Suhaimi KA, et al.

Oxf Med Case Reports, 2020 Oct;2020(10):omaa086.

PMID: 33133619 DOI: 10.1093/omcr/omaa086

Leiomyoma is a smooth muscle tumour that can arise in any part of the body especially the uterus. Even though it is traditionally linked with hormonal influence, it can also develop in extrauterine organs with a slight female predominance. It is indistinguishable with gastrointestinal stromal tumour (GIST) histologically. We report a case of a 30-year-old gentleman who presented with a huge painful mass in the right iliac fossa. Computed tomography revealed a 10 × 10 cm homogeneous mass arising from the terminal ileum; he subsequently underwent an open right hemicolectomy. Histology showed a well-circumscribed lesion composed of interlacing bundles of smooth muscle fibres of the submucosa with positive smooth muscle actin and H-Caldesmon stains but negative for DOG-1 and CD117 (c-kit) stains which were consistent with leiomyoma. Despite its rarity, this hormone-related tumour needs to be considered regardless of gender. Immunohistochemistry is paramount as it is histologically identical to GIST.

Matched MeSH terms: Leiomyoma

Fulltext Antenatal myomectomy: is it safe?

Nor Amirawati, A., Anizah, A., Shafiee, M,N.

Journal of Surgical Academia, 2017;7(2):46-48.

MyJurnal

Myomectomy is rarely performed in pregnancy due to risk of miscarriage or pregnancy loss, bleeding and possible
hysterectomy. Myomectomy is mainly reserved for unavoidable indications such as rapidly growing fibroid or severe
pain with possiblity of red degeneration for which medical treatment failed. However, good outcome had been
reported in selective second trimester myomectomies.

Matched MeSH terms: Leiomyoma

Fulltext Anti-Uterine Fibroid Effect of Standardized Labisia Pumila Var. Alata Extracts In Vitro and in Human Uterine Fibroid Cancer Xenograft Model

Zakaria N, Mohd KS, Ahmed Saeed MA, Ahmed Hassan LE, Shafaei A, Al-Suede FSR, et al.

Asian Pac J Cancer Prev, 2020 Apr 01;21(4):943-951.

PMID: 32334454 DOI: 10.31557/APJCP.2020.21.4.943

BACKGROUND: Uterine fibroids are a common type of solid tumor presenting in women of reproductive age. There are very few alternative treatment available from conventional treatment involving surgeries. Labisia pumila var. alata or locally known as 'Kacip Fatimah' was widely used as traditional medicine in Malaysia. This plant has been used to maintain a healthy female reproductive system. The present study aimed to evaluate anti fibroid potential of L. pumila extracts through in vitro apoptosis activity against uterine leiomyoma cells (SK-UT-1) and in uterine leiomyoma xenograft model. Evaluation of bioactive markers content were also carried out.

METHODS: Apoptotic induction of the extracts was determined by morphological examination of AO/PI dual staining assay by flourescent microscopy and flow cytometry analysis on Annexin V-FITC/PI stained cells. In vivo study was done in immune-compromised mouse xenograft model. HPLC analysis was employed to quantify marker compounds.

RESULTS: Morphological analysis showed L. pumila induced apoptosis in a dose dependent manner against SK-UT-1 cells. In vivo study indicated that L. pumila significantly suppressed the growth of uterine fibroid tumor. All tested extracts contain bioactive marker of gallic acid and cafeic acid.

CONCLUSION: This work provide significant data of the potential of L. pumila in management of uterine fibroids.
.

Matched MeSH terms: Leiomyoma/drug therapy*; Leiomyoma/pathology

Atypical (symplastic) leiomyoma of the uterus--a case report

Siti-Aishah MA, Noriah O, Malini MN, Zainul-Rashid MR, Das S

Clin Ter, 2011;162(5):447-50.

PMID: 22041803

A 30-year-old, nulliparous woman presented with a history of subfertility. On examination she was found to have uterine fibroid of 28 weeks size of gravid uterus and subsequently laporatomy myomectomy was performed. Multilobulated masses, with diameters ranging from 22 mm to 160 mm were found. Cut sections of the lobulated masses showed whitish whorled cut surface. One of the multilobulated masses had a cystic cavity, measuring 60x50x35 mm(3). Light microscopic findings of the mass with the cystic cavity showed a well-circumscribed cellular tumour composed of cells exhibiting moderate nuclear atypia which were enlarged, nuclei with prominent chromatin clumping and were distributed in areas. Some tumour cells showed large nuclear pseudoinclusions, multinucleated or multilobated tumour giant cells, smudging and few enlarged nucleoli. Mitotic activity was 4 MFs per 10 HPFs. Occasional cells with intracytoplasmic inclusions resembling rhabdoid - like features were seen. There were no atypical mitoses or tumour necroses were noted. Diagnosis of atypical leiomyoma or symplastic leiomyoma was made. Atypical or symplastic leiomyomas are rare in the region of Malaysia and the present case discusses its incidence in younger age, its morphological features along with diagnosis and clinical outcome.

Matched MeSH terms: Leiomyoma/diagnosis; Leiomyoma/pathology*; Leiomyoma/surgery; Leiomyoma/chemistry

Fulltext Case report: Leiomyoma of the anterior abdominal wall

Ernest Ong CW, Siow SL

Med J Malaysia, 2016 04;71(2):81-2.

PMID: 27326950 MyJurnal

Leiomyomas are benign soft tissue swellings of smooth muscle origin, most commonly found in the uterus. Extra uterine leiomyomas presenting as an abdominal mass is often a diagnostic challenge as such occurrence is rare. We present a rare case of primary abdominal wall leiomyoma, and highlight the importance of laparoscopic approach in the diagnosis and treatment of such tumour.

Matched MeSH terms: Leiomyoma/diagnosis*

Concordance between hysteroscopic impression and endometrial histopathological diagnosis

Gan DE, Jawan RA, Moy FM

Prev Med, 2013;57 Suppl:S21-3.

PMID: 23313791 DOI: 10.1016/j.ypmed.2012.12.026

The aim of this study was to evaluate the accuracy of hysteroscopic impression for diagnosing benign and malignant endometrial pathology.

Matched MeSH terms: Leiomyoma/diagnosis; Leiomyoma/pathology

Congenital Midline Tongue Base Mass in An Infant: Lingual Hamartoma

Fadzilah N, Azman M, See GB

J Clin Diagn Res, 2016 Sep;10(9):MD01-MD03.

PMID: 27790477

Lingual hamartoma is a rare finding of congenital midline posterior tongue mass. The lesion may be seen as a single anomaly or maybe associated with syndrome especially the Oral Facial Digital Syndrome (OFDS). Here, we report an otherwise normal and healthy two-month-old boy with a congenital midline base of tongue mass presented with snoring and episodic vomiting since the age of 1 month. Tumour excision from the area of foramen of caecum recovered a pinkish pedunculated tumour. Histopathology examination confirmed the diagnosis of leiomyomatous lingual hamartoma. Differential diagnosis, especially for midline tongue mass and other paediatric tongue lesions are discussed. We also discuss the epidemiology, histopathologic features, treatment and prognosis of lingual hamartoma based on the literature review.

Matched MeSH terms: Leiomyoma

Fulltext Degenerated uterine fibroid mimicking hydrometra: fallacy in CT

Tok Ch, Bux S, Mohamed S, Lim B

Biomed Imaging Interv J, 2006 Oct;2(4):e42.

PMID: 21614328 MyJurnal DOI: 10.2349/biij.2.4.e42

Fibroids are the commonest uterine neoplasms, occurring in 20% - 30% of women of reproductive age. In women who have pelvic masses of unknown cause, unusual manifestations of fibroids such as necrosis or degeneration may simulate a carcinoma or hydrometra resulting in problems with image interpretation. We report a case of an unsuspected large degenerated uterine fibroid in a lady mistakenly diagnosed as hydrometra on computed tomography scanning.

Matched MeSH terms: Leiomyoma

Fulltext Fertility drugs and rapid growth of leiomyomata

Rachagan SP

Med J Malaysia, 1994 Dec;49(4):428.

PMID: 7674984

Matched MeSH terms: Leiomyoma/pathology*

Goserelin versus leuprolide before hysterectomy for uterine fibroids

Lim SS, Sockalingam JK, Tan PC

Int J Gynaecol Obstet, 2008 May;101(2):178-83.

PMID: 18164303 DOI: 10.1016/j.ijgo.2007.10.020

To compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri.

Matched MeSH terms: Leiomyoma/pathology; Leiomyoma/therapy*

Huge uterine fibroid in a postmenopausal woman associated with polycythaemia: a case report

Abdul Ghaffar NA, Ismail MP, Nik Mahmood NM, Daud K, Abu Dzarr GA

Maturitas, 2008 Jun 20;60(2):177-9.

PMID: 18482807 DOI: 10.1016/j.maturitas.2008.03.013

Uterine fibroid or leiomyoma is the commonest benign uterine tumour. Its occurrence in the postmenopausal age group is rare and if enlargement of the fibroid noted during this time, the diagnosis of leiomyosarcoma is provisional until proven otherwise. A case of a postmenopausal woman with a huge uterine fibroid associated with polycythaemia is presented whereby the mass was noted to increase in size within 2 years. The patient was otherwise well except for the growing uterine mass. She had venesection done to treat her polycythaemia and later underwent surgery for total abdominal hysterectomy and bilateral salpingoophoorectomy. The histopathology report confirmed leiomyoma of uterus with no evidence of sarcomatous changes. It was suggested that large uterine myoma may cause secondary polycythaemia by three postulated mechanisms, i.e. presence of hypoxia suggesting shunting within the tumour, second, the uterine fibroid was compressing the ureters resulting in inappropriate excessive production of erythropoietin by the kidneys, and third, the tumour itself may have been producing the erythropoietin.

Matched MeSH terms: Leiomyoma/complications*

Fulltext Improvement in Quality of Life after Myomectomy

Ehab Helmy Abdel Malek Fahmy, Constance Liew Sat Lin, Alvin Oliver Payus, Rhanye Mac Guad, May Zaw Soe, Satishratnam Nagaratnam, et al.

Borneo Journal of Medical Sciences, 2020;14(1):55-59.

MyJurnal

Dysmenorrhea is one of the leading causes of pelvic pain and menstrual disorder among women during childbearing age. The burden of dysmenorrhea is greater than any other gynaecological complaint. Some women have severe dysmenorrhea which renders them incapacitated for days each menstrual cycle requiring absence from study or duty, frequently requiring pain killer, restriction of daily performance, poor sleep, negative moods such as anxiety and depression. A 31-year-old female presented with severe dysmenorrhea and heavy menstrual bleeding (HMB) as a cause of multiple uterine fibroids, underwent surgeries to remove 100 fibroids from her uterus which has improved her quality of life, eliminating her dysmenorrhea and menstrual abnormalities

Matched MeSH terms: Leiomyoma

Fulltext Inadvertent posterior lower segment caesarean section in a sacculated uterus

Choong KH, Sivanesaratnam V, Sinnathuray TA

Med J Malaysia, 1981 Dec;36(4):250-3.

PMID: 7334964

Matched MeSH terms: Leiomyoma/diagnosis*; Leiomyoma/surgery

Fulltext Jejunojejunal intussusception secondary to inflammatory fibroid polyp: A rare cause of small bowel obstruction

Tan JS, Teah KM, Hoe VC, Khairuddin A, Sellapan H, Hayati F, et al.

Ann Med Surg (Lond), 2020 Nov;59:251-253.

PMID: 33088499 DOI: 10.1016/j.amsu.2020.10.009

Background: Adult intussusception is a relatively rare clinical entity. The majority of cases of intussusception in adults are due to a pathologic condition that serves as a lead point and requires surgery. Small bowel intussusception is usually caused by benign or malignant neoplasms appearing at the head of the invagination. Inflammatory fibroid polyp (IFP) of the small bowel is an unusual benign neoplastic lesion that has been rarely reported to cause intussusception, especially in the jejunum.

Case presentation: We present a rare case of adult intussusception who presented with a triad of intestinal obstruction. Computed tomography revealed small bowel intussusception with bowel ischemia. Intraoperatively, she required resection of the small bowel and primary anastomosis. Macroscopic examination revealed a single pedunculated polyp, which is the lead point of intestinal obstruction and confirmed histologically.

Conclusion: Inflammatory fibroid polyp should be considered as a cause of intussusception among adults with small bowel obstruction.

Matched MeSH terms: Leiomyoma

Laparoscopic transgastric resection of gastroduodenal intussusception due to gastric leiomyoma

Siow SL, Wong CM, Febra S, Goh RET

Med J Malaysia, 2020 09;75(5):609-611.

PMID: 32918440

Gastric leiomyoma of the antrum intussuscepted into first part of the duodenum is a rare complication. We report here an 80-year-old woman who presented at the Sarawak General Hospital, Kuching, Sarawak, Malaysia with early satiety and epigastric fullness for 3 months. She had no prior medical or surgical history other than an uneventful open cholecystectomy. Upper endoscopy showed a large submucosal mass in the first part of duodenum with pyloric converging gastric folds. Computed tomography scan of the abdomen showed a gastroduodenal intussusception with a 4x6cm mass at the junction between the first and second part of duodenum. Laparoscopic transgastric resection was performed. Histopathological examination of the resected specimen confirmed leiomyoma. She remained well at 43 months follow-up.

Matched MeSH terms: Leiomyoma/complications*; Leiomyoma/surgery*

Laparoscopic versus abdominal myomectomy: trend and pattern of practice among reproductive age population in Kedah, Malaysia

Ahmad MF, Sheng KL, Kathirgamanathan S, Kannaiah K

Minerva Ginecol, 2018 10;70(5):644-645.

PMID: 29464941 DOI: 10.23736/S0026-4784.18.04183-7

Matched MeSH terms: Leiomyoma/pathology; Leiomyoma/surgery*

Fulltext Large lower segment myoma--myomectomy at lower segment caesarean section--a report of two cases

Omar SZ, Sivanesaratnam V, Damodaran P

Singapore Med J, 1999 Feb;40(2):109-10.

PMID: 10414171

Uterine leiomyoma is found in approximately 2% of pregnant women. One in ten women will have complications related to myoma in pregnancy. Myomectomy during pregnancy especially at Caesarean section is much discouraged in the literature. We present here 2 cases of large uterine myoma, situated in the anterior aspect of the lower segment, complicating pregnancy at term. Myomectomy in both instances allowed delivery of the fetus through the lower segment, making vaginal delivery in subsequent pregnancies possible.

Matched MeSH terms: Leiomyoma/surgery*

Fulltext Leiomyoma of duodenum. A case report

Thambi Dorai CR, Johaidy S

Med J Malaysia, 1988 Mar;43(1):87-9.

PMID: 3244327

Matched MeSH terms: Leiomyoma*

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