Displaying publications 221 - 240 of 963 in total

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  1. Disseminated sporotrichosis in a patient with a past history of lepromatous leprosy: a case report
    Wong SM, Tang JJ
    Med Mycol, 2012 May;50(4):404-6.
    PMID: 22074310 DOI: 10.3109/13693786.2011.630684
    Disseminated sporotrichosis is uncommon and usually occurs in patients who are immunodeficient. Here we describe a male patient who was otherwise in good physical condition, who presented with disseminated sporotrichosis. The only significant event in his past medical history was lepromatous leprosy which had been treated 42 years earlier.
    Matched MeSH terms: Skin/pathology
  2. Antibiotic Irrigation: A Promising Unconventional Method for Facial Carbuncle
    Ng JJ, Gendeh H, Ong HY, Gopalan S, Abdul Karaf JH
    Cureus, 2021 Apr 27;13(4):e14710.
    PMID: 34079672 DOI: 10.7759/cureus.14710
    Carbuncle is conventionally treated with combinations of intravenous antibiotics and surgical intervention; be it saucerization or incision and drainage. Cosmesis outcome might be unfavorable following surgical intervention, especially when the facial region is involved. Skin grafting surgery may even be needed as a second-stage procedure for a larger wound. We reported a series of three facial carbuncles treated successfully with a new improvised method. Our method includes performing a stab incision prior to draining of pus, coupled with minimal wound debridement, followed by regular irrigation of the wound with antibiotics containing solution. Based on the three cases reported in this article, we conclude that this method is more superior as there is more skin preservation, better patient tolerance, shorter hospital stays, and favorable cosmesis outcome.
    Matched MeSH terms: Skin; Skin Transplantation
  3. Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs
    Sengupta P, Chatterjee B
    Int J Pharm, 2017 Jun 30;526(1-2):353-365.
    PMID: 28461261 DOI: 10.1016/j.ijpharm.2017.04.068
    The Nanoemulgel drug delivery system is a formulation related intervention to improve the systemic delivery and therapeutic profile of lipophilic drugs. Nanoemulgel is an amalgamated formulation of two different systems in which nanoemulsion containing drug is incorporated into a gel base. The fusion of the two systems makes this formulation advantageous in several ways. Lipophilic drugs can be easily incorporated and the skin permeability of the incorporated drugs can be enhanced in several folds due to the finely distributed droplets of nanoemulsion phase. As a result, the pharmacokinetic and pharmacodynamic profiles of the lipophilic drugs are improved significantly. An increasing trend in topical nanoemulgel use in recent years has been noticed because of the better acceptability of the preparation to the patients due to their noninvasive delivery, avoidance of gastrointestinal side effects, easier applicability and good therapeutic and safety profile. Despite of having few limitations, nanoemulgel formulation can be considered as a potential and promising candidates for topical delivery of lipophilic drugs in the future. The aim of this review is to evaluate and report the current potential and future scope of nanoemulgel formulation for becoming an effective delivery system for poorly water soluble drugs. In this review, we have summarized and discussed the outcome of different studies on permeability, pharmacokinetic, pharmacodynamic and safety profile of the drugs delivered topically through nanoemulgel. Rationality of use along with the major challenges to overcome for nanoemulgel formulation has been discussed.
    Matched MeSH terms: Skin Absorption*
  4. Fulltext Retrospective descriptive study of patients with dermatological problems, at UMS Polyclinic, Kingfisher, Kota Kinabalu, Sabah. [Abstract]
    Khaing MS, Parash MTH, Shimmi SC, Kabir S, Chodanakar NC, Subramaniam P, et al.
    Malaysian Journal of Medicine and Health Sciences, 2019;15(106):89-89.
    MyJurnal
    ABSTRACTS FOR THE 1ST INTERNATIONAL BORNEO HEALTHCARE AND PUBLIC HEALTH CONFERENCE AND 4TH BORNEO TROPICAL MEDICINE AND INFECTIOUS DISEASE CONGRESS. New Frontiers in Health: Expecting the Unexpected; Held at the Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia; On 3rd-5th September 2019
    Introduction: Since January 2010, the UMS Polyclinic, situated at Riverside Plaza, Kingfisher Park, Kota Kinabalu, Sabah, provided general medical consultation as well as specialist consultations comprising of Internal Medicine, Endocrinology (Diabetes and related problems), Dermatology, Rheumatology, Cardiology including ECG and ECHO services, Orthopedic, Ophthalmology, ENT (Ear, Nose and Throat), Obstetrics and Gynecology, Pediatrics and Psychiatry. The purpose of this study was to look into the Dermatology consultations provided by the UMS Polyclinic in order to improve health care services, by reporting on the demographic characteristics of the patients with reference to the provisional diagnosis and management offered, as well as referrals to tertiary health care centers for further managements. Methods: It was a retrospective, descriptive study which included 76 patients who visited the Dermatology Specialist Clinic at UMS Polyclinic from January to December 2018.
    Results: The 76 patients comprised of 50 males and 26 female patients with the age ranged from 2 years to 86 years, with 5 children (under the age of 12 years).The catchment population of the patients were mainly from Universiti Malaysia Sabah, Kingfisher, and also from wide areas of Kota Kinabalu with a few from Kudat,Tamparuli, Telipok, Keningau, Kinarut and Beaufort, etc. The consultations comprised of 19 varieties of dermatological problems to which were given appropraite management. The period of the year 2018 under study showed highest attendance in February with 21 patients (27.6%) followed by 13 patients (17.1%) in October with December showing 11 patients (14.5% ).
    Conclusion: A total of 32 varieties of Dermatological problems were found among the 76 patients consulted. Acne Vulgaris was found to be the highest variant with 12 cases(15.7%) with Seborrhoeic Dermatitis seen as 5 cases (6.5%) followed by 4 cases (5.2%) each of Contact Dermatitis, Allergy/Hypersensitivity, Photosensitive Dermatitis, and Vitiligo. Certain patients had to be referred to Dermatology Department at Hospital Queen Elizabeth for further management, like for skin biopsy, and also for Electro-cautery machine, Phototherapy, and Laser, as we are still waiting for few equipments.
    Matched MeSH terms: Skin Diseases*
  5. A comparative study between xerographic, computer-assisted overlay generation and animated-superimposition methods in bite mark analyses
    Tai MW, Chong ZF, Asif MK, Rahmat RA, Nambiar P
    Leg Med (Tokyo), 2016 Sep;22:42-8.
    PMID: 27591538 DOI: 10.1016/j.legalmed.2016.07.009
    This study was to compare the suitability and precision of xerographic and computer-assisted methods for bite mark investigations. Eleven subjects were asked to bite on their forearm and the bite marks were photographically recorded. Alginate impressions of the subjects' dentition were taken and their casts were made using dental stone. The overlays generated by xerographic method were obtained by photocopying the subjects' casts and the incisal edge outlines were then transferred on a transparent sheet. The bite mark images were imported into Adobe Photoshop® software and printed to life-size. The bite mark analyses using xerographically generated overlays were done by comparing an overlay to the corresponding printed bite mark images manually. In computer-assisted method, the subjects' casts were scanned into Adobe Photoshop®. The bite mark analyses using computer-assisted overlay generation were done by matching an overlay and the corresponding bite mark images digitally using Adobe Photoshop®. Another comparison method was superimposing the cast images with corresponding bite mark images employing the Adobe Photoshop® CS6 and GIF-Animator©. A score with a range of 0-3 was given during analysis to each precision-determining criterion and the score was increased with better matching. The Kruskal Wallis H test showed significant difference between the three sets of data (H=18.761, p<0.05). In conclusion, bite mark analysis using the computer-assisted animated-superimposition method was the most accurate, followed by the computer-assisted overlay generation and lastly the xerographic method. The superior precision contributed by digital method is discernible despite the human skin being a poor recording medium of bite marks.
    Matched MeSH terms: Skin*
  6. Primary mucocutaneous histoplasmosis
    Dutt AK, Garai BK
    Med J Malaya, 1970 Mar;24(3):231-3.
    PMID: 4246808
    Matched MeSH terms: Skin Diseases/diagnosis*
  7. A report of the incidence of positive tuberculosis skin test reactors and the incidence of active Tuberculosis among school children in the Methodist schools, Kapit district, Sarawak, Malaysia
    Warren G
    Med J Malaya, 1965 Dec;20(2):123-5.
    PMID: 4221972
    Matched MeSH terms: Skin Tests*
  8. A subcutaneous retro-auricular abscess in a Dyak boy in Sarawak, probably caused by a trematode of the genus Poikilorchis, Fain and Vandepitte, 1957
    LIE KJ, WILLIAMS HI, MIYAZAKI I, WONG SK
    Med J Malaya, 1962 Sep;17:37-40.
    PMID: 13930508
    Matched MeSH terms: Skin Diseases*
  9. Two interesting skin conditions in children
    PAUL FM
    Med J Malaya, 1958 Mar;12(3):540-5.
    PMID: 13565025
    Matched MeSH terms: Skin Diseases*
  10. Lichen planus: variations in Indians
    Adam BA
    Med J Malaysia, 1973 Jun;27(4):284-8.
    PMID: 4270787
    Matched MeSH terms: Skin/pathology
  11. THE ISOLATION OF HISTOPLASMA CAPSULATUM FROM A PATIENT IN A CHEST HOSPITAL
    PONNAMPALAM JT
    Med J Malaysia, 1964 Mar;18:201-4.
    PMID: 14157186
    Matched MeSH terms: Skin Tests*
  12. Polymeric nanoparticles for topical delivery of alpha and beta arbutin: preparation and characterization
    Ayumi NS, Sahudin S, Hussain Z, Hussain M, Samah NHA
    Drug Deliv Transl Res, 2019 04;9(2):482-496.
    PMID: 29569027 DOI: 10.1007/s13346-018-0508-6
    To investigate the use of chitosan nanoparticles (CS-TPP-NPs) as carriers for α- and β-arbutin. In this study, CS-TPP-NPs containing α- and β-arbutin were prepared via the ionic cross-linking of CS and TPP and characterized for particle size, zeta potential, and dispersity index. The entrapment efficiency and loading capacity of various β-arbutin concentrations (0.1, 0.2, 0.4, 0.5, and 0.6%) were also investigated. SEM, TEM FTIR, DSC and TGA analyses of the nanoparticles were performed to further characterize the nanoparticles. Finally, stability and release studies were undertaken to ascertain further the suitability of the nanoparticles as a carrier system for α- and β-arbutin. Data obtained clearly indicates the potential for use of CS-TPP-NPs as a carrier for the delivery of α- and β-arbutin. The size obtained for the alpha nanoparticles (α-arbutin CSNPs) ranges from 147 to 274 d.nm, with an increase in size with increasing alpha arbutin concentration. β-arbutin nanoparticles (β-arbutin CSNPs) size range was from 211.1 to 284 dn.m. PdI for all nanoparticles remained between 0.2-0.3 while the zeta potential was between 41.6-52.1 mV. The optimum encapsulation efficiency and loading capacity for 0.4% α-arbutin CSNPs were 71 and 77%, respectively. As for β-arbutin, CSNP optimum encapsulation efficiency and loading capacity for 0.4% concentration were 68 and 74%, respectively. Scanning electron microscopy for α-arbutin CSNPs showed a more spherical shape compared to β-arbutin CSNPs where rod-shaped particles were observed. However, under transmission electron microscopy, the shapes of both α- and β-arbutin CSNP nanoparticles were spherical. The crystal phase identification of the studied samples was carried out using X-ray diffraction (XRD), and the XRD of both α and β-arbutin CSNPs showed to be more crystalline in comparison to their free form. FTIR spectra showed intense characteristic peaks of chitosan appearing at 3438.3 cm-1 (-OH stretching), 2912 cm-1 (-CH stretching), represented 1598.01 cm-1 (-NH2) for both nanoparticles. Stability studies conducted for 90 days revealed that both α- and β-arbutin CSNPs were stable in solution. Finally, release studies of both α- and β-arbutin CSNPs showed a significantly higher percentage release in comparison to α- and β-arbutin in their free form. Chitosan nanoparticles demonstrate considerable promise as a carrier system for α- and β-arbutin, the use of which is anticipated to improve delivery of arbutin through the skin, in order to improve its efficacy as a whitening agent.
    Matched MeSH terms: Skin Lightening Preparations/chemistry*
  13. Dermatofibrosarcoma protuberans of the scalp: therapeutic challenges
    Kanesen D, Zakaria Z, Ch'ng ES, Nandrajog P, Kandasamy R
    ANZ J Surg, 2019 03;89(3):261-264.
    PMID: 28513108 DOI: 10.1111/ans.14040
    Matched MeSH terms: Skin Neoplasms/surgery*
  14. The AirCirc: design and development of a thermal management prototype device for below-knee prosthesis leg socket
    Nurhanisah MH, Jawaid M, Ahmad Azmeer R, Paridah MT
    Disabil Rehabil Assist Technol, 2019 07;14(5):513-520.
    PMID: 29933703 DOI: 10.1080/17483107.2018.1479782
    This study describes a newly developed prosthetic leg socket design for a below-knee amputation. Excessive heat and the resulted perspiration within a prosthetic socket were the most common causes for reporting a reduced quality of life for prosthetic users. The product namely AirCirc means air circulation and it has been designed by approach of medical device design process in providing the amputees to maintain the skin temperature inside the socket. This device has been designed to provide the amputees with comfort and ultimate breathable. In order to design the device, the small hole was made in prosthetic socket surface since it has a function as air circulation. Four types of proposed sockets namely P1, P2, P3 and P4 and one control socket were compared on a single patient to determine the best design of prosthetic socket. The result successfully reveals that by using holes can be maintain the temperature inside prosthetic socket. In addition to the eco-friendly material, the woven kenaf was used as material that provides good strength as compared to glass fibre and offer sustainable and biodegradable product yet provides unique and aesthetic surface as came from woven kenaf itself. The objective of this paper is to provide the airflow prosthetic socket design and optimize the use of natural fibre in prostheses field. Thus, with the use of the environmental friendly material, functionality device and heat removal capability make the device suitable for maintaining a comfortable and healthy environment for prosthesis. Implications of Rehabilitation Newly developed prosthetic leg socket design for a below-knee amputation Device has been designed to provide the amputees with comfort and ultimate breathable Woven kenaf was used as material that provides good strength as compared to glass fibre for sustainable and biodegradable product Results show that by using holes can be maintain the temperature inside prosthetic socket.
    Matched MeSH terms: Skin Temperature*
  15. Fulltext A case of pustular psoriasis in a young boy
    Meera Kuppusamy, Tarita Taib
    Journal of Clinical and Health Sciences, 2017;2(1):39-42.
    MyJurnal
    We report a case of a 13-year-old boy who presented with acute onset of generalised erythematous skin and patchy areas of pustules for one week duration. He was well until one month ago when he started having small scaly plaques on his scalp and extensors of his legs. During the acute episode, he also had joint pain and bilateral conjunctivitis. Skin biopsy confirmed pustular psoriasis. He developed leucocytosis and transaminitis during the acute phase of the pustular eruption while on acitretin, which was then withheld. Subsequently, treatment with oral cyclosporine induced remission of his skin and joint disease. The case is hereby reported because of rarity of presentation and clinical features. Oral cyclosporine should be considered in patients with generalised pustular psoriasis complicated with transaminitis.
    Matched MeSH terms: Skin; Skin Diseases, Vesiculobullous
  16. Outcome of the Modified Meek Technique in the Management of Major Pediatric Burns
    Lee SZ, Halim AS, Wan Sulaiman WA, Mat Saad AZ
    Ann Plast Surg, 2018 09;81(3):295-301.
    PMID: 29994880 DOI: 10.1097/SAP.0000000000001565
    INTRODUCTION: The modified Meek micrografting technique has been used in the treatment of severely burned patients and a number of articles have examined the use of the modified Meek technique in adults and in mixed-age groups. However, there is a paucity of research pertaining to the outcome in the pediatric age group. The aim of this study is to present our favorable outcome in pediatric major burns using the modified Meek technique.

    METHODS: A retrospective review of burn cases in Hospital Universiti Sains Malaysia from 2010 to 2015 was conducted. Cases of major burns among pediatric patients grafted using the Meek technique were examined.

    RESULTS: Twelve patients were grafted using the Meek technique. Ten (91.7%) patients were male, whereas 2 (8.3%) were female. The average age of patients was 6 years (range, 2-11 years). The average total body surface area was 35.4% (range, 15%-75%). Most burn mechanisms were due to flame injury (66.7%) as compared with scalds injury (16.7%) and chemical injury (16.7%). There was no mortality. All patients were completely grafted with a good donor site scar. The average graft take rate was 82.3%, although 8 cases had positive tissue cultures from the Meek-grafted areas. The average follow-up duration was 3.6 years (range, 1.1-6.7 years). Only 1 case developed contracture over minor joint.

    CONCLUSIONS: The Meek technique is useful when there is a paucity of donor site in the pediatric group. The graft take is good, contracture formation is low, and this technique is cost-effective.

    Matched MeSH terms: Skin Transplantation/methods*
  17. Atypical Presentation of Pyogenic Granuloma of the Right Index Finger: A Rare Case Report
    Tan LS, Daud MH, Nasirudin N
    J Hand Surg Asian Pac Vol, 2018 Dec;23(4):577-580.
    PMID: 30428790 DOI: 10.1142/S2424835518720335
    Pyogenic granuloma, also known as lobular capillary hemangioma, is a benign vascular lesion of the skin or mucous membrane with rapid growth or repetitive trauma. Rarely seen in adult, its management varies and surgical intervention is usually common. We report a case of pyogenic granuloma of the right index finger in a 46-year-old gentleman who presented with painless swelling of the right index finger after a trivial injury. Wedge biopsy confirmed the diagnosis and excision of the granuloma measuring 3 cm × 3 cm × 2 cm was done with curettage and electrocautery over the base of granuloma. The wound subsequently healed well with good functional and aesthetic outcome.
    Matched MeSH terms: Skin/pathology*
  18. Anticipating local flaps closed-form solution on 3D face models using finite element method
    Kwan Z, Khairu Najhan NN, Yau YH, Luximon Y, M Nor F
    Int J Numer Method Biomed Eng, 2020 11;36(11):e3390.
    PMID: 32735083 DOI: 10.1002/cnm.3390
    A realistic three-dimensional (3D) computational model of skin flap closures using Asian-like head templates from two different genders, male and female, has been developed. The current study aimed to understand the biomechanics of the local flap designs along with the effect of wound closures on the respective genders. Two Asian head templates from opposite genders were obtained to use as base models. A third-order Yeoh hyperelastic model was adapted to characterize as skin material properties. A single layer composed of combined epidermis and dermis was considered, and the models were thickened according to respective anatomical positions. Each model gender was excised with a fixed defect size which was consequently covered by three different local flap designs, namely advancement, rotation, and rhomboid flaps. Post-operative simulation presented various scenarios of skin flap closures. Rotation and rhomboid flaps demonstrated maximal tension at the apex of the flap for both genders as well as advancement flap in the female face model. However, advancement flap closure in the male face model was presented otherwise. Yet, the deformation patterns and the peak tension of the discussed flaps were consistent with conventional local flap surgery. Moreover, male face models generated higher stresses compared to the female face models with a 70.34% mean difference. Overall, the skin flap operations were executed manually, and the designed surgery model met the objectives successfully while acknowledging the study limitations. NOVELTY FILE: 3D head templates were considered to address the gap as 3D face models were uncommonly employed in understanding the biomechanics of the local flaps realistically. Most of the existing studies focus on the 2D and 3D planar geometry in their models. As gender comparison has yet to be addressed, we intended to fill this gap by exploring the stress contours of the local flap designs in different genders. Create a 3D face model from two opposite genders which is capable of simulating closure of wounds using local flaps with a focus on advancement, rotation, and rhomboid flaps.
    Matched MeSH terms: Skin Transplantation*
  19. Familial lichen amyloidosis. Report of 19 cases in 4 generations of a Chinese family in Malaysia
    Rajagopalan K, Tay CH
    Br J Dermatol, 1972 Aug;87(2):123-9.
    PMID: 5057380 DOI: 10.1111/j.1365-2133.1972.tb16186.x
    Matched MeSH terms: Skin Diseases/genetics*
  20. Fulltext Leonine facies
    Low QJ, Cheo SW, Yap WYE
    Indian J Dermatol Venereol Leprol, 2020 2 19;87(4):589-591.
    PMID: 32068196 DOI: 10.4103/ijdvl.IJDVL_983_18
    Matched MeSH terms: Skin Diseases, Genetic/pathology*
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