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Fulltext Health innovations in patient decision support: Bridging the gaps and challenges

Ng CJ, Lee YK, Lee PY, Abdullah KL

Australas Med J, 2013;6(2):95-9.
PMID: 23483776 DOI: 10.4066/AMJ.2013.1655

Patient decision aids (PDAs) help to support patients in making an informed and value-based decision. Despite advancement in decision support technologies over the past 30 years, most PDAs are still inaccessible and few address individual needs. Health innovation may provide a solution to bridge these gaps. Information and computer technology provide a platform to incorporate individual profiles and needs into PDAs, making the decision support more personalised. Health innovation may enhance accessibility by using mobile, tablet and Internet technologies; make risk communication more interactive; and identify patient values more effectively. In addition, using databases to capture patient data and the usage of PDAs can help: developers to improve PDAs' design; clinicians to facilitate the decisionmaking process more effectively; and policy makers to make shared decision making more feasible and cost-effective. Health innovation may hold the key to advancing PDAs by creating a more personalised and effective decision support tool for patients making healthcare decisions.

Matched MeSH terms: Communication
Bedside teaching in undergraduate medical education: issues, strategies, and new models for better preparation of new generation doctors

Salam A, Siraj HH, Mohamad N, Das S, Rabeya Y

Iran J Med Sci, 2011 Mar;36(1):1-6.
PMID: 23365470

Bedside teaching is a vital component of medical education. It is applicable to any situation where teaching is imparted in the presence of patients. In teaching in the patients' presence, learners have the opportunities to use all of their senses and learn the humanistic aspect of medicine such as role modeling, which is vital but difficult to communicate in words. Unfortunately, bedside teaching has been on the decline. To investigate the reasons for the decline in bedside teaching, its importance and its revival, a review of literature was carried out using PubMed and other data bases. The review revealed that the major concerns of bedside teaching were time constraint, false preceptors' concern about patients' comfort, short stay of patients in hospitals, learner distraction by technology, lack of experience and unrealistic faculty expectation. Whatsoever the reasons, bedside teaching cannot be replaced with anything else. There are newer approaches of effective bedside teaching, and the core focus of all such approaches is educational process. A bedside teacher must learn how to involve patients and learners in the educational processes. Moreover, bedside teaching is the process through which learners acquire the skills of communication by asking patients' permission, establishing ground rules, setting time limit, introducing the team, diagnosing learner, diagnosing patient, conducting focused teaching, using simple language, asking patient if there is any question, closing with encouraging thanks, and giving feedback privately. It is most important to ensure a comfortable environment for all participants, the learner, the patient and the bedside teacher. Ongoing faculty development programs on educational processes and realistic faculty expectations may overcome the problems.

Matched MeSH terms: Communication
Fulltext Psychology in action: Social media communication, CSR, and consumer behavior management in banking

Liu Y, Naveed RT, Kanwal S, Tahir Khan M, Dalain AF, Lan W

PLoS One, 2023;18(8):e0289281.
PMID: 37590276 DOI: 10.1371/journal.pone.0289281

In today's digitally interconnected world, social media emerges as a powerful tool, offering different opportunities for modern businesses. Not only do organizations use social media for marketing purposes, but they also endeavor to influence consumer psychology and behavior. Although prior studies indicate social media's efficacy in disseminating corporate social responsibility (CSR) communications, there remains a dearth of research addressing the impact of CSR-related messaging from banks on consumers' brand advocacy behavior (CBAB). Our study seeks to bridge this gap, exploring the CSR-CBAB relationship within the banking sector of an emerging economy. Additionally, we investigate the roles of consumers' emotions and values in mediating and moderating their CBAB, introducing two mediating factors, consumer happiness (HP) and admiration (BRAD), and moderating variable altruistic values (ATVL). Data collection involved an adapted questionnaire targeting banking consumers. The structural analysis revealed a positive correlation between a bank's CSR-related social media communications and CBAB. HP and BRAD were identified as mediators in this relationship, while ATVL emerged as a moderator. These findings hold significant theoretical and practical implications. For instance, our research highlights the indispensable role of social media in effectively conveying CSR-related information to banking consumers, subsequently enhancing their advocacy intentions.

Matched MeSH terms: Communication
Fulltext Smart Wireless Sensor Technology for Healthcare Monitoring System Using Cognitive Radio Networks

Jabeen T, Jabeen I, Ashraf H, Ullah A, Jhanjhi NZ, Ghoniem RM, et al.

Sensors (Basel), 2023 Jul 02;23(13).
PMID: 37447952 DOI: 10.3390/s23136104

Programmable Object Interfaces are increasingly intriguing researchers because of their broader applications, especially in the medical field. In a Wireless Body Area Network (WBAN), for example, patients' health can be monitored using clinical nano sensors. Exchanging such sensitive data requires a high level of security and protection against attacks. To that end, the literature is rich with security schemes that include the advanced encryption standard, secure hashing algorithm, and digital signatures that aim to secure the data exchange. However, such schemes elevate the time complexity, rendering the data transmission slower. Cognitive radio technology with a medical body area network system involves communication links between WBAN gateways, server and nano sensors, which renders the entire system vulnerable to security attacks. In this paper, a novel DNA-based encryption technique is proposed to secure medical data sharing between sensing devices and central repositories. It has less computational time throughout authentication, encryption, and decryption. Our analysis of experimental attack scenarios shows that our technique is better than its counterparts.

Matched MeSH terms: Computer Communication Networks
Fulltext Influence of communication determinants on safety commitment in a high-risk workplace: a systematic literature review of four communication dimensions

Zara J, Nordin SM, Isha ASN

Front Public Health, 2023;11:1225995.
PMID: 37614453 DOI: 10.3389/fpubh.2023.1225995

Health, safety, and environment (HSE) are critical aspects of any industry, particularly in high-risk environments, such as the oil and gas industry. Continuous accident reports indicate the requirement for the effective implementation of safety rules, regulations, and practices. This systematic literature review examines the relationship between safety communication and safety commitment in high-risk workplaces, specifically focusing on the oil and gas industry. The review comprises 1,439 articles from 2004 to 2023, retrieved from the Scopus and Web of Science databases following the PRISMA comprehensive guidelines. This study considers safety communication, communication climate, and communication satisfaction to evaluate their influence on safety commitment under occupational health and safety. This study identifies safety commitment issues and their underlying factors, discussing measures for preventing and reducing accidents and incidents and highlighting preventive measures for future research. It also signifies the variables influencing accident and incident rates. The research underscores the importance of communication dimensions and the need for workers to possess adequate skills, knowledge, and attitudes regarding occupational safety and health procedures. Moreover, the study contributes to the industrial and academic domains by improving organizational safety commitment, promoting a safety culture, and developing effective communication strategies. Furthermore, practitioners may benefit from this comprehensive overview in developing, evaluating, and enhancing occupational safety.

Matched MeSH terms: Communication
Fulltext The effects of negative social media connotations on subjective wellbeing of an ageing population: A stressor-strain-outcome perspective

Zolkepli IA, Tariq R, Isawasan P, Shamugam L, Mustafa H

PLoS One, 2024;19(1):e0296973.
PMID: 38289938 DOI: 10.1371/journal.pone.0296973

In recent years, users' privacy concerns and reluctance to use have posed a challenge for the social media and wellbeing of its users. There is a paucity of research on elderly users' negative connotations of social media and the way these connotations contribute to developing passive behaviour towards social media use, which, in turn, affects subjective wellbeing. To address this research vacuum we employed the stressor-strain-outcome (SSO) approach to describe the evolution of passive social media use behaviour from the perspective of communication overload, complexity, and privacy. We conceptualized subjective wellbeing as a combination of three components-negative feelings, positive feelings, and life satisfaction. Negative and positive feelings were used to derive an overall affect balance score that fluctuates between 'unhappiest possible' and 'happiest possible'. The proposed research framework was empirically validated through 399 valid responses from elderly social media users. Our findings reveal that communication overload and complexity raise privacy concerns among social media users, which leads to passive usage of social media. This passive social media use improved the subjective wellbeing favourably by lowering negative feelings and raising positive feelings and life satisfaction. The findings also revealed that respondents' overall affect balance leans towards positive feelings as a consequence of passive social media use. This study contributes to the field of technostress by illuminating how the SSO perspective aid the comprehension of the way passive social media use influences the subjective wellbeing of its users.

Matched MeSH terms: Communication
Fulltext Whole-Genome Sequences of Five Oligotrophic Bacteria Isolated from Deep within Lechuguilla Cave, New Mexico

Gan HY, Gan HM, Tarasco AM, Busairi NI, Barton HA, Hudson AO, et al.

Genome Announc, 2014;2(6).
PMID: 25377711 DOI: 10.1128/genomeA.01133-14

Here, we report the whole-genome sequences and annotation of five oligotrophic bacteria from two sites within the Lechuguilla Cave in the Carlsbad Caverns National Park, NM. Three of the five genomes contain an acyl-homoserine lactone signal synthase ortholog (luxI) that is involved in cell-to-cell communication via quorum sensing.

Matched MeSH terms: Cell Communication
Interactions of pre-symbolic children with developmental disabilities with their mothers and siblings

Singh SJ, Iacono T, Gray KM

Int J Lang Commun Disord, 2015 Mar-Apr;50(2):202-14.
PMID: 25585674 DOI: 10.1111/1460-6984.12128

Depending on the severity of their disabilities, children with Down syndrome (DS) and with cerebral palsy (CP) may remain pre-symbolic for prolonged periods of time. When interacting with pre-symbolic children, communication partners have a role in identifying which of their behaviours are communicative, to be able to respond to those behaviours and maintain reciprocal interaction. To date, most research on these children's communication development has been conducted within the context of mother-child interaction. Seldom have they been observed interacting with other family members, and in interactions other than dyadic, despite these interactions also occurring daily.

Matched MeSH terms: Communication Disorders/diagnosis*; Communication Disorders/psychology*; Communication Disorders/therapy
Fulltext A comprehensive study of data collection schemes using mobile sinks in wireless sensor networks

Khan AW, Abdullah AH, Anisi MH, Bangash JI

Sensors (Basel), 2014 Feb 05;14(2):2510-48.
PMID: 24504107 DOI: 10.3390/s140202510

Recently sink mobility has been exploited in numerous schemes to prolong the lifetime of wireless sensor networks (WSNs). Contrary to traditional WSNs where sensory data from sensor field is ultimately sent to a static sink, mobile sink-based approaches alleviate energy-holes issues thereby facilitating balanced energy consumption among nodes. In mobility scenarios, nodes need to keep track of the latest location of mobile sinks for data delivery. However, frequent propagation of sink topological updates undermines the energy conservation goal and therefore should be controlled. Furthermore, controlled propagation of sinks' topological updates affects the performance of routing strategies thereby increasing data delivery latency and reducing packet delivery ratios. This paper presents a taxonomy of various data collection/dissemination schemes that exploit sink mobility. Based on how sink mobility is exploited in the sensor field, we classify existing schemes into three classes, namely path constrained, path unconstrained, and controlled sink mobility-based schemes. We also organize existing schemes based on their primary goals and provide a comparative study to aid readers in selecting the appropriate scheme in accordance with their particular intended applications and network dynamics. Finally, we conclude our discussion with the identification of some unresolved issues in pursuit of data delivery to a mobile sink.

Matched MeSH terms: Computer Communication Networks
Fulltext FSM-F: Finite State Machine Based Framework for Denial of Service and Intrusion Detection in MANET

N Ahmed M, Abdullah AH, Kaiwartya O

PLoS One, 2016;11(6):e0156885.
PMID: 27285146 DOI: 10.1371/journal.pone.0156885

Due to the continuous advancements in wireless communication in terms of quality of communication and affordability of the technology, the application area of Mobile Adhoc Networks (MANETs) significantly growing particularly in military and disaster management. Considering the sensitivity of the application areas, security in terms of detection of Denial of Service (DoS) and intrusion has become prime concern in research and development in the area. The security systems suggested in the past has state recognition problem where the system is not able to accurately identify the actual state of the network nodes due to the absence of clear definition of states of the nodes. In this context, this paper proposes a framework based on Finite State Machine (FSM) for denial of service and intrusion detection in MANETs. In particular, an Interruption Detection system for Adhoc On-demand Distance Vector (ID-AODV) protocol is presented based on finite state machine. The packet dropping and sequence number attacks are closely investigated and detection systems for both types of attacks are designed. The major functional modules of ID-AODV includes network monitoring system, finite state machine and attack detection model. Simulations are carried out in network simulator NS-2 to evaluate the performance of the proposed framework. A comparative evaluation of the performance is also performed with the state-of-the-art techniques: RIDAN and AODV. The performance evaluations attest the benefits of proposed framework in terms of providing better security for denial of service and intrusion detection attacks.

Matched MeSH terms: Communication
Fulltext Mapping national information and communication technology (ICT) infrastructure to the requirements of potential digital health interventions in low- and middle-income countries

Hui CY, Abdulla A, Ahmed Z, Goel H, Monsur Habib GM, Teck Hock T, et al.

J Glob Health, 2022 Dec 29;12:04094.
PMID: 36579436 DOI: 10.7189/jogh.12.04094

BACKGROUND: Digital health can support health care in low- and middle-income countries (LMICs) by overcoming problems of distance, poor infrastructure and the need to provide community practitioners with specialist support. We used five RESPIRE countries as exemplars (Bangladesh, India, Indonesia, Malaysia, Pakistan) to identify the digital health solutions that are valuable in their local setting, worked together with local clinicians and researchers to explore digital health policy, electricity/ICT infrastructure, and socio-cultural factors influencing users' ability to access, adopt and utilise digital health.
METHODS: We adopted the Joanna Briggs Institute's scoping review protocol and followed the Cochrane Rapid Review method to accelerate the review process, using the Implementation and Operation of Mobile Health projects framework and The Extended Technology Acceptance Model of Mobile Telephony to categorise the results. We conducted the review in four stages: (1) establishing value, (2) identifying digital health policy, (3) searching for evidence of infrastructure, design, and end-user adoption, (4) local input to interpret relevance and adoption factors. We used open-source national/international statistics such as the World Health Organization, International Telecommunication Union, Groupe Speciale Mobile, and local news/articles/government statistics to scope the current status, and systematically searched five databases for locally relevant exemplars.
RESULTS: We found 118 studies (2015-2021) and 114 supplementary online news articles and national statistics. Digital health policy was available in all countries, but scarce skilled labour, lack of legislation/interoperability support, and interrupted electricity and internet services were limitations. Older patients, women and those living in rural areas were least likely to have access to ICT infrastructure. Renewable energy has potential in enabling digital health care. Low usage mobile data and voice service packages are relatively affordable options for mHealth in the five countries.
CONCLUSIONS: Effective implementation of digital health technologies requires a supportive policy, stable electricity infrastructures, affordable mobile internet service, and good understanding of the socio-economic context in order to tailor the intervention such that it functional, accessible, feasible, user-friendly and trusted by the target users. We suggest a checklist of contextual factors that developers of digital health initiatives in LMICs should consider at an early stage in the development process.

Matched MeSH terms: Communication
The use of technology in vaccine safety communication: A systematic review of randomised controlled trials

Panickar R, Aziz Z, Mohd Sani N, Kamarulzaman A

Patient Educ Couns, 2023 Jul;112:107707.
PMID: 36989861 DOI: 10.1016/j.pec.2023.107707

OBJECTIVES: To identify technologies used in vaccine safety communication and evaluate their impact on vaccination intention, uptake, knowledge, attitude, and perceptions of consumers.
METHODS: We searched 6 electronic databases to identify randomised controlled trials assessing the impact of using technology in vaccine safety communication. The Cochrane Collaboration's tool for assessing risk of bias was used to evaluate each study.
RESULTS: We included 22 studies involving 27,109 participants from 8 countries; 15 studies assessed the use of videos and 7 examined innovative technologies. Using videos significantly improved knowledge (n = 3) and participant engagement (n = 2) compared to printed material. Among the innovative technologies, the use of virtual reality, and smartphone applications incorporating social networking or gamification significantly increased vaccination knowledge, confidence, and engagement. The studies showed that narrative messaging increased perceived disease severity (n = 2) and vaccination intention (n = 2).
CONCLUSIONS: While the use of innovative technologies is increasing, videos currently remain the most popular technology for vaccine safety communication. Communication technology, particularly with narrative messaging, improves patient engagement and comprehension.
PRACTICE IMPLICATIONS: Health authorities should increase focus on using videos and smartphone applications for vaccine safety communication. Collaboration among stakeholders is essential to develop guidelines on effective message content to complement the technology.

Matched MeSH terms: Communication
Occupational therapy interventions in promoting social communication skills among children with autism spectrum disorder: A scoping review

Rhaman N, A Rahman P

Med J Malaysia, 2024 Mar;79(Suppl 1):187-196.
PMID: 38555904

INTRODUCTION: Children with Autism Spectrum Disorder (ASD) often face significant challenges in verbal communication, social interaction, and exhibit repetitive behavioral patterns. These challenges persist across various developmental stages, particularly impacting their social communication abilities. This scoping review aims to explore the range of occupational therapy interventions that are employed to enhance social communication skills in children with ASD.
MATERIALS AND METHODS: A literature search was conducted independently on scientific databases: Scopus, Google Scholar, Science Direct, and Web of Science (WOS). The process was carried out according to the PRISMA guidelines.
RESULT: Of the 195 studies identified, 8 articles involving 185 participants, aged 17 months to 12 years old, across six countries met the inclusion criteria. The majority of studies indicate significant improvement in social communication abilities, while one study demonstrates insignificant results and another study presents mixed outcomes, utilising two different assessment tools.
CONCLUSION: Occupational therapy has showed promise in improving social communication in children with ASD. Nonetheless, this review emphasises the need for greater indepth study and long-term evaluation to better explain and sustain these benefits. More research is needed to develop OT interventions that are both effective and evidence-based.

Matched MeSH terms: Communication
Fulltext The impact of radiofrequency exposure on Aedes aegypti (Diptera: Culicidae) development

Nik Abdull Halim NMH, Mohd Jamili AF, Che Dom N, Abd Rahman NH, Jamal Kareem Z, Dapari R

PLoS One, 2024;19(2):e0298738.
PMID: 38412167 DOI: 10.1371/journal.pone.0298738

INTRODUCTION: Wireless communication connects billions of people worldwide, relying on radiofrequency electromagnetic fields (RF-EMF). Generally, fifth-generation (5G) networks shift RF carriers to higher frequencies. Although radio, cell phones, and television have benefitted humans for decades, higher carrier frequencies can present potential health risks. Insects closely associated with humans (such as mosquitoes) can undergo increased RF absorption and dielectric heating. This process inadvertently impacts the insects' behaviour, morphology, and physiology, which can influence their spread. Therefore, this study examined the impact of RF exposure on Ae. aegypti mosquitoes, which are prevalent in indoor environments with higher RF exposure risk. The morphologies of Ae. aegypti eggs and their developments into Ae. aegypti mosquitoes were investigated.
METHODS: A total of 30 eggs were exposed to RF radiation at three frequencies: baseline, 900 MHz, and 18 GHz. Each frequency was tested in triplicate. Several parameters were assessed through daily observations in an insectarium, including hatching responses, development times, larval numbers, and pupation periods until the emergence of adult insects.
RESULTS: This study revealed that the hatching rate for the 900 MHz group was the highest (79 ± 10.54%) compared to other exposures (p = 0.87). The adult emergence rate for the 900 MHz group was also the lowest at 33 ± 2.77%. A significant difference between the groups was demonstrated in the statistical analysis (p = 0.03).
CONCLUSION: This work highlighted the morphology sensitivity of Ae. aegypti eggs and their developments in the aquatic phase to RF radiation, potentially altering their life cycle.

Matched MeSH terms: Communication
Communication methods between physicians and Deaf patients: A scoping review

Yet AXJ, Hapuhinne V, Eu W, Chong EY, Palanisamy UD

Patient Educ Couns, 2022 Sep;105(9):2841-2849.
PMID: 35577636 DOI: 10.1016/j.pec.2022.05.001

OBJECTIVE: Deaf individuals often face communication challenges within healthcare settings. Given the importance of the role played by physicians in shaping patients' health outcomes, it is paramount to explore Deaf patient-physician interactions. This research aims to explore (1) the existing communication support and (2) the factors influencing its usage in medical consultations with Deaf patients.
METHODS: A scoping review was carried out and adhered to the Preferred Reporting System for Meta-Analysis. A comprehensive search strategy of four databases; PubMed, Medline, CINAHL Plus and Scopus, from January 2011 to June 2021 was applied. Thematic analysis was used to analyse the data.
RESULTS: Ten journal articles were included, and four themes were identified; patient experiences using communication methods, practitioners' cultural competence in Deaf culture, inherent challenges of communication methods, and extrinsic factors. Professional interpreters are often regarded as the preferred modality of communication but writing and lip-reading were commonly used in healthcare settings, with video remote interpreting the least common.
CONCLUSION: Healthcare professionals need to appreciate the heterogeneity of Deaf patients and their communication methods and adopt a more person-centred approach.
PRACTICE IMPLICATIONS: This review provides up-to-date insight on Deaf patient-physician interactions and provisional recommendations for practice, education and policy.

Matched MeSH terms: Communication
Fulltext Social Media in the Urology Practice | Opinion: NO

Da Silva RD, Leow JJ, Abidin ZA, Linden-Castro E, Castro EIB, Blanco LT, et al.

Int Braz J Urol, 2019 10 19;45(5):882-888.
PMID: 31626517 DOI: 10.1590/S1677-5538.IBJU.2019.05.04
Matched MeSH terms: Health Communication/methods; Health Communication/trends
Fulltext A model for online interactive remote education for medical physics using the Internet

Woo MK, Ng KH

J Med Internet Res, 2003 Jan-Mar;5(1):e3.
PMID: 12746208

Medical physics is a relatively small community but it spans great geographical distances, usually with a scarcity of experts whose expertise could greatly benefit students entering into the field. In addition there are many software systems for which an interactive education method would be most advantageous.

Matched MeSH terms: Computer Communication Networks/economics; Computer Communication Networks/trends
Fulltext Implementation of Building Information Modelling (BIM) in Malaysia: A review

Nuzul Azam Haron, Raja Putri Zarifh Ana Raja Soh, Aizul Nahar Harun

Pertanika Journal of Science & Technology, 2017;25(3):661-674.
MyJurnal

This paper seeks to clarify Building Information Modelling (BIM) and its implementation in Malaysia.
Most developed countries that have implemented BIM in the construction industry have found it effective. This paper reviews existing literature on the implementation of BIM and examines the implementation strategies that have been developed. The review highlights numerous advantages of BIM in construction, which include, among others, reducing cost, time, carbon burden and capital cost. BIM can also help increase broader efficiencies and improve coordination and communication between each party. However, implementing BIM is complicated and requires efforts from both the government and the private sector. While the implementation of BIM may reduce costs in developed countries, it may not do so in developing countries; in Malaysia, for instance, costs act as an initial barrier. Other obstacles to implementing BIM in Malaysia include application system requirements and lack of knowledge and readiness to change. To facilitate its implementation in the construction industry, the Malaysian government needs to hold seminars to promote a better understanding of BIM. They may also introduce a properly structured BIM course by preparing a standard code of practices and guidelines for BIM in the education sector.

Matched MeSH terms: Communication
Fulltext Language Mapping in Awake Surgery: Report of Two Cases with Review of Language Networks

Lim LH, Idris Z, Reza F, Wan Hassan WMN, Mukmin LA, Abdullah JM

Asian J Neurosurg, 2018 4 24;13(2):507-513.
PMID: 29682074 DOI: 10.4103/ajns.AJNS_176_16

The role of language in communication plays a crucial role in human development and function. In patients who have a surgical lesion at the functional language areas, surgery should be intricately planned to avoid incurring further morbidity. This normally requires extensive functional and anatomical mappings of the brain to identify regions that are involved in language processing and production. In our case report, regions of the brain that are important for language functions were studied before surgery by employing (a) extraoperative methods such as functional magnetic resonance imaging, transmagnetic stimulation, and magnetoencephalography; (b) during the surgery by utilizing intraoperative awake surgical methods such as an intraoperative electrical stimulation; and (c) a two-stage surgery, in which electrical stimulation and first mapping are made thoroughly in the ward before second remapping during surgery. The extraoperative methods before surgery can guide the neurosurgeon to localize the functional language regions and tracts preoperatively. This will be confirmed using single-stage intraoperative electrical brain stimulation during surgery or a two-stage electrical brain stimulation before and during surgery. Here, we describe two cases in whom one has a superficial lesion and another a deep-seated lesion at language-related regions, in which language mapping was done to preserve its function. Additional review on the neuroanatomy of language regions, language network, and its impairment was also described.

Matched MeSH terms: Communication
Fulltext Influence of out-of-field photon beam radiotherapy to the cancer cell survival

Raizulnasuha Ab Rashid, Nurhikmah Azam, Norhayati Dollah, Wan Nordiana W Abd Rahman

Jurnal Sains Nuklear Malaysia, 2018;30(2):47-56.
MyJurnal

The purpose of the study was to determine the effect of out-of-field photon beams radiotherapy to the cancer cell survival. In this study, HeLa and T24 cancer cells were irradiated with 6 MV and 10 MV photon beams in two different conditions, one with intercellular communication with the in-field cell and one without the communication. Cells survival was determined by clonogenic assay. In the presence of intercellular communication, the cell death was increased which indicate the presence of radiation induced bystander effects (RIBE). The effects were also dependent on the cell types and photon energy where the HeLa cells exhibit less survival compares to T24 cells and the effects were prominent at higher photon energy. This study demonstrates that the out-of-field cells in conjunction with RIBE plays important roles in the cells response towards megavoltage photon beam radiation therapy.

Matched MeSH terms: Cell Communication

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