Displaying publications 21 - 40 of 337 in total

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  1. Corrosion and surface modification on biocompatible metals: A review
    Asri RIM, Harun WSW, Samykano M, Lah NAC, Ghani SAC, Tarlochan F, et al.
    Mater Sci Eng C Mater Biol Appl, 2017 Aug 01;77:1261-1274.
    PMID: 28532004 DOI: 10.1016/j.msec.2017.04.102
    Corrosion prevention in biomaterials has become crucial particularly to overcome inflammation and allergic reactions caused by the biomaterials' implants towards the human body. When these metal implants contacted with fluidic environments such as bloodstream and tissue of the body, most of them became mutually highly antagonistic and subsequently promotes corrosion. Biocompatible implants are typically made up of metallic, ceramic, composite and polymers. The present paper specifically focuses on biocompatible metals which favorably used as implants such as 316L stainless steel, cobalt-chromium-molybdenum, pure titanium and titanium-based alloys. This article also takes a close look at the effect of corrosion towards the implant and human body and the mechanism to improve it. Due to this corrosion delinquent, several surface modification techniques have been used to improve the corrosion behavior of biocompatible metals such as deposition of the coating, development of passivation oxide layer and ion beam surface modification. Apart from that, surface texturing methods such as plasma spraying, chemical etching, blasting, electropolishing, and laser treatment which used to improve corrosion behavior are also discussed in detail. Introduction of surface modifications to biocompatible metals is considered as a "best solution" so far to enhanced corrosion resistance performance; besides achieving superior biocompatibility and promoting osseointegration of biocompatible metals and alloys.
    Matched MeSH terms: Biocompatible Materials*
  2. Recent advances of thermal properties of sugar palm lignocellulosic fibre reinforced polymer composites
    Asyraf MRM, Ishak MR, Norrrahim MNF, Nurazzi NM, Shazleen SS, Ilyas RA, et al.
    Int J Biol Macromol, 2021 Dec 15;193(Pt B):1587-1599.
    PMID: 34740691 DOI: 10.1016/j.ijbiomac.2021.10.221
    Biocomposites are materials that are easy to manufacture and environmentally friendly. Sugar palm fibre (SPF) is considered to be an emerging reinforcement candidate that could provide improved mechanical stiffness and strength to the biocomposites. Numerous studies have been recently conducted on sugar palm biocomposites to evaluate their physical, mechanical and thermal properties in various conditions. Sugar palm biocomposites are currently limited to the applications of traditional household products despite their good thermal stability as a prospective substitute candidate for synthetic fibres. Thus, thermal analysis methods such as TGA and DTG are functioned to determine the thermal properties of single fibre sugar palm composites (SPCs) in thermoset and thermoplastic matrix as well as hybrid SPCs. The biocomposites showed a remarkable change considering thermal stability by varying the individual fibre compositions and surface treatments and adding fillers and coupling agents. However, literature that summarises the thermal properties of sugar palm biocomposites is unavailable. Particularly, this comprehensive review paper aims to guide all composite engineers, designers, manufacturers and users on the selection of suitable biopolymers for sugar palm biocomposites for thermal applications, such as heat shields and engine components.
    Matched MeSH terms: Biocompatible Materials/chemistry*
  3. Efficacy and bone-contact biocompatibility of glass ionomer cement as a biomaterial for bone regeneration: A systematic review
    Tuygunov N, Zakaria MN, Yahya NA, Abdul Aziz A, Cahyanto A
    J Mech Behav Biomed Mater, 2023 Oct;146:106099.
    PMID: 37660446 DOI: 10.1016/j.jmbbm.2023.106099
    Bone regeneration is a rapidly growing field that seeks to develop new biomaterials to regenerate bone defects. Conventional bone graft materials have limitations, such as limited availability, complication, and rejection. Glass ionomer cement (GIC) is a biomaterial with the potential for bone regeneration due to its bone-contact biocompatibility, ease of use, and cost-effectiveness. GIC is a two-component material that adheres to the bone and releases ions that promote bone growth and mineralization. A systematic literature search was conducted using PubMed-MEDLINE, Scopus, and Web of Science databases and registered in the PROSPERO database to determine the evidence regarding the efficacy and bone-contact biocompatibility of GIC as bone cement. Out of 3715 initial results, thirteen studies were included in the qualitative synthesis. Two tools were employed in evaluating the Risk of Bias (RoB): the QUIN tool for assessing in vitro studies and SYRCLE for in vivo. The results indicate that GIC has demonstrated the ability to adhere to bone and promote bone growth. Establishing a chemical bond occurs at the interface between the GIC and the mineral phase of bone. This interaction allows the GIC to exhibit osteoconductive properties and promote the growth of bone tissue. GIC's bone-contact biocompatibility, ease of preparation, and cost-effectiveness make it a promising alternative to conventional bone grafts. However, further research is required to fully evaluate the potential application of GIC in bone regeneration. The findings hold implications for advancing material development in identifying the optimal composition and fabrication of GIC as a bone repair material.
    Matched MeSH terms: Biocompatible Materials/pharmacology
  4. Fulltext Analysis of machining pit by using electrical discharge machine die sinking
    Md Razak Daud, Wan Nor Shela Ezwane Wan Jusoh, Syahrullail Samion
    Journal of Engineering and Science Research, 2018;2(6):63-67.
    MyJurnal
    This study investigates metal removal rate (MRR) of the biomaterial by using discharge machine Neuar CNC A50 Electrical Discharge Machine Die Sinking (EDM DS). The purpose of this study is to compare machining curvature cup for material SKD 11 and stainless steel with shape curvature cup acetabular. The result showed that electrode wear is higher when high current is applied. For each applied current 0.5A and 3.0A could result electrode wear of 0.236 mm, 0.246 mm and 0.269 mm respectively. Mean time of complete discharged for each pit with 0.3mm depth with supply 0. 5A is 6.51 minutes; 1. 5A is 3.54 minutes and 3A is 1.52 minutes. The biggest mean parameter of the pit is 0.356 mm, with 3A of current is applied. From this study, it can be concluded that low current set may give lower electrode copper wear. The experiment will help a researcher to discharge biomaterial types of metal with small size of copper electrode use of EDM DS Neuar for discharge multi hole or micro pit.
    Matched MeSH terms: Biocompatible Materials
  5. Fulltext Biomedical and Microbiological Applications of Bio-Based Porous Materials: A Review
    Udenni Gunathilake TMS, Ching YC, Ching KY, Chuah CH, Abdullah LC
    Polymers (Basel), 2017 Apr 29;9(5).
    PMID: 30970839 DOI: 10.3390/polym9050160
    Extensive employment of biomaterials in the areas of biomedical and microbiological applications is considered to be of prime importance. As expected, oil based polymer materials were gradually replaced by natural or synthetic biopolymers due to their well-known intrinsic characteristics such as biodegradability, non-toxicity and biocompatibility. Literature on this subject was found to be expanding, especially in the areas of biomedical and microbiological applications. Introduction of porosity into a biomaterial broadens the scope of applications. In addition, increased porosity can have a beneficial effect for the applications which exploit their exceptional ability of loading, retaining and releasing of fluids. Different applications require a unique set of pore characteristics in the biopolymer matrix. Various pore morphologies have different characteristics and contribute different performances to the biopolymer matrix. Fabrication methods for bio-based porous materials more related to the choice of material. By choosing the appropriate combination of fabrication technique and biomaterial employment, one can obtain tunable pore characteristic to fulfill the requirements of desired application. In our previous review, we described the literature related to biopolymers and fabrication techniques of porous materials. This paper we will focus on the biomedical and microbiological applications of bio-based porous materials.
    Matched MeSH terms: Biocompatible Materials
  6. Review on characteristics of biomaterial and nanomaterials based polymeric nanocomposite membranes for seawater treatment application
    S E, G A, A F I, P S G, Y LT
    Environ Res, 2021 06;197:111177.
    PMID: 33864792 DOI: 10.1016/j.envres.2021.111177
    Membrane technology, especially nanofiltration (NF) has great attention to provide an imperative solution for water issues. The membrane is considered to be the heart in the separation plant. Understanding the membrane characteristics could allow predicting and optimizing the membrane performance namely flux, rejection and reduced fouling. The membrane development using biomaterials and nanomaterials provides a remarkable opportunity in the water application. This review focuses on the membrane characteristics of biomaterials and nanomaterials based nanofiltration. In this review, recent researches based on biomaterials and nanomaterials loaded membrane for salt rejection have been analyzed. Membrane fouling depends on the membrane characteristics and this review defined fouling as a ubiquitous bottleneck challenge that hampers the NF blooming applications. Fouling mitigation strategies via membrane modification using biomaterial (chitosan, curcumin and vanillin) and various other nanomaterials are critically reviewed. This review also highlights the membrane cleaning and focuses on concentrates disposal methods with zero liquid discharge system for resource recovery. Finally, the conclusion and future prospects of membrane technology are discussed. From this current review, it is apparent that the biomaterial and various other nanomaterials acquire exclusive properties that facilitate membrane advancement with improved capability for water treatment. Regardless of membrane material developments, still exist considerable difficulties in membrane commercialization. Thus, additional studies related to this field are needed to produce membranes with better performance for large‒scale applications.
    Matched MeSH terms: Biocompatible Materials
  7. Fulltext Dental Implants : Biomaterial, Biomechanical And Biological Considerations.
    Isa, Z.M., Hobkirk, J.A.
    Ann Dent, 2000;7(1):-.
    MyJurnal
    Currently many dental implant systems with varied and numerous components are available commercially, and with new implant systems and designs emerging, it is essential that the user understands that any system selected should be based on sound scientific principles and capable of osseoil!tegration. This has been defined in many different ways, with biomaterial, biological and biomechanical factors being the main considerations. The final restoration is based on both biological tissue and mechanical components. As the success of osseointegration is based on the clinical outcome, clinicians must ensure that the stresses that the superstructure, implant, and surrounding bone are subjected to are within the tolerable limits of the various components, even though the degree of tolerance has not yet been fully defined.
    Matched MeSH terms: Biocompatible Materials
  8. Fulltext In-situ high temperature XRD analysis of synthesized calcium phosphate biomaterial using DEHPA as the starting material
    Meor Yusoff Meor Sulaiman, Masliana Muslimin
    Journal of Nuclear and Related Technologies, 2009;2009(1):51-56.
    MyJurnal
    A process to produce calcium phosphate biomaterial was done using an organic based diethylhexyl phosphoric acid (DEHPA) as its starting material. The gel obtained from this reaction was used to study calcium phosphate transformation using in-situ XRD with temperature ranges from room temperature to 1300 o C. The results obtained from this analysis show the following phase transformation sequence gel > β-Ca2P2O7 > β-TCP + HA > α-TCP + HA. β-Ca2P2O7 was formed at 400 o C and the sample when heated up to 1000 o C, peaks of β- TCP and HA appeared showing the transformation of the β-Ca2P2O7 phase. When the sample was heated up further to 1200 o C, β-TCP transformed into α-TCP.
    Matched MeSH terms: Biocompatible Materials
  9. A review: Gelatine as a bioadhesive material for medical and pharmaceutical applications
    Ahmady A, Abu Samah NH
    Int J Pharm, 2021 Oct 25;608:121037.
    PMID: 34438009 DOI: 10.1016/j.ijpharm.2021.121037
    Bioadhesive polymers offer versatility to medical and pharmaceutical inventions. The incorporation of such materials to conventional dosage forms or medical devices may confer or improve the adhesivity of the bioadhesive systems, subsequently prolonging their residence time at the site of absorption or action and providing sustained release of actives with improved bioavailability and therapeutic outcomes. For decades, much focus has been put on scientific works to replace synthetic polymers with biopolymers with desirable functional properties. Gelatine has been considered one of the most promising biopolymers. Despite its biodegradability, biocompatibility and unique biological properties, gelatine exhibits poor mechanical and adhesive properties, limiting its end-use applications. The chemical modification and blending of gelatine with other biomaterials are strategies proposed to improve its bioadhesivity. Here we discuss the classical approaches involving a variety of polymer blends and composite systems containing gelatine, and gelatine modifications via thiolation, methacrylation, catechol conjugation, amination and other newly devised strategies. We highlight several of the latest studies on these strategies and their relevant findings.
    Matched MeSH terms: Biocompatible Materials
  10. Advances in guided bone regeneration membranes: a comprehensive review of materials and techniques
    Ali M, Mohd Noor SNF, Mohamad H, Ullah F, Javed F, Abdul Hamid ZA
    Biomed Phys Eng Express, 2024 Apr 17;10(3).
    PMID: 38224615 DOI: 10.1088/2057-1976/ad1e75
    Guided tissue/bone regeneration (GTR/GBR) is a widely used technique in dentistry to facilitate the regeneration of damaged bone and tissue, which involves guiding materials that eventually degrade, allowing newly created tissue to take its place. This comprehensive review the evolution of biomaterials for guided bone regeneration that showcases a progressive shift from non-resorbable to highly biocompatible and bioactive materials, allowing for more effective and predictable bone regeneration. The evolution of biomaterials for guided bone regeneration GTR/GBR has marked a significant progression in regenerative dentistry and maxillofacial surgery. Biomaterials used in GBR have evolved over time to enhance biocompatibility, bioactivity, and efficacy in promoting bone growth and integration. This review also probes into several promising fabrication techniques like electrospinning and latest 3D printing fabrication techniques, which have shown potential in enhancing tissue and bone regeneration processes. Further, the challenges and future direction of GTR/GBR are explored and discussed.
    Matched MeSH terms: Biocompatible Materials
  11. Fulltext Sonoproduction of nanobiomaterials - A critical review
    Low SS, Yew M, Lim CN, Chai WS, Low LE, Manickam S, et al.
    Ultrason Sonochem, 2022 Jan;82:105887.
    PMID: 34954629 DOI: 10.1016/j.ultsonch.2021.105887
    Ultrasound (US) demonstrates remarkable potential in synthesising nanomaterials, particularly nanobiomaterials targeted towards biomedical applications. This review briefly introduces existing top-down and bottom-up approaches for nanomaterials synthesis and their corresponding synthesis mechanisms, followed by the expounding of US-driven nanomaterials synthesis. Subsequently, the pros and cons of sono-nanotechnology and its advances in the synthesis of nanobiomaterials are drawn based on recent works. US-synthesised nanobiomaterials have improved properties and performance over conventional synthesis methods and most essentially eliminate the need for harsh and expensive chemicals. The sonoproduction of different classes and types of nanobiomaterials such as metal and superparamagnetic nanoparticles (NPs), lipid- and carbohydrate-based NPs, protein microspheres, microgels and other nanocomposites are broadly categorised based on the physical and/or chemical effects induced by US. This review ends on a good note and recognises US-driven synthesis as a pragmatic solution to satisfy the growing demand for nanobiomaterials, nonetheless some technical challenges are highlighted.
    Matched MeSH terms: Biocompatible Materials
  12. Human dried amniontic membrane (H-DAM) as a biomaterial patch on gastric perforation wound healing: macroscopic evaluation
    Ramadhani AT, Setiawan A
    Med J Malaysia, 2024 Aug;79(Suppl 4):68-71.
    PMID: 39215418
    INTRODUCTION: Gastric perforation is a rare occurrence, particularly in neonates. This is an emergency case in this population. The incidence of spontaneous gastric perforation in neonates is 1:2900 live births, with high mortality and morbidity rates. The primary treatment is surgical debridement and repair of the perforation, which has a high incidence of anastomotic leakage. At present, there is a plethora of studies investigating the efficacy of human dried amniotic membrane (H-DAM) technology in promoting wound healing. Consequently, researchers sought to ascertain whether there were differences in the number of adhesion and abscess classifications for the macroscopic evaluation of gastric perforation repair with HDAM as a biomaterial in New Zealand white rabbits.

    MATERIAL AND METHODS: A total of 30 male New Zealand rabbits underwent laparotomy and gastric perforation. These animals were then divided into three groups, with each group comprising 10 rabbits. Group 1 underwent primary repair, group 2 underwent omental patch repair, and group 3 underwent H-DAM patch repair. The rabbits were euthanised on the 7th day and the adhesion score and abscess classification were evaluated.

    RESULT: A total of 30 samples of rabbits were homogeneous. On macroscopic evaluation, it was found that the H-DAM had the lowest mean adhesion score and the lowest incidence of abscess formation compared to all other groups.

    CONCLUSIONS: It can be concluded that the utilisation of HDAM as a biomaterial patch in the treatment of gastric perforation in the rabbit model did not result in any instances of leakage, adhesion or infection.

    Matched MeSH terms: Biocompatible Materials
  13. Facile Determination of Molecular Structure Trends in Amphiphilic Core Corona Star Polymer Synthesis via Dielectric Property Measurement
    Hild F, Nguyen NT, Deng E, Katrib J, Dimitrakis G, Lau PL, et al.
    Macromol Rapid Commun, 2016 Aug;37(15):1295-9.
    PMID: 27315130 DOI: 10.1002/marc.201600149
    The use of dielectric property measurements to define specific trends in the molecular structures of poly(caprolactone) containing star polymers and/or the interbatch repeatability of the synthetic procedures used to generate them is demonstrated. The magnitude of the dielectric property value is shown to accurately reflect: (a) the number of functional groups within a series of materials with similar molecular size when no additional intermolecular order is present in the medium, (b) the polymer molecular size for a series of materials containing a fixed core material and so functional group number, and/or (c) the batch to batch repeatability of the synthesis method. The dielectric measurements are validated by comparison to spectroscopic/chromatographic data.
    Matched MeSH terms: Biocompatible Materials/chemical synthesis*
  14. Mineral and physichocemical characterization of cockle (Anadara granosa) shells as an alternative biomaterial for bone tissue engineering
    Hazmi AJ, Zuki AB, Noordin MM, Jalila A, Norimah Y
    Med J Malaysia, 2008 Jul;63 Suppl A:93-4.
    PMID: 19025000
    This study was conducted based on the hypothesis that mineral and physicochemical properties of cockle shells similarly resemble the properties of corals (Porites sp.). Hence, the mineral and physicochemical evaluations of cockle shells were conducted to support the aforementioned hypothesis. The results indicated that cockle shells and coral exoskeleton shared similar mineral and physicochemical properties.
    Matched MeSH terms: Biocompatible Materials/chemistry
  15. Cell attachment study of chicken fibroblast cell (DF-1) using ceramic microcarrier granule in bioreactors
    Mel M, Sopyan I, Nor YA
    Med J Malaysia, 2008 Jul;63 Suppl A:18-20.
    PMID: 19024963
    Tricalcium phosphate ceramic microcarrier has been developed and introduced to a new possibility for the culture of anchorage dependent animal cells of DF1. It was observed that the number of attached cells was increased with shorter time for both spinner vessel and stirred tank (ST) bioreactor. For those bioreactors, the total viable cell number that had been obtained is about 1.2 x 10(5) cell/ml.
    Matched MeSH terms: Biocompatible Materials*
  16. Synthesis of nanosized hydroxyapatite powders
    Zarina O, Radzali O
    Med J Malaysia, 2004 May;59 Suppl B:160-1.
    PMID: 15468867
    Hydroxyapatite powder was mechanochemically synthesized from calcium pyrophosphate (Ca2P2O7) and calcium carbonate (CaCO3) using a solid-state reaction. The two powders were mixed in distilled water, milled for 8 hours, dried and calcined at 1100 degrees C for 1 hour. The phase(s) formed was analyzed by x-ray diffraction (XRD). It was found that hydroxyapatite was not the only one formed. This result will be used as the starting point to produce a single-phase hydroxyapatite in terms of excess hydroxyl group in a mechanochemical reaction.
    Matched MeSH terms: Biocompatible Materials/chemical synthesis*
  17. Gene expressions screening of human cell line exposed to locally produced biomaterial
    Azlina A, Samsudin AR
    Med J Malaysia, 2004 May;59 Suppl B:166-7.
    PMID: 15468870
    In Malaysia, the field of genomics in toxicology is still in infancy. The purpose of this study is to focus on the use of toxicogenomics for determination of gene expressions changes in cultured human fibroblast cells treated with genotoxicology free biomaterial (using Ames test), a locally produced hyroxyapatite. Dose and time response is similar to Ames test with time interval up to 21 days. mRNA is extracted, followed with RT-PCR and polyacrilamide gel electrophoresis. Changes of the gene expressions compared to the non-treated fibroblast mRNA would suggest some gene interactions in the molecule level associated with the exposure of the fibroblast cell line to the biomaterials. Further analysis (cloning & sequencing) shall be carried out to investigate the genes involved as simple changes might not signified toxicity.
    Matched MeSH terms: Biocompatible Materials/toxicity*
  18. Biomaterials research in Malaysia--development in facilities and expertise for in-vivo evaluation
    Khalid K
    Med J Malaysia, 2004 May;59 Suppl B:133-4.
    PMID: 15468854
    Matched MeSH terms: Biocompatible Materials*
  19. The synthesis of hydroxyapatite through the precipitation method
    Shah RK, Fahmi MN, Mat AH, Zainal AA
    Med J Malaysia, 2004 May;59 Suppl B:75-6.
    PMID: 15468826
    Hydroxyapatite (HA) has been earmarked as suitable for implantation within the human of its chemical makeup to human bone. In this paper, HA powders were synthesized via the precipitation method where phosphoric acid (H3PO4) was titrated into calcium hydroxide solution [Ca(OH)2]. Two parameters such as temperature and stirring rate were identified as factors that influenced the amount and purity of HA powder. Phase identification of the synthesized powder was done using X-Ray Diffraction (XRD). The results show that HA phase can be synthesized from this titration process of Ca(OH)2 and H3PO4 with yield amount of HA powder around 45 - 61 grams but with less than hundred percent purity. In order to study the effect of heat treatment to HA crystals structure, HA powder was calcined at 850 degrees C for 2 hours. It's found that the degree of crystallinity increases after calcination because of lattice expansion when the materials were heated at higher temperature
    Matched MeSH terms: Biocompatible Materials/chemical synthesis*
  20. Study on the effect of Y2O3 addition to the fluorescent property of dental porcelain
    Nik Mohd Polo Kinin NM, Wan Mohd Arif WI, Zainal Arifm A
    Med J Malaysia, 2004 May;59 Suppl B:23-4.
    PMID: 15468800
    The appearance of dental porcelains is comparable to natural teeth. This study discusses the effect of Y2O3 addition to the fluorescent property of dental porcelains. The composition of dental porcelains contained Y2O3 as the fluorescent agent and base frit. The combinations of Y2O3 added consist of a series with 0.5, 1.0, 1.5, 2.0 and 2.5 wt% respectively, based on the total composition. In the extreme condition, fluorescent agents are added from 5.0 up to 10.0 wt%. In order to enhance the fluorescent property of dental porcelains, an opacifiying agent, cerium oxide (CeO2) was also added to dental porcelains composition. The fluorescent property was determined using Spectroline EF-1400C/F that emits 240 nm wavelength ultraviolet light. The microstructure was examined by Scanning Electron Microscope (SEM). The result shows that, the fluorescent properties displayed are similar to natural teeth when subjected to ultraviolet light. SEM micrograph was able to show the fluorescent agent dispersed in glass phase. Increasing additions of Y2O3 gave the fluorescent properties near to natural teeth.
    Matched MeSH terms: Biocompatible Materials*
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