Displaying publications 21 - 40 of 60 in total

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  1. Muhammad Dhamir Audi Azizul, Wan Munira Wan Jaafar, Azlina Mohd Khir
    MyJurnal
    This social psychology study sought to understand how the inability of former drug addicts controlling
    interpersonal conflict that occurs in the community resulted in relapse or back to their addiction. A
    qualitative phenomenological approach was taken to conduct interviews with former drug addicts that
    are participating in a rehab program in Cure and Care Service Centre, Kuala Pilah, Negeri Sembilan,
    Malaysia. Eight informants were consented and interviewed. Purposive sampling was used and
    responses were analyzed thematically. These themes included the issue of labeling drug addicts as
    convicts, isolation from the community and restricted from participating in community-based
    programs. Researcher suggests related agencies to work with rehabilitation officers in restructuring the
    rehabilitation learning module and improve the interpersonal conflict management module. Therefore,
    it is hoped that in the future, former drug addicts would be capable to manage interpersonal conflict
    and simultaneously avoid from recidivism in addiction.
    Matched MeSH terms: Behavior, Addictive
  2. Zahari Z, Salleh MR, Zahri Johari MK, Musa N, Ismail R
    Malays J Med Sci, 2011 Oct;18(4):44-57.
    PMID: 22589672 MyJurnal
    The dopamine D2 receptor gene (DRD2) plays a role in many diseases such as schizophrenia, Parkinson's disease, and addictive behaviour. Methods currently available for the detection of DRD2 polymorphisms are costly and cannot detect all 8 polymorphisms of our research interest simultaneously (Val96Ala, Leu141Leu, Val154Ile, Pro310Ser, Ser311Cys, TaqI A, A-241G, and -141C Ins/Del). Therefore, we developed a nested multiplex polymerase chain reaction (PCR) for simultaneous detection of these polymorphisms.
    Matched MeSH terms: Behavior, Addictive
  3. Mak KK, Lai CM, Watanabe H, Kim DI, Bahar N, Ramos M, et al.
    Cyberpsychol Behav Soc Netw, 2014 Nov;17(11):720-8.
    PMID: 25405785 DOI: 10.1089/cyber.2014.0139
    Internet addiction has become a serious behavioral health problem in Asia. However, there are no up-to-date country comparisons. The Asian Adolescent Risk Behavior Survey (AARBS) screens and compares the prevalence of Internet behaviors and addiction in adolescents in six Asian countries. A total of 5,366 adolescents aged 12-18 years were recruited from six Asian countries: China, Hong Kong, Japan, South Korea, Malaysia, and the Philippines. Participants completed a structured questionnaire on their Internet use in the 2012-2013 school year. Internet addiction was assessed using the Internet Addiction Test (IAT) and the Revised Chen Internet Addiction Scale (CIAS-R). The variations in Internet behaviors and addiction across countries were examined. The overall prevalence of smartphone ownership is 62%, ranging from 41% in China to 84% in South Korea. Moreover, participation in online gaming ranges from 11% in China to 39% in Japan. Hong Kong has the highest number of adolescents reporting daily or above Internet use (68%). Internet addiction is highest in the Philippines, according to both the IAT (5%) and the CIAS-R (21%). Internet addictive behavior is common among adolescents in Asian countries. Problematic Internet use is prevalent and characterized by risky cyberbehaviors.
    Matched MeSH terms: Behavior, Addictive/ethnology*; Behavior, Addictive/epidemiology
  4. Lai CM, Mak KK, Cheng C, Watanabe H, Nomachi S, Bahar N, et al.
    Cyberpsychol Behav Soc Netw, 2015 Oct;18(10):609-17.
    PMID: 26468915 DOI: 10.1089/cyber.2015.0069
    There has been increased research examining the psychometric properties on the Internet Addiction Test (IAT) in different populations. This population-based study examined the psychometric properties and measurement invariance of the IAT in adolescents from three Asian countries. In the Asian Adolescent Risk Behavior Survey (AARBS), 2,535 secondary school students (55.9% girls) aged 12-18 years from Hong Kong (n=844), Japan (n=744), and Malaysia (n=947) completed a survey in 2012-2013 school year. A nested hierarchy of hypotheses concerning the IAT cross-country invariance was tested using multigroup confirmatory factor analyses. Replicating past findings in Hong Kong adolescents, the construct of the IAT is best represented by a second-order three-factor structure in Malaysian and Japanese adolescents. Configural, metric, scalar, and partial strict factorial invariance was established across the three samples. No cross-country differences on Internet addiction were detected at the latent mean level. This study provided empirical support for the IAT as a reliable and factorially stable instrument, and valid to be used across Asian adolescent populations.
    Matched MeSH terms: Behavior, Addictive/diagnosis*; Behavior, Addictive/psychology
  5. Loo JM, Shi Y, Pu X
    J Gambl Stud, 2016 Jun;32(2):391-407.
    PMID: 26337063 DOI: 10.1007/s10899-015-9569-3
    The investigation of the interface between psychological constructs, compulsive consumption of alcohol and pathological gambling is an important avenue for development of future initiatives in social marketing or prevention programs. This cross-cultural study attempts to bridge the gap in literature by providing an evaluation of the predictive ability of psychological variables such as gambling urge, gambling-related erroneous cognitions and comorbid alcohol consumption on pathological gambling behaviour and its impact on overall quality of life indicators. Participants consist of 445 Macao and Australian young adults (Mean age = 23 years). Results indicate that probable pathological gamblers as compared with non-gamblers reported significantly lower quality of life in all domains-physical health, psychological well-being, social relationships and environment. Adults who drank more alcohol and have stronger erroneous cognitions evidenced higher pathological gambling behavior. Our research model fits both cohorts and interestingly, erroneous gambling-related cognitions serve as a full mediator for the predictive relationship between gambling urge and pathological gambling in the Macao sample, but serve as a partial mediator in the Australian sample. Targeting erroneous cognitions in future social marketing or preventive campaigns should demonstrate to be an important strategy in reducing the effects of urge to gamble among at-risk individuals. Further implications for the industry, marketing and governmental strategies are discussed.
    Matched MeSH terms: Behavior, Addictive/epidemiology; Behavior, Addictive/psychology*
  6. Rane A, Church S, Bhatia U, Orford J, Velleman R, Nadkarni A
    Addict Behav, 2017 11;74:1-8.
    PMID: 28554034 DOI: 10.1016/j.addbeh.2017.05.015
    AIM: To review the literature on psychosocial interventions for addiction affected family members in Low and Middle Income Countries (LMIC).

    METHODS: A systematic review with a detailed search strategy focussing on psychosocial interventions directed towards people affected by addiction without any gender, year or language specifications was conducted. Identified titles and abstracts were screened; where needed full papers retrieved, and then independently reviewed. Data was extracted based on the aims of the study, to describe the modalities, acceptability, feasibility and effectiveness of the interventions.

    RESULTS: Four papers met our selection criteria. They were published between 2003 and 2014; the total sample size was 137 participants, and two studies were from Mexico and one each from Vietnam and Malaysia. The predominantly female participants comprised of parents, spouses and siblings. The common components of all the interventions included providing information regarding addiction, teaching coping skills, and providing support. Though preliminary these small studies suggests a positive effect on affected family members (AFM). There was lowering of psychological and physical distress, along with a better understanding of addictive behaviour. The interventions led to better coping; with improvements in self-esteem and assertive behaviour. The interventions, mostly delivered in group settings, were largely acceptable.

    CONCLUSIONS: The limited evidence does suggest positive benefits to AFMs. The scope of research needs to be extended to other addictions, and family members other than spouse and female relatives. Indigenous and locally adapted interventions are needed to address this issue keeping in mind the limited resources of LMIC. This is a field indeed in its infancy and this under recognised and under-served group needs urgent attention of researchers and policy makers.

    Matched MeSH terms: Behavior, Addictive/psychology; Behavior, Addictive/therapy*
  7. Ang CS, Chan NN, Lee CS
    J Psychol, 2018 Jan 02;152(1):25-35.
    PMID: 29236584 DOI: 10.1080/00223980.2017.1399854
    Given that shyness has been consistently linked to Internet addiction in youth, an examination into the mediating effect of a desire to avoid loneliness on the shyness-Internet addiction link could offer potential insights into a possible explanatory mechanism as well as directions for Internet addiction prevention and intervention in young adulthood. Thus, the aim of this study is to investigate the mediating role of loneliness avoidance in the relationship between shyness and Internet addiction among 286 youth Internet users. Shyness was significantly and positively correlated with loneliness avoidance and Internet addiction. In addition, loneliness avoidance was significantly and positively correlated with Internet addiction. Most importantly, loneliness avoidance may predispose shy youth to become addicted to the Internet. Theoretical and practical implications of the research findings for youth wellness are addressed in this study.
    Matched MeSH terms: Behavior, Addictive/diagnosis; Behavior, Addictive/psychology*
  8. Ke GN, Wong SF
    Cyberpsychol Behav Soc Netw, 2018 Oct;21(10):637-645.
    PMID: 30256674 DOI: 10.1089/cyber.2018.0072
    This article designed and tested a cognitive behavioral-based preventive intervention program for youths with problematic Internet use (PIU) behavior. The program is the Psychological Intervention Program-Internet Use for Youth (PIP-IU-Y). A cognitive-based therapy approach was adopted. A total of 45 secondary students from four schools completed the intervention program that was conducted in a group format by registered school counselors. Three sets of self-reported data on Problematic Internet Use Questionnaire (PIUQ), Social Interaction Anxiety Scale (SIAS), and Depression Anxiety Stress Scale (DASS) were collected at three time points: 1 week before the intervention, immediately after the last intervention session, and 1 month after the intervention. Paired t-test results showed that the program was effective in preventing negative progression into more serious Internet addiction stages, and reducing anxiety and stress and interaction phobia of the participants. The effect was evident immediately at the end of the intervention session and was maintained 1 month after the intervention. This study is among the first to develop and test a preventive intervention program for youths with PIU. The effectiveness of our program in preventing negative progression of PIU and its symptoms in problematic users has led us to postulate that the program will also prevent normal users from developing serious symptoms. The majority of the intervention programs reported in the literature merely tailor to those who already have problems.
    Matched MeSH terms: Behavior, Addictive/prevention & control*; Behavior, Addictive/psychology
  9. Ching, Siew Mooi, Hanifatiyah Ali, Cheong, Ai Theng, Hani Syahida Salim
    MyJurnal
    Widespread use of the internet is a relatively recent phenomenon that is affecting different cultures worldwide in both positive and negative ways. This study aimed to determine the gender differences in the internet addiction among medical students in public university. Methods: 426 medical students from year one to four were invited to participate in the study. For data collection, we used a self-administered questionnaire consisting of socio-demographic and internet usage questions, the Internet Addiction Test (IAT) and the Depression Anxiety and Stress Scales 21 (DASS-21). Results: There were a total of 426 (270 female and 156 male) medical students included in this study. IA was high in both male and female students. There was a higher proportion of male students (44.9%) found to be addicted compared to female students (32.2%). There were positive correlations between the DASS-21 and IAT scores for both male and female students. For female students, longer hours spent online daily (p-value = 0.02), as well as high anxiety (p-value < 0.001) and depression scores (p-value = 0.037) were found to be most strongly associated with IA. Among male students, factors associated with IA were the availability of internet access at home (p-value=0.02) and high anxiety scores (p
    Matched MeSH terms: Behavior, Addictive
  10. Lua PL, Talib NS
    ASEAN Journal of Psychiatry, 2012;13(1):55-68.
    MyJurnal
    Objectives: This review aims to compile and evaluate all available randomised controlled trials (RCTs) of auricular acupuncture (AA) treatment in drug addiction population with emphasis on the length of treatment course, needle-points, outcome measures, reported side-effects and overall outcomes.
    Methods: Science Direct, Medline and EBSCOhost databases were searched. From the year 1990 until 2010, only full-length English articles incorporating RCTs related to AA studies (needle-based only) in drug addiction such as heroin, morphine, methamphetamine and cocaine were included. Studies involving the usage of various methods of electroacupuncture and investigations relating to cigarette-smoking or alcohol addiction were excluded.
    Results: Eight RCTs met all inclusion criteria comprising of 1,594 respondents (age = 19 - 46 years; male = 57% - 76%). Most were involved in cocaine addiction. Overall, trials were designed with brief periods of treatment course and utilised three to five standard National Acupuncture Detoxification Association (NADA) points (Sympathetic, Lung, Liver, Kidney and Shen men), but inconsistent sham points. All trials included urine toxicology test as the main outcome measure while data on side-effects incidence was insufficient. Conclusions: Overall, four of the RCTs reported positive outcomes although at this point, AA’s effectiveness and safety could not be substantially confirmed. For the future, high-quality RCTs of AA are urgently required to provide a clearer understanding on the usefulness of this complementary therapy in drug addiction treatment.
    Matched MeSH terms: Behavior, Addictive
  11. Nuraisyah Hani Zulkifley, Suriani Ismail, Rosliza Abdul Manaf, Zulkifley Hamid
    MyJurnal
    Introduction: One of the known factors that hindered smoking cessation is nicotine dependence. Measurement of the nicotine dependence is important to better understand cigarette smoking addiction dependence and ways to overcome it. Among methods of nicotine dependence measurement are self-reported Fagerstrom Test for Nicotine Dependence (FTND) and biochemical assessment such as saliva cotinine. Biochemical assessment can be used to measure the accuracy of the self-reported measurement of nicotine dependence. Objective: To explore the correlation between the FTND and the saliva cotinine of the smokers in three different timeline. Methods: A total of 61 male smokers who currently smoke cigarette on daily basis were recruited. The study used the one-group pretest-posttest study design and the data were collected three times. The self-reported measurement were measured by using FTND and the biochemical assessment measured by using saliva cotinine from Saliva Bio oral swab (SOS) with the sensitivity of 0.15ng/ml. Data analysis was conducted by using Pearson correlation. Results: There was a significant association between the FTND score and saliva cotinine level of the smokers at baseline, second and third data collection (p=0.014, p=0.003, p
    Matched MeSH terms: Behavior, Addictive
  12. Wong DTL, Sidi H, Salleh H, Tajjudin I
    MyJurnal
    With the availability of the Internet, pornographic materials are readily accessible. Pornographic materials may have a link to addiction and other deviant sexual behaviour. In this case report, we highlighted a link between voyeuristic disorder and internet sex addiction. Mr. SK is a 22-year-old single gentleman who was referred for psychiatric assessment due to voyeuristic acts. He had been watching pornographic materials since 16 years old and became addicted to it.
    Matched MeSH terms: Behavior, Addictive
  13. Liyana, H. M. A., Hidayah, N. A. B., Nasir, M.
    MyJurnal
    Thymoquinone (TQ) is the main pharmacologically active compound found in the seeds oil of Nigella
    Sativa. Various studies had been investigated on the therapeutic effects of TQ against several diseases such as
    anticancer research, antibacterial, and so on. As a result, a considerable amount of information has been
    generated from these researches thus providing a better understanding of the promising effects of this
    compound. However, research studies on the potential role of this compound on opioid addiction studies are
    still lacking. Therefore, the purpose of this paper is to highlight the potential role of TQ as a non-opioid
    substitution therapy in opioid addiction and the chances of this compound to be explored further with special
    attention to opioid substitution therapy.
    Matched MeSH terms: Behavior, Addictive
  14. Muhammad Adil Zainal Abidin, Hayati Kadi @ Shahar, Rosliza Abdul Manaf
    Int J Public Health Res, 2017;7(1):774-782.
    MyJurnal
    Smoking is the leading preventable cause of non-communicable disease mortality worldwide. Therefore, effort for the effective measure in smoking cessation is important. However, the central problem in the nicotine addiction treatment is relapse. A retrospective cohort study was done at Tanglin Quit Smoking Clinic to determine the outcome of smoking cessation and its predictors. A cohort of 770 smokers between 2008 and 2015 were identified through simple random sampling. Smokers were defined as current smoker, while smoking abstinence is defined as cessation more than 6 months and relapse as any smoking episode even a puff since the quit date. Majority were Malays, Muslims and had secondary or higher education. The mean initiating age for smoking was 17.6 years old, with majority smoke between 11 to 20 sticks, and had high nicotine dependence score (43%). At the end of the study 52.5% of them abstinence from smoking. The predictors for smoking cessation were number of quit attempt (1 to 10 times) (AOR = 1.582, 95% CI = 1.012-2.472) and pharmacotherapy (AOR = 0.711, 95% CI=0.511-0.989). More frequent follow up was required during the first crucial 6 months to prevent relapse. Number of follow up can enhance not only the medication compliance but also motivational aspect to smokers to reduce relapse rates. Healthcare provider should give extra attention to the potential relapser especially to those who attempt for the first time.
    Keywords: Malaysia, Quit Smoking Clinic, Smoking Cessation, Cohort, Survival analysis
    Matched MeSH terms: Behavior, Addictive
  15. Guan NC, Isa SM, Hashim AH, Pillai SK, Harbajan Singh MK
    Asia Pac J Public Health, 2015 Mar;27(2):NP2210-9.
    PMID: 22652253 DOI: 10.1177/1010539512447808
    The use of the Internet has been increasing dramatically over the decade in Malaysia. Excessive usage of the Internet has lead to a phenomenon called Internet addiction. There is a need for a reliable, valid, and simple-to-use scale to measure Internet addiction in the Malaysian population for clinical practice and research purposes. The aim of this study was to validate the Malay version of the Internet Addiction Test, using a sample of 162 medical students. The instrument displayed good internal consistency (Cronbach's α = .91), parallel reliability (intraclass coefficient = .88, P < .001), and concurrent validity with the Compulsive Internet Use Scale (Pearson's correlation = .84, P < .001). Receiver operating characteristic analysis showed that 43 was the optimal cutoff score to discriminate students with and without Internet dependence. Principal component analysis with varimax rotation identified a 5-factor model. The Malay version of the Internet Addiction Test appeared to be a valid instrument for assessing Internet addiction in Malaysian university students.
    Matched MeSH terms: Behavior, Addictive/epidemiology*
  16. Ching SM, Yee A, Ramachandran V, Sazlly Lim SM, Wan Sulaiman WA, Foo YL, et al.
    PLoS One, 2015;10(10):e0139337.
    PMID: 26431511 DOI: 10.1371/journal.pone.0139337
    This study was initiated to determine the psychometric properties of the Smart Phone Addiction Scale (SAS) by translating and validating this scale into the Malay language (SAS-M), which is the main language spoken in Malaysia. This study can distinguish smart phone and internet addiction among multi-ethnic Malaysian medical students. In addition, the reliability and validity of the SAS was also demonstrated.
    Matched MeSH terms: Behavior, Addictive/psychology*
  17. Lai CM, Mak KK, Watanabe H, Jeong J, Kim D, Bahar N, et al.
    Public Health, 2015 Sep;129(9):1224-36.
    PMID: 26343546 DOI: 10.1016/j.puhe.2015.07.031
    OBJECTIVES: This study examines the associations of Internet addiction with social anxiety, depression, and psychosocial well-being among Asian adolescents. A self-medication model conceptualizing Internet addiction as a mediating role in relating depression and social anxiety to negative psychosocial well-being was tested.
    STUDY DESIGN: A cross-sectional survey.
    METHODS: In the Asian Adolescent Risk Behavior Survey (AARBS), 5366 adolescents aged 12-18 years from six Asian countries (China, Hong Kong, Japan, South Korea, Malaysia, and Philippines) completed a questionnaire with items of the Internet Addiction Test (IAT), Social Anxiety Scale for Adolescents (SAS-A), Center for Epidemiological Studies Depression Scale (CESD), Self-Rated Health of the Nation Outcome Scales for Children and Adolescents (HoNOSCA-SR) in the 2012-2013 school year. Structural equation modelling was used to examine the mediating role of Internet addiction in depression, social anxiety, and subjective psychosocial well-being.
    RESULTS: Significant differences on the scores of IAT, SAS-A, CESD, and HoNOSCA-SR across the six countries were found. The proposed self-medication model of Internet addiction received satisfactory goodness-of-fit with data of all countries. After the path from social anxiety to Internet addiction had been discarded in the revised model, there was a significant improvement of the goodness-of-fit in the models for Japan, South Korea, and the Philippines.
    CONCLUSIONS: Depression and social anxiety reciprocally influenced, whereas depression associated with poorer psychosocial well-being directly and indirectly through Internet addiction in all six countries. Internet addiction mediated the association between social anxiety and poor psychosocial well-being in China, Hong Kong, and Malaysia.
    KEYWORDS: Adolescents; Asian; Depression; Internet addiction; Social anxiety; Structural equation modelling
    Matched MeSH terms: Behavior, Addictive/psychology*
  18. Tateno M, Teo AR, Shirasaka T, Tayama M, Watabe M, Kato TA
    Psychiatry Clin Neurosci, 2016 Dec;70(12):567-572.
    PMID: 27573254 DOI: 10.1111/pcn.12454
    AIM: Internet addiction (IA), also referred to as Internet use disorder, is a serious problem all over the world, especially in Asian countries. Severe IA in students may be linked to academic failure, attention-deficit hyperactivity disorder (ADHD), and forms of social withdrawal, such as hikikomori. In this study, we performed a survey to investigate the relation between IA and ADHD symptoms among college students.

    METHODS: Severity of IA and ADHD traits was assessed by self-report scales. Subjects were 403 college students (response rate 78%) who completed a questionnaire including Young's Internet Addiction Test (IAT) and the Adult ADHD Self-Report Scale-V1.1.

    RESULTS: Out of 403 subjects, 165 were male. The mean age was 18.4 ± 1.2 years, and mean total IAT score was 45.2 ± 12.6. One hundred forty-eight respondents (36.7%) were average Internet users (IAT < 40), 240 (59.6%) had possible addiction (IAT 40-69), and 15 (3.7%) had severe addiction (IAT ≥ 70). Mean length of Internet use was 4.1 ± 2.8 h/day on weekdays and 5.9 ± 3.7 h/day on the weekend. Females used the Internet mainly for social networking services while males preferred online games. Students with a positive ADHD screen scored significantly higher on the IAT than those negative for ADHD screen (50.2 ± 12.9 vs 43.3 ± 12.0).

    CONCLUSION: Our results suggest that Internet misuse may be related to ADHD traits among Japanese youth. Further investigation of the links between IA and ADHD is warranted.

    Matched MeSH terms: Behavior, Addictive/epidemiology*
  19. T'ng ST, Ho KH, Sim DE, Yu CH, Wong PY
    Psych J, 2020 Feb;9(1):96-107.
    PMID: 31797557 DOI: 10.1002/pchj.320
    Insufficient attention has been given to the integration of the mediating effect of Internet gaming disorder (IGD) symptoms on loneliness and four components of aggression-physical aggression, verbal aggression, anger, and hostility-in the Malaysian context. In the present study, 410 participants with (a) at least 1 year of Internet gaming experience and (b) between ages 20- to 39 years were recruited using the probability proportional to size sampling method. Participants were undergraduate students and working adults. Self-reported questionnaires (the Internet Gaming Disorder Scale, University of California, Los Angeles Loneliness Scale, and the Buss-Perry Aggression Questionnaire) were used. The present study found that loneliness positively predicted four components of aggression (i.e., anger, hostility, physical aggression, and verbal aggression) and symptoms of IGD. Relationships between loneliness and the four components of aggression were partially mediated by IGD symptoms. The present study enriches and consolidates existing empirical evidence, particularly in the Malaysian context. If the mediating effect is not emphasized, it may lead to spurious conclusions that can significantly diminish the effectiveness of interventions that are meant to manage aggression.
    Matched MeSH terms: Behavior, Addictive/psychology*
  20. Sim MS, Soga T, Pandy V, Wu YS, Parhar IS, Mohamed Z
    Metab Brain Dis, 2017 Dec;32(6):1767-1783.
    PMID: 28681200 DOI: 10.1007/s11011-017-0061-x
    Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of METH-induced addiction. The objective of this study was to establish a behavioral model of METH use and addiction using escalating doses of METH over 15 days and to determine the global miRNA expression profiling in NAc of METH-addicted rats. In the behavioral study, the experimental rats were divided into 3 groups of 9 each: a control group, a single dose METH (5 mg/kg) treatment group and a continuous 15 alternate days METH (0.25, 0.5, 1, 2, 3, 4, 5 mg/kg) treatment group. Following that, six rats in each group were randomly selected for global miRNA profiling. Addiction behavior in rats was established using Conditioned Place Preference task. The analysis of the miRNA profiling in the NAc was performed using Affymetric microarray GeneChip® System. The findings indicated that a continuous 15 alternate days METH treatment rats showed a preference for the drug-paired compartment of the CPP. However, a one-time acute treatment with 5 mg/kg METH did not show any significant difference in preference when compared with controls. Differential profiling of miRNAs indicated that 166 miRNAs were up-regulated and 4 down-regulated in the chronic METH-treatment group when compared to controls. In comparing the chronic treatment group with the acute treatment group, 52 miRNAs were shown to be up-regulated and 7 were down-regulated. MiRNAs including miR-496-3p, miR-194-5p, miR-200b-3p and miR-181a-5p, were found to be significantly associated with METH addiction. Canonical pathway analysis revealed that a high number of METH addiction-related miRNAs play important roles in the MAPK, CREB, G-Protein Couple Receptor and GnRH Signaling pathways. Our results suggest that dynamic changes occur in the expression of miRNAs following METH exposure and addiction.
    Matched MeSH terms: Behavior, Addictive/genetics; Behavior, Addictive/metabolism*
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