Displaying publications 401 - 420 of 5116 in total

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  1. Immunotactoid glomerulopathy--an unusual deposition disease: report of the first Malaysian case
    Cheah PL, Looi LM, Ghazalli R, Chua CT
    Malays J Pathol, 1999 Jun;21(1):59-62.
    PMID: 10879280
    A 31-year-old Malay female presented with nephrotic syndrome without renal impairment. Renal biopsy features were in keeping with immunotactoid glomerulopathy (ITG). Non-Congophilic deposits were seen causing thickening of the glomerular capillary basement membrane with segmental accentuation, and widening of the mesangium. Immunofluorescence examination showed moderate amounts of IgG and C3 in the glomerular capillary walls with some in the mesangium. Ultrastructurally, 20-nm thick fibrils with microtubular organisation were present predominantly in the subendothelial region with similar fibrils in the mesangium. Although immunotactoid glomerulopathy and fibrillary glomerulonephritis (FG) have been recognised as entities with extracellular fibrillary material in the kidney, to date much remains to be clarified regarding these 2 conditions. While the renal biopsy findings in this patient are consistent with ITG, her clinical presentation is unlike that of usual ITG in that she is of a much younger age and has no associated haemopoietic disorder. Response to initial treatment of 8 weeks of prednisolone therapy was poor.
    Matched MeSH terms: Capillaries/pathology; Glomerulonephritis/pathology; Kidney Glomerulus/pathology; Nephrotic Syndrome/pathology
  2. Fulltext Serum ferritin and lactate dehydrogenase in a case of hemophagocytic lymphohistiocytosis
    Leong CF, Cheong SK, Hamidah NH, Ainoon O, Kannaheswary Y
    Malays J Pathol, 1998 Dec;20(2):103-8.
    PMID: 10879271
    A 40-day-old baby girl presented with intermittent fever, lymphadenopathy, massive hepatosplenomegaly, progressive pancytopenia and features of disseminated intravascular coagulopathy. A bone marrow aspiration was performed and showed florid histiocytic proliferation with marked hemophagocytosis. Based on the diagnostic guideline for Hemophagocytic Lymphohistiocytosis proposed by the Familial Hemophagocytic Lymphohistiocytosis Study Group of Histiocyte Society, this patient has fulfilled most of the criteria. We have also found that serum ferritin and lactate dehydrogenase to be very high in this patient. It remains uncertain whether the disorder is reactive or neoplastic.
    Matched MeSH terms: Bone Marrow Cells/pathology; Histiocytes/pathology; Lymphocytes/pathology; Histiocytosis, Non-Langerhans-Cell/pathology
  3. The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus
    Lee KE, Umapathi T, Tan CB, Tjia HT, Chua TS, Oh HM, et al.
    Ann Neurol, 1999 Sep;46(3):428-32.
    PMID: 10482278 DOI: 10.1002/1531-8249(199909)46:3<428::AID-ANA23>3.0.C
    A novel Hendra-like paramyxovirus named Nipah virus (NiV) was the cause of an outbreak among workers from one abattoir who had contact with pigs. Two patients had only respiratory symptoms, while 9 patients had encephalitis, 7 of whom are described in this report. Neurological involvement was diverse and multifocal, including aseptic meningitis, diffuse encephalitis, and focal brainstem involvement. Cerebellar signs were relatively common. Magnetic resonance imaging scans of the brain showed scattered lesions. IgM antibodies against Hendra virus (HeV) were present in the serum of all patients. Two patients recovered completely. Five had residual deficits 8 weeks later.
    Matched MeSH terms: Brain/pathology; Nervous System Diseases/pathology*; Respirovirus Infections/pathology*; Encephalitis, Viral/pathology*
  4. Necrotizing angiitis of the small intestine related to AA-amyloidosis: a novel association
    Oweity T, West AB, Stokes MB
    Int. J. Surg. Pathol., 2001 Apr;9(2):149-54.
    PMID: 11484503
    A 71-year-old man with intestinal pseudo-obstruction was found to have a diffusely thickened adynamic small bowel with AA-amyloid in submucosal vessels and muscularis propria, foreign body giant cell reaction to amyloid, and necrotizing angiitis. The mucosa was unremarkable. Immunostains demonstrated numerous CD68+ monocyte/macrophages and CD8+ T cells associated with the amyloid deposits. The patient had no evidence of systemic vasculitis and no underlying cause for AA-amyloidosis was identified. Necrotizing angiitis coexistent with amyloid angiopathy has been reported in brain and temporal arteries, but not in the gastrointestinal tract and not with AA-amyloid. The inflammatory cell infiltrates in this case are consistent with a foreign-body and/or cell-mediated immunologic reaction to AA-amyloid, although a role for these cells in amyloid formation cannot be excluded.
    Matched MeSH terms: Amyloidosis/pathology*; Gastrointestinal Diseases/pathology*; Intestine, Small/pathology*; Vasculitis/pathology*
  5. Multiple system Erdheim-Chester disease with massive hypothalamic-sellar involvement and hypopituitarism
    Oweity T, Scheithauer BW, Ching HS, Lei C, Wong KP
    J. Neurosurg., 2002 Feb;96(2):344-51.
    PMID: 11838810
    Erdheim-Chester disease (ECD) is a rare multiple system histiocytosis that is characterized pathologically by xanthogranulomatous infiltrates and radiologically by symmetrical sclerosis of long bones. The diagnosis is often confirmed by biopsy of bone or of orbital or retroperitoneal soft tissue. Intracranial involvement is rare. The authors report a case of ECD in which the diagnosis was made after biopsy of a hypothalamic mass. The mass had been discovered during a workup for panhypopituitarism in a 55-year-old man with urological and bone disease. Aside from diabetes insipidus, other features of pituitary insufficiency have seldom been reported and no patients have presented with a hypothalamic tumor. The endocrinological and neurological aspects of ECD are discussed, as is its differential diagnosis. Reported cases of the disorder associated with hypopituitarism or found during biopsy of central nervous system structures are also reviewed.
    Matched MeSH terms: Hypopituitarism/pathology*; Hypopituitarism/physiopathology; Hypothalamic Neoplasms/pathology*; Hypothalamic Neoplasms/physiopathology; Sella Turcica/pathology*; Sella Turcica/physiopathology; Histiocytosis/pathology*; Histiocytosis/physiopathology
  6. Sarcocystis levinei infection in Philippine water buffaloes (Bubalus bubalis)
    Claveria FG, Cruz MJ
    Parasitol Int, 2000 Jan;48(3):243-7.
    PMID: 11227764
    Ultrastructural studies of sarcocysts obtained from Philippine water buffaloes revealed the presence of the commonly reported macroscopic species, Sarcocystis fusiformis, and the microscopic species Sarcocystis levinei (Dissanaike A, Kan S. Studies on Sarcocystis in Malaysia. I: Sarcocystis levinei n.sp. from the water buffalo Bubalus bubalis. Z Parasitenkd 1978;55:127-38), (Huong L, Dubey J, Uggla A. Redescription of Sarcocystis levinei Dissanaike and Kan, 1978 (Protozoa: Sarcocystidae) of the water buffalo (Bubalus bubalis). J Parasitol 1997;83:1148-52). The globular to oval microscopic cysts commonly observed in the muscles of the diaphragm and neck exhibit compartmentalized arrangement of zoites with septal partitions and measure 13-48 microns in diameter. The parasitophorous vacuolar membrane of sarcocyst bears minute and hair-like villar protrusions measuring 2.3-2.75 microns long emanating at certain distances from the primary cyst wall and lack microfilaments. Villar protrusions have expanded to dome-shaped base measuring 0.33-1.6 microns long by 0.22-1.0 micron wide, and intermediate and tapering distal segments bent approximately 90 degrees and run parallel to the cyst surface. The distal segments at some areas join to form conical tufts. The primary cyst wall bears numerous prominent undulations that are arranged in small clusters. The ground substance is 0.42-0.57 micron thick. This paper documents the first report of S. levinei in Philippine water buffaloes possessing the type 7 cyst wall.
    Matched MeSH terms: Diaphragm/pathology; Esophagus/pathology; Sarcocystosis/pathology; Muscle, Skeletal/pathology
  7. Fine needle aspiration cytology of lymph nodes in HIV-infected individuals
    Jayaram G, Chew MT
    Acta Cytol., 2000 Nov-Dec;44(6):960-6.
    PMID: 11127753
    OBJECTIVE: To assess the role of fine needle aspiration cytology (FNAC) in lymphadenopathy in human immunodeficiency virus-infected individuals (HIVII).

    STUDY DESIGN: Thirty-nine HIVII presenting with lymphadenopathy at University Hospital, Kuala Lumpur, were subjected to FNAC. Cytologic smears were routinely stained with May-Grünwald-Giemsa stain. Special stains and immunostains were used when necessary.

    RESULTS: In nine cases, the cytologic appearance was compatible with HIV type A and in one case with HIV type C lymphadenopathy. In 21 cases, acid-fast bacilli (AFB) were demonstrated in the cytologic smears, enabling a diagnosis of mycobacterial lymphadenitis. In one of these cases there was a concomitant infection with Penicillium marneffei that was overlooked on initial cytologic examination. The cause of granulomatous lymphadenitis could not be ascertained in one case, where neither AFB nor any other organisms were demonstrable. Two cases of histoplasma and one of cryptococcal lymphadenitis were diagnosed, as was one high grade non-Hodgkin's lymphoma that could be immunophenotyped on cytologic material. In three cases the aspirates were inadequate for a cytologic diagnosis.

    CONCLUSION: Lymph node FNAC is a valuable investigative modality in HIVII. Most opportunistic infections (bacterial and fungal) can be correctly identified, and high grade lymphoma can be diagnosed and phenotyped.
    Matched MeSH terms: Lymph Nodes/pathology; Lymphatic Diseases/pathology*; Lymphoma, AIDS-Related/pathology*; AIDS-Related Opportunistic Infections/pathology*
  8. Seeking representation in policy-making governmental bodies
    Abu Bakar S
    Malays J Pathol, 1997 Dec;19(2):93-7.
    PMID: 10879247
    Matched MeSH terms: Pathology/legislation & jurisprudence; Pathology/standards; Pathology/trends*; Pathology Department, Hospital
  9. Malignant paraganglioma of frontoethmoidal region
    Sharma HS, Madhavan M, Othman NH, Muhamad M, Abdullah JM
    Auris Nasus Larynx, 1999 Oct;26(4):487-93.
    PMID: 10530746
    Nonchromaffin paragangliomas are unusual tumours arising from widely distributed paraganglionic tissues probably of neural crest origin. In the head and neck region they are usually seen as carotid body or jugulotympanic tumours. Other rarely reported sites in the head and neck region are the orbit, nose and larynx. This report deals with a case of sinonasal paraganglioma which was initially treated with surgery and radiotherapy. Twenty two years later the tumour recurred and showed a rapid growth due to malignant transformation which we believe is late effect of radiotherapy. The clinical features, histopathology and role of radiotherapy in sinonasal paragangliomas together with a review of the medical literature have been discussed.
    Matched MeSH terms: Ethmoid Sinus/pathology*; Frontal Sinus/pathology*; Paraganglioma/pathology*; Paranasal Sinus Neoplasms/pathology*
  10. Odontogenic keratocyst with dentinoid formation
    Ng KH, Siar CH
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2003 May;95(5):601-6.
    PMID: 12738952
    Although rare, hard tissue deposits, namely dystrophic calcifications and cartilage, have been reported to occur in the connective tissue wall of the odontogenic keratocyst. However, dentinoid formation has not been previously documented. A case involving the left mandibular premolar-molar region in a 37-year-old Malay male is described here along with a brief review on the reported prevalence of hard tissue deposits in the odontogenic keratocyst. Differential diagnosis of this case from other dentinoid-forming odontogenic cysts and tumors-notably calcifying odontogenic cyst, odontoma, ameloblastic fibro-odontoma, central odontogenic fibroma and adenomatoid odontogenic tumor that may present with dentin/dentinoid formation-is discussed.
    Matched MeSH terms: Connective Tissue/pathology; Dentin/pathology*; Mandibular Diseases/pathology*; Odontogenic Cysts/pathology*
  11. Risk factors associated with umbilical vascular catheter-associated thrombosis in newborn infants
    Boo NY, Wong NC, Zulkifli SS, Lye MS
    J Paediatr Child Health, 1999 Oct;35(5):460-5.
    PMID: 10571759
    OBJECTIVE: To determine the risk factors associated with umbilical vascular catheter-associated thrombosis.

    METHODS: All consecutive inborn infants with umbilical arterial (UAC) and/or umbilical venous catheters (UVC) inserted for more than 6 h duration were included in the study. Each infant was screened for thrombosis in the abdominal aorta and inferior vena cava by 2-D abdominal ultrasonography within 48-72 h of insertion of umbilical vascular catheters. Subsequent serial scanning was performed at intervals of every 5-7 days, and within 48 h after removal of catheters.

    RESULTS: Upon removal of umbilical catheters, abdominal aortic thrombi were detected in 32/99 (32.3%) infants with UAC. Small thrombi were detected in the inferior vena cava of 2/49 (4.1%) infants with UVC (one of whom had both UAC and UVC). When compared with those who received only UVC (n = 18), infants who received either UAC alone (n = 68) or both UAC and UVC (n = 31) had significantly higher risk of developing thrombosis (odds ratio (OR): 7.6, 95% confidence interval (CI): 1.1, 325.5)). Logistic regression analysis of various potential risk factors showed that the only significant risk factor associated with the development of abdominal aortic thrombosis following insertion of UAC was longer duration of UAC in situ (for every additional day of UAC in situ, adjusted OR of developing thrombosis was: 1.2, 95% CI: 1.1, 1.3; P = 0.002).

    CONCLUSION: Umbilical arterial catheter-associated thrombosis was common. Umbilical arterial catheter should be removed as soon as possible when not needed. Upon removal of UAC, all infants should be screened for abdominal aortic thrombus by 2-D ultrasonography.

    Matched MeSH terms: Aorta, Abdominal/pathology*; Umbilical Veins/pathology*; Venae Cavae/pathology*; Venous Thrombosis/pathology*
  12. Cytology of Ki-1-positive anaplastic large cell lymphoma. A report of two cases
    Jayaram G, Abdul Rahman N
    Acta Cytol., 1997 Jul-Aug;41(4 Suppl):1253-60.
    PMID: 9990253
    Ki-1-positive anaplastic large cell lymphoma (Ki-1 ALCL), one of the more recently described pleomorphic types of lymphoma, affects mostly children and adolescents and is sometimes mistaken for carcinoma or sarcoma.
    Matched MeSH terms: Cell Nucleus/pathology; Lymph Nodes/pathology; Lymphocytes/pathology; Lymphoma, Large-Cell, Anaplastic/pathology*
  13. Severe complications induced by experimental bacterial superinfection of orf lesions
    Zamri-Saad M, Roshidah I, al-Ajeeli KS, Ismail MS, Kamarzaman A
    Trop Anim Health Prod, 1993 May;25(2):85-8.
    PMID: 8236484
    Twelve goats about 3 months of age were divided into 4 equal groups. Goats in Groups 1 and 2 were infected with orf virus followed by Corynebacterium pyogenes infection of Groups 1 and 3, 3 days after the first appearance of orf lesions. Goats in Group 4 were uninfected controls. Complicated orf lesions which consisted of wet suppurative scabs around the entire lips were observed in goats in Group 1. The lesions persisted for 24 days but were most severe from days 8 to 13. Goats in Group 2 developed lesions typical of orf virus infection that lasted 10 days, while goats in Group 3 developed small nodules of about 1 cm diameter, 48 hours following the introduction of C. pyogenes, which persisted for only 6 days. No lesion was observed in goats in Group 4. Two goats in Group 1 with complicated orf died after 16 and 22 days respectively.
    Matched MeSH terms: Corynebacterium Infections/pathology; Ecthyma, Contagious/pathology; Superinfection/pathology; Goat Diseases/pathology
  14. Antrochoanal polyp--a rare paediatric emergency
    Sharma HS, Daud AR
    Int J Pediatr Otorhinolaryngol, 1997 Jul 18;41(1):65-70.
    PMID: 9279638
    An antrochoanal polyp, a common clinical entity, with a rare presentation is being reported. A 12 year old boy was brought to Accident and Emergency department with an unusual sudden presentation of polypoidal mass filling the oral cavity up to his incisors as a result of which he could not swallow and speak. Prior to this episode he had no complaints of the disease. An emergency removal was planned and only during the operation could it be diagnosed as a antrochoanal polyp because of its pedicle in the lateral wall of the nose, which was confirmed by histopathological examination.
    Matched MeSH terms: Aphonia/pathology; Deglutition Disorders/pathology; Nasal Polyps/pathology; Nose/pathology
  15. Cytological analysis of breast lesions: a review of 780 cases
    Jayaram G, Alhady SF, Yip CH
    Malays J Pathol, 1996 Dec;18(2):81-7.
    PMID: 10879227
    780 breast cytology samples obtained over a one year period at the Breast Clinic of the University Hospital, Kuala Lumpur were reviewed. These included 745 fine needle aspirates (FNA's) and 35 nipple smears. The broad categories of cytodiagnoses were as follows: malignant: 95, suspicious or equivocal: 26, benign: 543, no proliferative lesion: 58 and inadequate: 58. The benign and malignant lesions were also subcategorized on cytological basis. The suspicious or equivocal lesions were subjected to biopsy and 17 of these proved to be malignant. 194 cases that were subjected to histological confirmation and 34 cases that were considered to be undisputably malignant (on the basis of clinical features, recurrences, metastases, etc.) were subjected to statistical analysis (total 228 cases). If the cytologically suspicious/equivocal category was considered as "test positive" the sensitivity of cytodiagnosis was 97.4% and the specificity 92%. The high degree of cytodiagnostic sensitivity and specificity make breast cytology a valuable adjunct in the evaluation of breast lesions.
    Matched MeSH terms: Adenocarcinoma/pathology*; Breast Neoplasms/pathology*; Neoplasm Recurrence, Local/pathology; Nipples/pathology*
  16. A longitudinal study of alveolar bone loss around maxillary central incisors in patients with leprosy in Malaysia
    Subramaniam K, Nah SH, Marks SC
    Lepr Rev, 1994 Jun;65(2):137-42.
    PMID: 7968186
    The loss of alveolar bone supporting the maxillary central incisors and the general periodontal conditions were evaluated after 14 years in the 12 patients remaining from an original group of 47 under treatment in Malaysia. Alveolar bone loss was minimal during this period even in the presence of periodontal inflammation. These data suggest that treatment protects patients with leprosy from alveolar bone loss and suggests that other skeletal deformities might respond similarly.
    Matched MeSH terms: Leprosy/pathology; Maxillary Diseases/pathology; Periodontium/pathology; Alveolar Bone Loss/pathology
  17. Unicystic ameloblastoma: a late recurrence with pseudo-glandular features. A case report
    Khoo SP, High AS, Awang MN
    Singapore Dent J, 1995 Jul;20(1):21-3.
    PMID: 9582685
    A case of unicystic ameloblastoma which recurred after 15 years showing unusual histological features is reported. The prominent pseudo-glandular features present are described. This case highlights the importance of extensive histological examination for more characteristic features of ameloblastoma to reach a correct diagnosis.
    Matched MeSH terms: Ameloblastoma/pathology*; Mandible/pathology; Mandibular Neoplasms/pathology*; Neoplasm Recurrence, Local/pathology*
  18. Tuberculoid granulomatous lesion of the pharynx--review of the literature
    Sharma HS, Kurl DN, Kamal MZ
    Auris Nasus Larynx, 1998 May;25(2):187-91.
    PMID: 9673733
    Pharyngeal involvement in tuberculosis is rare and is usually secondary to pulmonary tuberculosis. We report a very rare case of chronic granulomatous pharyngitis, which later turned out to be due to primary tuberculosis of the pharynx. The clinical presentation, diagnosis, treatment and complications of this rare clinical entity are presented.
    Matched MeSH terms: Pharyngeal Diseases/pathology; Pharynx/pathology; Tuberculoma/pathology; Tuberculosis, Pulmonary/pathology
  19. Cytophagic histiocytic panniculitis: a diagnostic dilemma
    Cheah PL, Looi LM, Tan PE, Bosco J, Kuperan P
    Hematol Oncol, 1992 Nov-Dec;10(6):331-7.
    PMID: 1296933
    Cytophagic histiocytic panniculitis (CHP) is a recently recognized entity that frequently poses a perplexing diagnostic problem. Although the classical case presents with a relapsing fever, subcutaneous nodules, pancytopenia and liver dysfunction, most patients have in addition a multitude of other manifestations which confuse the clinical picture. Notwithstanding the variable clinical course, the disease frequently terminates in fatal hemorrhage. Diagnosis is based on histological features. A lobular panniculitis with an infiltrate of cytologically benign cytophagocytic histiocytes in skin nodules is the sine qua non of CHP. Hence, a deep skin biopsy which includes subcutaneous fat is mandatory to establish the diagnosis. Published information regarding this newly described entity remains scarce and we report two cases of CHP, one occurring in a 30-year-old Kadazan man and another in a 17-year-old Chinese woman seen at the University Hospital, Kuala Lumpur. The latter case presented with exudative ascites, an unusual feature, possibly due to intra-abdominal panniculitis. In addition, we record the development of cirrhosis in the same patient.
    Matched MeSH terms: Histiocytes/pathology; Liver/pathology; Liver/physiopathology; Skin/pathology; Panniculitis/pathology
  20. Fournier's gangrene: its aetiology and management
    Thambi Dorai CR, Kandasami P
    Aust N Z J Surg, 1991 May;61(5):370-2.
    PMID: 2025192
    The clinical features and management of 12 patients with Fournier's gangrene are described. The patients differed from the usual description of Fournier's gangrene in that they were older, the disease had a less abrupt onset and a definite predisposing factor was identified in 10 of the 12 patients. The importance of early diagnosis and excision of necrotic tissue is emphasized.
    Matched MeSH terms: Bacterial Infections/pathology*; Genital Diseases, Male/pathology; Penis/pathology*; Scrotum/pathology*
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