Displaying publications 4901 - 4920 of 7301 in total

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  1. Predicting soil erosion potential under CMIP6 climate change scenarios in the Chini Lake Basin, Malaysia
    Rendana M, Idris WMR, Rahim SA, Rahman ZA, Lihan T
    Geosci Lett, 2023;10(1):1.
    PMID: 36619610 DOI: 10.1186/s40562-022-00254-7
    Climate change and soil erosion are very associated with environmental defiance which affects the life sustainability of humans. However, the potency effects of both events in tropical regions are arduous to be estimated due to atmospheric conditions and unsustainable land use management. Therefore, several models can be used to predict the impacts of distinct climate scenarios on human and environmental relationships. In this study, we aimed to predict current and future soil erosion potential in the Chini Lake Basin, Malaysia under different Climate Model Intercomparison Project-6 (CMIP6) scenarios (e.g., SSP2.6, SSP4.5, and SSP8.5). Our results found the predicted mean soil erosion values for the baseline scenario (2019-2021) was around 50.42 t/ha year. The mining areas recorded the highest soil erosion values located in the southeastern part. The high future soil erosion values (36.15 t/ha year) were obtained for SSP4.5 during 2060-2080. Whilst, the lowest values (33.30 t/ha year) were obtained for SSP2.6 during 2040-2060. According to CMIP6, the future soil erosion potential in the study area would reduce by approximately 33.9% compared to the baseline year (2019-2021). The rainfall erosivity factor majorly affected soil erosion potential in the study area. The output of the study will contribute to achieving the United Nations' 2030 Agenda for Sustainable Development.
  2. Fulltext Cardiovascular, respiratory and all-cause (natural) health endpoint estimation using a spatial approach in Malaysia
    Mazeli MI, Pahrol MA, Abdul Shakor AS, Kanniah KD, Omar MA
    Sci Total Environ, 2023 May 20;874:162130.
    PMID: 36804978 DOI: 10.1016/j.scitotenv.2023.162130
    In 2016, the World Health Organization (WHO) estimated that approximately 4.2 million premature deaths worldwide were attributable to exposure to particulate matter 2.5 μm (PM2.5). This study assessed the environmental burden of disease attributable to PM2.5 at the national level in Malaysia. We estimated the population-weighted exposure level (PWEL) of PM10 concentrations in Malaysia for 2000, 2008, and 2013 using aerosol optical density (AOD) data from publicly available remote sensing satellite data (MODIS Terra). The PWEL was then converted to PM2.5 using Malaysia's WHO ambient air conversion factor. We used AirQ+ 2.0 software to calculate all-cause (natural), ischemic heart disease (IHD), stroke, chronic obstructive pulmonary disease (COPD), lung cancer (LC), and acute lower respiratory infection (ALRI) excess deaths from the National Burden of Disease data for 2000, 2008 and 2013. The average PWELs for annual PM2.5 for 2000, 2008, and 2013 were 22 μg m-3, 18 μg m-3 and 24 μg m-3, respectively. Using the WHO 2005 Air Quality Guideline cut-off point of PM2.5 of 10 μg m-3, the estimated excess deaths for 2000, 2008, and 2013 from all-cause (natural) mortality were between 5893 and 9781 (95 % CI: 3347-12,791), COPD was between 164 and 957 (95 % CI: 95-1411), lung cancer was between 109 and 307 (95 % CI: 63-437), IHD was between 3 and 163 deaths, according to age groups (95 % CI: 2-394) and stroke was between 6 and 155 deaths, according to age groups (95 % CI: 3-261). An increase in estimated health endpoints was associated with increased estimated PWEL PM2.5 for 2013 compared to 2000 and 2008. Adhering the ambient PM2.5 level to the Malaysian Air Quality Standard IT-2 would reduce the national health endpoints mortality.
  3. Fulltext Fresh evidence on connectedness between prominent markets during COVID-19 pandemic
    Younis I, Hkiri B, Shah WU, Qureshi F, Ilyas M, Longsheng C
    Environ Sci Pollut Res Int, 2023 Feb;30(9):22430-22457.
    PMID: 36287363 DOI: 10.1007/s11356-022-23408-8
    Various empirical studies have examined the nexus between financial markets, but this study focused on the comovement among prominent markets. Our study examines the interrelationship among main financial markets, i.e., stock, oil, and commodity during the recent pandemic. The interconnections among the selected markets are investigated using a battery of wavelet coherence tools and the Granger causality test. From the wavelet coherence analysis, our findings indicate strong co-movements among the VIX, oil volatility, and commodity prices during pandemic and localized in all scales and over the sample period. The dependency strength among the considered economies is noted to increase in pandemic, which implies increased short- and long-term benefits for the investors. Moreover, Our result exhibits a feedback causality between OVIX and crude oil, VIX and S&P 500, and gasoline and VIX. Interestingly, a unidirectional causality exists between VIX and crude oil, S&P 500 and crude oil, Brent and crude oil, gasoline, crude oil, and VIX and OVIX. We advocate that the findings will be helpful for portfolio managers, investors, and officials around the world.
  4. Fulltext Investigation of Dielectric, Ferroelectric, and Strain Responses of (1 - x)[0.90(Bi0.5Na0.5)TiO3 - 0.10SrTiO3] - xCuO Ceramics
    Ullah A, Khan AS, Sarker MR, Iqbal MJ, Khan HU, Tirth V, et al.
    ACS Omega, 2023 Apr 04;8(13):12372-12378.
    PMID: 37033827 DOI: 10.1021/acsomega.3c00128
    The low-temperature sintering of (Bi0.5Na0.5)TiO3-based ceramics can be achieved by sintering aid CuO. Piezoelectric ceramics (1 - x)[0.90(Bi0.5Na0.5)TiO3 - 0.10SrTiO3] - xCuO (BNT-ST-Cu) with x = 0, 0.01, 0.02, 0.03, and 0.04 were prepared through the mixed oxide route. A tetragonal structure was indexed for the undoped sample. Its structure was found to be changed to a pseudocubic when Cu was added. For undoped Cu samples, the sintering temperature (T s) for sufficient densification was 1160 °C. However, T s was reduced to 1090-1120 °C for Cu-added specimens. Field emission scanning electron microscopy (FE-SEM) showed a uniform and dense grain morphology for all samples. The maximum dielectric constant temperature (T m) was decreased with the doping concentration of Cu and applied frequency. The strain was increased with Cu concentration and had the maximum value of 500 pm/V for the sample x = 0.02 with symmetric and slim strain loops.
  5. Fulltext Nystagmus and Abducens Nerve Palsy as an Early Presentation of Non-alcoholic Wernicke Encephalopathy
    Darussalam SH, Mohd Isa M, Md Saleh R, Mohmood A, Mohammad Razali A
    Cureus, 2024 Jan;16(1):e52121.
    PMID: 38344547 DOI: 10.7759/cureus.52121
    Wernicke encephalopathy (WE) is a rare but life-threatening syndrome that is commonly associated with chronic alcoholism. It has also been found to be associated with malnutrition, prolonged parenteral nutrition, hemodialysis, hyperemesis gravidarum, gastroplasty, and AIDS. It usually presents as a clinical triad of confusion, ophthalmoplegia, and gait ataxia. Nystagmus is usually the most common and earliest ophthalmologic sign. We report a case of non-alcoholic WE in a patient who had prior bariatric surgery and was treated for malnutrition and sepsis, with nystagmus being the initial presentation. The MRI of the brain was normal. The diagnosis of WE was made clinically and was supported by the patient's symptomatic and clinical recovery following intravenous thiamine treatment. It is essential to highlight that a high level of suspicion is needed to diagnose non-alcoholic WE to allow the commencement of appropriate treatment and reduce morbidity and mortality rates related to this condition.
  6. Fulltext Exploring Patient Safety Culture: A Study of Community Pharmacies in Karachi, Pakistan
    Khatri SA, Ahmad R, Osama M, Khan K, Khan MA, Ishaqui A, et al.
    Cureus, 2024 Jan;16(1):e52135.
    PMID: 38344495 DOI: 10.7759/cureus.52135
    Background Community pharmacies are integral to the healthcare system, actively contributing to patient safety through accurate dispensing, education, collaboration, monitoring, and the implementation of safety protocols. Their accessibility and role as medication experts make them key partners in promoting positive health outcomes for individuals and communities. Objective The current study will evaluate the patient safety culture (PSC) among community pharmacies in Karachi, Pakistan. Additionally, this study will measure the association between patient safety culture in community pharmacies and the demographic characteristics of the pharmacy staff. Methods A cross-sectional survey of pharmacy staff was conducted using a survey instrument developed by the US Agency for Healthcare Research and Quality (AHRQ). Demographic variables and assessments of safety culture in pharmacies were studied. The data were analyzed using descriptive statistics. Results Among the 102 participants, positive responses ranged from 30% to 87.5%. The highest positive response was for the dimension "mistakes in communication" (86.3%), followed by "communication across shifts" (82.2%) and "communication openness" (81.7%). The dimensions "overall perceptions of patient safety" and "response to mistakes" had the lowest positive responses (56.0% and 60.9%, respectively). Furthermore, many staff did not regularly record the errors, even if they impacted the practices. Conclusion There was an overall unfavorable perception of patient safety culture among the surveyed pharmacies of Karachi, Pakistan. However, the communication dimensions showed the highest positive response. There is a strong need to improve the overall perception of patient safety among the staff and develop an optimistic response to mistakes.
  7. Effects of pH and temperature on striped catfish Pangasianodon hypophthalmus juvenile: Data on growth performance and survival rate
    Abduh MY, Asra Aswadi NI, Husna NMA, Syazana S, Norazmi-Lokman NH
    Data Brief, 2024 Feb;52:109826.
    PMID: 38370024 DOI: 10.1016/j.dib.2023.109826
    The growth performance and survival rates of juvenile striped catfish, Pangasianodon hypophthalmus, reared at various levels of pH and temperature were described in this article. Two rearing trials were conducted separately for pH and temperature where both trials lasted for 35 days. One hundred and twenty juveniles (1.5 ± 0.23 g) were randomly stocked into 12 rectangle glass aquariums (n = 10 fish/tank; three replicates per treatment) with 100 L of water for each trial. The treatment consisted of four different pH level (7.5, 8.0, 8.5 and 9.0) and four different temperature level (26 °C, 28 °C, 30 °C and 32 °C). The survival of fish was counted at the end of experiments, and the weight of the juvenile was measured once a week. The quantification of feed intake was determined through the measurement of the residual weight of the feeds after the feeding process. Upon the conclusion of the experiment, the data pertaining to weight and feed intake were utilized to calculate the specific growth rate (SGR) and food conversion ratio (FCR) as indicators of growth performance. Additionally, the number of live fish was employed to ascertain the survival rate. The data obtained from the calculation of SGR, FCR and survival rate were next subjected to a normality test, one-way analysis of variance (ANOVA), and a Tukey post-hoc test. The information in this article will help in the business, experimental, and personal usage for P. hypophthalmus juveniles rearing process.
  8. Synthesis, spectral characterisation, biocidal investigation, in-silico and molecular docking studies of 4-[(2-chloro-4-methylphenyl)carbamoyl]butanoic acid derived triorganotin(IV) compounds
    Hanifa B, Bibi N, Sirajuddin M, Tiekink ERT, Kubicki M, Khan I, et al.
    J Biomol Struct Dyn, 2024;42(4):1826-1845.
    PMID: 37114651 DOI: 10.1080/07391102.2023.2204160
    Three triorganotin(IV) compounds, R3Sn(L), with R = CH3 (1), n-C4H9 (2) and C6H5 (3), and LH = 4-[(2-chloro-4-methylphenyl)carbamoyl]butanoic acid, were prepared and confirmed by various techniques. A five-coordinate, distorted trigonal-bipyramidal geometry was elucidated for tin(IV) centres both in solution and solid states. An intercalation mode was confirmed for the compound SS-DNA interaction by UV-visible, viscometric techniques and molecular docking. MD simulation revealed stable binding of LH with SS-DNA. Anti-bacterial investigation revealed 2 to be generally the most potent, especially against Sa and Ab, i.e. having the lowest MIC values (≤0.25 μg/mL) compared to the standard anti-biotics vancomycin-HCl (MIC = 1 μg/mL) and colistin-sulphate (MIC = 0.25 μg/mL). Similarly, the anti-fungal profile shows 2 exhibits 100% inhibition against Ca and Cn fungal strains and has MIC values (≤0.25 μg/mL) comparatively lower than standard drug fluconazole (0.125 and 8 μg/mL for Ca and Cn, respectively). Compound 2 has the greatest activity with CC50 ≤ 25 μg/mL and HC50 > 32 μg/mL performed against HEC239 and RBC cell lines. The anti-cancer potential was assessed against the MG-U87 cell line, using cisplatin as the standard (133 µM), indicates 2 displays the greatest activity (IC50: 5.521 µM) at a 5 µM dose. The greatest anti-leishmanial potential was observed for 2 (87.75 at 1000 μg/mL) in comparison to amphotericin B (90.67). The biological assay correlates with the observed maximum of 89% scavenging activity exhibited by 2. The Swiss-ADME data publicised the screened compounds generally follow the rule of 5 of drug-likeness and have good bioavailability potential.
  9. Fulltext Effects of Plyometric Training on Physical Fitness Attributes in Handball Players: A Systematic Review and Meta-Analysis
    Wang X, Zhang K, Samsudin SB, Hassan MZB, Yaakob SSNB, Dong D
    J Sports Sci Med, 2024 Mar;23(1):177-195.
    PMID: 38455436 DOI: 10.52082/jssm.2024.177
    This meta-analysis aimed to examine the effects of plyometric training on physical fitness attributes in handball players. A systematic literature search across PubMed, SCOPUS, SPORTDiscus, and Web of Science identified 20 studies with 563 players. Plyometric training showed significant medium-to-large effects on various attributes: countermovement jump with arms (ES = 1.84), countermovement jump (ES = 1.33), squat jump (ES = 1.17), and horizontal jump (ES = 0.83), ≤ 10-m linear sprint time (ES = -1.12), > 10-m linear sprint time (ES = -1.46), repeated sprint ability with change-of-direction time (ES = -1.53), agility (ES = -1.60), maximal strength (ES = 0.52), and force-velocity (muscle power) (ES = 1.13). No significant impact on balance was found. Subgroup analysis indicated more pronounced agility improvements in players ≤ 66.6 kg compared to > 66.6 kg (ES = -1.93 vs. -0.23, p = 0.014). Additionally, greater improvements were observed in linear sprint and repeat sprint ability when comparing training durations of > 8 weeks with those ≤ 8 weeks (ES = -2.30 to -2.89 vs. ES = -0.92 to -0.97). In conclusion, plyometric training effectively improves various physical fitness attributes, including jump performance, linear sprint ability, maximal strength, muscle power and agility.
  10. Fulltext Estimation of soil erodibility in Peninsular Malaysia: A case study using multiple linear regression and artificial neural networks
    Rehman MA, Abd Rahman N, Ibrahim ANH, Kamal NA, Ahmad A
    Heliyon, 2024 Apr 15;10(7):e28854.
    PMID: 38576554 DOI: 10.1016/j.heliyon.2024.e28854
    Soil erodibility (K) is an essential component in estimating soil loss indicating the soil's susceptibility to detach and transport. Data Computing and processing methods, such as artificial neural networks (ANNs) and multiple linear regression (MLR), have proven to be helpful in the development of predictive models for natural hazards. The present case study aims to assess the efficiency of MLR and ANN models to forecast soil erodibility in Peninsular Malaysia. A total of 103 samples were collected from various sites and K values were calculated using the Tew equation developed for Malaysian soil. From several extracted parameters, the outcomes of correlation and principal component analysis (PCA) revealed the influencing factors to be used in the development of ANN and MLR models. Based on the correlation and PCA results, two sets of influencing factors were employed to develop predictive models. Two MLR (MLR-1 and MLR-2) models and four neural networks (NN-1, NN-2, NN-3, and NN-4) optimized using Levenberg-Marquardt (LM) and scaled conjugate gradient (SCG) were developed and evaluated. The model performance validation was conducted using the coefficient of determination (R2), mean squared error (MSE), root mean squared error (RMSE), and Nash-Sutcliffe efficiency coefficient (NSE). The analysis showed that ANN models outperformed MLR models. The R2 values of 0.446 (MLR-1), 0.430 (MLR-2), 0.894 (NN-1), 0.855 (NN-2), 0.940 (NN-3), and 0.826 (NN-4); MSE values of 0.0000306 (MLR-1), 0.0000315 (MLR-2), 0.0000158 (NN-1), 0.0000261 (NN-2), 0.0000318 (NN-3), and 0.0000216 (NN-4) suggested the higher accuracy and lower modelling error of ANN models as compared with MLR. This study could provide an empirical basis and methodological support for K factor estimation in the region.
  11. Characteristics and health implications of fine particulate matter near urban road site in Islamabad, Pakistan
    Hussain S, Siddique A, Hassan M, Rasool K, Shahzad A, Asad Naqvi SA, et al.
    Environ Res, 2024 Apr 02;252(Pt 1):118862.
    PMID: 38574984 DOI: 10.1016/j.envres.2024.118862
    The escalating issue of air pollution has become a significant concern in urban regions, including Islamabad, Pakistan, due to the rise in air pollutant emissions driven by economic and industrial expansion. To gain a deeper understanding of air pollution, a study was conducted during winter 2022-2023, assessing physical, chemical, and biological factors in Islamabad. The findings revealed that the average concentration of fine particulate matter (PM2.5) was notably greater than the World Health Organization (WHO) guidelines, reaching 133.39 μg/m³. Additionally, the average concentration of bacteria (308.64 CFU/m³) was notably greater than that of fungi (203.55 CFU/m³) throughout the study. Analytical analyses, including SEM-EDS and FTIR, showed that the PM2.5 in Islamabad is composed of various particles such as soot aggregates, coal fly ash, minerals, bio-particles, and some unidentified particles. EF analysis distinguished PM2.5 sources, enhancing understanding of pollutants origin, whereas Spearman's correlation analysis elucidated constituent interactions, further explaining air quality impact. The results from the Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-OES) indicated a gradual increase in the total elemental composition of PM2.5 from autumn to winter, maintaining high levels throughout the winter season. Furthermore, a significant variation was found in the mass concentration of PM2.5 when comparing samples collected in the morning and evening. The study also identified the presence of semi-volatile organic compounds (SVOCs) in PM2.5 samples, including polycyclic aromatic hydrocarbons (PAHs) and phenolic compounds, with notable variations in their concentrations. Utilizing health risk assessment models developed by the US EPA, we estimated the potential health risks associated with PM2.5 exposure, highlighting the urgency of addressing air quality issues. These findings provide valuable insights into the sources and composition of PM2.5 in Islamabad, contributing to a comprehensive understanding of air quality and its potential environmental and health implications.
  12. Fulltext Adaptation and potential culture of wild Amphipods and Mysids as potential live feed in aquaculture: a review
    Suhaimi H, Abdul Rahman MI, Ashaari A, Ikhwanuddin M, Wan Rasdi N
    PeerJ, 2024;12:e17092.
    PMID: 38563012 DOI: 10.7717/peerj.17092
    Live foods such as phytoplankton and zooplankton are essential food sources in aquaculture. Due to their small size, they are suitable for newly hatched larvae. Artemia and rotifer are commonly used live feeds in aquaculture; each feed has a limited dietary value, which is unsuitable for all cultured species. Whereas, copepod and cladocerans species exhibit favorable characteristics that make them viable candidates as sources of essential nutrients for hatchery operations. Due to their jerking movements, it stimulates the feeding response of fish larvae, and their various sizes make them suitable for any fish and crustacean. Even though Artemia is the best live feed due to its proficient nutritional quality, the cost is very expensive, which is about half of the production cost. A recent study suggests the use of amphipods and mysids as alternative live feeds in aquaculture. High nutritional value is present in amphipods and mysids, especially proteins, lipids, and essential fatty acids that are required by fish larvae during early development. Amphipods and mysids are considered abundant in the aquatic ecosystem and have been used by researchers in water toxicity studies. However, the culture of amphipods and mysids has been poorly studied. There is only a small-scale culture under laboratory conditions for scientific research that has been performed. Thus, further research is required to find a way to improve the mass culture of amphipods and mysids that can benefit the aquaculture industry. This review article is intended to provide the available information on amphipods and mysids, including reproductive biology, culture method, nutritional value, feed enhancement, and the importance of them as potential live feed in aquaculture. This article is useful as a guideline for researchers, hatchery operators, and farmers.
  13. Effectiveness of Conventional Periodontal Treatment With Tetracycline Fiber Versus Minocycline Gel Application Subgingivally in Periodontitis Patients
    Zainuddin SLA, Latib N, Taib H, Ahmad B, Sabarudin MA, Wan Mohamad WM
    Cureus, 2024 Feb;16(2):e55167.
    PMID: 38558744 DOI: 10.7759/cureus.55167
    BACKGROUND: Locally delivered antibiotics are adjunctive therapies for the selective removal or inhibition of pathogenic microbes in combination with scaling and root planing (SRP) for the management of periodontitis.

    OBJECTIVE: The primary objective of this study was to evaluate the effectiveness of tetracycline fibers against minocycline gel when used as local drug delivery in conjunction with SRP for treating periodontitis.

    METHODS AND MATERIALS: This is a pilot randomized open single, blinded trial study comparing three treatment modalities: SRP with topical tetracycline fibers (SRP+T), SRP with topical minocycline HCL 2% gel (SRP+M), and SRP only as a control group. Probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) percentages were recorded at baseline, one month, and at the end of three months. The data were subjected to analysis using IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp. Repeated measures ANOVA was used to compare the clinical outcomes between the three treatment groups, accounting for the repeated measurements at baseline, one month, and three months. A p-value less than 0.05 at a 95% confidence interval was deemed statistically significant.

    RESULTS: There were statistically significant changes within the groups in all the clinical parameters, including pocket depth, clinical attachment loss, and bleeding on probing score, at different time intervals, with the greatest mean pocket depth changes seen in the tetracycline group after one month (mean changes = 1.4 mm, P < 0.001) and over three months (mean changes = 1.79 mm, p < 0.001). For clinical attachment loss, after one month, the highest improvement in clinical level was seen in the minocycline group (mean changes = 0.7mm, p < 0.05), and the overall improvement was seen in the control group (mean changes = 1.1mm, p < 0.05). The minocycline group showed greater mean changes in bleeding on probing percentage, with the greatest changes after one month (mean changes = 19.34%, p < 0.001) and over three months (mean changes = 26.42%, p <0.001). However, there was no significant difference between the groups.

    CONCLUSION: Locally delivered tetracycline and minocycline gel are effective as adjuncts to SRP and may improve the healing outcome in the management of periodontitis.

  14. Fulltext FEM Analysis of Various Multilayer Structures for CMOS Compatible Wearable Acousto-Optic Devices
    Hanif M, Jeoti V, Ahmad MR, Aslam MZ, Qureshi S, Stojanovic G
    Sensors (Basel), 2021 Nov 26;21(23).
    PMID: 34883867 DOI: 10.3390/s21237863
    Lately, wearable applications featuring photonic on-chip sensors are on the rise. Among many ways of controlling and/or modulating, the acousto-optic technique is seen to be a popular technique. This paper undertakes the study of different multilayer structures that can be fabricated for realizing an acousto-optic device, the objective being to obtain a high acousto-optic figure of merit (AOFM). By varying the thicknesses of the layers of these materials, several properties are discussed. The study shows that the multilayer thin film structure-based devices can give a high value of electromechanical coupling coefficient (k2) and a high AOFM as compared to the bulk piezoelectric/optical materials. The study is conducted to find the optimal normalised thickness of the multilayer structures with a material possessing the best optical and piezoelectric properties for fabricating acousto-optic devices. Based on simulations and studies of SAW propagation characteristics such as the electromechanical coupling coefficient (k2) and phase velocity (v), the acousto-optic figure of merit is calculated. The maximum value of the acousto-optic figure of merit achieved is higher than the AOFM of all the individual materials used in these layer structures. The suggested SAW device has potential application in wearable and small footprint acousto-optic devices and gives better results than those made with bulk piezoelectric materials.
  15. Fulltext LCMS dataset on compounds in Syzygium polyanthum (Wight) Walp. leaves variant from the East coast of Peninsular Malaysia
    Anuar TAFT, Ismail A, Mohamed Suffian IF, Abdul Hamid AA, Arzmi MH, Omar MN
    Data Brief, 2021 Dec;39:107485.
    PMID: 34761082 DOI: 10.1016/j.dib.2021.107485
    The data presented here is the liquid chromatography and mass spectrometry (LC-MS) profile of phytochemical compounds in the aqueous extract of Syzygium polyanthum (Wight) Walp. leaves. This plant is consumed raw and sometimes added to local dishes of people in Southeast Asia countries. Most importantly, it has ethnomedicinal values mainly in treating diabetes and hypertension, and at the same time, this plant has anti-microbial, anti-oxidant, anti-cancer, and anti-tumor properties [1]. There are chemical composition variations reported between the same species of different geographical locations, which eventually affect the plant's therapeutic potential [2], [3]. This dataset represents the identified compounds for S. polyanthum (Wight) Walp. leaves, a variant collected from Kuantan, a city located in the Pahang state on the East Coast of Peninsular Malaysia. The leaves were then dried in an open-air at room temperature for three weeks, ground, and then macerated in water inside a bath-sonicator, freeze-dried, and then run using LCMS. The LCMS was run using the ultra-performance liquid chromatography equipped with an electrospray time-of-flight mass spectrometer detector, operated in a negative-ion mode. The mass spectral features from samples raw data were matched with Traditional Medicine (en) and Waters Screening libraries in the Waters UNIFI™ Scientific Information System software version 1.7 (Waters, USA) for compounds identification.
  16. Bioinspired mp20 mimicking uricase in ZIF-8: Metal ion dependent for controllable activity
    Abdul Aziz SFN, Salleh AB, Normi YM, Mohammad Latif MA, Alang Ahmad SA
    Enzyme Microb Technol, 2024 Mar 21;178:110439.
    PMID: 38579423 DOI: 10.1016/j.enzmictec.2024.110439
    Mini protein mimicking uricase (mp20) has shown significant potential as a replacement for natural enzymes in the development of uric acid biosensors. However, the design of mp20 has resulted to an inactive form of peptide, causing of loss their catalytic activity. Herein, this paper delineates the impact of various metal cofactors on the catalytic activity of mp20. The metal ion-binding site prediction and docking (MIB) web server was employed to identify the metal ion binding sites and their affinities towards mp20 residues. Among the tested metal ions, Cu2+ displayed the highest docking score, indicating its preference for interaction with Thr16 and Asp17 residues of mp20. To assess the catalytic activity of mp20 in the presence of metal ions, uric acid assays was monitored using a colorimetric method. The presence of Cu2+ in the assays promotes the activation of mp20, resulting in a color change based on quinoid production. Furthermore, the encapsulation of the mp20 within zeolitic imidazolate framework-8 (ZIF-8) notably improved the stability of the biomolecule. In comparison to the naked mp20, the encapsulated ZIFs biocomposite (mp20@ZIF-8) demonstrates superior stability, selectivity and sensitivity. ZIF's porous shells provides excellent protection, broad detection (3-100 μM) with a low limit (4.4 μM), and optimal function across pH (3.4-11.4) and temperature (20-100°C) ranges. Cost-effective and stable mp20@ZIF-8 surpasses native uricase, marking a significant biosensor technology breakthrough. This integration of metal cofactor optimization and robust encapsulation sets new standards for biosensing applications.
  17. Fulltext The relationship of lifetime substance-use disorder with family functioning, childhood victimisation, and depression, among juvenile offenders in Malaysia
    Wahab S, Baharom MA, Abd Rahman FN, A Wahab K, Zulkifly MA, Azmi AD, et al.
    Addict Behav Rep, 2021 Dec;14:100359.
    PMID: 34136633 DOI: 10.1016/j.abrep.2021.100359
    INTRODUCTION: Adolescent substance use is a multifactorial social issue that leads to detrimental outcomes. The aim of this study is to understand the association of a lifetime history of substance abuse or dependence with family functioning, childhood victimisation, and depression, among adolescent male inmates in a juvenile detention centre in Malaysia.

    METHODS: This study was cross-sectional involving 230 inmates and was conducted in a juvenile detention centre in Malaysia. The mean age of the participants was 16.65 years, with the highest percentage from the Malay ethnicity (87.8% where n = 202). The Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID), Adolescent Alcohol and Drug Involvement Scale (AADIS), Family Adaptability and Cohesion Evaluation Scale (FACES) IV and Juvenile Victimization Questionnaire Second Revision (JVQ-R2) were used as instruments.

    RESULTS: The prevalence of a lifetime history of substance abuse and substance dependence is 72.6% and 58.3%, respectively. A lifetime history of substance abuse and dependence had a significant association with age, race, religion, and peer/sibling victimisation. Further analysis reveals that an increase in age can be a predictor of both lifetime history of substance abuse and dependence while peer/sibling victimisation may predict lifetime history of substance abuse. There was no significant association of lifetime substance-use disorder with family functioning and depression in the juvenile offenders.

    CONCLUSIONS: Adolescents exposed to peer/sibling victimisation might be at a higher risk of developing a substance-use disorder. At-risk groups need to be identified, assessed, and have intervention early to prevent adverse outcomes.

  18. Fulltext Frequency, management and impact of adverse events on treatment outcomes in patients with multidrug resistant tuberculosis in Balochistan, Pakistan
    Rafique S, Ahmad N, Khan S, Khan A, Atif M, Wahid A, et al.
    J Pharm Policy Pract, 2024;17(1):2332878.
    PMID: 38572376 DOI: 10.1080/20523211.2024.2332878
    BACKGROUND: Early detection, monitoring, and managing adverse events (AEs) are crucial in optimising treatment for multidrug-resistant tuberculosis (MDR-TB) patients.

    OBJECTIVES: To investigate the incidence, factors, management, and impact of AEs on treatment outcomes in MDR-TB patients.

    METHODS: This study reviewed the medical records of 275 MDR-TB patients at Fatimah Jinnah Institute of Chest Diseases in Quetta, Pakistan. Patient information was collected using a designed data collection form. Mann-Whitney U and Kruskal-Wallis tests examined the difference in AEs occurrences based on patients' characteristics. Multiple binary logistic regression identified factors associated with unsuccessful outcomes, with statistical significance set at a p-value 60 years(OR = 23.481), baseline body weight of 31-60 kg(OR = 0.180), urban residence(OR = 0.296), and experiencing ototoxicity (OR = 0.258) and hypothyroidism (OR = 0.136) were significantly associated with unsuccessful treatment outcomes.

    CONCLUSION: AEs were highly prevalent but did not negatively impact treatment outcomes. Patients at higher risk of developing AEs and unsuccessful outcomes should receive special attention for its early management.

  19. Fulltext Comparative stability analysis of Indonesian banks: Markov Switching-Dynamic Regression for Islamic and conventional sectors
    Mawardi I, Al Mustofa MU, Widiastuti T, Fanani S, Bakri MH, Hanafi Z, et al.
    PLoS One, 2024;19(4):e0301398.
    PMID: 38635825 DOI: 10.1371/journal.pone.0301398
    The banking industry necessitates implementing an early warning system to effectively identify the factors that impact bank managers and enable them to make informed decisions, thereby mitigating systemic risk. Identifying factors that influence banks in times of stability and crisis is crucial, as it ultimately contributes to developing an improved early warning system. This study undertakes a comparative analysis of the stability of Indonesian Islamic and conventional banking across distinct economic regimes-crisis and stability. We analyze monthly banking data from December 2007 to November 2022 using the Markov Switching Dynamic Regression technique. The study focuses on conducting a comparative analysis between Islamic banks, represented by Islamic Commercial Bank (ICB) and Islamic Rural Bank (IRB), and conventional banks, represented by the Conventional Commercial Bank (CCB) and Conventional Rural Bank (CRB). The findings reveal that both Islamic and conventional banks exhibit a higher probability of being in a stable regime than a crisis regime. Notably, Islamic banks demonstrate a greater propensity to remain in a stable regime than their conventional counterparts. However, in a crisis regime, the likelihood of recovery for Sharia-compliant institutions is lower than for conventional banks. Furthermore, our analysis indicates that larger banks exhibit higher stability than their smaller counterparts regarding assets and size. This study pioneers a comprehensive comparison of the Z-score, employed as a proxy for stability, between two distinct classifications of Indonesian banks: Sharia (ICB and IRB) and conventional (CCB and CRB). The result is expected to improve our awareness of the elements that affect the stability of Islamic and conventional banking in Indonesia, leading to a deeper comprehension of their dynamics.
  20. Fulltext Electron plasma diagnostics in ELTRAP by electron cyclotron resonance heating method
    Khan F, Ikram M, Rashdan M, Elsayed F, Ahmad P, Khandaker MU
    PLoS One, 2024;19(4):e0296845.
    PMID: 38635742 DOI: 10.1371/journal.pone.0296845
    Electron cyclotron resonance heating method of Particle-in-Cell code was used to analyze heating phenomena, axial kinetic energy, and self-consistent electric field of confined electron plasma in ELTRAP device by hydrogen and helium background gases. The electromagnetic simulations were performed at a constant power of 3.8 V for different RF drives (0.5 GHz- 8 GHz), as well as for 1 GHz constant frequency at these varying amplitudes (1 V-3.8 V). The impacts of axial and radial temperatures were found maximum at 1.8 V and 5 GHz as compared to other amplitudes and frequencies for both background gases. These effects are higher at varying radio frequencies due to more ionization and secondary electrons production and maximum recorded radial temperature for hydrogen background gas was 170.41 eV. The axial kinetic energy impacts were found more effective in the outer radial part (between 0.03 and 0.04 meters) of the ELTRAP device due to applied VRF through C8 electrode. The self-consistent electric field was found higher for helium background gas at 5 GHz RF than other amplitudes and radio frequencies. The excitation and ionization rates were found to be higher along the radial direction (r-axis) than the axial direction (z-axis) in helium background gas as compared to hydrogen background gas. The current studies are advantageous for nuclear physics applications, beam physics, microelectronics, coherent radiation devices and also in magnetrons.
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