Displaying publications 541 - 560 of 760 in total

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  1. Rehman S, Madni A, Jameel QA, Usman F, Raza MR, Ahmad F, et al.
    AAPS PharmSciTech, 2022 Nov 17;23(8):304.
    PMID: 36396831 DOI: 10.1208/s12249-022-02456-w
    The current study sought to create graphene oxide-based superstructures for gastrointestinal drug delivery. Graphene oxide has a large surface area that can be used to load anti-cancer drugs via non-covalent methods such as surface adsorption and hydrogen bonding. To enhance the bio-applicability of graphene oxide, nano-hybrids were synthesized by encapsulating the graphene oxide into calcium alginate hydrogel beads through the dripping-extrusion technique. These newly developed bio-nanocomposite hybrid hydrogel beads were evaluated in structural analysis, swelling study, drug release parameters, haemolytic assay, and antibacterial activity. Doxorubicin served as a model drug. The drug entrapment efficiency was determined by UV-spectroscopy analysis and was found to be high at ⁓89% in graphene oxide hybrid hydrogel beads. These fabricated hydrogel beads ensure the drug release from a hybrid polymeric matrix in a more controlled and sustained pattern avoiding the problems associated with a non-hybrid polymeric system. The drug release study of 12 h shows about 83% release at pH 6.8. In vitro drug release kinetics proved that drug release was a Fickian mechanism. The cytotoxic effect of graphene oxide hybrid alginate beads was also determined by evaluating the morphology of bacterial cells and red blood cells after incubation. Additionally, it was determined that the sequential encapsulation of graphene oxide in alginate hydrogel beads hides its uneven edges and lessens the graphene oxide's negative impacts. Also, the antibacterial study and biocompatibility of fabricated hydrogel beads made them potential candidates for gastrointestinal delivery.
  2. Hyder AA, Merritt M, Ali J, Tran NT, Subramaniam K, Akhtar T
    Bull World Health Organ, 2008 Aug;86(8):606-11.
    PMID: 18797618
    Scientific progress is a significant basis for change in public-health policy and practice, but the field also invests in value-laden concepts and responds daily to sociopolitical, cultural and evaluative concerns. The concepts that drive much of public-health practice are shaped by the collective and individual mores that define social systems. This paper seeks to describe the ethics processes in play when public-health mechanisms are established in low- and middle-income countries, by focusing on two cases where ethics played a crucial role in producing positive institutional change in public-health policy. First, we introduce an overview of the relationship between ethics and public health; second, we provide a conceptual framework for the ethical analysis of health system events, noting how this approach might enhance the power of existing frameworks; and third, we demonstrate the interplay of these frameworks through the analysis of a programme to enhance road safety in Malaysia and an initiative to establish a national ethics committee in Pakistan. We conclude that, while ethics are gradually being integrated into public-health policy decisions in many developing health systems, ethical analysis is often implicit and undervalued. This paper highlights the need to analyse public-health decision-making from an ethical perspective.
  3. Ahmad A, Li Z, Iqbal S, Aurangzeb M, Tariq I, Flah A, et al.
    Heliyon, 2024 Mar 15;10(5):e27392.
    PMID: 38495163 DOI: 10.1016/j.heliyon.2024.e27392
    Micro-expressions (ME) are rapidly occurring expressions that reveal the true emotions that a human being is trying to hide, cover, or suppress. These expressions, which reveal a person's actual feelings, have a broad spectrum of applications in public safety and clinical diagnosis. This study provides a comprehensive review of the area of ME recognition. A bibliometric and network analysis techniques is used to compile all the available literature related to ME recognition. A total of 735 publications from the Web of Science (WOS) and Scopus databases were evaluated from December 2012 to December 2022 using all relevant keywords. The first round of data screening produced some basic information, which was further extracted for citation, coupling, co-authorship, co-occurrence, bibliographic, and co-citation analysis. Additionally, a thematic and descriptive analysis was executed to investigate the content of prior research findings, and research techniques used in the literature. The year wise publications indicated that the published literature between 2012 and 2017 was relatively low but however by 2021, a nearly 24-fold increment made it to 154 publications. The three topmost productive journals and conferences included IEEE Transactions on Affective Computing (n = 20 publications) followed by Neurocomputing (n = 17) and Multimedia tools and applications (n = 15). Zhao G was the most proficient author with 48 publications and the top influential country was China (620 publications). Publications by citations showed that each of the authors acquired citations ranging from 100 to 1225. While publications by organizations indicated that the University of Oulu had the most published papers (n = 51). Deep learning, facial expression recognition, and emotion recognition were among the most frequently used terms. It has been discovered that ME research was primarily classified in the discipline of engineering, with more contribution from China and Malaysia comparatively.
  4. Awang MS, Abdullah JM, Abdullah MR, Tahir A, Tharakan J, Prasad A, et al.
    Med Sci Monit, 2007 Jul;13(7):CR330-2.
    PMID: 17599028
    Nerve conduction study is essential in the diagnosis of focal neuropathies and diffuse polyneuropathies. There are many factors that can affect nerve conduction velocity, and age is one of them. Most of the many studies of this effect, and the values from them, were on Caucasian subjects. Therefore, this study was designed to investigate the effect of age on conduction velocity among healthy Asian Malay subjects by analyzing its influence on the median, ulnar, and sural nerves.
  5. Ali A, Ramakrishnan S, Faisal F, Akram T, Salam S, Rahman SU
    Environ Dev Sustain, 2022 Aug 24.
    PMID: 36039365 DOI: 10.1007/s10668-022-02602-1
    The finance and natural resources revenue nexus play a critical role in an economy. The recent development and significant increase in academic literature regarding the resource-finance nexus are the primary motivations for conducting this study. This study aims to conduct a bibliometric analysis of 363 documents published between 1976 and 2021 collected from the Scopus database. The results have been demonstrated via graphs, tables, knowledge maps about the past trends, growth, and prospects using co-occurrence, co-authorship, and co-citation analysis via the VOSviewer tool. This study has identified prolific authors, journals, countries, academic institutions, and future pathways. The findings indicate that China has the highest share of publications (88, 24.2%), followed by Pakistan (58, 15.9%) and Turkey (37, 10.2%). The most productive academic institution is the Beijing Institute of Technology in China (13, 3.6%). This study proposes new avenues for further research concerning the resource-finance nexus, such as ecological footprint, sustainability, fiscal decentralization, green investment, energy prices, environmental quality, technological innovation, financial resource curse (especially the stock market resource curse), human capital, and renewable energy in policy development and sustainability towards the achievement of the SDGs.
  6. He S, Lunnen JC, Puvanachandra P, Amar-Singh, Zia N, Hyder AA
    Am J Public Health, 2014 Mar;104(3):e79-84.
    PMID: 24432924 DOI: 10.2105/AJPH.2013.301607
    We aimed to analyze the epidemiology of childhood unintentional injuries presenting to hospitals in 5 select sites in low- and middle-income countries (LMICs) (Bangladesh, Colombia, Egypt, Malaysia, and Pakistan).
  7. Taha M, Ismail NH, Aziza AN, Shah SA, Yousuf S
    Acta Crystallogr Sect E Struct Rep Online, 2013 Feb 01;69(Pt 2):o245.
    PMID: 23424524 DOI: 10.1107/S160053681300127X
    In the title compound, C(29)H(21)O(3)P, a coumarin-substitued ylid, the P atom is linked to three benzene rings and a planar coumarin moiety via a methyl-enecarbonyl group. The bond lengths in the P=C-C=O fragment clearly indicate a delocalized system involving the olefinic and carbonyl bonds. The mol-ecular structure is stabilized by an intra-molecular C-H⋯O inter-action that results in an S7 graph-set ring motif. In the crystal, mol-ecules are linked into a three-dimensional framework by C-H⋯O hydrogen bonds.
  8. Aqeel S, Khan SU, Khan AS, Alharbi M, Shah S, Affendi ME, et al.
    Sci Rep, 2024 Jun 15;14(1):13839.
    PMID: 38879689 DOI: 10.1038/s41598-024-64419-4
    With the urge to secure and protect digital assets, there is a need to emphasize the immediacy of taking measures to ensure robust security due to the enhancement of cyber security. Different advanced methods, like encryption schemes, are vulnerable to putting constraints on attacks. To encode the digital data and utilize the unique properties of DNA, like stability and durability, synthetic DNA sequences are offered as a promising alternative by DNA encoding schemes. This study enlightens the exploration of DNA's potential for encoding in evolving cyber security. Based on the systematic literature review, this paper provides a discussion on the challenges, pros, and directions for future work. We analyzed the current trends and new innovations in methodology, security attacks, the implementation of tools, and different metrics to measure. Various tools, such as Mathematica, MATLAB, NIST test suite, and Coludsim, were employed to evaluate the performance of the proposed method and obtain results. By identifying the strengths and limitations of proposed methods, the study highlights research challenges and offers future scope for investigation.
  9. Ali AS, Gari SR, Goodson ML, Walsh CL, Dessie BK, Ambelu A
    PMID: 38944842 DOI: 10.1080/09603123.2024.2374001
    The importance of diarrhea risk associated with wastewater exposure in agriculture is almost unknown. This study aimed to examine diarrheal infection and risk factors among farmers using wastewater for irrigation in Addis Ababa. A cross-sectional study was employed among 380 farmers (190 exposed and 190 unexposed farmers). Among these, a cohort of 200 adults (100 wastewater-exposed, 100 unexposed farmers) aged 25-69 years were selected and followed up biweekly for two successive vegetables growing seasons to examine the incidence of diarrhea. The incidence rate of reported diarrhea was 12 episodes per 1,000 person-weeks at risk and a maximum of 17 episodes per 1,000 person-weeks at risk. Strongly associated risk factors include washing body and clothes with wastewater [AOR: 4.2, 95%CI (1, 11.2)], using working clothes at home [AOR: 4.7, 95%CI (0.25, 87)], and wearing protective cloth [AOR: 5.6, 95 CI (0.3, 70)]. Moreover, hand washing after work, washing feet and boots, and on-site hand washing were significant determinants of farmers' diarrhea. Exposure to wastewater significantly contributes to the risk of diarrhea among adults. Significant determinants of diarrhea among farmers include washing the body and clothes with irrigation water, contamination with soil and irrigation water, and on-site hand washing. Increased risk factors include hand contamination, washing vegetables with irrigation water, eating raw vegetables, and using work clothes at home.
  10. Habib Khan Y, Sarriff A, Hayat Khan A, Azreen Syazril A, Mallhi TH
    Malays J Med Sci, 2015 Jul-Aug;22(4):73-5.
    PMID: 26715911 MyJurnal
    Infective endocarditis (IE) is the one of the most important causes of increased mortality and morbidity among haemodialysis patients. The reason for this increasing prevalence of infection among these patients is the use of haemodialysis catheters during dialysis, as these patients are highly susceptible to infections that are easily transmitted via blood access points. The present case was a geriatric end stage renal disease (ESRD) patient who was readmitted to the hospital two days after her scheduled haemodialysis session with symptoms of nosocomial endocarditis. Her concurrent medical complications were hypertension, non-insulin dependent diabetes mellitus, and ischemic heart disease. Based on her previous medical history and current examination, the patient was suspected to have IE due to catheter related infection. The goal of therapy is to manage the comorbidities and infection by provision of appropriate treatment based on close monitoring of the patient condition.
  11. Asyikeen WA, Siti-Azrin AH, Jalil NA, Zin AA, Othman NH
    Malays J Med Sci, 2016 Nov;23(6):44-51.
    PMID: 28090178 MyJurnal DOI: 10.21315/mjms2016.23.6.5
    Endometrial cancer is the most common gynaecologic malignancy among females worldwide. The purpose of this study was to determine the median survival time of endometrial cancer patients at the Hospital Universiti Sains Malaysia (USM).
  12. Chee LC, Siregar JA, Ghani ARI, Idris Z, Rahman Mohd NAA
    Malays J Med Sci, 2018 Feb;25(1):32-41.
    PMID: 29599633 MyJurnal DOI: 10.21315/mjms2018.25.1.5
    Background: Ruptured cerebral aneurysm is a life-threatening condition that requires urgent medical attention. In Malaysia, a prospective study by the Umum Sarawak Hospital, Neurosurgical Center, in the year 2000-2002 revealed an average of two cases of intracranial aneurysms per month with an operative mortality of 20% and management mortality of 25%. Failure to diagnose, delay in admission to a neurosurgical centre, and lack of facilities could have led to the poor surgical outcome in these patients. The purpose of this study is to identify the factors that significantly predict the outcome of patients undergoing a surgical clipping of ruptured aneurysm in the local population.

    Material and Method: A single center retrospective study with a review of medical records was performed involving 105 patients, who were surgically treated for ruptured intracranial aneurysms in the Sultanah Aminah Hospital, in Johor Bahru, from July 2011 to January 2016. Information collected was the patient demographic data, Glasgow Coma Scale (GCS) prior to surgery, World Federation of Neurosurgical Societies Scale (WFNS), subarachnoid hemorrhage (SAH) grading system, and timing between SAH ictus and surgery. A good clinical grade was defined as WFNS grade I-III, whereas, WFNS grades IV and V were considered to be poor grades. The outcomes at discharge and six months post surgery were assessed using the modified Rankin's Scale (mRS). The mRS scores of 0 to 2 were grouped into the "favourable" category and mRS scores of 3 to 6 were grouped into the "unfavourable" category. Only cases of proven ruptured aneurysmal SAH involving anterior circulation that underwent surgical clipping were included in the study. The data collected was analysed using the Statistical Package for Social Sciences (SPSS). Univariate and multivariate analyses were performed and aP-value of < 0.05 was considered to be statistically significant.

    Result: A total of 105 patients were included. The group was comprised of 42.9% male and 57.1% female patients. The mean GCS of the patients subjected to surgical clipping was 13, with the majority falling into the good clinical grade (78.1%). The mean timing of the surgery after SAH was 5.3 days and this was further categorised into early (day one to day three, 45.3%), intermediate (day four to day ten, 56.2%), and late (after day ten, 9.5%). The total favourable outcome achieved at discharge was 59.0% as compared to 41.0% of the unfavourable outcome, with an overall mortality rate of 10.5%. At the six-month post surgery review (n= 94), the patients with a favourable outcome constituted 71.3% as compared to 28.7% with an unfavourable outcome. The mortality, six months post surgery was 3.2%. On a univariate analysis of early surgical clipping, patients with a better GCS and good clinical grade had a significantly better outcome at discharge. Based on the univariate study, six months post surgery, the timing of the surgery and the clinical grade remained significant predictors of the outcome. On the basis of the multivariate analysis, male patients of younger age, with a good clinical grade, were associated with favourable outcomes, both at discharge and six months post surgery.

    Conclusion: In this study, we concluded that younger male patients with a good clinical grade were associated with a favourable outcome both at discharge and six months post surgery. We did not find the timing of the surgery, size of the aneurysm or duration of surgery to be associated with a patient's surgical outcome. Increasing age was not associated with the surgical outcome in a longer term of patient's follow up.

  13. Sayuthi S, Tharakan J, Pieter MS, Salmah WM, Madhavan M, Tahir A, et al.
    Malays J Med Sci, 2009 Jan;16(1):39-43.
    PMID: 22589647 MyJurnal
    We present our preliminary experience in neuropsychological testing in epilepsy surgery patients to demonstrate how these tests contributed to decide the laterality of epileptic focus, and to assess the effect of surgery on patient's cognitive function and quality of life. Preoperative neuropsychological tests consisting of Wechsler Adult Intelligence Scale-III (WAIS) for IQ, Wechsler Memory Scale-III (WMS) for memory and patients' quality of life (QOLIE 31) were administered to refractory epilepsy patients under evaluation for surgical treatment. These tests were repeated one year after surgery and we studied any changes in trends. A total of seven patients were recruited in this study between July 2004 and July 2006. The aetiologies of refractory epilepsy were pure mesial temporal sclerosis (MTS) in five patients, dysembryogenic neuroepithelial tumour (DNET) in one and dual lesion of cavernous angioma with ipsilateral MTS in one. The preoperative neuropsychological tests were all in concordance to MRI finding, and showed good contralateral function; five lateralises to the right and two to the left. The post-operative Engel seizure count (median 8.00, IQR 7.00-8.75), general IQ (88 vs. 79), performance IQ (94 vs. 79), verbal memory (89 vs. 71), non-verbal memory (88 vs. 75) and QOLIE (53.14 vs. 44.71) were better compared to preoperative values. The verbal IQ (84 vs. 84) was unchanged. Neuropsychological tests are useful as ancillary investigations to determine the laterality of seizure focus and integrity of function in the contralateral temporal lobe. Following successful surgical treatment, there is a trend towards improvement in memory, IQ and quality of life scores in this small group of patients.
  14. Tahlan S, Kumar S, Ramasamy K, Lim SM, Shah SAA, Mani V, et al.
    BMC Chem, 2019 Dec;13(1):90.
    PMID: 31384837 DOI: 10.1186/s13065-019-0608-5
    Benzimidazole is a valuable pharmacophore in the field of medicinal chemistry and exhibit wide spectrum of biological activity. Molecular docking technique is routinely used in modern drug discovery for understanding the drug-receptor interaction. The selected data set of synthesized benzimidazole compounds was evaluated for its in vitro anticancer activity against cancer cell lines (HCT116 and MCF7) by sulforhodamine B (SRB) assay. Further, molecular docking study of data set was carried out by Schrodinger-Maestro v11.5 using CDK-8 (PDB code: 5FGK) and ER-alpha (PDB code: 3ERT) as possible target for anticancer activity. Molecular docking results demonstrated that compounds 12, 16, N9, W20 and Z24 displayed good docking score with better interaction within crucial amino acids and corelate to their anticancer results. ADME results indicated that compounds 16, N9 and W20 have significant results within the close agreement of the Lipinski's rule of five and Qikprop rule within the range and these compounds may be taken as lead molecules for the discovery of new anticancer agents.
  15. Ibrahim M, Haider A, Lim JW, Mainali B, Aslam M, Kumar M, et al.
    Chemosphere, 2024 Jul 15;362:142860.
    PMID: 39019174 DOI: 10.1016/j.chemosphere.2024.142860
    The application of artificial neural networks (ANNs) in the treatment of wastewater has achieved increasing attention, as it enhances the efficiency and sustainability of wastewater treatment plants (WWTPs). This paper explores the application of ANN-based models in WWTPs, focusing on the latest published research work, by presenting the effectiveness of ANNs in predicting, estimating, and treatment of diverse types of wastewater. Furthermore, this review comprehensively examines the applicability of the ANNs in various processes and methods used for wastewater treatment, including membrane and membrane bioreactors, coagulation/flocculation, UV-disinfection processes, and biological treatment systems. Additionally, it provides a detailed analysis of pollutants viz organic and inorganic substances, nutrients, pharmaceuticals, drugs, pesticides, dyes, etc., from wastewater, utilizing both ANN and ANN-based models. Moreover, it assesses the techno-economic value of ANNs, provides cost estimation and energy analysis, and outlines promising future research directions of ANNs in wastewater treatment. AI-based techniques are used to predict parameters such as chemical oxygen demand (COD) and biological oxygen demand (BOD) in WWTP influent. ANNs have been formed for the estimation of the removal efficiency of pollutants such as total nitrogen (TN), total phosphorus (TP), BOD, and total suspended solids (TSS) in the effluent of WWTPs. The literature also discloses the use of AI techniques in WWT is an economical and energy-effective method. AI enhances the efficiency of the pumping system, leading to energy conservation with an impressive average savings of approximately 10%. The system can achieve a maximum energy savings state of 25%, accompanied by a notable reduction in costs of up to 30%.
  16. Iqbal J, Ahmad RB, Khan M, Fazal-E-Amin, Alyahya S, Nizam Nasir MH, et al.
    PLoS One, 2020;15(4):e0229785.
    PMID: 32271783 DOI: 10.1371/journal.pone.0229785
    Software development outsourcing is becoming more and more famous because of the advantages like cost abatement, process enhancement, and coping with the scarcity of needed resources. Studies confirm that unfortunately a large proportion of the software development outsourcing projects fails to realize anticipated benefits. Investigations into the failures of such projects divulge that in several cases software development outsourcing projects are failed because of the issues that are associated with requirements engineering process. The objective of this study is the identification and the ranking of the commonly occurring issues of the requirements engineering process in the case of software development outsourcing. For this purpose, contemporary literature has been assessed rigorously, issues faced by practitioners have been identified and three questionnaire surveys have been organized by involving experienced software development outsourcing practitioners. The Delphi technique, cut-off value method and 50% rule have also been employed. The study explores 150 issues (129 issues from literature and 21 from industry) of requirements engineering process for software development outsourcing, groups the 150 issues into 7 identified categories and then extricates 43 customarily or commonly arising issues from the 150 issues. Founded on 'frequency of occurrence' the 43 customarily arising issues have been ranked with respect to respective categories (category-wise ranking) and with respect to all the categories (overall ranking). Categories of the customarily arising issues have also been ranked. The issues' identification and ranking contribute to design proactive software project management plan for dealing with software development outsourcing failures and attaining conjectured benefits of the software development outsourcing.
  17. Bashir MA, Qing L, Dewil R, Xi Z, Razi U, Jingting L
    J Environ Manage, 2024 Sep;367:122058.
    PMID: 39106799 DOI: 10.1016/j.jenvman.2024.122058
    This study explores the association between natural resources rent, industrial value addition, banking development, renewable energy consumption, total reserves and environmental quality in the dynamic context of BRICS nations from 1995 to 2019. BRICS economies are responsible for global greenhouse gas emissions and confront pressing environmental challenges, including biodiversity loss and pollution. For the dependent variable, the environmental quality, the study constructed a composite index using PCA for all environmental indicators where interdependencies among variables are prevalent. Besides this, the study incorporates two interaction terms to determine the indirect influence of natural resource rent and banking development on environmental quality through the mediating role of industrial value addition. By applying the CS-ARDL technique, the outcomes of the study reveal that natural resources rent, industrial value addition, and total reserves positively influence ENQ, indicating the adverse consequences of industrial sectors on environmental quality and continued environmental degradation due to resource-intensive industrial production, underscoring the urgency of sustainable resource management. In contrast, banking development and renewable energy consumption negatively influence ENQ, signifying the positive role of developed banking sectors in supporting eco-friendly projects and enhancing environmental quality. This study offers valuable insights for policy interventions to foster a more sustainable future.
  18. Kanwal A, Bilal M, Rasool N, Zubair M, Shah SAA, Zakaria ZA
    Pharmaceuticals (Basel), 2022 Nov 11;15(11).
    PMID: 36422521 DOI: 10.3390/ph15111392
    Terpenes are a group of natural products made up of molecules with the formula (C5H8)n that are typically found in plants. They are widely employed in the medicinal, flavor, and fragrance industries. The total synthesis of terpenes as well as their origin and biological potential are discussed in this review.
  19. Basit A, Ahmad N, Khan AH, Javaid A, Syed Sulaiman SA, Afridi AK, et al.
    PLoS One, 2014;9(4):e93206.
    PMID: 24705411 DOI: 10.1371/journal.pone.0093206
    Various studies have reported culture conversion at two months as a predictor of successful treatment outcome in multidrug-resistant tuberculosis (MDR-TB).
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