MATERIALS AND METHODS: A mixed-method approach was employed among undergraduate dental technology students in Malaysia. The Depression, Anxiety, and Stress Scale (DASS-21) was adapted and modified for dental technology students. The content of the questionnaire was validated by two experienced faculty experts. Construct validity and internal consistency were measured. An online survey was created using Google Forms and disseminated to 10 Bachelor of Dental Technology (BDT) students. Meanwhile, qualitative data were obtained through one-on-one semi-structured interviews, employing a phenomenology approach and thematic analysis to explore students' experiences in the new educational landscape.
RESULTS: All students answered the survey, predominantly females. Prevalence of depression (60% normal, 10% mild, 30% moderate), anxiety (30% normal, 30% mild, 10% moderate, 10% severe, 20% extremely severe), and stress (70% normal, 10% mild, 10% moderate, 10% severe) was reported. Qualitatively, three major themes emerged: "Problems with adaptations", "Anxious about returning to campus", and "Concern about the future". The first theme included sub-themes: "Difficulties in transitioning to hybrid learning" and "Disruption in study-life balance". The second theme had four sub-themes: "Fear of being infected", "Fear of being stigmatized", "Increased vigilance in personal safety measures", and "Confusion about standard operating procedure". The third theme included sub-themes: "Fear of another lockdown" and "Concerns about timely completion of academic requirements".
CONCLUSIONS: This study highlights the complex mental health challenges dental technology students faced post-pandemic, underscoring the need for flexible academic policies, global collaborations, and targeted strategies to support their resilience and well-being.
METHODOLOGY: A retrospective 10-year analysis of third- and fourth-degree perineal tears in a tertiary centre was conducted. The maternal, neonatal factors and their respective outcomes after the repair of an OASI were examined and compared between minor (3a and 3b perineal tears) and major anal sphincter tears (3c and 4th-degree perineal tears).
RESULTS: Five hundred twenty patients with OASIS were included into the study. Birthweight ≥ 3.5 kg was significantly associated with having a major anal sphincter tear in this study population, OR 1.91 (95% CI 1.21-3.02), p = 0.006. There was no significant difference in having faecal or flatus incontinence after the repair; however, major anal sphincter tears appeared to be more complicated to repair compared to minor anal sphincter tears, requiring involvement of the consultant, p < 0.001.
CONCLUSION: Neonatal birthweight ≥ 3.5 kg was the most significant factor in predicting the severity of OASIS in this study population. After appropriate repair, the rates of reported complications appeared similar between the two groups. However, significantly more expertise and resources were required for the repair of higher degree OASIS.
METHODS: Clinical and imaging data of patients with early-stage cervical cancer who were pathologically diagnosed at our hospital between January 2020 and June 2025 were retrospectively analyzed. All patients underwent routine MRI, diffusion-weighted imaging (DWI), APT imaging, and dynamic contrast-enhanced MRI (DCE-MRI) before treatment. Apparent diffusion coefficient (ADC), APT values, and semi-quantitative DCE-MRI parameters were measured. According to pathological findings, patients were divided into two groups: DSI ≥1/2 and DSI <1/2. Normally distributed continuous variables were compared using independent-samples t-tests, whereas skewed variables were compared using non-parametric tests. Receiver operating characteristic (ROC) analysis was performed to assess the sensitivity, specificity, and area under the curve (AUC) of ADC, APT, DCE-MRI parameters, and their combination for predicting DSI. Diagnostic performance was compared using the DeLong test.
RESULTS: A total of 61 patients were included, with 33 in the DSI <1/2 group and 28 in the DSI (≥1/2) group. The ADC values were significantly lower in the DSI ≥1/2 group compared to the DSI <1/2 group (P
METHODS: Autologous HSCT patients aged 18 years old and above were recruited from Hospital Ampang, Malaysia, between April 2019 to December 2020. Mucositis assessments were conducted daily, whilst blood and saliva were collected prior to conditioning regimen, on Day 0, Day+7 and 6-month. Baseline and inflammatory predictors in a repeated time measurement of moderate-severe mucositis were assessed by multiple logistic regression and generalized estimating equations, respectively.
RESULTS: Of the 142 patients analyzed, oral mucositis and diarrhea (representing GI mucositis) were reported as 68.3% and 95.8%, respectively. Predictive factors for moderate-severe oral mucositis were BEAM or busulphan-based regimens (odds ratio (OR)=9.2, 95% confidence interval (CI)=1.16-72.9, p-value (p) = 0.005) and vomiting (OR=4.6, 95% CI 1.68-12.3, p = 0.004). Predictive factors for moderate-severe GI mucositis were BEAM or busulphan-based regimens (OR=3.9, 95% CI 1.05-14.5, p = 0.023), female sex (OR = 3.3, 95% CI 1.43-7.44, p = 0.004) and body mass index (OR=1.08, 95% CI 1.02-1.15, p = 0.010). Cytokines analyses were performed in 96 patients. Saliva and plasma interleukin-6 (OR=1.003, 95% CI 1.001-1.004, p < 0.001 and OR=1.01, 95% CI 1.001-1.015, p = 0.029), and plasma tumor necrosis factor-alpha (OR=0.91, 95% CI 0.85-0.99, p = 0.019) were predictive of moderate-severe oral mucositis in a time-dependent model.
CONCLUSION: This study provides real-world evidence and insights into patient- and treatment-related factors affecting oral and GI mucositis in HSCT.