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  1. Hashim S, Beh HK, Hamil MS, Ismail Z, Majid AM
    Pharmacognosy Res, 2016 Oct-Dec;8(4):238-243.
    PMID: 27695261
    CONTEXT: Orthosiphon stamineus is a medicinal herb widely grown in Southeast Asia and tropical countries. It has been used traditionally as a diuretic, abdominal pain, kidney and bladder inflammation, gout, and hypertension.
    AIMS: This study aims to develop and validate the high-performance thin layer chromatography (HPTLC) method for quantification of rosmarinic acid (RA), 3'-hydroxy-5,6,7,4'-tetramethoxyflavone (TMF), sinensitin (SIN) and eupatorin (EUP) found in ethanol, 50% ethanol and water extract of O. stamineus leaves.
    MATERIALS AND METHODS: HPTLC method was conducted using an HPTLC system with a developed mobile phase system of toluene: ethyl acetate: formic acid (3:7:0.1) performed on precoated silica gel 60 F254 TLC plates. The method was validated based on linearity, accuracy, precision, limit of detection, limit of quantification (LOQ), and specificity, respectively. The detection of spots was observed at ultraviolet 254 nm and 366 nm.
    RESULTS: The linearity of RA, TMF, SIN, and EUP were obtained between 10 and 100 ng/spot with high correlation coefficient value (R2) of more than 0.986. The limit of detection was found to be 122.47 ± 3.95 (RA), 43.38 ± 0.79 (SIN), 17.26 ± 1.16 (TMF), and 46.80 ± 1.33 ng/spot (EUP), respectively. Whereas the LOQ was found to be 376.44 ± 6.70 (RA), 131.45 ± 2.39 (SIN), 52.30 ± 2.01 (TMF), and 141.82 ± 1.58 ng/spot (EUP), respectively.
    CONCLUSION: The proposed method showed good linearity, precision, accuracy, and high sensitivity. Hence, it may be applied in a routine quantification of RA, SIN, TMF, and EUP found in ethanol, 50% of ethanol and water extract of O. stamineus leaves.
    SUMMARY: HPTLC method provides rapid estimation of the marker compound for routine quality control analysis.The established HPTLC method is rapid for qualitative and quantitative fingerprinting of Orthosiphon stamineus extract used for commercial product.Four identified markers (RA, SIN, EUP and TMF) found in three a different type of O. stamineus extracts specifically ethanol, 50% ethanol and water extract were successfully quantified using HPTLC method. Abbreviations Used: HPTLC: High-performance thin layer chromatography; RA: Rosmarinic acid; TMF: 3'-hydroxy-5,6,7,4'-tetramethoxyflavone; SIN: Sinensitin; EUP: Eupatorin; E: Ethanol; EW: 50% ethanol; W: Water; BK: Batu Kurau; KB: Kepala Batas; S: Sik; CJ: Changkat Jering; SB: Sungai Buloh.
    KEYWORDS: rosmarinic acid; Eupatorin; Orthosiphon stamineus; high-performance thin-layer chromatography; sinensitin; validation
    Matched MeSH terms: Abdominal Pain
  2. Nilesh K, V Vande A, K Veerabhadrappa S
    PMID: 28413598 DOI: 10.15171/joddd.2017.011
    Osteomas are benign bone tumors which arise from the cortex or medulla of craniofacial and jaw bones. They are usually asymptomatic or present as slow-growing painless masses. Larger lesions may present with aesthetic (facial asymmetry) and functional disturbances (jaw deviation, difficulty in breathing, pain, and sensory deficits). This paper highlights a case of solitary peripheral osteoma composed of a compact bony mass arising from the lower border of the mandible in an adult female patient. The lesion presented with discomfort during deglutition, which was attributed to impingement of muscles of the oral cavity floor, including the anterior belly of digastric muscle.
    Matched MeSH terms: Pain
  3. Anusha Balasubramanian, Irfan Mohamad, Purushotman Ramasamy, Avatar Singh Mohan Singh, Lina Ling Chooi, Ferdinand Jesudian Kovilpillai
    MyJurnal
    Plunging epidermoid cyst of the floor of mouth is indeed an uncommon entity. A 34-year old Malay
    gentleman had presented to our centre with a floor of mouth lesion that extended into the submental
    region. Clinical findings and imaging studies pointed towards the impression of a plunging ranula.
    Histopathological examination of a completely excised mass via intraoral approach, confirmed the
    diagnosis of an epidermoid cyst. He was well on follow up with no subsequent recurrence. We discuss
    the nature of epidermoid cyst and its surgical management.
    Matched MeSH terms: Pain Management
  4. Deros, B.M., Daruis, D.D.I., Ghani, J.A., Saleh, C., Wazir, R.M., Yasim, M.K., et al.
    MyJurnal
    This An Ergonomic hazard often exists in any industry. However, majority of the employees are not aware of practicing good body posture until the MSDs symptoms become permanent and chronic. The main objective of this study is to determine the manual handling problems among workers at an electronic component manufacturing company. The scope of this study focused on the study entire body disorders among workers on electronic manufacturing company using the Rapid Entire Body Assessment (REBA). A cross sectional study involving observation of the workplace, the work task and the working environment, photographs and videos taken during the observation. Later, a survey questionnaire was given to the respondents to obtain their socio-demography information, work activity and health problems. Rapid Entire Body Assessment (REBA) was conducted on all respondents to determined REBA scores in different work positions. The study was conducted at an electronic component manufacturing company located in Klang Valley, Selangor. A total of 124 workers were surveyed and REBA assessment was performed on 20 workers at Company X production area. It includes 5 categories of position at Company X, such as:loading steel bar into casing; pushing the steel bar, turning movement while adjusting the steel bar, adjusting steel bar into the loading area, unloading steel bar from casing into the machine. The study found that turning section has the highest MSDs problems regarding manual handling because majority of the respondents in the turning department felt the pain while performing their work. This is due to their job demand, which they need to handle with tools weighing from 200 to 400 kg. The REBA scores showed that17 out of 20 respondents performing turning operations, moving and pushing the steel bar recorded the highest score of 11 or more which are categorize in the very high risk group. The position of pushing and turning steel bar while moving the steel bar has higher risk that contributed to the ergonomics risk factor, which in-turn can contribute to Muscular Skeletal Disorders (MSDs). More detailed investigation and remedial measures should be taken immediately, especially for the workers performing the manual handlings activities.
    Matched MeSH terms: Pain
  5. Kabilmiharbi, N, Selamat, F.E
    MyJurnal
    Manual workers in plastics industry are often exposed to work related discomfort and pain while performing their daily
    task. These exposure leads to common occupational diseases such as Work-related Musculoskeletal Disorder (WMSD) or
    low back pain (LBP) which in turn will affect their working performance. The main objective for this study is to
    analyse the working posture of a manual worker that works in a polypropylene fibrillated yarn industry using RULA
    assessment in CATIA P3 V5R14 software. The subject were selected from the packaging area as the manual handling
    work are only present in that area. Based on the RULA analysis done by constructing the worker posture in the
    software, several awkward postures were identified to be high in risk factors. The postures that is high in risk is
    postures 3 which is due to lifting heavy loads and twisting or turning of the trunk. The postures obtained the final
    RULA analysis score of 7 and this indicates that changes must be done immediately. It is recommended that the
    company should increase the ergonomic awareness among the manual workers especially while performing their work
    and to redesign the working posture for the manual workers.
    Matched MeSH terms: Low Back Pain
  6. Boey CC, Goh KL
    Dig Liver Dis, 2001 Mar;33(2):140-4.
    PMID: 11346142
    AIM: To look at predictors of consulting behaviour among children with recurrent abdominal pain in a rural community in Malaysia.

    SUBJECTS AND METHODS: A sample of 1462 school-children aged between 9 and 15 years were randomly selected from all schools in Kuala Langat, a rural district in Malaysia. Those with recurrent abdominal pain, defined according to Apley's criteria, were recruited and divided into consulters and non-consulters. A consulter was defined as a child who had sought the help of a medical practitioner at least once in the past year for recurrent abdominal pain. A detailed clinical, social and family history was obtained in all recruited children.

    RESULTS: A total of 161 children were recruited: 78 (48.4%) consulters, 83 (51.6%) non-consulters. Of the consulters, 40 were boys, 38 were girls (male:female ratio = 1.1:1). The two sexes did not show a significant difference in prevalence of consulters [p=0.189). Of the ethnic groups, only Indians had a significantly higher likelihood to consult a doctor (Indians, p=0.006; Malays, p=0.742; Chinese, p=0.050]. Younger children (under 12 years) had a significantly higher chance of having been brought to see a medical practitioner (p=0.014). Children in whom age of onset of abdominal pain was below ten years were also more likely to have been seen by a doctor (p=0.012). Children who had consulted a doctor were more likely to be missing school because of abdominal pain (p<0.001). Pain severity was not a significant factor (p=0.429). Multiple logistic regression analysis revealed that the only variable that remained significantly associated with health-care consultation was school absence (p<0.001).

    CONCLUSIONS: Children who saw their doctors for recurrent abdominal pain were also more likely to be those who missed school on account of abdominal pain. Following multiple regression analysis, other factors were no longer significant.

    Matched MeSH terms: Abdominal Pain/diagnosis*; Abdominal Pain/epidemiology*; Abdominal Pain/psychology
  7. Rafiq MT, Hamid MSA, Hafiz E, Chaudhary FA, Khan MI
    Curr Rheumatol Rev, 2021;17(4):421-427.
    PMID: 34315379 DOI: 10.2174/1573397117666210727095552
    INTRODUCTION: Knee Osteoarthritis (OA) is a weight-bearing joint disease and is more common in overweight and obese persons. The objective of the study was to assess the feasibility and acceptability of Instructions of Daily Care (IDC) on pain, mobility, and Body Mass Index (BMI) among knee OA participants who are overweight or obese.

    MATERIALS AND METHODS: The study was an open-label randomized controlled trial of six weeks. Forty overweight and obese participants with knee OA were randomly divided into two groups by a computer-generated number. The participants in the Instruction Group (IG) were provided with leaflets explaining IDC for the duration of six weeks. Both groups were instructed to take low doses of the non-steroid anti-inflammatory drug (NSAIDs) on alternate days. The outcome measures were pain, mobility and BMI. The feasibility and acceptability of knee pain and mobility were assessed using a questionnaire designed by experts in rehabilitation.

    RESULTS: Participants in the IG reported more statistically significant pain relief as assessed by the Western Ontario and McMaster Universities Osteoarthritis Index score (p=0.001) and improvement in mobility (p=0.000) assessed by the Timed Up and Go test score after six weeks compared to the Control Group (CG). Both groups did not demonstrate any significant change in BMI (p-value > 0.05). The results of descriptive statistics showed a significantly higher satisfaction score for participants who received a combination of IDC and NSAIDs, indicating an acceptable intervention.

    CONCLUSION: The IDC is effective and acceptable in terms of improving pain and mobility and should be recommended as the usual care of treatment.

    Matched MeSH terms: Pain
  8. Katijjahbe MA, Royse C, Granger C, Denehy L, Md Ali NA, Abdul Rahman MR, et al.
    Heart Lung Circ, 2021 Aug;30(8):1232-1243.
    PMID: 33608196 DOI: 10.1016/j.hlc.2020.12.009
    OBJECTIVES: To investigate the specific clinical features of pain following cardiac surgery and evaluate the information derived from different pain measurement tools used to quantify and describe pain in this population.

    METHODS: A prospective observational study was undertaken at two tertiary care hospitals in Australia. Seventy-two (72) adults (mean age, 63±11 years) were included following cardiac surgery via a median sternotomy. Participants completed the Patient Identified Cardiac Pain using numeric and visual prompts (PICP), the McGill Pain Questionnaire-Short Form version 2 (MPQ-2) and the Medical Outcome Study 36-item version 2 (SF-36v2) Bodily Pain domain (BP), which were administered prior to hospital discharge, 4 weeks and 3 months postoperatively.

    RESULTS: Participants experienced a high incidence of mild (n=45, 63%) to moderate (n=22, 31%) pain prior to discharge, which reduced at 4 weeks postoperatively: mild (n=28, 41%) and moderate (n=5, 7%) pain; at 3 months participants reported mild (n=14, 20%) and moderate (n=2, 3%) pain. The most frequent location of pain was the anterior chest wall, consistent with the location of the surgical incision and graft harvest. Most participants equated "pressure/weight" to "aching" or a "heaviness" in the chest region (based on descriptor of pain in the PICP) and the pain topography was persistent at 4 weeks and 3 months postoperatively. Each pain measurement tool provided different information on pain location, severity and description, with significant change (p<0.005) over time.

    CONCLUSION: Mild-to-moderate pain was frequent after sternotomy, improved over time and was mostly located over the incision and mammary (internal thoracic) artery harvest site. Persistent pain at 3 months remained a significant problem in the community within this surgical population.

    Matched MeSH terms: Pain Measurement
  9. Abdul Hayei NA, Yahya NA, Safii SH, Saub R, Vaithilingam RD, Baharuddin NA
    BMC Oral Health, 2021 03 31;21(1):169.
    PMID: 33789646 DOI: 10.1186/s12903-021-01540-0
    BACKGROUND: The influence of scaler tip design on root surface roughness, tooth substance loss and patients' pain perception is investigated.

    METHODS: This article was divided into the following parts: Part 1 Surface roughness and substance loss: an in vitro study, which involves intact extracted teeth sectioned and treated using a piezoelectric ultrasonic device (PM200 EMS Piezon, Switzerland) with a conventional scaler tip (FS-407) and a Perio Slim (PS) scaler tip (Perio Slim DS-016A). All sectioned samples for tooth surface roughness (n = 20) and tooth substance loss (n = 46) analyses were measured and compared using a 3D surface texture analyser and scanning electron microscope (SEM) respectively, at baseline and following scaling. Part 2 Pain Perception: a clinical study, which was a split mouth study design including 30 participants with gingivitis and/or mild chronic periodontitis; treated with supra-gingival scaling from teeth #13 to #23. Subjects were randomised to group A or group B. Group A was treated first with PS scaler tips, whereas group B was treated first with conventional scaler tips. Pain perception was recorded using the visual analogue scale (VAS).

    RESULTS: In vitro study: both scaler tips caused significant reduction in root substance roughness after scaling (p  0.05) was observed. The PS scaler tip caused statistically significantly less root substance loss (p pain score during scaling using the PS scaler tip (median: 3) than when using the conventional scaler tip (median: 5) (p pain was observed compared than a wide (conventional) scaler tip design.

    Matched MeSH terms: Pain Perception
  10. Yeoh SC, Goh CF
    Drug Deliv Transl Res, 2021 Apr 28.
    PMID: 33907986 DOI: 10.1007/s13346-021-00988-5
    Salicylates have a long history of use for pain relief. Salicylic acid and methyl salicylate are among the widely used topical salicylates namely for keratolytic and anti-inflammatory actions, respectively. The current review summarises both passive and active strategies, including emerging technologies employed to enhance skin permeation of these two salicylate compounds. The formulation design of topical salicylic acid targets the drug retention in and on the skin based on the different indications including keratolytic, antibacterial and photoprotective actions, while the investigations of topical delivery strategies for methyl salicylate are limited. The pharmacokinetics and metabolisms of both salicylate compounds are discussed. The current overview and future perspectives of the topical delivery strategies are also highlighted for translational considerations of formulation designs.
    Matched MeSH terms: Pain
  11. Mohamad F, Yahya AS, Abdul Rashid A, Devaraj NK, Abdul Manap AH
    Malays Fam Physician, 2021 Mar 25;16(1):121-123.
    PMID: 33948151 DOI: 10.51866/cr1117
    Ectopic pregnancy is an extra-uterine pregnancy and is a potentially life-threatening condition that can lead to death from intra-peritoneal hemorrhage. This case reports a rare occurrence of ruptured tubal pregnancy in which the patient presented early with abdominal pain and a negative urine pregnancy test but subsequently presented again with evidence of intra-peritoneal hemorrhage. A negative urine pregnancy test is often used to rule out pregnancy, but it is not 100% sensitive. Complete assessment is critical in this important diagnosis in order to plan for the appropriate emergency management.
    Matched MeSH terms: Abdominal Pain
  12. Mazlinda Musa, Segaran Ramodran, Floreta Yusop, Nur Shiela Abdul Majid, Nur Fatihah, Aqilah Roslin, et al.
    MyJurnal
    Introduction: Nursing is an emotionally stressful occupation where nurses themselves are at risk of internalizing negative emotions when caring for patients who are suffering, in pain, anguish, and facing death. Studies indicate an individual`s ability to emotionally express or vent these internalize negative emotions is associated with intrinsic happiness and well-being. Similarly, in the context of UMS, student nurses are at times exposed to overwhelming negative emotions during clinical postings and raise the question to what extent students use emotional expressive- ness to vent such emotions. This study is to assess perceived happiness and emotional expressiveness and determine correlates of these attributes among student nurses in UMS. Methods: This study entails a cross-sectioned design involving 90 (N) participants selected through convenient stratified sampling from 1st year (n=30), 2nd year (n=30) and 3rd year (n=30) student nurses. Ethical clearance for this study was obtained from REC UMS and the respon- dent’s consent. Two validated instruments, the Intrinsic Happiness Index (IHI, with 10 Likert scaled items, α =0.78) and Emotional Expressiveness Scale (EES, 17 Likert scaled item α =0.82) were used in this study. Results: Among 90 nursing students in this study, 81%(n=72) scored high and 19% (n=18) scored low in the happiness index. On emotional expressiveness ratings, 68% scored high with 32% scoring low. Higher happiness index scores correlated positively with high emotional expressive scores. First year students had significantly higher perceived happiness score (p=0.02) and higher emotional expressiveness score (p=0.03) compared to 2nd or 3rd-year students. Conclu- sion: Finding in this study imply that although the majority of student had good emotional disposition, but a small percentage of students have lower perceived happiness and emotional expressiveness, which may affect long term psychological well-being. This paper will discuss some remedial strategies to address the issue.
    Matched MeSH terms: Pain
  13. Guan NC, Beng TS, Sue-Yin L, Kanagasundram S
    Indian J Palliat Care, 2021 02 17;27(1):83-88.
    PMID: 34035622 DOI: 10.4103/IJPC.IJPC_122_20
    Context: While pain is a common complaint among palliative cancer patients, there is little research looking into nonpharmacological methods for the reduction of pain in the palliative setting.

    Aim: This study aims to study the efficacy of 5-min mindful breathing for rapid reduction of pain in a palliative care setting.

    Methods: This is a sub-analysis of the previous randomized controlled study on distress reduction. Sixty patients were recruited and randomly assigned to either the intervention (5-min mindful breathing) or the control (5-min normal listening) group. Participants reported their pain on a 10-item analog scale at baseline, immediately after intervention and 10 min postintervention. Changes in pain scores were further analyzed.

    Results: Pain scores decreased for both the intervention and control groups. However, the reduction of pain did not reach statistical difference in both groups (P > 0.05).

    Conclusion: Five-minute mindful breathing is a quick and easy to administer therapy but does not have significant effects in terms of pain reduction in palliative settings. Future research and directions are nonetheless suggested and encouraged to look for short-term mindfulness-based therapies on pain reduction for this population.

    Matched MeSH terms: Pain
  14. Ramli M, Nora M, Roszaman R, Hatta S
    Malays Fam Physician, 2012;7(1):24-7.
    PMID: 25606241 MyJurnal
    OBJECTIVE: To analyse the features of patients with vaginismus first presented to a gynaecologist for infertility before being referred for psychiatric evaluation and management. The case series aim to provide some insight on features and presentations of Asian women with vaginismus. Vaginismus is characterised by persistent or recurrent difficulties in vaginal penetration despite the woman's wish for coitus. Avoidance, phobia, anticipatory fear of pain and involuntary pelvic muscle contraction are the most common symptoms.

    METHOD: We report a series of cases of Malaysian women who had been suffering from vaginismus and 'infertility'. All the cases had never been attended to medically and there were long delays in seeking intervention. There was no history of traumatic sexual experience or any major psychiatric illness in these patients. Majority of the patients had prominent symptoms of anxiety.

    CONCLUSION: The cases illustrate that it is important to rule out the possibility of vaginismus among patients with infertility. The former have unique psychological features which require psychological interventions.
    Matched MeSH terms: Pain
  15. Jamal SM, Fathil SM, Nidzwani MM, Ismail AK, Yatim FM
    Med J Malaysia, 2011 Aug;66(3):231-3.
    PMID: 22111446
    The study compared the effectiveness of ketamine and midazolam/fentanyl as procedural sedation and analgesia agents for reduction of fractures and dislocated joints. Forty-one adult patients were enrolled by convenience sampling. They were randomized to receive ketamine or midazolam/fentanyl. Depth of sedation, pain score, procedural outcome and memory of the procedure were documented. The ketamine group had deeper sedation, but there was no statistical difference in other variables between the two groups. Three patients in the midazolam/fentanyl group had oxygen desaturation. More adverse effects were associated with ketamine. Intravenous ketamine is as effective as midazolam/fentanyl for procedural sedation.
    Matched MeSH terms: Pain/diagnosis; Pain/etiology; Pain/prevention & control*
  16. Ali NM, Mohd Yusof H, Yeap SK, Ho WY, Beh BK, Long K, et al.
    PMID: 25045389 DOI: 10.1155/2014/350507
    Evaluation of anti-inflammatory and antinociceptive activities of untreated mung bean (MB), germinated mung bean (GMB), and fermented mung bean (FMB) was performed on both in vitro (inhibition of inflammatory mediator, nitric oxide(NO)) and in vivo (inhibition of ear oedema and reduction of response to pain stimulus) studies. Results showed that both GMB and FMB aqueous extract exhibited potent anti-inflammatory and antinociceptive activities in a dose-dependent manner. In vitro results showed that GMB and FMB were potent inflammatory mediator (NO) inhibitors at both 2.5 and 5 mg/mL. Further in vivo studies showed that GMB and FMB aqueous extract at 1000 mg/kg can significantly reduce ear oedema in mice caused by arachidonic acid. Besides, both 200 mg/kg and 1000 mg/kg concentrations of GMB and FMB were found to exhibit potent antinociceptive effects towards hotplate induced pain. With these, it can be concluded that GMB and FMB aqueous extract exhibited potential anti-inflammatory and antinociceptive effects.
    Matched MeSH terms: Pain
  17. Poh F, Chow MB
    Med J Malaysia, 2014 Feb;69(1):37-9.
    PMID: 24814629
    Chest pain is a common presenting complaint in the emergency room of which acute aortic syndrome is a sinister cause associated with high morbidity. A contrastenhanced CT aortogram is often performed for initial evaluation at the first instance of suspicion. We present a patient with Stanford Type A intramural haematoma complicated by haemopericardium and acute cardiac tamponade and highlight the relevant CT signs that would alert the managing physician to urgent echocardiogram correlation and emergent cardiothoracic intervention.
    Matched MeSH terms: Chest Pain
  18. Ganasegeran K, Perianayagam W, Nagaraj P, Al-Dubai SA
    Occup Med (Lond), 2014 Jul;64(5):372-5.
    PMID: 24727561 DOI: 10.1093/occmed/kqu039
    BACKGROUND:
    Low back pain (LBP) is the most costly ailment in the work force. Risky work behaviour and psychological stress are established risk factors.

    AIMS:
    To explore the associations between workplace risk factors, psychological stress and LBP among Malaysian railway workers.

    METHODS:
    A cross-sectional study was carried out on railway workers in Malaysia. Socio-demographics, workplace risk factors for LBP, perceived psychological stress and history of LBP over the previous month were obtained by direct interviews using a structured closed-ended questionnaire. Descriptive, bivariate and logistic regression analyses were conducted.

    RESULTS:
    There were 513 study participants (70% response rate). The prevalence of LBP in the previous month was 69%. Multivariate analysis yielded four significant predictors of LBP: employment of ≥ 10 years, lifting and lowering heavy loads, prolonged standing posture and psychological stress.

    CONCLUSIONS:
    The high prevalence of LBP and its significant associations with physical and psychological stress factors in railway workers points to an urgent need for preventive measures, particularly among workers in high-risk occupations.
    Matched MeSH terms: Low Back Pain/etiology*; Low Back Pain/epidemiology; Low Back Pain/psychology
  19. Chong NJ, Aziz Z
    PMID: 23533507 DOI: 10.1155/2013/627182
    We aimed to assess the efficacy of Centella asiatica for improvement of the signs and symptoms of chronic venous insufficiency (CVI). We searched 13 electronic databases including the Cochrane Central Register of Controlled Trials for randomised controlled trials assessing the efficacy of Centella asiatica for CVI. Two review authors independently selected studies, assessed the risks of bias of included studies and extracted data. The treatment effects of similar studies were pooled whenever appropriate. Eight studies met the inclusion criteria. The pooling of data of similar studies showed that Centella asiatica significantly improved microcirculatory parameters such as transcutaneous partial pressure of CO2 and O2, rate of ankle swelling and venoarteriolar response. Three out of the eight studies did not provide quantitative data. However, these studies reported that patients treated with Centella asiatica showed significant improvement in CVI signs such as leg heaviness, pain and oedema. Our results show that Centella asiatica may be beneficial for improving signs and symptoms of CVI but this conclusion needs to be interpreted with caution as most of the studies were characterised by inadequate reporting and thus had unclear risks of bias, which may threaten the validity of the conclusions.
    Matched MeSH terms: Pain
  20. Esposito DH, Freedman DO, Neumayr A, Parola P
    Euro Surveill, 2012 Nov 08;17(45).
    PMID: 23153473
    As of 4 November, 2012, 100 patients with an acute muscular Sarcocystis-like illness associated with travel to Tioman Island, Malaysia, have been identified. Thirty-five travelled there mostly during July and August 2011 and 65 mostly during July and August 2012, suggesting an ongoing outbreak. Epidemiological investigations are ongoing. Public health agencies and practicing clinicians should be aware of this rarely-reported disease in humans and consider it as differential diagnosis in travellers returning from Tioman Island.
    Matched MeSH terms: Musculoskeletal Pain/complications; Musculoskeletal Pain/etiology; Musculoskeletal Pain/parasitology
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