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A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever

Wahid SF, Sanusi S, Zawawi MM, Ali RA

Southeast Asian J Trop Med Public Health, 2000 Jun;31(2):259-63.
PMID: 11127322

The impact of dengue on liver function was studied on fifty serologically confirmed dengue cases admitted to Hospital Universiti Kebangsaan Malaysia (HUKM). Twenty-five of these patients had classic dengue fever (DF) and 25 had grade 1 or 2 dengue hemorrhagic fever (DHF). There were more (60%) DHF patients with hepatomegaly compared to DF (40%) but the difference was not statistically significant. Analysis of the liver profile showed that liver dysfunction was commoner in DHF compared to DF, indicating that the degree of liver impairment may be related to the severity of DHF. Hyperbilirubinemia was noted in 3 (12%) DHF and 2 (8%) DF patients. The mean (range) serum bilirubin was higher in DHF [14.2(5-50) micromol/l] compared to DF [10.9(5-30) micromol/l)] (p > 0.05). Elevated levels of serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were observed more frequently in DHF (20 and 12 patients respectively) compared to DF (16 and 8 patients respectively). Nine (36%) DHF and 6 (24%) DF patients had concomitant elevation of ALT and ALP levels. The mean (range) serum ALT levels were 109.3(23-325) U/l in DHF and 90.8(13-352) U/l in DF (p > 0.05). The mean (range) serum ALP levels were 102.2(15-319) U/l in DHF and 93.3(34-258) U/l in DF (p > 0.05). The ALT and ALP levels were significantly higher in DHF patients with spontaneous bleeding than those without bleeding (p < 0.05) None of the patients developed fulminant hepatitis. The immunoregulatory cells, which include the T (CD3), B (CD 19), CD4, CD8, CD5 and natural killer (NK) cells were significantly lower in DHF compared to DF patients (p < 0.05). However, the reduction in these cell counts did not correlate with the liver dysfunction seen in DHF patients. In conclusion, hepatomegaly and liver dysfunction were commoner in DHF compared to DF.
Analyzing the mediating effect of economic performance on the relationship between green construction practices and health and safety performance in Nigeria

Onubi HO, Yusof N, Hassan AS, Bahdad AAS

Environ Sci Pollut Res Int, 2021 Jul;28(27):36598-36610.
PMID: 33709310 DOI: 10.1007/s11356-021-13334-6

The adoption of green construction practices (GCP) has been on the increase in recent years as a means of reducing the negative effects of construction on the natural environment. However, GCP have been discovered to expose the construction workers to numerous health and safety (HS) risks, resulting from a decline in safety investment due to the economic burden associated with its adoption. This study explores the means through which GCP influence the HS performance of construction projects through economic performance. To obtain the views of contractors, a survey questionnaire was developed, and data was collected from project managers and site managers of "class A" contractors, with a response rate of 81.55%. The partial least squares structural equation modeling (PLS-SEM) technique was adopted to analyze the data. The results show that the effect of GCP on HS performance is fully mediated by economic performance. The study concludes that for projects that adopt GCP to have high levels of HS performance, they are required to have an optimal economic performance. Efforts should be intensified by the government in providing subsidies, tax waivers, and other incentives for adopters of GCP to ensure the economic performance of their projects since it guarantees high HS performance.
Fulltext Dynamic similarity distance with mean average precision tool

Nur Atikah Arbain, Mohd Sanusi Azmi, Sharifah Sakinah Syed Ahmad, Azah Kamilah Muda, Intan Ermahami A. Jalil, King Ming Tiang

Pertanika Journal of Science & Technology, 2017;25(106):11-18.
MyJurnal

In recent years, many classification models have been developed and applied to increase their accuracy. The concept of distance between two samples or two variables is a fundamental concept in multivariate analysis. This paper proposed a tool that used different similarity distance approaches with ranking method based on Mean Average Precision (MAP). In this study, several similarity distance methods were used, such as Euclidean, Manhattan, Chebyshev, Sorenson and Cosine. The most suitable distance measure was based on the smallest value of distance between the samples. However, the real solution showed that the results were not accurate as and thus, MAP was considered the best approach to overcome current limitations.
Isodose mapping of terrestrial gamma radiation dose rate of Selangor state, Kuala Lumpur and Putrajaya, Malaysia

Sanusi MS, Ramli AT, Gabdo HT, Garba NN, Heryanshah A, Wagiran H, et al.

J Environ Radioact, 2014 Sep;135:67-74.
PMID: 24787672 DOI: 10.1016/j.jenvrad.2014.04.004

A terrestrial gamma radiation survey for the state of Selangor, Kuala Lumpur and Putrajaya was conducted to obtain baseline data for environmental radiological health practices. Based on soil type, geological background and information from airborne survey maps, 95 survey points statistically representing the study area were determined. The measured doses varied according to geological background and soil types. They ranged from 17 nGy h(-1) to 500 nGy h(-1). The mean terrestrial gamma dose rate in air above the ground was 182 ± 81 nGy h(-1). This is two times higher than the average dose rate of terrestrial gamma radiation in Malaysia which is 92 nGy h(-1) (UNSCEAR 2000). An isodose map was produced to represent exposure rate from natural sources of terrestrial gamma radiation.
Predicting terrestrial gamma dose rate based on geological and soil information: case study of Perak state, Malaysia

Ramli AT, Apriantoro NH, Heryansyah A, Basri NA, Sanusi MS, Abu Hanifah NZ

J Radiol Prot, 2016 Mar;36(1):20-36.
PMID: 26583298 DOI: 10.1088/0952-4746/36/1/20

An extensive terrestrial gamma radiation dose (TGRD) rate survey has been conducted in Perak State, Peninsular Malaysia. The survey has been carried out taking into account geological and soil information, involving 2930 in situ surveys. Based on geological and soil information collected during TGRD rate measurements, TGRD rates have been predicted in Perak State using a statistical regression analysis which would be helpful to focus surveys in areas that are difficult to access. An equation was formulated according to a linear relationship between TGRD rates, geological contexts and soil types. The comparison of in situ measurements and predicted TGRD dose rates was tabulated and showed good agreement with the linear regression equation. The TGRD rates in the study area ranged from 38 nGy h(-1) to 1039 nGy h(-1) with a mean value of 224 ± 138 nGy h(-1). This value is higher than the world average as reported in UNSCEAR 2000. The TGRD rates contribute an average dose rate of 1.37 mSv per year. An isodose map for the study area was developed using a Kriging method based on predicted and in situ TGRD rate values.
Radiological mapping of Kelantan, Malaysia, using terrestrial radiation dose rate

Garba NN, Ramli AT, Saleh MA, Sanusi SM, Gabdo HT

Isotopes Environ Health Stud, 2016 Jun;52(3):214-8.
PMID: 26540360 DOI: 10.1080/10256016.2016.1095189

Measurements of the environmental terrestrial gamma radiation dose rate (TGRD) in each district of Kelantan state, Malaysia, were carried out using a portable hand-held radiation survey meter and global positioning system. The measurements were done based on geology and soil types of the area. The mean TGRD was found to be 209 nGy h(-1). Few areas of relatively enhanced activity were observed in Pasir Mas, Tanah Merah and Jeli districts, which have a mean TGRD between 300 and 500 nGy h(-1). An isodose map of the area was produced using ArcGIS software version 9.3.
Natural radioactivity measurements in Pahang State, Malaysia

Gabdo HT, Ramli AT, Saleh MA, Garba NN, Sanusi M

Isotopes Environ Health Stud, 2016 Jun;52(3):298-308.
PMID: 26999725 DOI: 10.1080/10256016.2016.1128428

This study was aimed at providing the baseline data of terrestrial gamma dose rates and natural radioactivity to assess the corresponding health risk in the ambient environment of the Pahang State. Terrestrial gamma radiation (TGR) from 640 locations was measured with the mean value found to be 176 ± 5 nGy h(-1). Ninety-eight soil samples were analysed using a high-purity germanium detector (HPGe), and the mean concentrations of the radionuclides (226)Ra, (232)Th and (40)K are 110 ± 3, 151 ± 5 and 542 ± 51 Bq kg(-1), respectively.(226)Ra and (232)Th concentrations were found to be three times the world average, while that of (40)K is quite higher than the world average value. The acid-intrusive geological formation has the highest mean concentrations for (226)Ra (215 ± 6 Bq kg(-1)), (232)Th (384 ± 12 Bq kg(-1)) and (40)K (1564 ± 153 Bq kg(-1)). The radium equivalent activities (Req) and the external hazard index (Hex) for the various soil types were also calculated. Some of the soil types were found to have values exceeding the internationally recommended levels of 370 Bq kg(-1) and the unity value, respectively.
Comparative EST analyses provide insights into gene expression in two asexual developmental stages of Eimeria tenella

Ng ST, Sanusi Jangi M, Shirley MW, Tomley FM, Wan KL

Exp Parasitol, 2002 11 13;101(2-3):168-73.
PMID: 12427472

The protozoan parasite Eimeria tenella has a complex life cycle that includes two major asexual developmental stages, the merozoite and the sporozoite. The expressed sequence tag (EST) approach has been previously used to study gene expression of merozoites. We report here the generation and analysis of 556 ESTs from sporozoites. Comparative analyses of the two datasets reveal a number of transcripts that are preferentially expressed in a specific stage, including previously uncharacterised sequences. The data presented indicate the invaluable potential of the comparative EST analysis for providing information on gene expression patterns in the different developmental stages of E. tenella.
A successful pregnancy outcome of homozygous familial hypercholesterolaemia patient on statin therapy

Mohd Kasim NA, Al-Khateeb A, Chua YA, Sanusi AR, Mohd Nawawi H

Malays J Pathol, 2021 Apr;43(1):87-93.
PMID: 33903311

Homozygous familial hypercholesterolaemia (HoFH) is a rare genetic disorder of lipoprotein metabolism mainly due to mutation of the low-density lipoprotein (LDL)-receptor gene (LDLR). It is a life-threatening disease that causes accelerated, multi-vessel atherosclerosis presented in early childhood. Pregnancy in HoFH may pose early coronary morbidity and mortality to both the foetus and mother. The combination of HoFH and pregnancy can be a fatal condition. While statins are very effective in lowering low-density lipoprotein cholesterol (LDL-C) levels, they are generally contraindicated during pregnancy, thus their use during pregnancy is uncommon. On the other hand, lipid apheresis (LA) has turned into an effective treatment to control cholesterol level amid pregnancy. However, the procedure is not widely available in our region. To date, there are scarcely documented case reports of HoFH in pregnancy in which the majority of them underwent LA to keep LDL-C at a low level. We report a rare case of successful pregnancy outcome of HoFH patient treated with lipid-lowering drugs including statin without LA therapy. Apart from that, we also discussed the genetic findings of the proband and all screened family members in which to the best of our knowledge, the first study using the whole-exome sequencing technique to identify the causative gene mutations for familial hypercholesterolaemia among the Malaysian population.
Fate of Pulpotomized Teeth in Pediatric Patients: A 3-year Case Series in a Malaysian Dental Teaching Hospital

Sanusi SY, Jamaludin SA, Al-Batayneh OB, Sinor MZ, Khamis MF

Int J Clin Pediatr Dent, 2020 6 26;13(1):79-84.
PMID: 32581485 DOI: 10.5005/jp-journals-10005-1712

Aim: This 3-year retrospective case series evaluated the clinical and radiographic outcome of ferric sulfate and formocresol pulpotomy in primary molar teeth in a dental teaching hospital in Malaysia.
Materials and methods: Clinical and radiographic records of all pediatric patients who had pulpotomy of primary molar teeth between July 2005 and October 2008 were evaluated. A total of 55 pulpotomized primary molars were observed. Clinical assessments were carried out during the second visit to assess the presence of sinus tract, gingival swelling, excessive tooth mobility, tenderness to percussion, and abnormal exfoliation of the treated teeth. Periapical radiographs were reviewed for evidence of pathologic root resorption, radicular and/or periapical radiolucency, and abnormal pulp canal calcification. Treatments were regarded as failure in the presence of one or more of the above clinical and/or radiographic signs and symptoms.
Results: Of 55 pulpotomized teeth, 26 (47.3%) remained free from any clinical signs and symptoms and 48 (87.3%) showed no pathological radiographic findings. The clinical success rates of ferric sulfate and formocresol pulpotomy were 44.4% and 60.0%, respectively, whereas the radiographic success rates of ferric sulfate and formocresol pulpotomy were 86.7% and 90.0%, respectively. Although teeth treated with formocresol had higher both clinical and radiographic success rates compared with those treated with ferric sulfate, it was not statistically significant.
Conclusion: The clinical success rates of pulpotomy were lower compared with radiographic success rates. Ferric sulfate is an alternative to formocresol; however, the use of both agents in the dental undergraduate teaching at Universiti Sains Malaysia can still be recommended.
Clinical significance: Formocresol and ferric sulfate are advocated as pulpotomy agents in primary molar teeth since both agents showed comparable clinical and radiographic success rates.
How to cite this article: Sanusi SY, Jamaludin SA, Al-Batayneh OB, et al. Fate of Pulpotomized Teeth in Pediatric Patients: A 3-year Case Series in a Malaysian Dental Teaching Hospital. Int J Clin Pediatr Dent 2020;13(1):79-84.
Fulltext Comprehensive computational target fishing approach to identify Xanthorrhizol putative targets

Shahid M, Azfaralariff A, Law D, Najm AA, Sanusi SA, Lim SJ, et al.

Sci Rep, 2021 01 15;11(1):1594.
PMID: 33452398 DOI: 10.1038/s41598-021-81026-9

Xanthorrhizol (XNT), is a bioactive compound found in Curcuma xanthorrhiza Roxb. This study aimed to determine the potential targets of the XNT via computational target fishing method. This compound obeyed Lipinski's and Veber's rules where it has a molecular weight (MW) of 218.37 gmol-1, TPSA of 20.23, rotatable bonds (RBN) of 4, hydrogen acceptor and donor ability is 1 respectively. Besides, it also has half-life (HL) values 3.5 h, drug-likeness (DL) value of 0.07, oral bioavailability (OB) of 32.10, and blood-brain barrier permeability (BBB) value of 1.64 indicating its potential as therapeutic drug. Further, 20 potential targets were screened out through PharmMapper and DRAR-CPI servers. Co-expression results derived from GeneMANIA revealed that these targets made connection with a total of 40 genes and have 744 different links. Four genes which were RXRA, RBP4, HSD11B1 and AKR1C1 showed remarkable co-expression and predominantly involved in steroid metabolic process. Furthermore, among these 20 genes, 13 highly expressed genes associated with xenobiotics by cytochrome P450, chemical carcinogenesis and steroid metabolic pathways were identified through gene ontology (GO) and KEGG pathway analysis. In conclusion, XNT is targeting multiple proteins and pathways which may be exploited to shape a network that exerts systematic pharmacological effects.
Fulltext Muslims' views on the permissibility of organ donation: The case of Malaysia

Tumin M, Noh A, Mohd Satar N, Tafran K, Abdullah N, Wan Md Adnan WAH, et al.

International e-Journal of Science, Medicine & Education, 2016;10(1):41-46.
MyJurnal

Background: Some argue that Malaysia’s extremely low organ donation rate is attributed to religion, specifically Islam. Testing this argument, this study asked Malaysian Muslims their views regarding various issues on organ donation and examined whether their decisions to donate organs are framed by religious beliefs.
Materials and Methods: This study investigated the perspectives of Malaysian Muslims between October and December 2013 in Kuala Lumpur. Self-administered questionnaires were distributed to 900 people, with 829 responses collected (92% response rate). Respondents’ verbal consent was taken before proceeding with the survey.
Results: The survey found that more than half of respondents felt that organ donation is permitted in
Islam and that it is a communal responsibility. However, the same proportions were unsure on the issues of rewards for organs or on whether Islam permits the procuring of organs from brain dead patients.
Conclusions: Malaysian Muslims are not against organ donation; however, encouraging organ donation requires the state to address public concerns on Islam’s views on this sensitive issue through effective policy tools to help address these gaps in Malaysian Muslims’ understanding of organ donation. The organ donation rate could improve by using Islamic scholars as ambassadors for an organ donation drive to convey the message of Malaysia’s urgent need for organ donation.
Fulltext Land use conversion from peat swamp forest to oil palm agriculture greatly modifies microclimate and soil conditions

Anamulai S, Sanusi R, Zubaid A, Lechner AM, Ashton-Butt A, Azhar B

PeerJ, 2019;7:e7656.
PMID: 31632845 DOI: 10.7717/peerj.7656

Oil palm (Elaeis guineensis) agriculture is rapidly expanding and requires large areas of land in the tropics to meet the global demand for palm oil products. Land cover conversion of peat swamp forest to oil palm (large- and small-scale oil palm production) is likely to have negative impacts on microhabitat conditions. This study assessed the impact of peat swamp forest conversion to oil palm plantation on microclimate conditions and soil characteristics. The measurement of microclimate (air temperature, wind speed, light intensity and relative humidity) and soil characteristics (soil surface temperature, soil pH, soil moisture, and ground cover vegetation temperature) were compared at a peat swamp forest, smallholdings and a large-scale plantation. Results showed that the peat swamp forest was 1.5-2.3 °C cooler with significantly greater relative humidity, lower light intensities and wind speed compared to the smallholdings and large-scale plantations. Soil characteristics were also significantly different between the peat swamp forest and both types of oil palm plantations with lower soil pH, soil and ground cover vegetation surface temperatures and greater soil moisture in the peat swamp forest. These results suggest that peat swamp forests have greater ecosystem benefits compared to oil palm plantations with smallholdings agricultural approach as a promising management practice to improve microhabitat conditions. Our findings also justify the conservation of remaining peat swamp forest as it provides a refuge from harsh microclimatic conditions that characterize large plantations and smallholdings.
Fulltext Palm vitamin E reduces locomotor dysfunction and morphological changes induced by spinal cord injury and protects against oxidative damage

Zadeh-Ardabili PM, Rad SK, Rad SK, Khazaài H, Sanusi J, Zadeh MH

Sci Rep, 2017 10 30;7(1):14365.
PMID: 29085045 DOI: 10.1038/s41598-017-14765-3

Spinal cord injury (SCI) occurs following different types of crushes. External and internal outcomes of SCI are including paralysis, cavity, and cyst formation. Effects of dietary derived antioxidants, such as palm vitamin E on central nervous system (CNS) encourage researchers to focus on the potential therapeutic benefits of antioxidant supplements. In the present study, experiments were carried out to evaluate the neuro-protective effect of the palm vitamin E on locomotor function and morphological damages induced SCI. Seventy-two male rats (Sprague-Dawley) were randomly divided into four groups: sham (laminectomy); control (supplemented with the palm vitamin E at a dose of 100 mg/kg/day); untreated-SCI (partial crush, 30-33% for 20 sec); treated-SCI (partial crush, 30-33% for 20 sec supplemented with the palm vitamin E at a dose of 100 mg/kg/day). The treatment with the palm vitamin E significantly improved the hind limb locomotor function, reduced the histopathological changes and the morphological damage in the spinal cord. Also, the palm vitamin E indicated a statistically significant decrease in the oxidative damage indicators, malondialdehyde (MDA) level and glutathione peroxidase (GPx) activity in the treated-SCI compared to the untreated-SCI.
Impact of social media-based dance therapy in treating depression symptoms among victims of Russia-Ukraine war

Ahmad J, Okwuowulu C, Sanusi B, Bello SA, Talabi FO, Udengwu N, et al.

Health Promot Int, 2022 Dec 01;37(6).
PMID: 36508393 DOI: 10.1093/heapro/daac172

The objective of this study was to ascertain the impact of social media-based dance therapy in reducing symptoms of depression among evacuees of the Russia-Ukraine war. The participants were randomly assigned to no dance therapy (n = 162) and social media-based dance therapy groups (n = 162). The dance therapy group took part in 12 sessions of dance therapy while the no dance therapy group did not receive any intervention. The result showed that before the dance therapy intervention, participants in both groups reported severe depression symptoms. After the intervention, participants in the dance therapy group dropped from severe depression to normal depression while those in the no dance therapy group dropped to major depression. During the follow-up assessment after 3 months, participants in the no dance therapy group reported moderate depression while those in the dance therapy group still maintained their normal depression classification with a drop in their depression score from 46 to 26. Overall, the result showed that there was a significant main effect of time and the depression score of the participants, F(1,304) 203.143, p = 0.001, eta = 0.401. No interactive effect of gender and the impact of the treatment on reduction in depression symptoms was detected, F(1,304) 3.232, p = 0.073. However, there was a significant main effect of treatment condition on depression symptoms, F(1,304) 495.023, p = 0.001. We highlighted the implication of these results on health promotion.
Agroforestry orchards support greater butterfly diversity than monoculture plantations in the tropics

Wan Zaki WM, Yahya MS, Norhisham AR, Sanusi R, van der Meer PJ, Azhar B

Oecologia, 2023 Mar;201(3):863-875.
PMID: 36914820 DOI: 10.1007/s00442-023-05348-3

Large-scale deforestation in the tropics, triggered by logging and subsequent agricultural monoculture has a significant adverse impact on biodiversity due to habitat degradation. Here, we measured the diversity of butterfly species in three agricultural landscapes, agroforestry orchards, oil palm, and rubber tree plantations. Butterfly species were counted at 127 sampling points over the course of a year using the point count method. We found that agroforestry orchards supported a greater number of butterfly species (74 species) compared to rubber tree (61 species) and oil palm plantations (54 species) which were dominated by generalist (73%) followed by forest specialists (27%). We found no significant difference of butterfly species composition between agroforestry orchards and rubber tree plantation, with both habitats associated with more butterfly species compared to oil palm plantations. This indicates butterflies were able to persist better in certain agricultural landscapes. GLMMs suggested that tree height, undergrowth coverage and height, and elevation determined butterfly diversity. Butterfly species richness was also influenced by season and landscape-level variables such as proximity to forest, mean NDVI, and habitat. Understanding the factors that contributed to butterfly species richness in an agroecosystem, stakeholders should consider management practices to improve biodiversity conservation such as ground vegetation management and retaining adjacent forest areas to enhance butterfly species richness. Furthermore, our findings suggest that agroforestry system should be considered to enhance biodiversity in agricultural landscapes.
Isodose mapping of terrestrial gamma radiation in Sarawak-Borneo: Insights from surface-weathered soil analysis

Idris HN, Sanusi MSM, Ramli AT, Solleh MRM, Yahaya F, Ya'cob MZ, et al.

Appl Radiat Isot, 2024 Jul;209:111327.
PMID: 38642443 DOI: 10.1016/j.apradiso.2024.111327

Presentation of baseline data on terrestrial gamma radiation (TGR) levels is crucial for assessing the annual effective dose received by the public due to natural radiation exposure. Cumulative doses from various sources can become significant, warranting a spatial understanding of TGR distribution. Few countries have comprehensively mapped TGR on a national scale, often facing challenges due to remote or inaccessible regions. This study investigated the influence of weathered soil groups on TGR dose rates in Sarawak-Borneo, Malaysia, to facilitate insights for TGR projection and isodose mapping. A total of 1044 TGR dose rate measurements were collected using NaI (Tl) scintillation detector survey meters, with a mean of 100 nGy h-1 and a range of 8-375 nGy h-1. Non-parametric statistical analyses of variance using Welch's ANOVA, Brown-Forsythe, and Kruskal-Wallis validated (P-sig.=.000) notable dissimilarities among six categories of superficial-weathered soil. Graphical analysis using Sinclair's cumulative plot revealed deviations at intervals of 50, 80, 100, 120, 175, and 205 nGy h-1. These deviations indicate distinct lithological influences. Skeletal soil (entisols) and podzolic soils had high mean dose rates (148 and 113 nGy h-1, respectively) due to limited development, thus preserving abundant uranium (U) and thorium (Th). Meanwhile, gleysols and thionic soils exhibited compatible means (90 and 82 nGy h-1, respectively), while alluvial (or transported soils) and organic soils displayed lower dose rate ranges (mean of 76 and 47 nGy h-1, respectively), reflecting rapid hydrolysis weathering processes. Simple linear regression analysis revealed a strong relationship between TGR dose rate and mean value of weathered soil groups (y = 0.851x + 0.141 nGy h-1), signifying the significance and magnitude of weathered soil groups' impact on TGR dose rates. The obtained R-value is 0.704, indicating a strong linear correlation among soil group variables, and a Durbin-Watson statistic of 1.41, suggesting positive autocorrelation among residuals, thus positive relationships. An isodose map was successfully developed using the Kriging technique, aligning with lithological features of the study area. Semivariogram analysis reveals spatial dependence within a range of 1.47°, supporting the Kriging technique's suitability for spatial inference. In conclusion, this study has successfully revealed the relationship between TGR dose rates and superficial-weathered soil in Sarawak-Borneo. While the linear relationship is applicable to the Sundaland-Borneo tectonic block, it has potential to be used as a valuable tool for spatial inference of TGR dose rates in isodose development with similar lithologial characteristics, aiding in radiation exposure assessment and environmental monitoring.
Fulltext Southeast Asian Medicinal Plants as a Potential Source of Antituberculosis Agent

Sanusi SB, Abu Bakar MF, Mohamed M, Sabran SF, Mainasara MM

Evid Based Complement Alternat Med, 2017;2017:7185649.
PMID: 29081822 DOI: 10.1155/2017/7185649

Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one-third of the world's population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Plant-derived medicines have since been used in traditional medical system for the treatment of numerous ailments worldwide. There were nine major review publications on antimycobacteria from plants in the last 17 years. However, none is focused on Southeast Asian medicinal plants. Hence, this review is aimed at highlighting the medicinal plants of Southeast Asian origin evaluated for anti-TB. This review is based on literatures published in various electronic database. A total of 132 plants species representing 45 families and 107 genera were reviewed; 27 species representing 20.5% exhibited most significant in vitro anti-TB activity (crude extracts and/or bioactive compounds 0-<10 µg/ml). The findings may motivate various scientists to undertake the project that may result in the development of crude extract that will be consumed as complementary or alternative TB drug or as potential bioactive compounds for the development of novel anti-TB drug.
Valorization of seafood waste: A review of life cycle assessment studies in biorefinery applications

Yusoff MA, Mohammdi P, Ahmad F, Sanusi NA, Hosseinzadeh-Bandbafha H, Vatanparast H, et al.

Sci Total Environ, 2024 Aug 26.
PMID: 39197788 DOI: 10.1016/j.scitotenv.2024.175810

The escalating challenges posed by seafood waste generated by the fishing and aquaculture industries underscore the urgent need for innovative solutions that promote both environmental conservation and economic viability within the seafood sector. Seafood waste biorefinery emerges as a promising solution, offering the potential to transform waste materials into valuable products. However, it is essential to recognize that seafood waste biorefinery operations also entail environmental impacts that warrant careful consideration. Environmental assessment tools like Life Cycle Assessment (LCA) provide a valuable framework for assessing these impacts comprehensively. This review critically examines LCA studies in seafood waste biorefinery, focusing on key concepts, emerging technologies, and potential product avenues. Despite the growing body of research in this area, direct comparisons between published studies prove challenging due to discrepancies in feedstocks, processing techniques, value-added products, and LCA methodologies. Nevertheless, the findings consistently demonstrate significant reductions in environmental impacts achieved through seafood waste biorefinery processes. The selection of technologies significantly influences both product quality and sustainability measures. High energy consumption, including diesel fuel consumption in fishing vessels and electricity consumption in processing steps, should be carefully considered and reduced to mitigate associated environmental impacts. In conclusion, while seafood waste biorefinery processes hold significant promise for providing environmental and economic benefits, substantial challenges remain. This review provides invaluable insights for researchers, policymakers, and stakeholders, emphasizing the importance of continuous interdisciplinary collaboration and methodological standardization to advance sustainable waste management practices in the seafood industry.
Incidence and Outcomes of Postoperative Atrial Fibrillation after Coronary Artery Bypass Grafting of a Randomized Controlled Trial: A Blinded End-of-cycle Analysis

Musa AF, Dillon J, Taib MEM, Yunus AM, Sanusi AR, Nordin MN, et al.

Rev Cardiovasc Med, 2022 Apr;23(4):122.
PMID: 39076222 DOI: 10.31083/j.rcm2304122

OBJECTIVE: The objective of this study is to analyse the incidence of postoperative atrial fibrillation (POAF), demography, post-operative outcomes including morbidity and mortality, length of Cardiac Intensive Care Unit (CICU) stay, High Dependency Unit (HDU) stay, and total hospital stay in patients undergoing coronary bypass grafting (CABG) at Institut Jantung Negana (IJN).
METHODS: We conducted a prospective, randomised, controlled trial. We supplied the treatment group with Tocovid capsules and the control group with placebo containing palm superolein.
RESULTS: Since January 2019, we have recruited the target population of 250 patients. However, the result is still blinded as we are still analysing blood samples for tocotrienol levels. 89.2% of patients completed the study with a 3.6% mortality and a 7.6% attrition rate. 35.2% of the patients developed POAF, the mean time being 46.06 ± 26.96 hours post-CABG. We did not observe any statistically significant difference when we compared left atrial size, New York Heart Association (NYHA) functional class, ejection fraction and premorbid history, besides EuroSCORE II (The European System for Cardiac Operative Risk Evaluation II) status except for older age group, right atrial size, and pleural effusion. There was also no difference in bypass time, cross clamp time or number of anastomoses. However, we noted a significant difference in death (p = 0.01) and renal failure requiring dialysis (p = 0.007) among patients with POAF; those patients also had a longer CICU stay (p = 0.005), HDU stay (p = 0.02), and total hospital stay (p = 0.001).
CONCLUSIONS: POAF is associated with a higher incidence of renal failure and death while it increases CICU, HDU, and total hospital stay. It remains to be seen whether Tocovid reduces POAF and its associated sequelae.
CLINICAL TRIAL REGISTRATION: NCT03807037 (Registered on 16 January 2019).

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