Displaying publications 701 - 720 of 963 in total

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  1. Fulltext Remission of recalcitrant dermatomyositis following a chiropractic adjustment
    Chu ECP, Lo FS, Bhaumik A
    J Family Med Prim Care, 2019 Nov;8(11):3742-3744.
    PMID: 31803683 DOI: 10.4103/jfmpc.jfmpc_839_19
    Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by progressive muscle weakness and pathognomonic skin eruptions. Systemic corticosteroid with or without an immunosuppressive agent is the current treatment of choice in most cases. Cutaneous disease in DM is often refractory and can become the most challenging component to manage effectively. Here, we report a case of recalcitrant DM in a 66-year-old female who sought chiropractic attention for recent episodes of pain and paresthesia in the neck and exacerbation of joint pain. As expected, the musculoskeletal complaints including neck pain, peripheral arthralgia, and muscle weakness that resolved within 1 month after starting treatment. Unexpectedly, dramatic remission of the characteristic skin rashes occurred concurrently. The underlying therapeutic mechanisms of chiropractic remain elusive. This case highlights the importance of family physicians becoming familiar with diagnosing the condition and using a multidisciplinary team approach to treat recalcitrant DM.
    Matched MeSH terms: Skin Diseases
  2. Not all swellings are lymph nodes! A case of subcutaneous panniculitis-like T-cell lymphoma
    Tee Evelyn Wy Yap CT, Evelyn Yap WY
    Med J Malaysia, 2019 Oct;74(5):441-442.
    PMID: 31649225
    Subcutaneous Panniculitis-like T-cell Lymphoma (SPTL) is a rare cutaneous neoplasm of mature cytotoxic T cells, first described in 1991 by Gonzalez et al. The incidence of SPTL in Asian countries ranges from 2.3% to 3%. In Malaysia, only 5 cases were reported from 2001 to 2004 in Hospital Kuala Lumpur, Malaysia. SPTL typically presents as skincoloured or erythematous subcutaneous nodules, most often on the extremities and trunk, but it can also involve the face, back and neck. Diagnosis of SPTL is made based on correlation of clinical findings and subcutaneous tissue biopsy along with immunohistochemical staining patterns.
    Matched MeSH terms: Skin Neoplasms
  3. EDR2 film for skin dose measurement in coronary angiography
    Ying C, Kandaiya S
    Sains Malaysiana, 2012;41:133-140.
    Patient skin dose measurements were performed at the cardiology department in a hospital in Penang, Malaysia using EDR films during coronary angiography (CA) procedures. The EDR2 film was first characterized in terms of dose and energy dependence as well reproducibility. For patient dose measurements, the films were placed on the table underneath the patient for an under couch tube position. A total of 27 CA procedures were studied. Results for peak skin doses (PSD) ranged from 35 to 684 mGy while the dose area product (DAP) values were from 5.5 to 93.1 Gy cm2. DAP correlated reasonably with PSD for CA procedure (R2= 0.8212). The highest PSD value in this study is below the threshold dose value of 2 Gy for early transient skin injury recommended by the Food and Drug Administration (FDA 1994).
    Matched MeSH terms: Skin
  4. Peri-oral bullous impetigo: a diagnostic dilemma for dentist
    Zakaria A, Sockalingam S
    Sains Malaysiana, 2013;42:89-91.
    Bullous impetigo is a highly contagious skin infection commonly affecting children due to epidermolytic toxins of bacteria Staphylococcus sp. This presentation described a case of a 3 year-old Indian girl with bullous lesion around the peri-oral region. The lesion was initially thought to be of viral origin and was treated symptomatically. However, the lesion progressed without any resolution with more vesicles at distant sites. The patient was also having fever and refused any oral intake. At this point, a probable diagnosis of bacterial skin infection was considered and the patient was admitted. Intra-venous fluid was administered to rehydrate the patient and she was treated with topical antibiotic and antipyretic. The lesion resolved within 14 days without scarring. As dental practitioners, we should be aware of bacterial infection around the peri-oral region and consider it as part of a differential diagnosis so that an appropriate treatment can be given.
    Matched MeSH terms: Skin Diseases, Bacterial
  5. Artesunate attenuates 2, 4-dinitrochlorobenzene-induced atopic dermatitis by down-regulating Th17 cell responses in BALB/c mice
    Bai XY, Liu P, Chai YW, Wang Y, Ren SH, Li YY, et al.
    Eur J Pharmacol, 2020 May 05;874:173020.
    PMID: 32087254 DOI: 10.1016/j.ejphar.2020.173020
    Steroidal agent is a standard clinical treatment of atopic dermatitis; however, have serious side effects. Artesunate is reported to exhibit anti-inflammatory properties although its effect on atopic eczema remains unknown. We investigated the therapeutic effects and possible mechanism of systemic artesunate on DNCB-induced atopic dermatitis in a BALB/c mouse model. To ascertain artesunate (5 and 10 mg/kg) efficacy, skin dermatitis severity and ear, spleen, and lymph node weight were evaluated. Skin tissue mRNA and protein expression and serum cytokine levels were examined. Artesunate significantly improved atopic dermatitis symptoms, decreasing the dermatitis score, ear weight difference, spleen weight, and lymph node weight compared with those following DNCB treatment. Artesunate reduced ear and skin epidermal thickness and mast cell infiltration, as determined using hematoxylin-eosin and toluidine blue staining, respectively. The basal level of IgE (287.67 ± 70.41 ng/ml) and TNF-α (19.94 ± 3.98 pg/ml) were Significantly elevated by DNCB (IgE: 1273.23 ± 176.53 ng/ml; TNF-α: 57.53 ± 3.87 pg/ml), while markedly been suppressed in the treatment group (AS-L: IgE: 1100.25 ± 135.32 ng/ml; TNF-α: 38.47 ± 3.26 pg/ml; AS-H: IgE: 459.46 ± 74.75 ng/ml; TNF-α: 24.38 ± 3.85 pg/ml). Among Th17 cell-related factors, DNCB treatment increased mRNA expression of IL-6, IL-17, IL-23, STAT3, and ROR-γt, but reduced TGF-β and SOCS 3; While artesunate reverse these changes. Compared with the model group, artesunate promoted SOCS3 protein and significantly inhibited ROR-γt protein and STAT3 phosphorylation. Thus, artesunate attenuates DNCB-induced atopic dermatitis by inhibiting the release of inflammatory cytokines and downregulating Th17 cell responses in atopic dermatitis mice.
    Matched MeSH terms: Skin/drug effects; Skin/immunology; Skin/pathology
  6. Fulltext Delineation of musculocontractural Ehlers-Danlos Syndrome caused by dermatan sulfate epimerase deficiency
    Lautrup CK, Teik KW, Unzaki A, Mizumoto S, Syx D, Sin HH, et al.
    Mol Genet Genomic Med, 2020 05;8(5):e1197.
    PMID: 32130795 DOI: 10.1002/mgg3.1197
    BACKGROUND: Musculocontractural Ehlers-Danlos Syndrome (mcEDS) is a rare connective tissue disorder caused by biallelic loss-of-function variants in CHST14 (mcEDS-CHST14) or DSE (mcEDS-DSE), both of which result in defective dermatan sulfate biosynthesis. Forty-one patients with mcEDS-CHST14 and three patients with mcEDS-DSE have been described in the literature.

    METHODS: Clinical, molecular, and glycobiological findings in three additional patients with mcEDS-DSE were investigated.

    RESULTS: Three patients from two families shared craniofacial characteristics (hypertelorism, blue sclera, midfacial hypoplasia), skeletal features (pectus and spinal deformities, characteristic finger shapes, progressive talipes deformities), skin features (fine or acrogeria-like palmar creases), and ocular refractive errors. Homozygous pathogenic variants in DSE were found: c.960T>A/p.Tyr320* in patient 1 and c.996dupT/p.Val333Cysfs*4 in patients 2 and 3. No dermatan sulfate was detected in the urine sample from patient 1, suggesting a complete depletion of DS.

    CONCLUSION: McEDS-DSE is a congenital multisystem disorder with progressive symptoms involving craniofacial, skeletal, cutaneous, and cardiovascular systems, similar to the symptoms of mcEDS-CHST14. However, the burden of symptoms seems lower in patients with mcEDS-DSE.

    Matched MeSH terms: Skin
  7. Fulltext Preauricular Pilomatricoma Manifesting as an Aggressive Mass
    Tang PP, Kalimuthu S, Mokhtar SM, Wahab SA
    Oman Med J, 2019 Mar;34(2):160-163.
    PMID: 30918611 DOI: 10.5001/omj.2019.29
    Pilomatricoma is an uncommon benign skin tumor arising from the hair follicle. It usually occurs in the head and neck region and is typically found in the pediatric age group particularly girls. The tumor has inconsistent clinical features and may manifest as a small superficial lesion with benign features or a large and seemingly aggressive lesion with local invasion. Due to its variable clinical presentations, it can occasionally be misdiagnosed as a malignant tumor. We encountered a case of pilomatricoma in a 12-year-old girl with a left preauricular swelling for two years, which became progressively larger and more painful in the few weeks before presentation. Clinically, the swelling resembled a malignant parotid tumor. Multiple fine-needle aspirations were performed, but the cytology results were all inconclusive. Subsequent computed tomography scan revealed a well-defined calcified subcutaneous mass with suspicious parotid involvement. The case was posted for tumor excision and superficial parotidectomy. Intraoperatively, however, the mass could be easily separated from the parotid gland. Histopathological examination of the excised specimen showed characteristic ghost cells, basophilic cells, and ossifications typical of pilomatricoma. In conclusion, preauricular pilomatricoma may pose a diagnostic dilemma. A heightened knowledge of the disease is needed for early recognition of its clinical and imaging features to prevent aggressive therapy than is required.
    Matched MeSH terms: Skin Neoplasms
  8. Cutaneous immune reaction: its usefulness in the evaluation of small-pox immunity in dark races
    Doraisingham M
    Journal of the Malaya Branch of the British Medical Association, 1940;4:314-18.
    1. Observations made on groups of light and dark skinned individuals indicate that the percentage of dark skinned people who can be recognized as immune by their reaction to vaccination is considerably lower than in the case of people with a lesser skin pigmentation.
    2. It is suggested that the reading of "immune reaction" is influenced considerably by the intensity of skin pigment found in the individual.
    3. It would appear that while the usefulness of immune reaction readings in light-skinned peope is very great, its value is limited when applied to those with dark skins.
    Matched MeSH terms: Skin Pigmentation
  9. 'Pai Syndrome' with anterior alveolar polyp: A variant of a rare clinical entity
    Debnath KK, Kanapaty Y, Yong DJ, Chandran S, Bakri A
    Med J Malaysia, 2019 Jun;74(3):229-230.
    PMID: 31256179
    'Pai syndrome' (PS) is a rare congenital syndrome. Presented here, a new-born baby-girl who exhibited the characteristic features of having a midline nasal (septal) polyp, an anterior alveolar process polyp, and a pericallosal lipoma associated with corpus callosum dysgenesis of the brain. Both polyps were lined with stratified-squamous epithelium. The overall features were largely consistent with those described by Pai et al., in 1987. A midline cleft-lip (with or without cleft-alveolus) is one of the most common features of the syndrome which was however absent in this case. Instead, an anterior alveolar polyp is present, which is relatively rare.
    Matched MeSH terms: Skin Diseases
  10. Atititude of asians to calcium and vitamin d rich foods and supplements: a systematic review
    Chin Yi Chan, Norazlina Mohamed, Soelaiman Ima-nirwana, Kok-yong Chin
    Sains Malaysiana, 2018;47:1801-1810.
    The prevalence of osteoporosis is increasing in Asian countries. Optimum calcium intake and vitamin D level are
    important to prevent osteoporosis. The attitude of the society towards calcium food sources and supplements, as well
    as sun exposure, influence their bone health practices. This review aimed to summarize the current literature on the
    attitude of Asians on calcium and vitamin D rich foods and supplements to understand the barriers among the Asians
    in achieving adequate calcium intake and vitamin D level. Studies showed that most Asians have a negative attitude
    towards calcium-rich foods, mainly dairy products due to lactose intolerance, aversion to the taste of dairy products or
    the absence of motivation. Although they took supplements to fill the gap in their diet, they were not aware of the daily
    recommended intake of calcium. Besides, the majority of them have a negative attitude towards sun exposure due to the
    fear of getting skin cancer or tanning. As a conclusion, most of Asians are still not aware of the importance of calcium
    and vitamin D for their health and their negative attitude must be corrected to prevent the rise of osteoporosis.
    Matched MeSH terms: Skin Neoplasms
  11. Anaphylaxis after ingestion of dust mite (Dermatophagoides farinae)-contaminated food: A case report
    Rangkakulnuwat P, Sanit S, Lao-Araya M
    Trop Biomed, 2020 Jun 01;37(2):318-323.
    PMID: 33612801
    Domestic mites have been recognized as the most common allergen responsible for respiratory allergy. Herein, we report a case of anaphylaxis due to ingestion of dust mitecontaminated food. A 14-year-old boy presented to the Emergency Department with chest discomfort, wheezing, eyelid angioedema, and urticarial rash twice in a month after eating meals, including tempura fried squids and onion fritters (containing wheat flour, eggs, squid, and onion). Anaphylaxis had been diagnosed and successfully treated. The investigations showed that the patient was sensitive to house dust mites. Positive skin prick-to-prick test response to incriminated flour and negative tests to wheat allergen extract and uncontaminated flour were demonstrated. The microscopic analysis of causative cooking flour identified the presence of Dermatophagoides farinae. During the oral food challenge test, the patient was able to eat tempura-fried squids and onion fritters, made with uncontaminated flour, without any adverse reaction. Hence, oral ingestion of dust mite-contaminated food was the culprit of this severe allergic reaction.
    Matched MeSH terms: Skin Tests
  12. Fulltext Antimicrobial activity of Nigella sativa L. seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds
    Emeka LB, Emeka PM, Khan TM
    Pak J Pharm Sci, 2015 Nov;28(6):1985-90.
    PMID: 26639493
    Microbial resistance to existing antibiotics has led to an increase in the use of medicinal plants that show beneficial effects for various infectious diseases. The study evaluates the susceptibility of multidrug resistant Staphylococcus aureus to Nigella sativa oil. Staphylococcus aureus was isolated from 34 diabetic patient's wounds attending the Renaissance hospital, Nsukka, Southeast Nigeria. The isolates were characterized and identified using standard microbiological techniques. Isolates were cultured and a comparative In vitro antibiotic susceptibility test was carried out using the disk diffusion method. Of the 34 samples collected, 19(56%) showed multidrug resistance to the commonly used antibiotics. Nigella sativa oil was then studied for antibacterial activity against these multidrug resistant isolates of Staphylococcus aureus in varying concentration by well diffusion method. The oil showed pronounced dose dependent antibacterial activity against the isolates. Out of 19 isolates, 8(42%) were sensitive to undiluted oil sample; 4(21%) of these showed sensitivity at 200 mg/ml, 400 mg/ml and 800 mg/ml respectively. Eleven (58%) of the isolates were completely resistant to all the oil concentrations. The present study, reports the isolation of multi-drug resistant S. aureus from diabetic wounds and that more than half of isolates were susceptible to different concentrations N. sativa oil.
    Matched MeSH terms: Staphylococcal Skin Infections/diagnosis; Staphylococcal Skin Infections/drug therapy*; Staphylococcal Skin Infections/microbiology
  13. Skin and Eye Irritation Assessment of Oil Palm ( Elaeis guineensis) Leaf Extract for Topical Application
    Yusof NZ, Abd Gani SS, Azizul Hasan ZA, Idris Z
    Int J Toxicol, 2018 05 07;37(4):335-343.
    PMID: 29734825 DOI: 10.1177/1091581818773979
    Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (OPLE), particularly on skin and eye irritation. In this study, potential hazard of OPLE on skin and eye irritation was evaluated as an initial step to the safety assessment of OPLE. In vitro cell viability study of OPLE on normal human dermal fibroblasts showed that OPLE was nontoxic to the cells with percentage viability more than 90% after 24 and 48 hours of incubation. Skin irritation potential of OPLE was evaluated using in vitro SkinEthic reconstructed human epidermis (RHE) model (Organization for Economic Cooperation and Development [OECD] Test Guideline 439, 2015), while eye irritation potential was evaluated using in vitro SkinEthic Human corneal epithelium (HCE) model (OECD test guideline 492, 2017). Hazard identification results showed that OPLE at 1%, 5%, and 10% (wt/wt) was classified as nonirritant to the skin and eye where mean tissue viabilities of SkinEthic RHE and SkinEthic HCE were more than 50% and 60%, respectively. Therefore, we recommend a further safety assessment, such as human patch testing, to confirm the nonirritant of OPLE.
    Matched MeSH terms: Skin
  14. Fulltext Multiple concurrent primary extramammary Paget’s disease
    Leelavathi, M., Norazirah, M.N., Nur Amirah, A.P.
    Malays Fam Physician, 2016;11(1):18-21.
    MyJurnal
    Extramammary Paget’s disease (EMPD) is a rare malignant disorder of the skin, which was described
    in as early as the nineteenth century. EMPD usually occurs as a single lesion in the apocrine sweat
    gland–bearing skin with abundant hair follicles. Here, we present an elderly man who suffered from
    a non-resolving chronic genital pruritus for 8 months. Initially, he was managed for recurrent fungal
    infection and eczema. Later, a diagnosis of the rare condition multiple primary EMPD was made
    based on the histopathology findings and appropriate treatment was given.
    Matched MeSH terms: Skin
  15. Fulltext An 8-Year-Old Child with Delayed Diagnosis of Netherton Syndrome
    Leung AKC, Barankin B, Leong KF
    Case Rep Pediatr, 2018;2018:9434916.
    PMID: 29527381 DOI: 10.1155/2018/9434916
    We report an 8-year-old boy with Netherton syndrome who was misdiagnosed and treated as severe atopic dermatitis. The diagnosis of Netherton syndrome was not made until the child was 8 years of age. We discuss the pitfalls in the diagnosis and alert physicians to the proper and early diagnosis of this syndrome. The child was treated with a low dose (0.25 mg/kg) of oral acitretin and a topical moisturizer with marked improvement of his skin and pruritus in 2 months. At 6-month follow-up, the skin was almost clear of erythema and scaling, and the hair was longer and stronger. The dose of acitretin was reduced to 0.12 mg/kg for another 6 months and then discontinued.
    Matched MeSH terms: Skin
  16. Moringa oleifera standardised aqueous leaf extract-loaded hydrocolloid film dressing: in vivo dermal safety and wound healing evaluation in STZ/HFD diabetic rat model
    Chin CY, Ng PY, Ng SF
    Drug Deliv Transl Res, 2019 04;9(2):453-468.
    PMID: 29560587 DOI: 10.1007/s13346-018-0510-z
    Previously, Moringa oleifera leaf (MOL) standardised aqueous extract-loaded films were successfully developed and they showed potential wound healing activity in vitro. The objective of this study was to evaluate in vivo dermal safety as well as wound healing efficacy of these MOL film dressings (containing 0.1, 0.5 and 1% MOL) on diabetic rat model. The acute dermal toxicity was carried out on healthy rats, and signs of toxicity over 14 days were observed. For wound healing studies, excision and abrasion wounds were created out on the STZ/HFD-induced diabetic rat model and the wound healing was studied over 21 days. The wound healing evaluation determined by histology staining, hydroxyproline assay and ELISA assays on wound healing related-growth factors, cytokines and chemokines. MOL film formulations exhibited no signs of dermal toxicities. In excision wound model, 0.5% film significantly enhanced the wound closure by 77.67 ± 7.28% at day 7 compared to control group. While in abrasion wounds, 0.5% MOL films accelerated wound closure significantly at 81 ± 4.5% as compared to the control. The histology findings and hydroxyproline assay revealed that high collagen deposition and complete re-epithelialisation were observed for the wounds treated with 0.5 and 1% MOL films. All MOL film dressings had successfully tested non-toxic via in vivo safety dermal toxicity. It was concluded that the 0.5% MOL extract-loaded film had proven to be the most promising approach to accelerate diabetic wound healing process in both full-thickness excision and partial thickness abrasion wounds on the HFD/STZ-induced diabetic type II model.
    Matched MeSH terms: Skin/drug effects*; Skin/metabolism; Skin/pathology
  17. Fulltext Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization
    Liew YK, Awang Hamat R, van Belkum A, Chong PP, Neela V
    Clin Vaccine Immunol, 2015 May;22(5):593-603.
    PMID: 25809633 DOI: 10.1128/CVI.00493-14
    The exoproteome of Staphylococcus aureus contains enzymes and virulence factors that are important for host adaptation. We investigated the exoprotein profiles and cytokine/chemokine responses obtained in three different S. aureus-host interaction scenarios by using two-dimensional gel electrophoresis (2-DGE) and two-dimensional immunoblotting (2D-IB) combined with tandem mass spectrometry (MS/MS) and cytometric bead array techniques. The scenarios included S. aureus bacteremia, skin and soft tissue infections (SSTIs), and healthy carriage. By the 2-DGE approach, 12 exoproteins (the chaperone protein DnaK, a phosphoglycerate kinase [Pgk], the chaperone GroEL, a multisensor hybrid histidine kinase, a 3-methyl-2-oxobutanoate hydroxymethyltransferase [PanB], cysteine synthase A, an N-acetyltransferase, four isoforms of elongation factor Tu [EF-Tu], and one signature protein spot that could not be reliably identified by MS/MS) were found to be consistently present in more than 50% of the bacteremia isolates, while none of the SSTI or healthy-carrier isolates showed any of these proteins. By the 2D-IB approach, we also identified five antigens (methionine aminopeptidase [MetAPs], exotoxin 15 [Set15], a peptidoglycan hydrolase [LytM], an alkyl hydroperoxide reductase [AhpC], and a haptoglobin-binding heme uptake protein [HarA]) specific for SSTI cases. Cytokine and chemokine production varied during the course of different infection types and carriage. Monokine induced by gamma interferon (MIG) was more highly stimulated in bacteremia patients than in SSTI patients and healthy carriers, especially during the acute phase of infection. MIG could therefore be further explored as a potential biomarker of bacteremia. In conclusion, 12 exoproteins from bacteremia isolates, MIG production, and five antigenic proteins identified during SSTIs should be further investigated for potential use as diagnostic markers.
    Matched MeSH terms: Staphylococcal Skin Infections/immunology; Staphylococcal Skin Infections/metabolism; Staphylococcal Skin Infections/microbiology
  18. Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar
    Sideek MA, Teia A, Kopecki Z, Cowin AJ, Gibson MA
    J Mol Histol, 2016 Feb;47(1):35-45.
    PMID: 26644005 DOI: 10.1007/s10735-015-9645-0
    We have recently shown that Latent transforming growth factor-beta-1 binding protein-2 (LTBP-2) has a single high-affinity binding site for fibroblast growth factor-2 (FGF-2) and that LTBP-2 blocks FGF-2 induced cell proliferation. Both proteins showed strong co-localisation within keloid skin from a single patient. In the current study, using confocal microscopy, we have investigated the distribution of the two proteins in normal and fibrotic skin samples including normal scar tissue, hypertrophic scars and keloids from multiple patients. Consistently, little staining for either protein was detected in normal adult skin and normal scar samples but extensive co-localisation of the two proteins was observed in multiple examples of hypertrophic scars and keloids. LTBP-2 and FGF-2 were co-localised to fine fibrous elements within the extracellular matrix identified as elastic fibres by immunostaining with anti-fibrillin-1 and anti-elastin antibodies. Furthermore, qPCR analysis of RNA samples from multiple patients confirmed dramatically increased expression of LTBP-2 and FGF-2, similar TGF-beta 1, in hypertrophic scar compared to normal skin and scar tissue. Overall the results suggest that elevated LTBP-2 may bind and sequester FGF-2 on elastic fibres in fibrotic tissues and modulate FGF-2's influence on the repair and healing processes.
    Matched MeSH terms: Skin/injuries; Skin/metabolism*; Skin/pathology
  19. Drug permeation enhancement, efficacy, and safety assessment of azelaic acid loaded SNEDDS hydrogel to overcome the treatment barriers of atopic dermatitis
    Parveen N, Sheikh A, Molugulu N, Annadurai S, Wahab S, Kesharwani P
    Environ Res, 2023 Nov 01;236(Pt 2):116850.
    PMID: 37558118 DOI: 10.1016/j.envres.2023.116850
    Atopic dermatitis is one of the most widespread chronic inflammatory skin conditions that can occur at any age, though the prevalence is highest in children. The purpose of the current study was to prepare and optimize the azelaic acid (AzA) loaded SNEDDS using Pseudo ternary phase diagram, which was subsequently incorporated into the Carbopol 940 hydrogel for the treatment of atopic dermatitis. The composition was evaluated for size, entrapment efficiency, in vitro, ex vivo, and in vivo studies. The polydispersity index of the optimized preparation was found to be less than 0.5, and the size of the distributed globules was found to be 151.20 ± 3.67 nm. The SNEDDS hydrogel was characterized for pH, viscosity, spreadability, and texture analysis. When compared to the marketed formulation, SNEDDS hydrogel was found to have a higher rate of permeation through the rat skin. In addition, a skin irritation test carried out on experimental animals showed that the SNEDDS formulation did not exhibit any erythematous symptoms after a 24-h exposure. In conclusion, the topical delivery of AzA through the skin using SNEDDS hydrogel could prove to be an effective approach for the treatment of atopic dermatitis.
    Matched MeSH terms: Skin
  20. Fulltext Pyogenic granuloma-like lesion in children: Should we wait?
    Chooi LK, Saad AZM, Durairajanayagam S
    Indian J Plast Surg, 2017 6 16;50(1):104-106.
    PMID: 28615821 DOI: 10.4103/ijps.IJPS_25_17
    Malignant melanoma is a potentially lethal cutaneous malignancy. Melanoma in paediatrics is rare as compared to adult melanoma. The clinicopathological characteristics of paediatric melanoma are different from adult melanoma, and the presence of melanoma mimics which occurs frequently in children (Spitz naevi) resulted in diagnosis uncertainty. We reported a 9-year-old girl who presented with a slow-growing, pyogenic granuloma-like lesion which was diagnosed with melanoma. It is important to have a high index of suspicion in paediatric skin lesion that would usually be deemed benign. Early tissue biopsy in a suspicious lesion prevents delayed diagnosis and treatment.
    Matched MeSH terms: Skin Neoplasms
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