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Fulltext Application of neurotransmitters and dental stem cells for pulp regeneration: A review

Ramli H, Yusop N, Ramli R, Berahim Z, Peiris R, Ghani N

Saudi Dent J, 2023 Jul;35(5):387-394.
PMID: 37520592 DOI: 10.1016/j.sdentj.2023.05.004

INTRODUCTION: Although there have been many studies on stem cells, few have investigated how neurotransmitters and stem cell proliferation interact to regenerate dental pulp. Dental pulp regeneration is an innovative procedure for reviving dental pulp, if feasible for the entire tooth. Upon tooth injury, activated platelets release serotonin and dopamine in bulk to mobilize dental pulp stem cells to mediate natural dental repair. This has induced research on the role of neurotransmitters in increasing the proliferation rate of stem cells. This review also covers prospective future treatments for dental pulp regeneration.
METHODS: A literature search was performed via PubMed and ScienceDirect from 2001 to 2022, using the keywords "neurotransmitter," "stem cell," "tooth regeneration," "tooth repair," "regenerative dentistry," and "dental pulp." Different inclusion/exclusion criteria were used, and the search was restricted to English articles.
RESULTS: Nine publications reporting neurotransmitter interactions with stem cells for tooth and pulp regeneration were selected.
CONCLUSION: Neurotransmitters were found to interact with dental stem cells. Evidence pointing to neurotransmitters as a factor in the increased proliferation of stem cells was found. This review thus gives hope for tooth pulp regeneration and repair.
MyWSL: Malaysian words sign language dataset

Johari RT, Ramli R, Zulkoffli Z, Saibani N

Data Brief, 2023 Aug;49:109338.
PMID: 37600131 DOI: 10.1016/j.dib.2023.109338

Deaf and hard-of-hearing individuals use sign language as a means of communication. However, those around them, especially family members like the children of deaf adults, may face communication challenges if they are unfamiliar with sign language. This issue has prompted numerous researchers to conduct studies on sign language translation and recognition. However, there is currently no publicly available dataset specifically for Malaysian sign language. This article introduces an image dataset of the Malaysian Sign Language (MySL) hand gestures used in everyday situations. The dataset, named MyWSL2023, comprises 3,500 images of ten static Malaysian sign language words collected from five participants (two males and three females) aged between 20 and 21 years old. The data collection took place indoors under normal lighting conditions. The MyWSL2023 dataset, which has been made freely accessible to all researchers, serves as a valuable resource for not only investigating and developing automated systems for hearing-impaired and deaf individuals but also gesture and sign language recognition using vision-based methods. The dataset can be accessed for free at https://data.mendeley.com/datasets/zvk55p7ktd.
Acute lower limb ischaemia secondary to aortic compression from uterine fibroid

Nawawi SH, Wan Ibrahim WZ, Yahya MM, Ramli R

BMJ Case Rep, 2023 Aug 17;16(8).
PMID: 37591622 DOI: 10.1136/bcr-2022-253129

A woman in her early 50s with uncontrolled diabetes mellitus and a huge uterine fibroid presented to the emergency department with diabetic ketoacidosis and bilateral acute lower limb ischaemia. Vascular and advanced imaging studies confirmed distal aortic compression by a huge uterine fibroid, resulting in extensive lower limb arterial thrombosis. After resuscitation, the patient underwent emergency hysterectomy, thromboembolectomy and amputation of the right leg. She remained critically ill and died of fulminant sepsis and multiorgan failure 10 days later. This case reports the effects of external vascular compression by a large pelvic mass.
Fulltext Passively mode locked thulium and thulium/holmium doped fiber lasers using MXene Nb2C coated microfiber

Ahmad H, Ramli R, Ismail NN, Aidit SN, Yusoff N, Samion MZ

Sci Rep, 2021 Jun 02;11(1):11652.
PMID: 34078979 DOI: 10.1038/s41598-021-90978-x

As a result of the emergence of two-dimensional (2D) materials for various opto-electronics applications, a new class of materials named MXenes have been attracting interests due to their outstanding nonlinear properties. In this work, an MXene niobium carbide (Nb2C) was proposed and demonstrated as a saturable absorber to induce mode-locking in thulium- and thulium/holmium-doped fiber lasers. The Nb2C solution was first prepared using the liquid exfoliation technique, and then deposited onto a microfiber for integration into the laser cavity. Stable mode-locking operation was observed in both laser cavities, where the center wavelengths of the laser were recorded at 1944 nm for the TDFL and 1950 nm for the THDFL. The generated pulses in the TDFL and THDFL had repetition rates of 9.35 and 11.76 MHz respectively, while their corresponding pulse widths were 1.67 and 1.34 ps. Both of the lasers were highly stable, having SNR values of more than 52 dB and showed no major fluctuations when tested for their long-term stabilities. The results demonstrate an excellent performance of the Nb2C as a saturable absorber, offering opportunities to further explore MXenes for future photonics devices.
Fulltext Painless Giant Submandibular Gland Sialolith: A Case Report

Thong HK, Othman IA, Ramli R, Sabir Husin Athar PP

Cureus, 2021 Nov;13(11):e19429.
PMID: 34926020 DOI: 10.7759/cureus.19429

Sialolithiasis is one of the most common diseases involving the salivary glands. It is a condition that occurs due to an obstruction in a salivary gland or its duct due to a calculus. The formation of a salivary stone is believed to be secondary to the deposition of mineral salts around a nidus, which is frequently associated with a recurrent bacterial infection. Patients with submandibular sialolithiasis usually present with acute swelling over the neck associated with pain, fever, and purulent intraoral discharge. The size of the calculus varies from <1 mm to a few centimeters. The frequency of sialolithiasis is relatively common. It is estimated to affect 12 in 1000 of the adult population. However, the occurrence of giant sialoliths, >15 mm in any diameter, is rare. Here, we describe our experience with a case of giant submandibular sialolithiasis measuring 25 mm presenting as a painless submandibular mass. The patient underwent submandibular gland excision followed by a full recovery.
Bicornuate bicollis uterus with right cervical stenosis and ipsilateral renal agenesis

Nik Mhd Nor NS, Ahmad Khairuddin SND, Ramli R

BMJ Case Rep, 2024 Jan 09;17(1).
PMID: 38199665 DOI: 10.1136/bcr-2023-259175
Tuberculosis (TB) of the genital tract presenting with secondary amenorrhoea

Abdul Mulalek N, Wan Abas WR, Muhammad Tamyez F, Ramli R

BMJ Case Rep, 2023 Dec 18;16(12).
PMID: 38110342 DOI: 10.1136/bcr-2023-258548
Fulltext Recurrent Temporal Infections: The Link to Systemic Lupus Erythematosus

Shuhardi SA, Mohamed Said MS, Kew TY, Ramli R

Am J Case Rep, 2023 Dec 29;24:e942163.
PMID: 38155491 DOI: 10.12659/AJCR.942163

BACKGROUND Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse manifestations. The involvement of the musculoskeletal system is very common, and infection is one of the manifestations, which can involve any part of the body. We report a case of a middle-aged woman with recurrent episodes of infection of her left temple. CASE REPORT A 51-year old woman was referred to our clinic following failures to eradicate infection on her left temple for 9 months. Examination revealed facial asymmetry, with diffuse non-tender swelling involving her left temple area, which extended to her cheek. Computed tomography and magnetic resonance imaging (MRI) showed a periosteal reaction of the zygomatic bone. Left temporalis muscle thickening and residual osteomyelitis of the zygomatic bone were also shown by MRI. In view of the unresolved infection with incision and drainage and antibiotics, further blood investigations led to the discovery of SLE. The antinuclear antibody and anti-double-stranded DNA were positive. In addition, low nephelometry markers, C3 (26.7 mg/dL) and C4 (8.24 mg/dL), were observed. This patient was treated with 200 mg of oral hydrochloroquine once daily and 5 mg of oral prednisolone once daily. After 6 months of treatment, the infection subsided, and the structures involved showed remarkable healing. The patient is still taking the same dose and frequency of both drugs at the present time. CONCLUSIONS Temporalis pyomyositis and osteomyelitis of the zygomatic bone could be manifestation of SLE disease; however, the involvement of infection cannot be ruled out.
Fulltext Survey dataset on occupational stress, job satisfaction, and job performance among male fertility patients

Majid NFH, Muhamad S, Kusairi S, Ramli R

Data Brief, 2024 Apr;53:110152.
PMID: 38375144 DOI: 10.1016/j.dib.2024.110152

This article presents data on occupational stress, job satisfaction, and job performance among male fertility patients. The data were collected from 11 November 2021 until 30 October 2022. A quantitative research approach was employed, involving a questionnaire development and survey. A sample of 309 was selected, using simple random sampling, from the pool of male patients that had undergone seminal fluid analysis (SFA) and received treatment from four private fertility clinics in Malaysia. Respondents were asked to give their consent by signing a consent form, for ethical research purposes. The questionnaire asked respondents about their demographics, sperm quality, occupational stress, job satisfaction, and job performance. The data could help other researchers to develop research on management issue in the context of male fertility, as well as organisations to maintain the health and welfare of their employees.
Fulltext A checklist of the bats of Peninsular Malaysia and progress towards a DNA barcode reference library

Lim VC, Ramli R, Bhassu S, Wilson JJ

PLoS One, 2017;12(7):e0179555.
PMID: 28742835 DOI: 10.1371/journal.pone.0179555

Several published checklists of bat species have covered Peninsular Malaysia as part of a broader region and/or in combination with other mammal groups. Other researchers have produced comprehensive checklists for specific localities within the peninsula. To our knowledge, a comprehensive checklist of bats specifically for the entire geopolitical region of Peninsular Malaysia has never been published, yet knowing which species are present in Peninsular Malaysia and their distributions across the region are crucial in developing suitable conservation plans. Our literature search revealed that 110 bat species have been documented in Peninsular Malaysia; 105 species have precise locality records while five species lack recent and/or precise locality records. We retrieved 18 species from records dated before the year 2000 and seven species have only ever been recorded once. Our search of Barcode of Life Datasystems (BOLD) found that 86 (of the 110) species have public records of which 48 species have public DNA barcodes available from bats sampled in Peninsular Malaysia. Based on Neighbour-Joining tree analyses and the allocation of DNA barcodes to Barcode Index Number system (BINs) by BOLD, several DNA barcodes recorded under the same species name are likely to represent distinct taxa. We discuss these cases in detail and highlight the importance of further surveys to determine the occurences and resolve the taxonomy of particular bat species in Peninsular Malaysia, with implications for conservation priorities.
Spermatogonial Stem Cells Protein Identification in In Vitro Culture from Non-Obstructive Azoospermia Patient

Abdul Wahab AY, Md Isa ML, Ramli R

Malays J Med Sci, 2016 May;23(3):40-8.
PMID: 27418868

Spermatogonial stem cells (SSCs) are classifiedas a unique adult stem cells that have capability to propagate, differentiate, and transmit genetic information to the next generation. Studies on human SSCs may help resolve male infertility problems, especially in azoospermia patients. Therefore, this study aims to propagate SSCs in-vitro with a presence of growth factor and detect SSC-specific protein cell surface markers.
Fulltext Nasal bridge intramuscular hemangioma

Hamir Basah Z, Mohamad I, Ramza Ramli R, Gayadh MK, Mutum SS

Case Rep Otolaryngol, 2015;2015:412625.
PMID: 25709848 DOI: 10.1155/2015/412625

Intramuscular haemangioma (IMH) is a benign mesenchymal tumour. It appears as a deep, nontender mass within the soft tissue, particularly in the extremities. This tumour may not be obvious on clinical examination. Head and neck IMHs represent only 13.5% of the total IMHs. The most common site for a head and neck IMH is the masseter muscle, followed by trapezius, sternocleidomastoid, and very rarely temporalis muscle. We present a patient with left nasal bridge swelling which was excised and histologically confirmed as intramuscular hemangioma.
Fulltext Wide distribution of virulence genes among Enterococcus faecium and Enterococcus faecalis clinical isolates

Soheili S, Ghafourian S, Sekawi Z, Neela V, Sadeghifard N, Ramli R, et al.

ScientificWorldJournal, 2014;2014:623174.
PMID: 25147855 DOI: 10.1155/2014/623174

Enterococcus, a Gram-positive facultative anaerobic cocci belonging to the lactic acid bacteria of the phylum Firmicutes, is known to be able to resist a wide range of hostile conditions such as different pH levels, high concentration of NaCl (6.5%), and the extended temperatures between 5(°)C and 65(°)C. Despite being the third most common nosocomial pathogen, our understanding on its virulence factors is still poorly understood. The current study was aimed to determine the prevalence of different virulence genes in Enterococcus faecalis and Enterococcus faecium. For this purpose, 79 clinical isolates of Malaysian enterococci were evaluated for the presence of virulence genes. pilB, fms8, efaAfm, and sgrA genes are prevalent in all clinical isolates. In conclusion, the pathogenicity of E. faecalis and E. faecium could be associated with different virulence factors and these genes are widely distributed among the enterococcal species.
Fatal injuries among motorcyclists in Klang Valley, Malaysia

Ramli R, Oxley J, Noor FM, Abdullah NK, Mahmood MS, Tajuddin AK, et al.

J Forensic Leg Med, 2014 Aug;26:39-45.
PMID: 25066171 DOI: 10.1016/j.jflm.2014.06.007

Motorcycle fatalities constitute the majority of road traffic deaths in Malaysia. The aims of this study were to describe the pattern of fatal injuries among Klang Valley fatal motorcyclists and to describe the factors associated with fatal (vs non-fatal) injuries.
Fulltext Utility of DNA barcoding for rapid and accurate assessment of bat diversity in Malaysia in the absence of formally described species

Wilson JJ, Sing KW, Halim MR, Ramli R, Hashim R, Sofian-Azirun M

Genet. Mol. Res., 2014;13(1):920-5.
PMID: 24634112 DOI: 10.4238/2014.February.19.2

Bats are important flagship species for biodiversity research; however, diversity in Southeast Asia is considerably underestimated in the current checklists and field guides. Incorporation of DNA barcoding into surveys has revealed numerous species-level taxa overlooked by conventional methods. Inclusion of these taxa in inventories provides a more informative record of diversity, but is problematic as these species lack formal description. We investigated how frequently documented, but undescribed, bat taxa are encountered in Peninsular Malaysia. We discuss whether a barcode library provides a means of recognizing and recording these taxa across biodiversity inventories. Tissue was sampled from bats trapped at Pasir Raja, Dungun Terengganu, Peninsular Malaysia. The DNA was extracted and the COI barcode region amplified and sequenced. We identified 9 species-level taxa within our samples, based on analysis of the DNA barcodes. Six specimens matched to four previously documented taxa considered candidate species but currently lacking formal taxonomic status. This study confirms the high diversity of bats within Peninsular Malaysia (9 species in 13 samples) and demonstrates how DNA barcoding allows for inventory and documentation of known taxa lacking formal taxonomic status.
Clinico-epidemiological nature and antibiotic susceptibility profile of Acinetobacter species

Biglari S, Hanafiah A, Ramli R, Mostafizur Rahman M, Mohd Nizam Khaithir T

Pak J Med Sci, 2013 Apr;29(2):469-73.
PMID: 24353558

Acinetobacter spp. has emerged as an important opportunistic pathogen responsible for nosocomial infections in many health-care settings worldwide. The study describes the clinico-epidemiology and antimicrobial susceptibility of Acinetobacter spp. in a tertiary health-care institution. Methodology : Acinetobacter spp. were isolated from 141 specimens of the patients who reported to Universiti Kebangsaan Medical Centre (UKMMC). The sources of specimens were wound, skin and soft tissue, respiratory and urinary tract from patients in various wards. Clinio-epidemiological features of patients infected with Acinetobacter spp. were recorded. Standard bacteriological techniques with API 20NE kits and disk diffusion method were followed for identification and antibiotic sensitivity of the organisms.
Fulltext The effects of water parameters on monthly seagrass percentage cover in Lawas, East Malaysia

Ahmad-Kamil EI, Ramli R, Jaaman SA, Bali J, Al-Obaidi JR

ScientificWorldJournal, 2013;2013:892746.
PMID: 24163635 DOI: 10.1155/2013/892746

Seagrass is a valuable marine ecosystem engineer. However, seagrass population is declining worldwide. The lack of seagrass research in Malaysia raises questions about the status of seagrasses in the country. The seagrasses in Lawas, which is part of the coral-mangrove-seagrass complex, have never been studied in detail. In this study, we examine whether monthly changes of seagrass population in Lawas occurred. Data on estimates of seagrass percentage cover and water physicochemical parameters (pH, turbidity, salinity, temperature, and dissolved oxygen) were measured at 84 sampling stations established within the study area from June 2009 to May 2010. Meteorological data such as total rainfall, air temperature, and Southern Oscillation Index were also investigated. Our results showed that (i) the monthly changes of seagrass percentage cover are significant, (ii) the changes correlated significantly with turbidity measurements, and (iii) weather changes affected the seagrass populations. Our study indicates seagrass percentage increased during the El-Nino period. These results suggest that natural disturbances such as weather changes affect seagrass populations. Evaluation of land usage and measurements of other water physicochemical parameters (such as heavy metal, pesticides, and nutrients) should be considered to assess the health of seagrass ecosystem at the study area.
Fulltext High genetic diversity of Enterococcus faecium and Enterococcus faecalis clinical isolates by pulsed-field gel electrophoresis and multilocus sequence typing from a hospital in Malaysia

Weng PL, Ramli R, Shamsudin MN, Cheah YK, Hamat RA

Biomed Res Int, 2013;2013:938937.
PMID: 23819125 DOI: 10.1155/2013/938937

Little is known on the genetic relatedness and potential dissemination of particular enterococcal clones in Malaysia. We studied the antibiotic susceptibility profiles of Enterococcus faecium and Enterococcus faecalis and subjected them to pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). E. faecium and E. faecalis displayed 27 and 30 pulsotypes, respectively, and 10 representative E. faecium and E. faecalis isolates (five each) yielded few different sequence types (STs): ST17 (2 isolates), ST78, ST203, and ST601 for E. faecium, and ST6, ST16, ST28, ST179, and ST399 for E. faecalis. Resistance to tazobactam-piperacillin and ampicillin amongst E. faecium isolates was highly observed as compared to E. faecalis isolates. All of the isolates were sensitive to vancomycin and teicoplanin. The presence of epidemic and nosocomial strains of selected E. faecium STs: 17, 78, and 203 and E. faecalis ST6 as well as high rates of resistance to multiple antibiotics amongst E. faecium isolates is of a particular concern.
Antibacterial effects of ellagitannins from Acalypha wilkesiana var. macafeana hort.: surface morphology analysis with environmental scanning electron microscopy and synergy with antibiotics

Din WM, Jin KT, Ramli R, Khaithir TM, Wiart C

Phytother Res, 2013 Sep;27(9):1313-20.
PMID: 23109276 DOI: 10.1002/ptr.4876

The present study served to gain further insight into the bactericidal effects of ellagitannins from Acalypha wilkesiana var. macafeana hort. against pathogenic bacteria. Ellagitannins from the aerial parts of A. wilkesiana var. macafeana hort. (EAW) inhibited the growth of Bacillus cereus (ATCC 11778), Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 11632) and Methicillin-resistant Staphylococcus aureus (MRSA) clinical strain with inhibition zones equal to 11.01 ± 1.53 mm, 16.63 ± 0.11 mm, 11.40 ± 1.10 mm and 8.22 ± 0.19 mm, respectively. The minimal inhibition concentration and the minimal bactericidal concentration of ellagitannins from A. wilkesiana var. macafeana hort. (EAW) against MRSA were 750 µg/mL and 3000 µg/mL, respectively. We then examined the synergistic effect of EAW with three antibiotics, i.e. ampicillin, streptomycin and tetracycline, via the checkerboard assay and time-kill assay and observed that EAW is synergistic with ampicillin against S. aureus (ATCC 11632). Environmental electron scanning microscopy analysis showed cell lysis against S. aureus (ATCC 11632) upon treatment with the ellagitannin fraction. The ellagitannin fraction from A. wilkesiana var. macafeana hort. is bactericidal against gram-positive bacteria tested and works synergistically with ampicillin against S. aureus. Morphology analysis of the cell suggests that the bactericidal property of the ellagitannin fraction mechanism involves lysis of the cell wall. In summary, our studies demonstrate that A. wilkesiana var. macafeana hort. produces bactericidal ellagitannins of clinical and/or cosmetological value.
Schwannoma of the tongue in a ten-year old child

Husain S, Husain S, Yunus MR, Yunus MR, Ramli R, Ramli R, et al.

J Pak Med Assoc, 2011 May;61(5):500-1.
PMID: 22204190

The case of a 10-year-old girl is presented who had a slow-growing, painless swelling on the left side of the tongue since six months. This was associated with disturbances in mastication and phonation. Examination revealed a 5 cm x 4 cm. globular smooth, mobile mass on left side of the tongue. There was no neurological deficit and no neck nodes palpable. She underwent excision of the mass under general anaesthesia. Complete enucleation with primary closure was carried out. The patient had an uneventful postoperative recovery and histological evaluation was consistent with schwannoma. The patient was recurrence free after one year.

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