OBJECTIVE: This study aims to comprehensively analyze existing research on the link between physical activity and mental health and identify the level of physical activity and mental health status, the barriers to physical activity, and SCI's impacts on psychological well-being in individuals with SCI.
METHODS: An electronic search strategy will be used to identify prevalence studies published since 1993 in health-related databases such as PubMed, MEDLINE, COCHRANE Library, and Wiley Library using the following query: "Spinal Cord Injury" OR "Paraplegia" OR "Tetraplegia" AND "Physical Activity" OR "Exercise" AND "Mental Health" OR "Mental Illness" OR "Mental Disorder." Bibliographies of primary studies and review articles meeting the inclusion criteria will be searched manually to identify further eligible studies. The risk of bias in the included studies will be appraised using the Joanna Briggs Institute checklist for prevalence studies by 2 review authors. Any disagreement will be resolved by reaching a consensus.
RESULTS: Funding was received in October 2023, data collection will commence in July 2024, and the results are expected by 2025. We will summarize the selection of the eligible studies using a flowchart. The data from the studies will be extracted and tabulated. This scoping review will be published in a peer-reviewed journal in accordance with PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines.
CONCLUSIONS: This scoping review underscores the complex relationship between physical activity and mental health among individuals with SCI, highlighting the level of physical activity and mental health status, barriers to physical activity engagement, and psychological implications. Understanding these dynamics is crucial in devising tailored interventions aimed at enhancing mental well-being. This synthesis of evidence emphasizes the need for personalized strategies to promote physical activity, addressing unique challenges faced by this population to foster improved mental health outcomes and overall quality of life.
TRIAL REGISTRATION: Open Science Framework osf.io/ugx7d; https://osf.io/ugx7d/.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/56081.
MATERIALS AND METHODS: The screening process yielded 13 studies conducted in various countries and regions. These studies, employing designs such as cross-sectional, cohort, and clinical trials, focused on CKD patients across different stages, including early and late-stage CKD.
RESULTS: The study revealed that musculoskeletal disorders are a considerable concern within the CKD population but are insufficiently explored among ESKD patients. Common musculoskeletal disorders identified include osteoarthritis, osteoporosis, fibromyalgia, carpopedal spasm, and chronic musculoskeletal pain syndrome. The prevalence of these disorders varied, with sub-group analysis revealing higher prevalence among hemodialysis patients compared to preand non-dialysis patients. While musculoskeletal pain remains consistent across CKD stages, potential confounding factors, such as palliative care settings and mobility issues warrant careful consideration.
CONCLUSION: The study underscores the importance of understanding and addressing musculoskeletal disorders in the CKD population, emphasizing the need for tailored interventions and future research endeavors.
METHODS: A comprehensive literature search was conducted to gather information on the synthesis methods, complex matrices, characterization techniques, and potential applications of CDs derived from medicinal plants in cancer therapy.
RESULT: Carbon dots (CDs) have emerged as a subject of significant interest due to their favorable chemical and biological properties. Various precursors, including graphite, carbon black, and organic molecules, are utilized in the synthesis of CDs through chemical or physical methods. Notably, CDs derived from medicinal plants offer environmentally friendly alternatives, leveraging complex matrices such as aqueous, alcoholic, and hydroalcoholic extracts. This review emphasizes the green synthesis approaches, characterization techniques, and diverse applications of CDs, including drug transport, bioimaging, biosensing, and anti-cancer therapies. Furthermore, it highlights the advantages and disadvantages of different synthesis methods, aiding researchers in selecting appropriate techniques for continuous production.
CONCLUSION: Carbon dots (CDs) represent a transformative advancement in nanotheranostics, offering a versatile platform for precise cancer diagnosis and therapy. With inherent anticancer properties, CDs hold promise in photodynamic therapy (PDT) and photothermal therapy (PTT), enabling precise tumor targeting while minimizing systemic toxicity. To address the limitations of standalone PDT and PTT, researchers are exploring multimodal treatment approaches integrating CDs. By leveraging the unique properties of CDs derived from medicinal plants, a new era of precision cancer therapy may be realized, emphasizing enhanced therapeutic outcomes and reduced adverse effects.
METHODS: A systematic review was conducted to explore all prognostic risk factors in studies published from the initial to June 2024 among 5 Databases included PubMed / Medline, Scopus, EBSCOhost, Web of Science, and Cochran Library. The quality of the methodology was analyzed using the Newcastle-Ottawa Scale. Data analysis was performed using the Statistical Package for Social Sciences (SPSS) version 29.
RESULTS: Sixty-four studies involving 18,958 participants with a mean age of 38.46 years and females 63.03% were included in the quantitative meta-analysis. Functional outcomes were primarily measured using the Modified Rankin Scale (mRS), with scores ≥ 2 or ≥ 3 indicating poor outcomes in 35.00% and 60.00% of studies, respectively. For general information, age (InOR = 0.98, 95% CI 0.53-1.43), intracranial hemorrhage (OR = 3.79, 95% CI 2.77-5.20), and ischemic infarction (OR = 3.18, 95% CI 2.40-4.23) were associated with poor functional outcomes. For general and neurological symptoms, headache (OR = 0.22, 95% CI 0.17-0.29), seizure (OR = 2.74, 95% CI 1.76-4.27), focal deficit (OR = 4.72, 95% CI 3.86-5.78), coma (OR = 11.60, 95% CI 6.12-21.98), and consciousness alteration (OR = 7.07, 95% CI 4.15-12.04) were outstanding factors. The blood biomarkers of NLR (log OR = 1.72, 95% CI 0.96-2.47), lymphocytes (Cohen's d = -0.63, 95 CI -0.78--0.47), and D-dimer (lnOR = 1.34, 95% CI 0.87-1.80) were the three most frequently reported factors. Parenchymal lesion (OR = 4.71, 95% CI 1.12-19.84) and deep cerebral venous thrombosis (OR = 6.30, 95% CI 2.92-13.63) in radiological images were two frequently reported factors. CVST patients with cancer (OR = 3.87, 95% CI 2.95-5.07) or high blood glucose levels (OR = 3.52, 95% CI 1.61-7.68) were associated with poor functional outcomes. In the meta-regression analysis, ischemic infarction (P = 0.032), consciousness alteration (P
MATERIALS AND METHODS: This scoping review followed the rigorous methodological framework; searched Medline (via OVID and EMBSCO), Scopus, and Web of Science; and selected studies relevant to validated instruments used to evaluate the PES and ESS among parents of DHH children below 6 years old. Before selecting and reviewing relevant articles, two reviewers independently assessed article titles and abstracts from the data sources. Two reviewers verified half of the first reviewer's extracted data.
RESULTS: Overall, 3060 articles were retrieved from the database search, and 139 were selected for full-text review following title and abstract reviews. Ultimately, this study included 22 articles. Among them, 23 and 12 validated instruments, most of which are generic measures, were used for assessing PES and ESS, respectively. Three condition-specific instruments were identified and designed to be administered following cochlear implantation surgery.
CONCLUSIONS: This study revealed that healthcare professionals who interact with parents of DHH children lack the necessary instruments, particularly for parents of children undergoing cochlear implantation surgery. Therefore, it is necessary to develop condition-specific instruments for parents who consider cochlear implantation for their children.