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Fulltext Health related quality of life using commercially prepared food supplements, multivitamins and minerals - a meta-analysis

R.(III) P. Dioso

ASM Science Journal, 2014;8(1):55-66.
MyJurnal

Through the six domains of the health-related quality of life (HRQOL) - physical, psychological, level of independence, social relationship, environment and spirituality or religion - ten out of one hundred randomly selected studies were analysed and evaluated as a theoretical outcome of self care using health products such as food supplements, multivitamins and minerals. A reconstructed HRQOL tool was used in the qualitative and the quantitative analysis and evaluation of the ten selected studies. A Critical Appraisal Skills Programme tool was also used in making sense of the evidences of the study trials. The Population, Intervention, Comparison and Outcome guide focused the protocol for the selection of the studies used in this meta-analysis. A probability sampling generated a uniform distribution of the populations. The manner of consuming or the route of administration, the volume and the preparation of commercially prepared health products were neither analysed nor evaluated as the exclusion criteria. Of the ten studies, nine gave a high significance to the six domains of the (O.R. = 90% / p =

Matched MeSH terms: Dietary Supplements
Fulltext Development and characterisation of Vitex negundo Linn. noodles

Tan, L.S., Leila, M., Rabeta, M.S.

Food Research, 2018;2(1):68-75.
MyJurnal

Formulation 2 (1 g w/w) was the most favourable and was chosen for further analyses to
compare its composition with that of a control (0 g w/w). Total phenolic content (TPC) of
the fresh noodles remained higher than that of the control even after cooking. However,
after cooking, the carbohydrate and protein contents showed significant increases. The
results showed that the lemuni-supplemented noodles have a longer shelf life compared to
the control. The colour parameters L* and a* also showed significant differences as the
lightness decreased, and the redness increased after the substitution. The L*, a* and b*
values decreased significantly after the noodles of both formulations were cooked. The
tensile strength, adhesiveness, and hardness of the lemuni noodles were significantly
higher than those of the control. Thus, the Vitex negundo Linn. leaf has the potential to
increase the health benefits of food products.

Matched MeSH terms: Dietary Supplements
Fulltext Effect of exogenous emulsifier on growth performance, fat digestibility, apparent metabolisable energy in broiler chickens

Tan, Hui San, Abdoreza Soleimani Farjam, Goh, Yong Meng, Idrus Zulkifli, Evi Croes, Sarathi Karmakar Partha, et al.

Journal of Biochemistry, Microbiology and Biotechnology, 2016;4(1):7-10.
MyJurnal

This research was done to evaluate the effect of a commercial exogenous emulsifier
(polyethylene glycol ricinoleate (PEGR)) with high hydrophilic-to-lipophilic balance (HLB)
supplementation to broiler chicken diets on growth performance, digestibility of fat and
apparent metabolisable energy (AME) content in week 1, 3 and 5. A total of 360 one-day-old
male Cobb broiler chicks were assigned in groups of 30 to 12 battery cages. The chicks were
randomly assigned to two dietary treatments, with 6 replicate cages per treatment. The diets
were either standard broiler starter and finisher, with rice bran oil (RBO) as supplemented fat
source or similar diets + 0.05% emulsifier (RBOV). Feed intakes of RBOV groups significantly
increased compared to those of RBO groups from week 2 till 4 while body weights of RBOV
diets significantly increased in week 4 and 5. Both RBOV and RBO groups had similar FCR
except for week 5. Addition of this strongly hydrophilic emulsifier showed no significant
difference in fat digestibility of both RC and RV groups but higher AME was noted for the
treatment than for the control groups at week 5. Therefore, supplementing the exogenous
emulsifier into a broiler diet enriched with rice bran oil improved body weight and AME
content at week 5 with minimal effect on fat digestibility.

Matched MeSH terms: Dietary Supplements
Fulltext Inculcating halal values in seaweed production for competitive positioning

Normawaty Mohammad Noor, Sarina Muhammad Noor, Weliyadi, Rukisah Salleh

International Medical Journal Malaysia, 2018;17(101):37-40.
MyJurnal

Seaweed industry is important in several countries including Malaysia, Japan, Indonesia, and the Philippines. The seaweed, Kappaphycus is widely used in a variety of food products as an excellent nutritional supplement. There are several stages in producing raw Kappaphycus for industry such as cultivation and harvest. Most of these steps follow a traditional way which has been practiced from one generation to another. As seaweed is part of the main ingredients in many final produce, its processing must incorporate cleanliness and quality aspect. Therefore, a focus on Halal is of utmost importance. Halal is a concept that stresses on shariah law and ensuring the utmost quality which benefits most producers especially in food and supplement products. However, the knowledge of Halal is still limited in marine production including seaweed. The seaweed process has gone through numerous stages yet none of them has been checked on its
Halalness aspect. This study is to deliberate on the aspect of Halalness for each stage involved, including cultivation and harvesting. To achieve this, observations and literature search were performed and findings showed that there is lack of hygienic practices in handling seaweed production. Therefore, conjoint initiatives among university-industry-government are needed to enhance the value proposition of the seaweed production as it complies with the concept of Halalness. This will contribute towards the development of Halal ecosystem from seed to harvest of quality seaweed production.

Matched MeSH terms: Dietary Supplements
Desiccation tolerance in Phaleria macrocarpa Embryonic Axes

Ahmed Asrity S, Tsan FY, Ding P, Syed Aris S

Sains Malaysiana, 2014;43:1471-1475.

Phaleria macrocarpa seeds are rapidly killed with desiccation to moisture content (MC) below 20%. Desiccation tolerance of their embryonic axes was studied for storage and germplasm conservation purposes. Embryonic axes were extracted aseptically from fresh seeds obtained from fully ripe fruits in a horizontal laminar air flow cabinet. They were then desiccated under aseptic condition for periods ranging from 0-8 h. For each desiccation treatment, embryonic axes were drawn randomly for the determination of MC according to ISTA, electrolyte leakage and proliferation on Murashige and Skoog (MS) media supplemented with 1 mg/l 6-benzylaminopurine (BAP) and 1 mg/l 2,4-dichlorophenoxyacetic acid (2,4-D). The results obtained from this study indicated that the embryonic axes could tolerate dehydration down to 13.6% with desiccation for 8 h while retaining relatively high viability of 76.7%. This was supported by only gradual increment of electrolyte leakage with the desiccated embryonic axes. All non-desiccated embryonic axes with MC of 52.5% were capable to grow into normal plantlets in vitro but dehydration to MC of 36.0% and further down to 13.6% generally resulted in callus formation with up to 16.7% of the embryonic axes while at least 60.0% of the other embryonic axes were still capable to proliferate as normal plantlets in vitro.

Matched MeSH terms: Dietary Supplements
Foliar Boron spray for improved yield, oil quality and water use efficiency in water stressed sunflower

Shehzad MA, Maqsood M, Abbas T, Ahmad N

Sains Malaysiana, 2016;45:1497-1507.

Boron (B) is a mineral considered essential for improving sunflower (Helianthus annuus L.) resistance to drought. B supplements (0, 15-, 30- and 45 mg L-1) under well-watered and variable water deficit levels (64 and 53 mm irrigation depths) were evaluated for their effects on growth, oil quality and water use efficiency (WUE) in a field study for two consecutive years (i.e. 2011 and 2012). The duration of 50% inflorescence emergence, 50% flowering and 50% maturity stages were reduced with increasing moisture stress. All B application rates improved sunflower growth compared to no B control treatment. The moisture deficit treatments of 64 and 53 mm irrigation depths significantly (p<0.05) reduced the yield-related components. Achenes/head, achenes weight and achene yield under water stress conditions were considerably improved by foliar application of B at 30 mg L-1. An increase in protein contents and a decrease in oil contents were observed with B foliar application under moisture deficit treatments. Foliar application of B (30 mg L-1) on water stressed plants also resulted in increased WUE. The highest net benefits were achieved with B concentration of 30 mg L-1 under well-watered and mild deficit water level of 64 mm irrigation depth. The highest application rate of B (45 mg L-1) gave the best results at the most severe water deficit level. In conclusion, the B rates of 30 and 41 mg L-1 performed best for improving drought tolerance in terms of higher sunflower productivity under mild and higher water deficit conditions

Matched MeSH terms: Dietary Supplements
Fulltext Lower ileostomy output among patients with postoperative colorectal cancer after being supplemented with partially hydrolyzed guar gum: Outcome of a pilot study

Ho CY, Majid HA, Jamhuri N, Ahmad AF, Selvarajoo TA

Nutrition, 2022 06 01;103-104:111758.
PMID: 35843037 DOI: 10.1016/j.nut.2022.111758

BACKGROUND: High stoma output is a significant complication after bowel surgery that causes dehydration, resulting in acute kidney injury, electrolyte imbalances, unintentional weight loss, and malnutrition. This study evaluates the postoperative ileostomy output among patients with colorectal cancer after being supplemented with partially hydrolyzed guar gum.
METHODS: This cross-sectional study collected sociodemographic and clinical characteristics, stoma output, and dietary intake upon discharge, hospitalization, and readmission within 30 d of discharge.
RESULTS: A total of 29 participants were recruited, with 72.4% having moderate malnutrition risk. Patients who received partially hydrolyzed guar gum (PHGG) fiber reported lower stoma output with firmer output consistency than patients who received standard care (SC) (P < 0.05 and P < 0.01). Patients who received PHGG achieved higher energy, protein, and soluble fiber intake than did the SC group (P < 0.01) upon discharge. There was a significant inverse association between soluble fiber (PHGG fiber + dietary soluble fiber) intake and ileostomy output (r, -0.494; P = 0.006).
CONCLUSIONS: Partially hydrolyzed guar gum fiber acts as an agent to hold water, reduce the speed of gastrointestinal tract transit, increase effluent viscosity, and potentially decrease water losses. Supplementation with PHGG fiber appeared to minimize ileostomy output and improve clinical outcomes among postoperative ileostomy patients. This needs to be evaluated further with a randomized controlled trial to confirm this preliminary finding.

Matched MeSH terms: Dietary Supplements
Fulltext Antioxidant Potential of Red Palm-Pressed Mesocarp Olein

Teh SS, Mah SH, Lau HLN, Teng KT, Loganathan R

J Oleo Sci, 2021 Dec 03;70(12):1719-1729.
PMID: 34759109 DOI: 10.5650/jos.ess21147

Oxidative stress occurs due to the imbalance amount of the free radicals and antioxidants in human body which often associated with numerous chronic diseases. The antioxidant properties of red palm-pressed mesocarp olein (PPMO) have not been widely studied. Therefore, antioxidant properties of PPMO relative to commercially available edible oils, namely red palm olein (RPO), palm olein (PO), extra virgin olive oil (OO) and extra virgin coconut oil (CNO) were studied. PPMO exhibited significant higher phytonutrients which more than 2-fold compared to the edible oils. Overall, antioxidant screening indicated that PPMO has significantly higher antioxidant activities than RPO, PO and CNO in term of DPPH, H2O2, NO scavenging and FIC; and significantly higher H2O2 and FIC than OO. The outcomes of this study reveal that PPMO is as good as commercially available edible oil, also a good source for food applications and dietary nutritional supplements. More importantly, the utilization of PPMO could mitigate oil palm waste problem and results in positive environmental impact.

Matched MeSH terms: Dietary Supplements
Fulltext Impact of pH and butyric acid on butanol production during batch fermentation using a new local isolate of Clostridium acetobutylicum YM1

Al-Shorgani NKN, Kalil MS, Yusoff WMW, Hamid AA

Saudi J Biol Sci, 2018 Feb;25(2):339-348.
PMID: 29472788 DOI: 10.1016/j.sjbs.2017.03.020

The effect of pH and butyric acid supplementation on the production of butanol by a new local isolate of Clostridium acetobutylicum YM1 during batch culture fermentation was investigated. The results showed that pH had a significant effect on bacterial growth and butanol yield and productivity. The optimal initial pH that maximized butanol production was pH 6.0 ± 0.2. Controlled pH was found to be unsuitable for butanol production in strain YM1, while the uncontrolled pH condition with an initial pH of 6.0 ± 0.2 was suitable for bacterial growth, butanol yield and productivity. The maximum butanol concentration of 13.5 ± 1.42 g/L was obtained from cultures grown under the uncontrolled pH condition, resulting in a butanol yield (YP/
S
) and productivity of 0.27 g/g and 0.188 g/L h, respectively. Supplementation of the pH-controlled cultures with 4.0 g/L butyric acid did not improve butanol production; however, supplementation of the uncontrolled pH cultures resulted in high butanol concentrations, yield and productivity (16.50 ± 0.8 g/L, 0.345 g/g and 0.163 g/L h, respectively). pH influenced the activity of NADH-dependent butanol dehydrogenase, with the highest activity obtained under the uncontrolled pH condition. This study revealed that pH is a very important factor in butanol fermentation by C. acetobutylicum YM1.

Matched MeSH terms: Dietary Supplements
Fulltext Protective effects of pulp and kernel oils from Canarium odontophyllum fruit in normal and hypercholesterolemic rabbits

Faridah Hanim, S, Azrina, A., Khoo, H. E, Amin, I.

International Food Research Journal, 2015;22(4):1318-1326.
MyJurnal

This study aimed to determine the protective effects of CO pulp and kernel oils supplementation to normocholesterolemic and hypercholesterolemic rabbits. Rabbits from the treatment groups were supplemented with CO pulp and kernel oils for four weeks. Bloods were drawn from all experimental groups at baseline and fourth week to determine protective effects of CO oils supplementation on plasma total antioxidant status (TAS) and catalase (CAT) activity. Liver function tests (ALT, AST, and GGT activities) were also determined for all the groups. The results showed that CO oil supplementation increased plasma TAS in both normal and hypercholesterolemic groups. Plasma CAT activities in the hypercholesterolemic groups supplemented with CO oils were significantly reduced but not for the normocholesterolemic groups. Significant reduction of plasma AST was observed for the hypercholesterolemic rabbits given CO pulp and kernel oils compared with the hypercholesterolemic control rabbits, but not for plasma ALT and GGT. In the normocholesterolemic rabbits, CO pulp oil had caused a significant elevation of plasma ALT, AST, and GGT levels as compared to the negative control rabbits. Therefore, CO pulp and kernel oils are somehow not hepatotoxic, and the oils are potent functional foods.

Matched MeSH terms: Dietary Supplements
Effects of fermented soybean meal on carbon and nitrogen metabolisms in large intestine of piglets

Zhang YT, Lu DD, Chen JY, Yu B, Liang JB, Mi JD, et al.

Animal, 2018 Oct;12(10):2056-2064.
PMID: 29362016 DOI: 10.1017/S1751731118000058

Fermented soybean meal (FSM), which has lower anti-nutritional factors and higher active enzyme, probiotic and oligosaccharide contents than its unfermented form, has been reported to improve the feeding value of soybean meal, and hence, the growth performance of piglets. However, whether FSM can affect the bacterial and metabolites in the large intestine of piglets remains unknown. This study supplemented wet-FSM (WFSM) or dry-FSM (DFSM) (5% dry matter basis) in the diet of piglets and investigated its effects on carbon and nitrogen metabolism in the piglets' large intestines. A total of 75 41-day-old Duroc×Landrace×Yorkshire piglets with an initial BW of 13.14±0.22 kg were used in a 4-week feeding trial. Our results showed that the average daily gain of piglets in the WFSM and DFSM groups increased by 27.08% and 14.58% and that the feed conversion ratio improved by 18.18% and 7.27%, respectively, compared with the control group. Data from the prediction gene function of Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) based on 16S ribosomal RNA (rRNA) sequencing showed that carbohydrate metabolism function families in the WFSM and DFSM groups increased by 3.46% and 2.68% and that the amino acid metabolism function families decreased by 1.74% and 0.82%, respectively, compared with the control group. These results were consistent with those of other metabolism studies, which showed that dietary supplementation with WFSM and DFSM increased the level of carbohydrate-related metabolites (e.g. 4-aminobutanoate, 5-aminopentanoate, lactic acid, mannitol, threitol and β-alanine) and decreased the levels of those related to protein catabolism (e.g. 1,3-diaminopropane, creatine, glycine and inosine). In conclusion, supplementation with the two forms of FSM improved growth performance, increased metabolites of carbohydrate and reduced metabolites of protein in the large intestine of piglets, and WFSM exhibited a stronger effect than DFSM.

Matched MeSH terms: Dietary Supplements
Nutraceuticals and COVID-19: A mechanistic approach toward attenuating the disease complications

Paudel KR, Patel V, Vishwas S, Gupta S, Sharma S, Chan Y, et al.

J Food Biochem, 2022 Dec;46(12):e14445.
PMID: 36239436 DOI: 10.1111/jfbc.14445

Nutraceuticals have emerged as potential compounds to attenuate the COVID-19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access. Therefore, current research is focused on developing newer advanced formulations from potential drug candidates including nutraceuticals with desirable properties viz, affordability, ease of availability, ease of administration, stability under room temperature, and potentially longer shelf-lives. As such, various nutraceutical-based products such as compounds could be promising agents for effectively managing COVID-19 symptoms and complications. Most importantly, regular consumption of such nutraceuticals has been shown to boost the immune system and prevent viral infections. Nutraceuticals such as vitamins, amino acids, flavonoids like curcumin, and probiotics have been studied for their role in the prevention of COVID-19 symptoms such as fever, pain, malaise, and dry cough. In this review, we have critically reviewed the potential of various nutraceutical-based therapeutics for the management of COVID-19. We searched the information relevant to our topic from search engines such as PubMed and Scopus using COVID-19, nutraceuticals, probiotics, and vitamins as a keyword. Any scientific literature published in a language other than English was excluded. PRACTICAL APPLICATIONS: Nutraceuticals possess both nutritional values and medicinal properties. They can aid in the prevention and treatment of diseases, as well as promote physical health and the immune system, normalizing body functions, and improving longevity. Recently, nutraceuticals such as probiotics, vitamins, polyunsaturated fatty acids, trace minerals, and medicinal plants have attracted considerable attention and are widely regarded as potential alternatives to current therapeutic options for the effective management of various diseases, including COVID-19.

Matched MeSH terms: Dietary Supplements
The Inclusion of Folic Acid in Weekly Iron-Folic Acid Supplements Confers no Additional Benefit on Anemia Reduction in Nonpregnant Women: A Randomized Controlled Trial in Malaysia

Samson KLI, Loh SP, Lee SS, Sulistyoningrum DC, Khor GL, Mohd Shariff ZB, et al.

J Nutr, 2021 Aug 07;151(8):2264-2270.
PMID: 33978167 DOI: 10.1093/jn/nxab115

BACKGROUND: Weekly iron-folic acid (IFA) supplements are recommended for all menstruating women in countries where anemia prevalence is ≥20%; however, it is unknown whether the inclusion of folic acid in weekly IFA supplements reduces anemia.
OBJECTIVES: We examined whether the inclusion of folic acid in weekly IFA supplements conferred any benefit on hemoglobin (Hb) concentration, anemia reduction, or iron status [ferritin and soluble transferrin receptor (sTfR)], over iron alone.
METHODS: In this secondary analysis of a randomized controlled trial in Malaysia, n = 311 nonpregnant women (18-45 y old) received 60 mg Fe with either 0, 0.4, or 2.8 mg folic acid once-weekly for 16 wk. Fasting blood was collected at baseline and 16 wk. A generalized linear model (normal distribution with identity link) was used to assess Hb concentration at 16 wk (primary outcome).
RESULTS: At baseline, 84% of women had low folate status (plasma folate 0.05). Baseline plasma folate concentration did not modify the effect of treatment on Hb concentration at 16 wk. Among all women, the risks of anemia [risk ratio (RR): 0.65; 95% CI: 0.45, 0.96; P = 0.03] and iron deficiency based on ferritin (RR: 0.30; 95% CI: 0.20, 0.44; P

Matched MeSH terms: Dietary Supplements
Fulltext Factors Associated with Low Vitamin D Status among Older Adults in Kuwait

ALbuloshi T, Kamel AM, Spencer JPE

Nutrients, 2022 Aug 15;14(16).
PMID: 36014846 DOI: 10.3390/nu14163342

Low vitamin D levels among older people represent a significant health problem worldwide. This study aimed to examine the factors associated with vitamin D deficiency in older people (aged ≥ 65) in the Kuwaiti population. A cross-sectional study was conducted in seven primary healthcare centers across Kuwait (November 2020 to June 2021). The participants (n = 237) had their serum vitamin D (25(OH)D) concentrations (analyzed using LC-MS) classified as sufficiency 75 nmol/L (30 ng/mL) or deficiency < 75 nmol/L (below 30 ng/mL). The data were collected using self-administered questionnaires and face-to-face interviews with participants in geriatric clinics. Binomial logistic regression analysis was applied to assess factors associated with vitamin D deficiency. Vitamin D deficiency was found to be present in two thirds of the participants (n = 150, 63%), with a higher prevalence of deficiency in participants who did not receive vitamin D supplements, compared to those who did (84% vs. 16%, p = 0.001). The results from the binary logistic regression showed that a low duration of sun exposure (OR = 0.24, 95% C.I. [0.08−0.7], p = 0.011), dark skin pigmentation (OR = 4.46, 95% [1.35−20.49], p = 0.026), and lower caloric intake (OR = 0.9, 95% C.I. [0.85−0.96], p = 0.001) were risk factors for vitamin D deficiency. Furthermore, a significant inverse relationship was found between vitamin D levels and parathyroid hormone (PTH) levels (OR = 1.16, 95% C.I. [1.04−1.31], p = 0.016). These findings support the recommendation that vitamin D supplementation and adequate sunlight exposure are necessary for raising low vitamin D levels in older people in Kuwait.

Matched MeSH terms: Dietary Supplements
Effects of eggshell and seashell powder as natural dietary calcium supplements on growth, molting frequency, and carapace calcium composition of juvenile red claw crayfish, Cherax quadricarinatus

Shahroom A, Shapawi R, Mustafa S, Abd Halid NF, Estim A, Daning Tuzan A

PeerJ, 2023;11:e15449.
PMID: 37456888 DOI: 10.7717/peerj.15449

The growth performance of red claw crayfish, Cherax quadricarinatus, fed diets with different sources and concentrations of natural calcium was evaluated. Formulated diets containing 30% protein and 8% lipid were prepared using supplementation of 0 (control), 3%, 6%, 9% eggshell, and 6% seashell. C. quadricarinatus juveniles with an average total weight of 0.21 ± 0.01 g and length of 25.0 ± 0.10 mm were obtained from ten ovigerous females bred in captivity. An aquarium with a size of 0.72 m² was divided into eight compartments with an area of 0.09 m² per compartment and was individually stocked with juvenile crayfish. A total of eight juvenile crayfish were used per dietary treatment. There were five dietary treatments in total and each of these treatments were replicated three times. The addition of eggshell and seashell powder exerted positive effects on the growth performance, molting frequency, and survival of the crayfish. Crayfish fed with a 6% eggshell-supplemented diet exhibited the best overall growth performance. The calcium percentage of the carapace increased with the increase in calcium content of the diets. Meanwhile, the performance of diets comprising eggshells and seashells was not significantly different (P > 0.05). Considering the low cost and abundance of eggshells, the addition of 6% of this product to the diet is recommended for the best growth of juvenile C. quadricarinatus.

Matched MeSH terms: Dietary Supplements
Steroids masquerading as natural herbs: a case for regulatory control

Reti S

N Z Med J, 2002 Aug 9;115(1159):U125.
PMID: 12362169
Matched MeSH terms: Dietary Supplements
Fulltext The Effects of Combined Exercise with Citrulline Supplementation on Body Composition and Lower Limb Function of Overweight Older Adults: A Systematic Review and Meta-Analysis

Xie S, Li S, Shaharudin S

J Sports Sci Med, 2023 Sep;22(3):541-548.
PMID: 37711701 DOI: 10.52082/jssm.2023.541

The combined exercise with citrulline (CIT) supplementation is a potential adjuvant treatment approach to address the declining body composition and lower limb function of overweight older adults. However, research on this approach is limited. Thus, this study performed a meta-analysis review to explore the effects of combined exercise with CIT supplementation on body composition and lower limb function among overweight older adults. The search strategy and manuscript development of this study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Eligible studies were first searched through four databases (Web of Science, Scopus, PubMed, and EBSCO) from January 2003 until April 2023, followed by screening. The main inclusion criteria for the article selection are as follows: 1) Randomized Controlled Trial studies; 2) Participants aged over 55; 3) Studies involved exercise with CIT supplementation for the experimental group and exercise with Placebo (PLA) supplementation for the control group; 4) Body composition and lower limb function were measured at pre- and post-intervention. Subsequently, the Cochrane risk of bias assessment tool was utilized to evaluate the selected studies' quality. The Standardized Mean Difference (SMD) was chosen as the suitable effect scale index, and the mean differences of the data from the selected articles were analyzed using Revman 5.4 software with a 95% Confidence Interval (CI). A total of seven studies fulfilled the inclusion criteria and were selected for the meta-analysis. The included studies involved 105 males and 198 females, where 157 belonged to the PLA group and 146 from the CIT group. Significant improvements were observed among overweight older adults with CIT supplementation in 6-Minute Walking Test (6MWT) (P = 0.04, I2 = 4%), SMD (95% CI) = -0.28 (-0.54, -0.01), and Lower Limb Strength (LLS) (P < 0.01, I2 = 30%), SMD (95% CI) = -0.38 (-0.65, -0.12) compared to those with PLA supplementation. Combined exercise with CIT supplementation could be an effective non-pharmaceutical intervention to improve the physical function of overweight older adults by increasing their muscle strength.

Matched MeSH terms: Dietary Supplements
Fulltext Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Phang SCW, Ahmad B, Abdul Kadir K, M Palanisamy UD

Adv Nutr, 2023 Sep;14(5):1159-1169.
PMID: 37321474 DOI: 10.1016/j.advnut.2023.06.006

There are a large number of studies that have reported benefits of tocotrienol-rich fraction (TRF) in various populations with different health status. To date, no systematic reviews have examined randomized controlled trials (RCTs) on the effect of TRF supplementations specifically in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aim to examine the changes in HbA1c (glycated hemoglobin), blood pressure, and serum Hs-CRP (C-reactive protein high sensitivity) levels at post-TRF supplementation. Online databases including PubMed, Scopus, OVID Medline, and Cochrane Central Register of Controlled Trials were searched from inception until March 2023 for RCTs supplementing TRF in patients with T2DM. A total of 10 studies were included in the meta-analysis to estimate the pooled effect size. The Cochrane Risk-of-Bias (RoB) Assessment Tool was utilized to evaluate the RoB in individual studies. The meta-analysis revealed that TRF supplementation at a dosage of 250-400 mg significantly decreased HbA1c (-0.23, 95% CI: -0.44, -0.02, P < 0.05, n = 754), particularly where the intervention duration is less than 6 mo (-0.47%, 95% CI: -0.90, -0.05, P < 0.05, n = 126) and where duration of diabetes is less than 10 y (-0.37, 95% CI: -0.68, -0.07, P < 0.05, n = 83). There was no significant reduction in systolic and diastolic blood pressure and serum Hs-CRP (P > 0.05). The present meta-analysis demonstrated that supplementing with TRF in patients with T2DM decreased HbA1c but does not decrease systolic and diastolic blood pressure and serum Hs-CRP.

Matched MeSH terms: Dietary Supplements
The effects of vitamin C supplementation on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis

Nosratabadi S, Ashtary-Larky D, Hosseini F, Namkhah Z, Mohammadi S, Salamat S, et al.

Diabetes Metab Syndr, 2023 Aug;17(8):102824.
PMID: 37523928 DOI: 10.1016/j.dsx.2023.102824

BACKGROUND AND AIM: It has been suggested that taking vitamin C supplements may improve glycemic control in patients with type 2 diabetes mellitus (T2DM). However, there has not been a thorough evaluation of the actual impact or certainty of the findings. This systematic review and meta-analysis was conducted to determine the effect of vitamin C supplementation on glycemic profile in T2DM patients.
METHODS: A systematic search was performed across online databases including Scopus, Web of Science, and PubMed/Medline to identify relevant randomized controlled trials (RCTs) published until July 2022. A random-effects model was applied for the meta-analysis.
RESULTS: The present meta-analysis included a total of 22 RCTs with 1447 patients diagnosed with T2DM.A pooled analysis revealed a significant decrease in levels of serum hemoglobin A1c (HbA1c), fasting insulin, and fasting blood glucose (FBG) in vitamin C-treated T2DM patients compared with their untreated counterparts. The dose-response evaluation displayed a substantial linear association between the intervention duration and changes in serum HbA1c levels. However, the analysis did not demonstrate any significant effect of vitamin C on serum values of homeostasis model assessment of insulin resistance(HOMA-IR) in diabetic patients. Subgroup analyses indicated that high-dose vitamin C administration (≥1000 mg/d) considerably decreased serum HOMA-IR levels.
CONCLUSION: These findings suggest that long-term (≥12 weeks) and high-dose vitamin C supplementation (≥1000 mg/d) may ameliorate glycemic profile in T2DM patients. However, additional high-quality RCTs are necessary to validate these results.

Matched MeSH terms: Dietary Supplements
Fulltext Multiple micronutrient supplementation improves growth and reduces the risk of anemia among infants in Gaza Strip, Palestine: a prospective randomized community trial

Albelbeisi A, Shariff ZM, Mun CY, Rahman HA, Abed Y

Nutr J, 2020 12 05;19(1):133.
PMID: 33278899 DOI: 10.1186/s12937-020-00652-7

BACKGROUND: Infants and young children 6-24 months of age are the most nutritionally vulnerable groups, as their needs for vitamins and minerals are high relative to the amount of food they consume. This study determines the effect of Micronutrient Powder Supplementation (MNP) on growth and hemoglobin of infants in Gaza Strip, Palestine.
METHOD: This was a two-arm parallel-group randomized controlled trial conducted in two health care clinics of the United Nations Relief and Work Agency (UNRWA) at the Middle Area governorate of Gaza Strip, Palestine. A total of 200 healthy infants aged 6-month-old were recruited and randomized to receive 3 sachets/week of MNP for 12 months alongside with the National Micronutrient Supplement (NMS) (n = 100) or NMS alone (n = 100). Weight, length, blood hemoglobin, and dietary intakes were measured at 6, 9, 12, 15, 18, and 21 (3 months after the end of intervention) months of age. Analysis was by intention to treat.
RESULTS: The experimental group had a higher concentration of hemoglobin at 12 and 15 months than did the control group, and a significant difference (p

Matched MeSH terms: Dietary Supplements

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