Displaying publications 101 - 120 of 2391 in total

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  1. Teng CL
    Family Physician, 1996;9(3):23-24.
    This article chronicles the popular health beliefs of the Malays and Chinese regarding chickenpox, as seen through the eyes of a doctor. The interplay of several factors, namely, a marriage of two major cultures, chickenpox in pregnancy, concurrence of two major festivals make this a unique study in medical socio-anthropology.
    Matched MeSH terms: Pregnancy
  2. Begum KS, Sachchithanantham K, De Somsubhra S
    Clin Exp Obstet Gynecol, 2011;38(1):14-20.
    PMID: 21485717
    The increasing prevalence of maternal obesity worldwide provides a major challenge to obstetric practice from preconception to postpartum. Maternal obesity can result in unfavorable outcomes for the woman and fetus. Maternal risks during pregnancy include gestational diabetes and chronic hypertension leading to preeclampsia. The fetus is at risk for stillbirth and congenital anomalies. Intrapartum care, normal and operative deliveries, anesthetic and operative interventions in the obese demand extra care. Obesity in pregnancy can also affect health later in life for both mother and child. For women, these risks include heart disease and hypertension. Children have a risk of future obesity and heart disease. Women and their offspring are at increased risk for diabetes. Obstetrician-gynecologists should be well informed to prevent and treat this epidemic. Interventions directed at weight loss and prevention of excessive weight gain during pregnancy must begin in the preconception period.
    Matched MeSH terms: Pregnancy; Pregnancy Complications/etiology*; Pregnancy Outcome
  3. Teoh SK, Wong WP
    Med J Malaysia, 1977 Sep;32(1):90-5.
    PMID: 609353
    Matched MeSH terms: Pregnancy; Pregnancy Complications; Pregnancy, Multiple*
  4. Muhammad Aliff M, Muhammad Shazwan S, Nur Fariha MM, Hayati AR, Nur Syahrina AR, Maizatul Azma M, et al.
    Malays J Pathol, 2016 Dec;38(3):285-294.
    PMID: 28028299 MyJurnal
    BACKGROUND: Antiphospholipid syndrome (APS) is a multisystem disease that may present as venous or arterial thrombosis and/or pregnancy complications with the presence of antiphospholipid antibodies. Until today, heterogeneity of pathogenic mechanism fits well with various clinical manifestations. Moreover, previous studies have indicated that genes are differentially expressed between normal and in the disease state. Hence, this study systematically searched the literature on human gene expression that was differentially expressed in Obstetric APS.

    METHODOLOGY: Electronic search was performed until 31st March 2015 through PubMed and Embase databases; where the following Medical Subject Heading (MeSH) terms were used and they had been specified as the primary focus of the articles; gene, antiphospholipid, obstetric, and pregnancy in the title or abstract. From 502 studies retrieved from the search, only original publications that had performed gene expression analyses of human placental tissue that reported on differentially expressed gene in pregnancies with Obstetric APS were included. Two reviewers independently scrutinized the titles and the abstracts before examining the eligibility of studies that met the inclusion criteria. For each study; diagnostic criteria for APS, method for analysis, and the gene signature were extracted independently by two reviewers. The genes listed were further analysed with the DAVID and the KEGG pathways.

    RESULTS: Three eligible gene expression studies involving obstetric APS, comprising the datasets on gene expression, were identified. All three studies showed a reduction in transcript expression on PRL, STAT5, TF, DAF, ABCA1, and HBEGF in Obstetric APS. The high enrichment score for functionality in DAVID had been positive regulation of cell proliferation. Meanwhile, pertaining to the KEGG pathway, two pathways were associated with some of the listed genes, which were ErBb signalling pathway and JAK-STAT signalling pathway.

    CONCLUSION: Ultimately, studies on a genetic level have the potential to provide new insights into the regulation and to widen the basis for identification of changes in the mechanism of Obstetric APS.
    Matched MeSH terms: Pregnancy; Pregnancy Complications/genetics*; Pregnancy Complications/immunology*
  5. Rahimi R, Omar E, Tuan Soh TS, Mohd Nawi SFA, Md Noor S
    Malays J Pathol, 2018 Aug;40(2):169-173.
    PMID: 30173235 MyJurnal
    INTRODUCTION: Leptospirosis is a zoonotic disease caused by spirochaete of the genus Leptospira. Human infection occurs after exposure to water or soil contaminated by urine from an infected animal. Most patients manifest as self-limited systemic illness. However 10% of patients manifest as severe disease associated with high fatality. The disease affects mostly men, cases involving pregnant women are uncommon. We presented a case of leptospirosis in a pregnant woman leading to mortality of both mother and foetus.

    CASE REPORT: A 28-year-old woman at 18 weeks of gestation, had shortness of breath and collapsed. She was brought unconscious to the emergency department and died shortly after arrival. A week prior to this, she had presented to the same hospital with pain on both thighs. Examination of the patient and ultrasound of the foetus revealed normal findings. Post mortem examination revealed hepatosplenomegaly and congested lungs; no jaundice, meningeal inflammation or cardiac abnormalities was evident. Histopathology examination of the lungs revealed pulmonary haemorrhages and oedema. Multiple infarcts were seen in the spleen and the kidneys showed foci of acute tubular necrosis. Laboratory investigations revealed Leptospira IgM antibody and PCR for leptospira were positive. This case illustrates the subtleness of clinical presentation of leptospirosis. The diagnosis was obscure even at post-mortem and was only suspected following histopathological examination, leading to further investigations.

    CONCLUSION: Leptospirosis may have a subtle presentation and a high index of suspicion for this infection is required for early identification of the disease.

    Matched MeSH terms: Pregnancy; Pregnancy Complications, Infectious/diagnosis*; Pregnancy Complications, Infectious/pathology*
  6. Sivalingam N, Thavarasah AS
    Family Practitioner, 1988;11:65-67.
    Matched MeSH terms: Pregnancy
  7. Wan Azman WA, Haizal HK
    JUMMEC, 2005;8:18-22.
    Peripartum cardiomyopathy (PPCM) is a life-threatening cardiomyopathy of an unknown cause that occurs in the peripartum period in previously healthy women and this article discusses the challenges that lie in diagnosing and managing this rare yet lethal disease. KEYWORDS: Peripartum, cardiomyopathy, pregnancy, cardiac failure
    Matched MeSH terms: Pregnancy
  8. Tharmaseelan NK
    Singapore Med J, 1990 Dec;31(6):627-8.
    PMID: 2177919
    A rare case of gestational trophoblastic disease (GTD) in a 54-year old Malay woman is described. A total abdominal hysterectomy with bilateral salphingo-oopherectomy was done. She was given methotrexate therapy as she had persistent high levels of serum B hCG.
    Matched MeSH terms: Pregnancy
  9. Hisham HJ, Chuah SY, Syarif HL, Nik Nasri I, Fairulnizam MN
    Med J Malaysia, 1998 Mar;53(1):76-81.
    PMID: 10968142
    A study was conducted to compare the blood lead levels of 97 pregnant women warded at the Kuala Lumpur Hospital, according to their ethnicity, residence and place of work. The lead content of venous blood samples was determined with a graphic furnace atomic absorption spectrometer. Blood lead levels of Klang Valley women seem to have decreased from 17.3 micrograms/dl in 1982 to 7.71 micrograms/dl in the present study most probably attributed to the phasing out of leaded gasoline. This level is below the 10 micrograms/dl recommended by the United States Environmental Protection Agency for the public, even though 27.8% of them still have blood lead levels that are equal to or in excess of 10 micrograms/dl. The study shows that certain segments of the population such as Indians (geometric mean = 9.35 micrograms/dl) and housewives (geometric mean = 9.55 micrograms/dl) may still experience blood lead levels that are slightly elevated than the rest of the population.
    Matched MeSH terms: Pregnancy/blood*
  10. Kumarasamy S, Arumugam K
    Med J Malaysia, 1991 Sep;46(3):252-4.
    PMID: 1839921
    A case of combined intra- and extra-uterine pregnancy is reported. Awareness of this condition, a high index of suspicion, the proper interpretation of physical signs and ultrasound findings together with early resort to laparoscopy resulted in a favourable outcome.
    Matched MeSH terms: Pregnancy*
  11. George E, Adeeb N, Ahmad J
    Med J Malaysia, 1980 Dec;35(2):129-30.
    PMID: 7266404
    Serum ferritin concentration has been measured in pregnant women at their first antenatal visit. Results were analysed according to trimesters. With progression of the pregnancy there is a fall in serum ferritin concentrations. Haemoglobin and red cell indices cannot be used to predict iron status supplemental iron therapy raised the serum ferritin levels.
    Matched MeSH terms: Pregnancy*
  12. Safiee AI, Ghazali WAHW
    Gynecol Minim Invasive Ther, 2021 01 30;10(1):47-49.
    PMID: 33747774 DOI: 10.4103/GMIT.GMIT_22_19
    Cornual pregnancy happens when implantation occurs in the cavity of a rudimentary horn of the uterus, which may or may not be communicating with the uterine cavity. The diagnosis of cornual pregnancy remains challenging, and rupture of a cornual pregnancy usually causes massive bleeding. Early diagnosis and treatment, therefore, are very crucial and key to prevent mortality. Historically, the management of cornual pregnancies included wedge resection through open surgery or even hysterectomy. In this case report, we would like to highlight a case of late second trimester cornual pregnancy, at 19-week and 3-day gestation, which was managed laparoscopically.
    Matched MeSH terms: Pregnancy; Pregnancy, Cornual
  13. Nik-Ahmad-Zuky NL, Seoparjoo A, Husna EIE
    J Med Case Rep, 2021 Sep 08;15(1):448.
    PMID: 34493340 DOI: 10.1186/s13256-021-03030-x
    BACKGROUND: Placenta accreta is known to be associated with significant maternal morbidity and mortality-primarily due to intractable bleeding during abortion or delivery at any level of gestation. The complications could be reduced if placenta accreta is suspected in a patient with a history of previous cesarean delivery and the gestational sac/placenta is located at the lower part of the uterus. Then, a proper management plan can be instituted, and complications can be reduced. The diagnosis of placenta accreta in the first trimester of pregnancy is considered uncommon.

    CASE PRESENTATION: A 34-year-old Malay, gravida 4, para 3, rhesus-negative woman was referred from a private hospital at 13 weeks owing to accreta suspicion for further management. She has a history of three previous lower-segment cesarean sections. She also had per vaginal bleeding in the early first trimester, which is considered to indicate threatened miscarriage. Transabdominal ultrasound revealed features consistent with placenta accreta spectrum. She was counseled for open laparotomy and hysterectomy because of potential major complication if she continued with the pregnancy. Histopathological examination revealed placenta increta.

    CONCLUSION: A high index of suspicion of placenta previa accreta must be in practice in a patient with a history of previous cesarean deliveries and low-lying placenta upon ultrasound examination during early gestation.

    Matched MeSH terms: Pregnancy; Pregnancy Trimester, First
  14. Chandrasekharan N
    Med J Malaya, 1968 Sep;23(1):47-50.
    PMID: 4237556
    Matched MeSH terms: Pregnancy*
  15. Chan LK, Lee KL, Tan SE
    Med J Malaya, 1967 Dec;22(2):94-8.
    PMID: 4231985
    Matched MeSH terms: Pregnancy*
  16. Ong HC
    Trop Geogr Med, 1974 Dec;26(4):384-8.
    PMID: 4456697
    Matched MeSH terms: Pregnancy*; Pregnancy Complications/epidemiology; Pregnancy Complications, Hematologic/epidemiology; Pregnancy Complications, Infectious/epidemiology
  17. Beck AJ, Lim BL
    Acta Trop, 1973;30(4):251-60.
    PMID: 4147874
    Matched MeSH terms: Pregnancy; Pregnancy, Animal
  18. Woon FC, Chin YS, Ismail IH, Batterham M, Abdul Latiff AH, Gan WY, et al.
    PLoS One, 2019;14(6):e0216439.
    PMID: 31233513 DOI: 10.1371/journal.pone.0216439
    BACKGROUND: Despite perennial sunshine, vitamin D deficiency is prevalent among Malaysians especially pregnant women. This study determines the vitamin D status and its associated factors among third trimester pregnant women attending government health clinics in Selangor and Kuala Lumpur, Malaysia.

    METHODS: Information on socio-demographic characteristics, obstetrical history, and sun exposure were obtained through face-to-face interviews. Vitamin D intake was assessed using a semi-quantitative food frequency questionnaire (FFQ). Serum 25-hydroxyvitamin D concentration was measured and classified as deficient (< 30 nmol/L), insufficient (30-50 nmol/L), and sufficient (≥ 50 nmol/L).

    RESULTS: Of the 535 pregnant women recruited, 42.6% were vitamin D deficient. They consumed an average of 8.7 ± 6.7 μg of vitamin D daily. A total of 80.4% of the vitamin D were obtained from the food sources, while 19.6% were from dietary supplements. Fish and fish products showed the highest contribution to vitamin D intake (35.8%). The multivariable generalized linear mixed models, with clinic as a random effect, indicates that higher intake of vitamin D is associated with lower odds of vitamin D deficiency among pregnant women (OR = 0.96; 95% CI = 0.93-0.99). The odds of having vitamin D deficiency was reduced by 87% in non-Malays (OR = 0.14; 95% CI = 0.05-0.41) compared to Malays. No associations were found between age, educational level, monthly household income, work status, gravidity, parity, pre-pregnancy body mass index, total hours of sun exposure, total percentage of body surface area, and sun exposure index per day with vitamin D deficiency.

    CONCLUSION: Vitamin D deficiency is prevalent among Malaysian pregnant women. Considering the possible adverse obstetric and fetal outcomes of vitamin D deficiency during pregnancy, future nutrition education should emphasise on vitamin D-fortified foods consumption among pregnant women by taking into consideration ethnic differences.
    Matched MeSH terms: Pregnancy*
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