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Factors influencing COVID-19 vaccine hesitancy and acceptance among the Pakistani population

Chaudhary FA, Ahmad B, Khalid MD, Fazal A, Javaid MM, Butt DQ

Hum Vaccin Immunother, 2021 Oct 03;17(10):3365-3370.
PMID: 34236952 DOI: 10.1080/21645515.2021.1944743

This study examined the factors associated with acceptance of the COVID-19 vaccine compared to hesitance in the Pakistani population and specifically focusing on the perceived beliefs, knowledge, concerns, risk, and safety perception relating to the COVID-19 vaccine. A total of 423 subjects were recruited from the Pakistan Institute of Medical Sciences, Islamabad, Pakistan. A 27-item valid and reliable questionnaire was used to assess socio-demographic characteristics, acceptance, and hesitance toward COVID-19 vaccine, perceived beliefs, knowledge, perceived concerns, risk, and safety of COVID-19 vaccines and its source of information. Chi-square tests and logistic regression were used for analysis. About 53% of the participants were planning to get vaccinated and a significantly greater proportion of better educated, higher income, and healthier participants in the vaccine acceptance group (p
Fulltext Determining the Association between Oral Health Status and Self-Perceived Oral Health Satisfaction among Residents in the Largest Care Home in East Coast Malaysia

Farah Mohd, Muhammad Zubir Yuso, Nor Iziana Ismail, Nor Mulyani Musa

IIUM Medical Journal Malaysia, 2019;18(102):3-0.
MyJurnal

Little is known about the association between actual and selfperceived oral health status among residents living in a care home. This study aimed to assess their oral health status and to determine its association with their selfperceived oral health satisfaction. Materials and method: A cross-sectional study was conducted from July to August 2018 among 75 residents of Rumah Ehsan, Terengganu (the largest care home in east coast Malaysia). The oral health status and oral hygiene of the participants were examined. Their sociodemographic profile and self-perceived oral health status were collected through structured interviews. Chi-square, Man-Whitney, and multiple logistic regression tests were used to test the factors associated with the self-perceived oral health satisfaction of the participants. Results: Unsurprisingly, the majority of the participants had poor oral health with high median DMF-T score of 29.0 (IQR=12) and majority (86.7%) had poor oral hygiene. It was intriguing to know that the majority of them (64%) perceived they have good oral health status with 68% satisfied with their current oral health status. There was no significant association between their actual oral health status and their perceived satisfaction. However, increasing age, Malay and those eating dependently were less likely to satisfy with their oral health status. Meanwhile, those who were dependent on the staff to brush their teeth were more likely satisfied with their oral health status. Conclusion: There was a wide discrepancy between the actual and self-perceived oral health status among residents in care homes. Hence, it is crucial to improving awareness and knowledge among them in order to improve their oral health. Factors contributed to their oral health satisfaction should be acknowledged by all dental practitioners.
Fulltext Is there any Need for Health Intervention on Pediculosis Capitis in Public Primary Schools in Kuantan, Pahang?

Muhammad Aqlan Mohd Zak, Nor Faiza Mohd Tohit, Razman Mohd Rus

IIUM Medical Journal Malaysia, 2019;18(102):46-0.
MyJurnal

Pediculosis capitis among primary school children is a global problem which poses significant consequences among school children and caregivers alike. Previous studies showed an association between pediculosis capitis and sociodemographic factors such as school location, age, gender, ethnicity, parental education, monthly household income, number of siblings and number of family members. Primary schools in Malaysia consist of National School and National-type school (Chinese) and (Tamil), all of which have different sociodemographic backgrounds. Thus, this study aims to investigate and compare the prevalence of pediculosis capitis among children of different types of primary school in Kuantan to properly plan for future intervention. Materials and method: An analytical crosssectional study using stratified random sampling was carried out. The schools were stratified according to their types. Number of respondents from each school was determined by proportionate-to-size. Respondents from standard one to six were given self-administered validated questionnaire. Then, their hair and scalp were examined for the evidence of pediculosis capitis. Data was analysed using descriptive statistics. Results: There were 1,365 respondents involved in this study; consisting of students from National Schools (n=791), Chinese Schools (n=424) and Tamil Schools (n=150). The overall median age was 8.0 years. Majority of them were males (53.41%), of Malays ethnicity (60.29%), with household income between RM1000-RM2999 (31.87%) and from urban school location (98.68%). The overall prevalence of pediculosis capitis was 9.6% (n=131). The prevalence of pediculosis capitis among the selected schools was found to be the highest in National-type school (Tamil) at 33.33% (n=50), followed by National School at 7.33% (n=58) and National-type school (Chinese) at 5.42% (n=23). Conclusion: Pediculosis capitis showed an endemicity in all types of primary schools. Hence, preventive measures are necessary to reduce the transmission of head lice among school children.
Fulltext Colon Cancer in Patients Younger Than Age 50 in Kuantan: Case Series

Nurul Syazwani Abd Khalid, Muhammad Afiq Kodiron, Mohd Yusof Sainal, Faisel Elagili, Azmi Md Nor

IIUM Medical Journal Malaysia, 2019;18(102):55-0.
MyJurnal

Colorectal cancer (CRC) is the second most common cancer in Malaysia. In general, patients aged > 65 years comprise the majority of the population with CRC. However, recent reports indicate its increasing incidence in younger populations. We describe 4 cases of early onset colorectal cancer in Kuantan. Materials and method: This is a descriptive study of a small series of patients. Data between 2018 and 2019 were obtained from medical charts. Results: We diagnosed four patients under the age of 50 with colon cancer (75% male), the median age was 36 (23-47), with no comorbidities. None of the patient had family history of colorectal cancer. The majority of our patients presented with complication of tumour (2 perforation, 1 obstruction) required emergency surgeries. Only one patient presented with with rectal bleeding and was found to have tumor of the rectosigmoid junction. Two patients had tumor at descending colon and one at the splenic flexure. From this case series, we found there were one patient for every stage of colorectal cancer. Carcinoembryonic (CEA) levels were elevated at baseline in only two patients. Conclusion: Incidence of colon cancer rises among young patients in Kuantan. Further studies are needed to clarify the clinical and biological characteristics of colon cancer, improve its treatment strategies, and promote better outcomes in young patients.
Profil mahasiswa institusi pengajian tinggi terhadap amalan kepenggunaan

Nurazlina Dol, Elistina Abu Bakar, Zuroni Md. Jusoh, Afida Mastura Muhammad Arif

Jurnal Pengguna Malaysia - Malaysian Journal of Consumer, 2020;34(1):1-22.
MyJurnal

Kerancakan IR 4.0 telah menjadikan teknologi internet sebagai saluran komunikasi dan carian maklumat utama kepada pengguna internet. Di sebalik pembangunan ini, pengguna dibelenggu dengan pelbagai masalah pasaran yang melibatkan produk dan perkhidmatan. Memandangkan golongan muda sering menjadi mangsa dalam pelbagai masalah pasaran, kajian terhadap mahasiswa Institusi Pengajian Tinggi (IPT) di Malaysia amatlah penting agar mereka dapat memahami dan melaksanakan tanggungjawab sebagai pengguna dengan baik melalui amalan kepenggunaan seharian. Tujuan kajian ini adalah untuk menentukan profil mahasiswa IPT berkaitan amalan kepenggunaan agar tanggungjawab mereka sebagai pengguna dapat diperbaiki. Pemboleh ubah yang dikaji adalah faktor demografi iaitu jantina, umur, etnik, tahap pendidikan, bidang pengajian, tempoh menjadi ahli kelab pengguna, dan status keahlian di dalam kelab pengguna serta faktor tingkah laku iaitu amalan kepenggunaan. Kajian ini melibatkan seramai 800 mahasiswa IPT daripada sepuluh buah IPT yang dipilih secara persampelan rawak berperingkat. Penganalisisan data menggunakan analisis Ujian Khi Kuasa Dua dengan menggunakan perisian Statistical Package Social Sciences (SPSS). Hasil pemprofilan mendapati ciri responden yang perlu diberi penekanan dalam pendidikan pengguna ialah mereka daripada etnik Melayu dan Cina, yang masih bujang, dan mempunyai tahap pendidikan diploma dan ijazah sarjana muda tanpa mengira jantina, umur, asal, IPT, semester pengajian, bidang pengajian, dan keahlian dalam kelab pengguna. Kajian ini memberi implikasi kepada Kementerian Perdagangan Dalam Negeri, dan Hal Ehwal Pengguna (KPDNHEP), persatuan pengguna, dan pihak institusi dalam meningkatkan program pendidikan pengguna melalui seminar kepenggunaan, penerbitan, edaran bahan berkaitan kepenggunaan, pertandingan serta penyampaian melalui media massa dan media sosial berpandukan ciri-ciri mahasiswa yang perlu diberi penekanan agar tahap amalan kepenggunaan mahasiswa IPT di Malaysia semakin kukuh pada masa akan datang.
Fulltext Hypermethylation analysis of p16 and p15 promoters in chronic lymphocytic leukaemia patients and normal individuals.

Amira M, Sarina S, Azlan H, Muhammad Farid J, Chang KM

IIUM Medical Journal Malaysia, 2019;18(1):35-43.
MyJurnal

Chronic Lymphocytic Leukaemia (CLL) is a common type of leukaemia in persons of predominantly European descent but is rare in the Asian population. Disparities in CLL incidence among people of Asian and European descent may be related to the genetic make-up of the two different populations. Hypermethylation event might be one of the silencing mechanisms that inactivate the tumour suppressor genes in CLL. The aim of this study was to determine the hypermethylation status of p16INK4aand p15INK4bamong CLL patients and normal individuals. Materials & Methods: A total of 25 CLL patients and 25 normal individuals were recruited for this study and their genomic DNA were extracted from the peripheral blood. The hypermethylation status of p16INK4aand p15INK4bweredetermined using Methylation Specific-PCR (MS-PCR) whereas DNA sequencing method was applied to selected samples for validation of the MS-PCR results. We also evaluated the association between hypermethylation of these genes with the clinical and demographic characteristics of each group of subjects. Results: Among the CLL patients, p15INK4bpartial-methylation occurred in 6 (24%) subjects while methylation occurred in 1 (4%) subject. All the remaining patients were unmethylated at p15INK4b. All the samples showed unmethylation at p16INK4a. Statistically significant associations were found between p15INK4bhypermethylation with the presence of CLL (p=0.01) and with race (p=0.02). Conclusion: Further study using a larger sample size is warranted to explore the significance of DNA methylation incidenceamong the CLL patients of the Malaysian population. Hence, we suggest that hypermethylation at p15INK4bhas a huge influence that kick-starts CLL disease among Malaysians and MS-PCR technique is applicable to be used in methylation study.
Correction to: Does globalization affect the green economy and environment? The relationship between energy consumption, carbon dioxide emissions, and economic growth

Anser MK, Usman M, Godil DI, Shabbir MS, Sharif A, Tabash MI, et al.

Environ Sci Pollut Res Int, 2021 Oct;28(37):51119.
PMID: 34213726 DOI: 10.1007/s11356-021-15192-8
Fulltext Bicarbonate Therapy in Renally Compromised Critically Ill Patients with Metabolic Acidosis: Study of Clinical Outcomes and Mortality Rate

Rafique Z, Tariq MH, Khan AU, Farrukh MJ, Khan N, Burki AM, et al.

Int J Gen Med, 2021;14:2817-2826.
PMID: 34194241 DOI: 10.2147/IJGM.S296095

Background: Metabolic acidosis is the most frequent medical condition occurring in critically ill renally compromised patients. This study was aimed to determine clinical outcomes of bicarbonate therapy in renally compromised critically ill patients having metabolic acidosis.
Methods: A prospective longitudinal cohort study was undertaken in three military hospitals in Rawalpindi, Pakistan. All patients fulfilling the inclusion criteria who were admitted to the ICU of any of the three study hospitals from July 2019 to March 2020 were studied for clinical outcomes of bicarbonate therapy using an evidence-based clinical checklist. Outcome measures include changes in blood pH, serum potassium, and sodium levels, blood pressure and weight, along with other clinically significant laboratory parameters.
Results: Eighty-one patients fulfilling the inclusion criteria were evaluated. The mean age of the patients was 55.61±19.5 years, while the mean weight was 63.43±14.19 Kg. A mortality rate of 45.7% was observed. Disease-related complications including hypoxia, cardiac failure, multiple organ failure, elevated blood pressure, and ischemic heart disease (IHD) were found to be associated with a higher mortality rate (P<0.005). Whereas using Fisher's exact test, concomitant administration of sodium chloride, along with bicarbonate therapy was associated with a low mortality rate and had no significant impact on sodium loading or weight gain. Moreover, various drug-drug interactions were found to be associated with a higher mortality rate (P<0.05).
Conclusion: Bicarbonate therapy was not found to affect the mortality rate in critically ill renally compromised patients with metabolic acidosis.
Fulltext Improved Ablative Properties of Nanodiamond-Reinforced Carbon Fiber-Epoxy Matrix Composites

Farooq U, Ali MU, Hussain SJ, Ahmad MS, Zafar A, Ghafoor U, et al.

Polymers (Basel), 2021 Jun 22;13(13).
PMID: 34206302 DOI: 10.3390/polym13132035

The influence of nanodiamonds (NDs) on the thermal and ablative performance of carbon-fiber-reinforced-epoxy matrix compositeswas explored. The ablative response of the composites with 0.2 wt% and 0.4 wt% NDs was studied through pre-and post-burning morphologies of the composite surfaces by evaluation of temperature profiles, weight loss, and erosion rate. Composites containing 0.2 wt% NDs displayed a 10.5% rise in erosion resistance, whereas composites containing 0.4 wt% NDs exhibited a 12.6% enhancement in erosion resistance compared to neat carbon fiber-epoxy composites. A similar trend was witnessed in the thermal conductivity of composites. Incorporation of composites with 0.2 wt% and 0.4 wt% NDs brought about an increase of 37 wt% and 52 wt%, respectively. The current study is valuable for the employment of NDs in carbon fiber composite applications where improved erosion resistance is necessary.
Fulltext Parental experience and use of probiotics among children aged twelve months and above

Muhammad Kashif Munir, Sana Rehman, Samina Khaliq, Hajra Azhar, Iqra Riaz, Atif Amin Baig

Asian Journal of Medicine and Biomedicine, 2019;3(1):9-14.
MyJurnal

Probiotics are the food products containing live microorganisms which when up-taken in sufficient quantities, converse health benefits to consumers. This study was aimed to find parental awareness, level of utilization, assessment of their experiences and sentiments about probiotics among their children.This descriptive study was undertaken in King Edward Medical University Lahore during July 2017 to January 2018. A total of 127 questionnaires were successfully completed comprising 45 (35.5%) from health care staff, 52 (40.9%) from parents visiting pediatric outpatients and 30 (23.6%) from school teachers. Maternal parent remained predominant in this study as there were 109 (85.8%) female and 18(14.2%) male respondents. Only 20(15.7%) were familiar with the term probiotics, 49 (38.6%) were somewhat familiar while 58 (45.6%) had no idea about term. On pursuing about preferences regarding probiotics use majority 106/127 (83.5%) of parents like to available in liquid as it is easy to consume for children. Use of probiotics among children is not very much common however it is been prescribed for number of gastrointestinal problems. Only a limited class of people is familiar with health benefits probiotics. Around 20% users do not know about the organism present in specific probiotic is also of astonishing. Due to different social set up health care providers and family physicians must discuss about the dietary supplements in terms of potential risks and benefits
A step toward reducing air pollution in top Asian economies: The role of green energy, eco-innovation, and environmental taxes

Chien F, Sadiq M, Nawaz MA, Hussain MS, Tran TD, Le Thanh T

J Environ Manage, 2021 Nov 01;297:113420.
PMID: 34333309 DOI: 10.1016/j.jenvman.2021.113420

Environmental degradation is significantly studied both in the past and the current literature; however, steps towards reducing the environmental pollution in carbon emission and haze pollution like PM2.5 are not under rational attention. This study tries to cover this gap while considering the carbon emission and PM2.5 through observing the role of renewable energy, non-renewable energy, environmental taxes, and ecological innovation for the top Asian economies from 1990 to 2017. For analysis purposes, this research considers cross-sectional dependence analysis, unit root test with and without structural break (Pesaran, 2007), slope heterogeneity analysis, Westerlund and Edgerton (2008) panel cointegration analysis, Banerjee and Carrion-i-Silvestre (2017) cointegration analysis, long-short run CS-ARDL results, as well as AMG and CCEMG for robustness check. The empirical evidence in both the short- and long-run has confirmed the negative and significant effect of renewable energy sources, ecological innovation, and environmental taxes on carbon emissions and PM2.5. Whereas, non-renewable energy sources are causing environmental degradation in the targeted economies. Finally, various policy implications related to carbon emission and haze pollution like PM2.5 are also provided to control their harmful effect on the natural environment.
Feasibility and Acceptability of Instructions of Daily Care in Overweight and Obese Knee Osteoarthritis Participants

Rafiq MT, Hamid MSA, Hafiz E, Chaudhary FA, Khan MI

Curr Rheumatol Rev, 2021;17(4):421-427.
PMID: 34315379 DOI: 10.2174/1573397117666210727095552

INTRODUCTION: Knee Osteoarthritis (OA) is a weight-bearing joint disease and is more common in overweight and obese persons. The objective of the study was to assess the feasibility and acceptability of Instructions of Daily Care (IDC) on pain, mobility, and Body Mass Index (BMI) among knee OA participants who are overweight or obese.
MATERIALS AND METHODS: The study was an open-label randomized controlled trial of six weeks. Forty overweight and obese participants with knee OA were randomly divided into two groups by a computer-generated number. The participants in the Instruction Group (IG) were provided with leaflets explaining IDC for the duration of six weeks. Both groups were instructed to take low doses of the non-steroid anti-inflammatory drug (NSAIDs) on alternate days. The outcome measures were pain, mobility and BMI. The feasibility and acceptability of knee pain and mobility were assessed using a questionnaire designed by experts in rehabilitation.
RESULTS: Participants in the IG reported more statistically significant pain relief as assessed by the Western Ontario and McMaster Universities Osteoarthritis Index score (p=0.001) and improvement in mobility (p=0.000) assessed by the Timed Up and Go test score after six weeks compared to the Control Group (CG). Both groups did not demonstrate any significant change in BMI (p-value > 0.05). The results of descriptive statistics showed a significantly higher satisfaction score for participants who received a combination of IDC and NSAIDs, indicating an acceptable intervention.
CONCLUSION: The IDC is effective and acceptable in terms of improving pain and mobility and should be recommended as the usual care of treatment.
Fulltext Clitorienolactones and Isoflavonoids of Clitorea ternatea Roots Alleviate Stress-Like Symptoms in a Reserpine-Induced Zebrafish Model

Ngadni MA, Akhtar MT, Ismail IS, Norazhar AI, Lee SY, Maulidiani M, et al.

Molecules, 2021 Jul 07;26(14).
PMID: 34299411 DOI: 10.3390/molecules26144137

Clitorea ternatea has been used in Ayurvedic medicine as a brain stimulant to treat mental illnesses and mental functional disorders. In this study, the metabolite profiles of crude C. ternatea root extract (CTRE), ethyl acetate (EA), and 50% aqueous methanol (50% MeOH) fractions were investigated using ultrahigh-performance liquid chromatography-diode array detector-tandem mass spectrometry (UHPLC-DAD-MS/MS), while their effect on the stress-like behavior of zebrafish, pharmacologically induced with reserpine, was investigated. A total of 32 compounds were putatively identified, among which, a series of norneolignans, clitorienolactones, and various flavonoids (flavone, flavonol, isoflavone, and isoflavanone) was found to comprise the major constituents, particularly in the EA and 50% MeOH fractions. The clitorienolactones, presently unique to the species, were present in both the free and glycosylated forms in the roots. Both the EA and 50% MeOH fractions displayed moderate effects on the stress-induced zebrafish model, significantly decreasing freezing duration and elevating the total distance travelled and average velocity, 72 h post-treatment. The results of the present study provide further evidence that the basis for the use of C. ternatea roots in traditional medicine to alleviate brain-related conditions, such as stress and depression, is attributable to the presence of clitorienolactones and the isoflavonoidal constituents.
Fulltext Evaluation of high resolution melting technique for detection of jak2-v617f mutation in formalin-fixed paraffin-embedded specimen from myeloproliferative neoplasm cases.

Mohammad Reza Abdullahi, Nor Zamzila Abdullah, Naznin Muhammad, Norlela-wati A. Talib

IIUM Medical Journal Malaysia, 2019;18(2):95-101.
MyJurnal

Myeloproliferative neoplasm (MPN) is a group of myeloid disorders which leads to erythrocytosis, thrombocytosis and leucocytosis. MPN with BCR-ABL positive is chronic myeloid leukaemia (CML) while BCR-ABL negative MPN includes polycythaemia Vera (PV), essential thrombocytemia (ET) and primary myelofibrosis (PMF). One of the major criteria for diagnosis of BCR-ABL negative MPN is the presence of JAK2-V617F mutation which is positive in 95% of PV and around 60% of ET and MF. Beside peripheral blood specimen, formalin-fixed paraffin-embedded (FFPE) marrow specimen can be used for detection of this mutation. Unfortunately, FFPE produces low quality DNA that put a challenge for successful amplification of DNA. We aimed to evaluate the utility of High Resolution Melting (HRM) analysis for detection of JAK2-V617F mutation in FFPE specimen from MPN cases. Materials andMethods:This study is a descriptive cross-sectional study. Forty FFPE marrow specimens were retrieved from the years 2014-2016. Bio-Rad Precision Melt Analysis software was used for analysis of HRM data. Allele-specific PCR was done for validation of results. Positive samples were subjected to Sanger sequencing. Results:JAK2-V617F mutation was positive in 13 out of 40 MPN cases. Level of agreement between HRM and AS-PCR was 97.5%. Conclusion:HRM is a rapid and powerful diagnostic assay which is suitable for detection of JAK2-V617F mutation in FFPE marrow specimen.
Fulltext In-vitro study: camp overshoot caused by chronic morphine alleviated by the synergistic combination of zamzam water and methadone in human primary glioblastoma cell line (u-87 mg).

Shariff Halim, Ridzuan PM, Nasir Mohamad, Nur Husna Zakaria, Nur Atikah Muhammad

IIUM Medical Journal Malaysia, 2019;18(2):47-52.
MyJurnal

Zamzam water is blessed water originated from Mecca and is believed by Muslims to have the ability to cure illness. This ability to cure illness is due to the fact that zamzam water has higher concentration of minerals especially sodium, calcium and magnesium which play a vital role. Sodium is reported to be involved in the regulation of the Mu-Opioid Receptor, which indirectly leads to the production of cAMP. Hence, this current study was carried out to investigate the synergistic effects of zamzam water and methadone combination on cAMP levels in human primary glioblastoma cell line (U-87 MG) after chronic morphine administration. Materials and Methods:The time course and concentration of morphine on U-87 MG cell line was determined. The U-87 MG cell line was incubated with morphine (25 μL/mL) for 24h, to make the cell dependent on morphine and later treated with different combinations of 3.2 mL of zamzam water and methadone (5, 10, 25 μL/mL). The levels of cAMP was determined using the enzyme-linked immunosorbent assay kit. Results:The result revealed that 3.2 mL of zamzam water incubated with 10 μl/mL of methadone significantly prevented the overshoot production of cAMP level (p
Fulltext Changes in hamstring eccentric peak torques and angles of peak torque following 90 minutes of soccer specific exertions

Muhammad Hamdan, Ang, Geik Yong, Raihana Sharir, Kian, Yeo Wee, Raja Mohammed Firhad Raja Azidin

Movement Health & Exercise, 2020;9(2):85-100.
MyJurnal

This study aimed to investigate the effects of a ball-oriented soccer match-play simulation on the hamstrings eccentric torque production. Seven male recreational athletes volunteered for this study. Participants completed 90- minutes of the ball-oriented soccer simulation interceded by a 15-minute half time interval with five successful trials of hamstrings eccentric contractions on an isokinetic dynamometer at selected time points throughout the simulation. A 2 (limb: dominant; non-dominant) × 4 (time: 0 min; 45 min; 60 min; 105 min) “split-plots” analysis of variance (SPANOVA) revealed significant reductions in hamstrings eccentric peak torques over time, while no significant change was apparent in hamstrings eccentric angles of peak torque. There was also no interaction effect of limb dominance over time for both peak torque and angles of peak torque parameters. The observed changes suggest that exertions from a ball-oriented soccer match-play simulation may have detrimental effects on the hamstrings eccentric strength parameters thus may increase risk of ACL injury. High variabilities in angles of peak torques were also observed in this study. Future exploration is warranted in order to address the extent of variabilities that may be present in larger sample sizes thus providing a better understanding of the influence of these variabilities on the muscular strength parameters of ACL injury risk. The findings suggest firstly, that fatigue from soccer-specific exertions during match-play may increase an athlete’s susceptibility to ACL injury, and secondly, that with accumulating fatigue, the nondominant limb may be equally at risk of injury as the dominant limb, contradicting previous findings from epidemiological studies.
Fulltext The Role of Soft Tissue Coverage in Limb Salvaging and Reconstructive Surgery of Foot and Ankle

Ren Yi KOW, Akmal Azim Ahmad Alwi, Muhammad Firdaus Abas, Chooi Leng Low

IIUM Medical Journal Malaysia, 2019;18(101):21-0.
MyJurnal

Since humans evolutionally adapt to a bipedal gait, the foot is important to allow humans to stand up, walk, run, and to jump. Without the soft tissues and bones at the foot and ankle, our lower limbs could not support the weight of the body. Crush injury of the foot and ankle is a consequence of high energy trauma leading to combined bone and soft tissue loss or destruction. The treatment of crush injury of the foot and ankle remains a challenge as it is associated with high morbidity. We report two cases of traumatic injury of footand ankle to highlight the paramount importance of soft tissue coverage in limb salvaging and reconstructive surgery of foot and ankle.
Moving towards sustainability: how do natural resources, financial development, and economic growth interact with the ecological footprint in Malaysia? A dynamic ARDL approach

Khan MK, Abbas F, Godil DI, Sharif A, Ahmed Z, Anser MK

Environ Sci Pollut Res Int, 2021 Oct;28(39):55579-55591.
PMID: 34138439 DOI: 10.1007/s11356-021-14686-9

Without enhancing the quality of the environment, the goals of sustainable development remain unachievable. In order to minimize the damage to the planet, sustainable practices need to be considered. This study is conducted to identify some of the drivers behind the increasing sustainability issues and tried to investigate the impact of natural resources, financial development, and economic growth on the ecological footprint in Malaysia from the year 1980-2019 by utilizing the dynamic simulated autoregressive distribution lag approach. It was identified that financial development, economic growth, and natural resources are the determinants behind the upsurge of the ecological footprint as all three show a positive and significant effect on ecological footprint. However, in the long run, the presence of the Environmental Kuznets Curve hypothesis was also validated in Malaysia. Therefore, it is recommended to increase awareness among the public regarding the adoption of sustainable practices in everyday life and to use green technologies that offer maximum efficiency and minimum damage to the environment in commercial and domestic activities. Finally, based on the research results, a comprehensive policy framework was proposed which could allow the Malaysian economy to attain the objectives of Sustainable Development Goals (SDGs) 7, 8, and 13.
Fulltext Assessment of Disulfide-linked Gold Nanoparticles as Colorimetric Sensor for Human Chorionic Gonadotropin Detection

Mohd Hafiz Abu Hassan, Syaza Azhari, Muhammad Anas Yuzairi Mohd Yusri

Malaysian Journal of Science, Health & Technology, 2017;5(1):1-5.
MyJurnal

Gold nanoparticles (AuNPs) are a highly versatile compound to be used in sensing components due to their unique physicochemical and optical properties. Due to its flexibility for surface conjugation, glutathione disulfide-linked gold nanoparticle (AuNP-GSSG) was produced in this study to assess its sensing performance as a colorimetric sensor for human chorionic gonadotropin (HCG). Spectroscopic characterization of AuNP-GSSG confirmed the conjugation of GSSG onto the surfaceofAuNPs.AuNP-GSSGalsoshowedhighsensoryperformancewithgoodlinearityandlowdetectionlimit.However,due to the high percentage of interference, usage of AuNP-GSSG as an HCG sensor requires further pre-treatment step to reduce the interference and increase the sensoraccuracy.
Fulltext Kemiskinan adalah satu fenomena multidimensi: suatu pemerhatian awal

Parthiban S.Gopal, Muhammad AlNaufal Abdul Rahman, Nor Malina Malek, Paramjit Singh Jamir Singh, Law, Chee Hong

Malaysian Journal of Social Sciences and Humanities, 2021;6(1):40-51.
MyJurnal

Kemiskinan merupakan satu fenomena yang dialami oleh seseorang individu tanpa kerelaan dan kehendak mereka. Kemiskinan boleh dikategorikan kepada dua jenis iaitu material dan bukan material. Miskin material terdiri daripada miskin pendapatan dan bukan pendapatan iaitu pendidikan, akses kepada kesihatan, pekerjaan dan kemudahan awam. Manakala miskin bukan material ialah berkait berkenaan ciri-ciri sahsiah seperti emosi, psikologi dan rohani. Kesemua keadaan yang berlaku ini menyebabkan seseorang yang miskin mengalami kesukaran untuk keluar dari situasi kemiskinan sekiranya tiada tindakan yang dilakukan oleh pihak bertanggungjawab. Pengukuran kemiskinan adalah langkah awal dalam mengenal pasti golongan miskin. Terdapat dua jenis iaitu pengukuran kemiskinan undimensi yang melihat kemiskinan dari sudut pendapatan sahaja dan pengukuran kemiskinan multidimensi yang melihat pada aspek holistik serta kemanusiaan. Terdapat banyak kelemahan pada pengukuran unidimensi kerana ia hanya mengukur kemiskinan dari perspektif pendapatan sahaja. Hal ini sudah tentulah tidak komprehensif dalam pengenalpastian golongan yang miskin. Oleh itu pengukuran kemiskinan multidimensi akan diterokai bagi memahami dengan lebih lanjut seperti perbezaannya dengan pengukuran unidimensi dan mengapakah Indeks Kemiskinan Multidimensi (IKM) adalah pengukur kemiskinan yang paling sesuai lagi berkesan. Kajian ini menggunakan data sekunder sebagai metodologi kajian. Hasil kajian ini dijangka bukan sahaja boleh mengetahui berapa ramai yang miskin dan peratusannya, malahan kita juga boleh mengetahui dimensi penyumbang utama kepada masalah kemiskinan. Melalui pengukuran ini, sesuatu program atau pemberian insentif dapat disalurkan dengan tepat kepada kumpulan sasaran.

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