Displaying publications 1 - 20 of 80 in total

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  1. Fulltext Merging worlds of nanomaterials and biological environment: factors governing protein corona formation on nanoparticles and its biological consequences
    Foroozandeh P, Aziz AA
    Nanoscale Res Lett, 2015;10:221.
    PMID: 25995715 DOI: 10.1186/s11671-015-0922-3
    Protein corona has became a prevalent subject in the field of nanomedicine owing to its diverse role in determining the efficiency, efficacy, and the ultimate biological fate of the nanomaterials used as a tool to treat and diagnose various diseases. For instance, protein corona formation on the surface of nanoparticles can modify its physicochemical properties and interfere with its intended functionalities in the biological microenvironments. As such, much emphasis should be placed in understanding these complex phenomena that occur at the bio-nano interface. The main aim of this review is to present different factors that are influencing protein-nanoparticle interaction such as physicochemical properties of nanoparticle (i.e., size and size distribution, shape, composition, surface chemistry, and coatings) and the effect of biological microenvironments. Apart from that, the effect of ignored factors at the bio-nano interface such as temperature, plasma concentration, plasma gradient effect, administration route, and cell observer were also addressed.
  2. Fulltext Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
    Foroozandeh P, Aziz AA
    Nanoscale Res Lett, 2018 Oct 25;13(1):339.
    PMID: 30361809 DOI: 10.1186/s11671-018-2728-6
    Nanoparticle science is rapidly changing the landscape of various scientific fields and defining new technological platforms. This is perhaps even more evident in the field of nanomedicine whereby nanoparticles have been used as a tool for the treatment and diagnosis of many diseases. However, despite the tremendous benefit conferred, common pitfalls of this technology is its potential short and long-term effects on the human body. To understand these issues, many scientific studies have been carried out. This review attempts to shed light on some of these studies and its outcomes. The topics that were examined in this review include the different possible uptake pathways of nanoparticles and intracellular trafficking routes. Additionally, the effect of physicochemical properties of nanoparticle such as size, shape, charge and surface chemistry in determining the mechanism of uptake and biological function of nanoparticles are also addressed.
  3. Fulltext A sonochemical approach to the direct surface functionalization of superparamagnetic iron oxide nanoparticles with (3-aminopropyl)triethoxysilane
    Sodipo BK, Aziz AA
    Beilstein J Nanotechnol, 2014;5:1472-6.
    PMID: 25247130 DOI: 10.3762/bjnano.5.160
    We report a sonochemical method of functionalizing superparamagnetic iron oxide nanoparticles (SPION) with (3-aminopropyl)triethoxysilane (APTES). Mechanical stirring, localized hot spots and other unique conditions generated by an acoustic cavitation (sonochemical) process were found to induce a rapid silanization reaction between SPION and APTES. FTIR, XPS and XRD measurements were used to demonstrate the grafting of APTES on SPION. Compared to what was reported in literature, the results showed that the silanization reaction time was greatly minimized. More importantly, the product displayed superparamagnetic behaviour at room temperature with a more than 20% higher saturation magnetization.
  4. Optimization of sonochemical method of functionalizing Amino-Silane on superparamagnetic iron oxide nanoparticles using Central Composite Design
    Sodipo BK, Aziz AA
    Ultrason Sonochem, 2020 Jun;64:104856.
    PMID: 31889660 DOI: 10.1016/j.ultsonch.2019.104856
    Optimization of sonochemical method of functionalizing a Silane coupling agent, Amino-Silane on Superparamagnetic Iron Oxide Nanoparticles (SPION) using Central Composite Design is reported. The Amino-Silane is grafted on the SPION in an iced bath environment using a Vibra-Cell 20 kHz ultrasonic irradiator with 13 mm diameter horn. Throughout the experiment amplitude of the ultrasonic device is maintained at 47%. The percentage atomic compositions of various APTES elements which bind to the SPION due to the ultrasonic irradiation were determined using X-ray photoelectron spectrometer (XPS). The influence of ultrasonic irradiation time and amount of APTES required for facile, rapid and effective functionalization of Organo-metallic compound on SPION are optimized. The optimized sonication time and amount of APTES are 8.49 min and 3.40 ml, respectively. The predicted results were validated with experimental data. Using the optimized values APTES were functionalized on the SPION experimentally and the results were compared. The experimental results validate the predicted data. Results show that very minimum sonication time is required for effective grafting of APTES on SPION.
  5. One minute synthesis of amino-silane functionalized superparamagnetic iron oxide nanoparticles by sonochemical method
    Sodipo BK, Aziz AA
    Ultrason Sonochem, 2018 Jan;40(Pt A):837-840.
    PMID: 28946493 DOI: 10.1016/j.ultsonch.2017.08.040
    Superparamagnetic iron oxide nanoparticles (SPION) are material of interest for biomedical research and related applications. Recently, several works have reported facile sonochemical method of functionalizing nanoparticles with organic coupling agents. Herein, we present the influence of ultrasonic irradiation on the rate of functionalization of 3-amino propyl triethoxyl silane (APTES) on SPION. The effect of sonication on the process is investigated by varying the sonication period between 1 and 20min. Grafting of the organo-metallic molecules on SPION is demonstrated through FTIR and XPS. The results show that in one minute, organo-silane compound can be functionalized onto SPION through unique conditions generated from ultrasonic irradiation. The XPS survey spectra of the as-synthesized APTES-SPION at different sonication periods revealed that absorbed energy due to silanization reactions in all the samples appeared at same peaks. The percentage atomic concentrations of all the elements present in the as-synthesized APTES-SPION are determined by the software CASAXPS. The result demonstrated that highest percentage atomic concentration is observed at the one minute sonication period.
  6. Fulltext Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions
    Misbah H, Aziz AA, Aminudin N
    BMC Complement Altern Med, 2013;13:118.
    PMID: 23718315 DOI: 10.1186/1472-6882-13-118
    Diabetes is a serious metabolic disorder affecting the metabolism of carbohydrate, protein and fat. A number of studies have shown that diabetes mellitus is associated with oxidative stress, leading to an increased production of reactive oxygen species. Ficus deltoidea is traditionally used in Malaysia for regulating blood sugar, blood pressure and cholesterol levels. The use of F. deltoidea as an alternative medicinal herb is increasingly gaining popularity with the sale of F. deltoidea tea bags and capsules in the local market. The present study was undertaken to investigate the antidiabetic and antioxidant activities of the fruits from different varieties of F. deltoidea, employing in vitro methods.
  7. Phytoremediation of soil contaminated with used lubricating oil using Jatropha curcas
    Agamuthu P, Abioye OP, Aziz AA
    J Hazard Mater, 2010 Jul 15;179(1-3):891-4.
    PMID: 20392562 DOI: 10.1016/j.jhazmat.2010.03.088
    Soil contamination by used lubricating oil from automobiles is a growing concern in many countries, especially in Asian and African continents. Phytoremediation of this polluted soil with non-edible plant like Jatropha curcas offers an environmental friendly and cost-effective method for remediating the polluted soil. In this study, phytoremediation of soil contaminated with 2.5 and 1% (w/w) waste lubricating oil using J. curcas and enhancement with organic wastes [Banana skin (BS), brewery spent grain (BSG) and spent mushroom compost (SMC)] was undertaken for a period of 180 days under room condition. 56.6% and 67.3% loss of waste lubricating oil was recorded in Jatropha remediated soil without organic amendment for 2.5% and 1% contamination, respectively. However addition of organic waste (BSG) to Jatropha remediation rapidly increases the removal of waste lubricating oil to 89.6% and 96.6% in soil contaminated with 2.5% and 1% oil, respectively. Jatropha root did not accumulate hydrocarbons from the soil, but the number of hydrocarbon utilizing bacteria was high in the rhizosphere of the Jatropha plant, thus suggesting that the mechanism of the oil degradation was via rhizodegradation. These studies have proven that J. curcas with organic amendment has a potential in reclaiming hydrocarbon-contaminated soil.
  8. Clinical evaluation of watermarked medical images
    Zain JM, Fauzi AM, Aziz AA
    Conf Proc IEEE Eng Med Biol Soc, 2007 10 20;2006:5459-62.
    PMID: 17946306
    Digital watermarking medical images provides security to the images. The purpose of this study was to see whether digitally watermarked images changed clinical diagnoses when assessed by radiologists. We embedded 256 bits watermark to various medical images in the region of non-interest (RONI) and 480K bits in both region of interest (ROI) and RONI. Our results showed that watermarking medical images did not alter clinical diagnoses. In addition, there was no difference in image quality when visually assessed by the medical radiologists. We therefore concluded that digital watermarking medical images were safe in terms of preserving image quality for clinical purposes.
  9. Endobronchial actinomycosis: is a repeat bronchoscopy after treatment necessary?
    How SH, Ramachandram K, Aziz AA
    Br J Hosp Med (Lond), 2006 Jan;67(1):42-3.
    PMID: 16447411 DOI: 10.12968/hmed.2006.67.1.20327
  10. Effect of Cell Age on Uptake and Toxicity of Nanoparticles: The Overlooked Factor at the Nanobio Interface
    Foroozandeh P, Aziz AA, Mahmoudi M
    ACS Appl Mater Interfaces, 2019 Oct 30;11(43):39672-39687.
    PMID: 31633323 DOI: 10.1021/acsami.9b15533
    Clinical translation of nanotechnologies has limited success, at least in part, due to the existence of several overlooked factors on the nature of the nanosystem (e.g., physicochemical properties of nanoparticles), nanobio interfaces (e.g., protein corona composition), and the cellular characteristics (e.g., cell type). In the past decade, several ignored factors including personalized and disease-specific protein corona (a layer of formed biomolecules at the surface of nanoparticles upon their entrance into a biological fluid), incubating temperature, local temperature gradient, cell shape, and cell sex has been introduced. Here, it was hypothesized and validated cell age as another overlooked factor in the field of nanomedicine. To test our hypothesis, cellular toxicity and uptake profiles of our model nanoparticles (i.e., PEGylated quantum dots, QDs) were probed in young and senescent cells (i.e., IMR90 fibroblast cells from human fetal lung and CCD841CoN epithelial cells from human fetal colon) and the outcomes revealed substantial dependency of cell-nanoparticles interactions to the cell age. For example, it was observed that the PEGylated QDs were acutely toxic to senescent IMR90 and CCD841CoN cells, leading to lysosomal membrane permeabilization which caused cell necrosis; in contrast, the young cells were resilient to the exact same amount of QDs and the same incubation time. It was also found that the formation of protein corona could delay the QDs' toxicity on senescent cells. These findings suggest that the cellular aging process have a capacity to cause deteriorative effects on their organelles and normal functions. The outcomes of this study suggest the proof-of-concept that cell age may have critical role in biosystem responses to nanoparticle technologies. Therefore, the effect of cell age should be carefully considered on the nanobio interactions and the information about cellular age (e.g., passage number and age of the cell donor) should be included in the nanomedicine papers to facilitate clinical translation of nanotechnologies and to help scientists to better design and produce safe and efficient diagnostic/therapeutic age-specific nanoparticles.
  11. Nucleation and growth of zinc oxide nanorods directly on metal wire by sonochemical method
    Rayathulhan R, Sodipo BK, Aziz AA
    Ultrason Sonochem, 2017 Mar;35(Pt A):270-275.
    PMID: 27756524 DOI: 10.1016/j.ultsonch.2016.10.002
    ZnO nanorods were directly grown on four different wires (silver, nickel, copper, and tungsten) using sonochemical method. Zinc nitrate hexahydrate and hexamethylenetetramine (HMT) were used as precursors. Influence of growth parameters such as precursors' concentration and ultrasonic power on the grown nanorods were determined. The results demonstrated that the precursor concentration affected the growth structure and density of the nanorods. The morphology, distribution, and orientation of nanorods changed as the ultrasonic power changed. Nucleation of ZnO nanorods on the wire occurred at lower ultrasonic power and when the power increased, the formation and growth of ZnO nanorods on the wires were initiated. The best morphology, size, distribution, and orientation of the nanorods were observed on the Ag wire. The presence of single crystal nanorod with hexagonal shaped was obtained. This shape indicates that the ZnO nanorods corresponded to the hexagonal wurtzite structure with growth preferential towards the (002) direction.
  12. Understanding consumer participation in managing ICT waste: Findings from two-staged Structural Equation Modeling-Artificial Neural Network approach
    Najmi A, Kanapathy K, Aziz AA
    Environ Sci Pollut Res Int, 2021 Mar;28(12):14782-14796.
    PMID: 33219501 DOI: 10.1007/s11356-020-11675-2
    For environmental management, the role of consumers is extremely important in the settings of reverse logistics. Though it is a manufacturer's extended responsibility to handle the waste however by becoming the supplier of the end of life products, consumers' participation needed to be encouraged and hence require proper attention. For the said purpose, the present study is conducted whereby crucial determinants of consumer reversing behavior were identified and analyzed by the help of a unique two-staged methodology of partial least square-structural equation modeling and artificial neural network. The data comprised of 746 collected by the survey from ICT users whereby the findings reported to have significant relationships of return intention and reversing behavior with their determinants. Moreover, the aforementioned unique methodology helps in generating more robust results as findings from ANN reported to have moral norm as most important variable which according to PLS-SEM was second most significant construct, whereas attitude was found to be second most important as per ANN which according to PLS-SEM is the most significant construct. Nevertheless, the study offers insights which contributes in the literature of environmental management, reverse logistics, and consumer behavior. Lastly, based on the findings, the managerial implications and recommendations are accordingly discussed.
  13. Fulltext Recent Advances in Inorganic Nanomaterials Synthesis Using Sonochemistry: A Comprehensive Review on Iron Oxide, Gold and Iron Oxide Coated Gold Nanoparticles
    Ali Dheyab M, Aziz AA, Jameel MS
    Molecules, 2021 Apr 22;26(9).
    PMID: 33922347 DOI: 10.3390/molecules26092453
    Sonochemistry uses ultrasound to improve or modify chemical reactions. Sonochemistry occurs when the ultrasound causes chemical effects on the reaction system, such as the formation of free radicals, that intensify the reaction. Many studies have investigated the synthesis of nanomaterials by the sonochemical method, but there is still very limited information on the detailed characterization of these physicochemical and morphological nanoparticles. In this comprehensive review, recent advances in the sonochemical synthesis of nanomaterials based on iron oxide nanoparticles (Fe3O4NP), gold nanoparticles (AuNP) and iron oxide-coated gold nanoparticles (Fe3O4@Au NP) are discussed. These materials are the most studied materials for various applications, such as medical and commercial uses. This review will: (1) address the simple processing and observations on the principles of sonochemistry as a starting point for understanding the fundamental mechanisms, (2) summarize and review the most relevant publications and (3) describe the typical shape of the products provided in sonochemistry. All in all, this review's main outcome will provide a comprehensive overview of the available literature knowledge that promotes and encourages future sonochemical work.
  14. Fulltext Healthy Aging and its Determinants Among Community-dwelling Older Persons in East Coast, Malaysia: A Multidimensional Assessment
    Ghazali S, Aziz AA, Amin RM
    Oman Med J, 2023 Nov;38(6):e573.
    PMID: 38293270 DOI: 10.5001/omj.2023.124
    OBJECTIVES: Exploring the possibility of healthy aging among older persons is crucial for achieving optimal health in the growing older population. This study aimed to determine the prevalence, pattern, and determinants of healthy aging among older persons in Terengganu, Malaysia.

    METHODS: We conducted a community-based cross-sectional study involving older persons aged % 60 years. An interviewer-guided questionnaire, anthropometric measurements, and physical assessments were administered to operationalize healthy aging based on a multidimensional concept.

    RESULTS: Among the 765 older persons surveyed, only 14.1% (95% CI: 11.64?"16.59) were classified as healthy agers. Multiple logistic regression analysis revealed that superior intrinsic religiosity (odds ratio (OR) = 3.42; 95% CI: 1.34?"8.73), higher social interaction (OR = 2.82; 95% CI: 1.32?"6.04), larger calf circumference (OR = 2.05; 95% CI: 1.24?"3.38), taking water intake % 5 cups per day (OR = 2.01; 95% CI: 1.23?"3.30), better gait speed (OR = 1.71; 95% CI: 1.04?"2.80), having savings (OR = 1.71; 95% CI: 1.10?"2.66), and normal waist circumference (OR = 1.63; 95% CI: 1.04?"2.55) were found positively associated with healthy aging.

    CONCLUSIONS: Only one in 10 older persons in the state met all the criteria for healthy aging. Specific aspects of religious status, social interaction, socioeconomic, behavioral, physical, and nutritional factors were found to predict healthy ageing in this population. These important determinants should be considered in developing a well-defined and comprehensive public health policy to promote healthy aging in the nation.

  15. Fulltext Gene expression profiles in human HepG2 cells treated with extracts of the Tamarindus indica fruit pulp
    Razali N, Aziz AA, Junit SM
    Genes Nutr, 2010 Dec;5(4):331-41.
    PMID: 21189869 DOI: 10.1007/s12263-010-0187-5
    Tamarindus indicaL. (T. indica) or locally known as asam jawa belongs to the family of Leguminosae. The fruit pulp had been reported to have antioxidant activities and possess hypolipidaemic effects. In this study, we attempted to investigate the gene expression patterns in human hepatoma HepG2 cell line in response to treatment with low concentration of the fruit pulp extracts. Microarray analysis using Affymetrix Human Genome 1.0 S.T arrays was used in the study. Microarray data were validated using semi-quantitative RT-PCR and real-time RT-PCR. Amongst the significantly up-regulated genes were those that code for the metallothioneins (MT1M, MT1F, MT1X) and glutathione S-transferases (GSTA1, GSTA2, GST02) that are involved in stress response. APOA4, APOA5, ABCG5 and MTTP genes were also significantly regulated that could be linked to hypolipidaemic activities of the T. indica fruit pulp.
  16. Fulltext Retrocaval ureter: the importance of intravenous urography
    Hassan R, Aziz AA, Mohamed SK
    Malays J Med Sci, 2011 Oct;18(4):84-7.
    PMID: 22589677
    Retrocaval ureter is a rare cause of hydronephrosis. Its rarity and non-specific presentation pose a challenge to surgeons and radiologists in making the correct diagnosis. Differentiation from other causes of urinary tract obstruction, especially the more common urolithiasis, is important for successful surgical management. Current practice has seen multislice computed tomography (MSCT) rapidly replaces intravenous urography (IVU) in the assessment of patients with hydronephrosis due to suspected urolithiasis, especially ureterolithiasis. However, MSCT, without adequate opacification of the entire ureter, may allow the physician to overlook a retrocaval ureter as the cause of hydronephrosis. High-resolution IVU images can demonstrate the typical appearance that leads to the accurate diagnosis of a retrocaval ureter. We reported a case that illustrates this scenario and highlights the importance of IVU in the assessment of a complex congenital disorder involving the urinary tract.
  17. Fulltext Validation of the Malay version of the Inventory of Functional Status after Childbirth questionnaire
    Noor NM, Aziz AA, Mostapa MR, Awang Z
    Biomed Res Int, 2015;2015:972728.
    PMID: 25667932 DOI: 10.1155/2015/972728
    This study was designed to examine the psychometric properties of Malay version of the Inventory of Functional Status after Childbirth (IFSAC).
  18. Validity and Reliability Analysis of the 'SayangKU' (MyLove) in Intervention for Addressing Adolescents Involved in Free Sex
    Ghani FA, Latif AA, Aziz AA, Khan A
    J Relig Health, 2015 Aug;54(4):1375-86.
    PMID: 25189148 DOI: 10.1007/s10943-014-9935-y
    A module entitled 'SayangKU' (MyLove), based on the Islamic perspective, was developed as an instrument to assist adolescents that involved in premarital sexual activity. The module comprises four phases: Love of God (Allah), Love of the Prophet, Love of Oneself, and Love of the Ummah (world). From analysis of Rasch, the value of item reliability was .80 and an individual reliability was .95. Dimensionality value was more than 40 % variance explained by measures, and level of agreement among experts was 86.88 %. The posttest shows the better result from pretest and proves the effectiveness of the module.
  19. Fulltext Knowledge, attitude and practice of oral health promoting factors among caretakers of children attending day-care centers in Kubang Kerian, Malaysia: a preliminary study
    Mani SA, Aziz AA, John J, Ismail NM
    J Indian Soc Pedod Prev Dent, 2010 Apr-Jun;28(2):78-83.
    PMID: 20660972 DOI: 10.4103/0970-4388.66741
    The role of caretakers at day-care centers has become more imperative in promoting oral health care in children since many new mothers opt to work outside their homes, leaving their children at day-care centers. The aim of this study is to assess the knowledge, attitude and practice of oral health promoting factors among secondary caretakers of children attending day-care centers.
  20. Fulltext Estimating glomerular filtration rate in adult kidney transplant recipients in the Asian population
    Kamaruzaman L, Mohd R, Zaki FM, Hod R, Aziz AA
    Saudi J Kidney Dis Transpl, 2019 6 30;30(3):587-596.
    PMID: 31249222 DOI: 10.4103/1319-2442.261331
    Estimation of glomerular filtration rate (GFR) in renal transplant patients is often assessed by application of creatinine-based equations. The aim was to correlate the estimated GFR (eGFR) using creatinine-based equations [Cockroft-Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Nankivell] with gold standard 51Cr-EDTA in kidney transplant patients in the Asian population. This is a single-center, cross-sectional study involving adult renal transplant patients. Background demographic data, medications, office blood pressure, and baseline investigations were taken. Correlations between measured GFR and eGFR were analyzed and Pearson's correlation coefficients, bias, and accuracy were assessed. Thirty-seven renal transplant patients with a mean age of 46 ± 13 years were recruited. Majority were Chinese (68%), Malay (24%), and Indian (8%). The median duration of the transplant was 84 (interquartile range 60,132) months. The mean measured GFR was 71 ± 21 mL/min/1.73 m2. Cockroft-Gault and CKD-EPI has the best correlation with 51Cr-EDTA with Pearson correlation coefficients of 0.733 (P <0.001) and 0.711 (P < 0.001), respectively. All formulae showed >80% accuracy with eGFR lies between 30% of the measured value. CKD-EPI and MDRD had the greatest accuracy with 89.2% each. Clinician may use any of these three serum creatinine-based equations to estimate GFR in kidney transplant recipients.
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