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  1. Al-Haddad A, Che Ab Aziz ZA
    Int J Biomater, 2016;2016:9753210.
    PMID: 27242904 DOI: 10.1155/2016/9753210
    Bioceramic-based root canal sealers are considered to be an advantageous technology in endodontics. The aim of this review was to consider laboratory experiments and clinical studies of these sealers. An extensive search of the endodontic literature was made to identify publications related to bioceramic-based root canal sealers. The outcome of laboratory and clinical studies on the biological and physical properties of bioceramic-based sealers along with comparative studies with other sealers was assessed. Several studies were evaluated covering different properties of bioceramic-based sealers including physical properties, biocompatibility, sealing ability, adhesion, solubility, and antibacterial efficacy. Bioceramic-based sealers were found to be biocompatible and comparable to other commercial sealers. The clinical outcomes associated with the use of bioceramic-based root canal sealers are not established in the literature.
  2. Alarami N, Sulaiman E, Al-Haddad A
    Am J Dent, 2017 Aug;30(4):197-200.
    PMID: 29178701
    PURPOSE: To evaluate fracture resistance and failure mode of endodontically-treated mandibular molars restored with different intra-radicular techniques.

    METHODS: 75 human mandibular molars were randomly divided into five equal groups. Teeth were standardized, endodontically-treated and restored according the assigned group as follows: amalgam core only, prefabricated titanium post in the distal canal and amalgam core, composite core only; fiber post in the distal canal and composite core. One group of untreated sound teeth was used as a control. Non-precious metal crowns were fabricated and cemented on the prepared specimens with Rely X U200 resin cement. All specimens were subjected to a compressive load at crosshead speed 0.5 mm/minute, 25° to the long axis of the tooth. Failure loads and modes were recorded.

    RESULTS: Mean failure loads among the groups were significantly different (P= 0.035). Post-hoc multiple pair-wise comparisons revealed the amalgam core and composite core groups produced significantly lower fracture resistance than the control group (P= 0.041 and P= 0.025, respectively) and no significant differences among the different intra-radicular techniques (P> 0.05). The composite core with fiber post and amalgam core with titanium posts showed the highest percentage of favorable failures (67%) and non-favorable failures (87%) respectively.

    CLINICAL SIGNIFICANCE: The composite core with fiber post is the most appropriate intraradicular restoration in cases of severely compromised molars.

  3. Chew ST, Eshak Z, Al-Haddad A
    Microsc Res Tech, 2023 Jul;86(7):754-761.
    PMID: 37078493 DOI: 10.1002/jemt.24323
    To assess the interfacial adaptation and penetration depth of three different bioceramic-based sealers (CeraSeal, EndoSeal MTA, Nishika Canal Sealer BG) compared to an epoxy resin-based sealer (AH Plus) in oval root canals. Fourty extracted single-rooted mandibular premolar with oval canal were prepared and randomly allocated according to the obturation into; CeraSeal, EndoSeal MTA, Nishika Canal Sealer BG and AH Plus. The roots were sectioned at 3, 6 and 9 mm from the apex. The sealer adaptation and the penetration depth were evaluated under confocal laser scanning microscope. One-way ANOVA and Repeated measure ANOVA were used to statistically analyze the data. Nishika Canal Sealer BG showed significantly higher sealer adaptation than EndoSeal MTA (P 
  4. Al-Haddad A, Abu Kasim NH, Che Ab Aziz ZA
    Dent Mater J, 2015;34(4):516-21.
    PMID: 26235718 DOI: 10.4012/dmj.2015-049
    This study evaluated and compared the sealer thickness and interfacial adaptation of bioceramic sealers (Sankin Apatite III, MTA Fillapex(®), EndoSequence(®) BC) to root dentin against AH Plus(®) sealer. Sixty extracted single-root premolars were prepared and equally divided into four groups. Sealers were labeled with 0.1% Rhodamine B fluorescent dye. Roots were dissected along the transverse plane at 1 mm (apical), 3 mm (middle), and 6 mm (coronal) levels. Sealer-to-whole canal area ratio was evaluated. Percentage of gap-containing region to canal circumference was calculated using a confocal laser microscope. Sealer thickness was significantly higher at apical and middle levels than at coronal level. EndoSequence BC had the significantly highest thickness compared with MTA Fillapex and AH Plus. The coronal level had significantly less interfacial gaps compared with apical and middle levels. Bioceramic sealers showed more gaps compared with AH Plus, with no significant differences among them.
  5. Al-Haddad A, Arsheed NAA, Yee A, Kohli S
    Saudi Dent J, 2024 Jan;36(1):11-19.
    PMID: 38375394 DOI: 10.1016/j.sdentj.2023.10.004
    PURPOSE: This systematic review is aimed to evaluate in fixed prosthodontics treated teeth, the effect of the BOPT on periodontal health compared to the horizontal preparation technique using a chamfer finishing line or to the baseline.

    METHODS: The electronic databases Cochrane Central Library, PubMed, Scopus, and ScienceDirect were searched based on specific MeSH keywords. The Randomized controlled clinical trials (RCTs) and prospective clinical trials on BOPT printed in English up to July 2022 were selected. Screening, selection, and data extraction were done. The studies were assessed for risk of bias, and descriptive and meta-analyses were performed.

    RESULTS: Eight studies were included in the systematic review and only three RCTs were involved in the meta-analysis. Two RCTs were assessed as low risk while one has some concerns. were grouped as good, fair, and poor based on NOS. Three of the prospective studies were considered to be of good quality and one study was fair. The meta-analysis revealed no statistically significant difference in the effect of BOPT and chamfer preparation on periodontal health status and success rate (P > 0.05).

    CONCLUSIONS: Considering the limitation of this review, the BOPT is comparable to chamfer preparation and it resulted in an acceptable effect to maintain periodontal health with a high success rate. However, more evidence is required to support these findings.

  6. Penukonda R, Pattar H, Nambiar P, Al-Haddad A
    Saudi Dent J, 2023 Jul;35(5):468-475.
    PMID: 37520597 DOI: 10.1016/j.sdentj.2023.05.008
    PURPOSE: This review aimed to assess the incidence, anatomical characteristics, identification, and clinical management using conventional techniques and advanced tools to manage MMCs successfully.

    METHODS: Medline/PubMed and Scopus databases were searched using "Middle mesial canal," "Middle mesial root canal," OR "Accessory mesial canal" keywords from 1 January 1970 and 1 February 2023. The most pertinent articles were chosen for the review from the retrieved articles. In addition, relevant articles were added by manually searching the list of references.

    RESULTS: The incidence of MMC is noticeable in younger people, and the confluent canal is the most common type. The majority of MMCs merged with mesiobuccal (MB) canals rather than mesiolingual (ML) canals. Clinical management could be employed using the standard endodontics protocol, and recent radiography technologies, magnification, rotary, and obturation materials can facilitate the procedures.

    CONCLUSION: The possibility of the incidence of MMC is not unusual. Detection and thorough debridement followed by obturation of the canal could increase the success rate of clinical outcomes.

  7. Kohli S, Al-Haddad A, Siew AY, Nam WL, Hamdan HD, Roslan QA
    Am J Dent, 2021 04;34(2):75-79.
    PMID: 33940663
    PURPOSE: To compare the bleaching efficacy of in-office (Opalescence), professional home (LumiBrite), over the counter (WhiteLight) and natural (strawberry extract) bleaching agents.

    METHODS: 80 teeth were selected and divided into two groups which were stained with black coffee and red wine respectively. The stained specimens were subdivided into four subgroups to be bleached with Opalescence, LumiBrite, WhiteLight and strawberry extract. Color measurements were made using spectrophotometer at baseline level, after staining, after bleaching and 1 week after bleaching. The ΔE₀₀ was calculated post bleaching (ΔE₀₀1), after 1-week follow up (ΔE₀₀2) and color changes between 1-week follow up and baseline (ΔE₀₀3). Data were analyzed by paired t-test and ANOVA with a significant difference of P< 0.05.

    RESULTS: Paired t-test showed significant differences in ΔE₀₀1 and ΔE₀₀2 for both stained specimens (P< 0.001). For black coffee stained specimens, Whitelight had significantly higher ΔE₀₀2 compared to the other bleaching agents (P< 0.05). For red wine stain, Whitelight also showed the significantly lowest ΔE₀₀1 (P< 0.001) and the highest ΔE₀₀2 (P< 0.001) compared to other groups. LumiBrite showed the significantly lowest ΔE₀₀3 for red wine stained specimens (P< 0.05). Whitelight had the poorest bleaching efficacy with deterioration effect after 1-week follow up. Opalescence, LumiBrite and strawberry extract had clinically perceptible and comparable bleaching efficacy. Strawberry extract appeared to be a potential natural bleaching agent with a desirable effect.

    CLINICAL SIGNIFICANCE: Commercial tooth bleaching agents can cause several undesirable side effects such as damage to enamel, hypersensitivity and even affecting the pulp. Strawberry extract is a natural, effective bleaching agent that may have reduced side effects.

  8. Hamidi H, Sharifi Haddad A, Mohammadian E, Rafati R, Azdarpour A, Ghahri P, et al.
    Ultrason Sonochem, 2017 Mar;35(Pt A):243-250.
    PMID: 27720591 DOI: 10.1016/j.ultsonch.2016.09.026
    CO2flooding process as a common enhanced oil recovery method may suffer from interface instability due to fingering and gravity override, therefore, in this study a method to improve the performance of CO2flooding through an integrated ultraosund-CO2flooding process is presented. Ultrasonic waves can deliver energy from a generator to oil and affect its properties such as internal energy and viscosity. Thus, a series of CO2flooding experiments in the presence of ultrasonic waves were performed for controlled and uncontrolled temperature conditions. Results indicate that oil recovery was improved by using ultrasound-assisted CO2flooding compared to conventional CO2flooding. However, the changes were more pronounced for uncontrolled temperature conditions of ultrasound-assisted CO2flooding. It was found that ultrasonic waves create a more stable interface between displacing and displaced fluids that could be due to the reductions in viscosity, capillary pressure and interfacial tension. In addition, higher CO2injection rates, increases the recovery factor in all the experiments which highlights the importance of injection rate as another factor on reduction of the fingering effects and improvement of the sweep efficiency.
  9. Sulaiman E, Alarami N, Wong YI, Lee WH, Al-Haddad A
    Dent Med Probl, 2018 10 18;55(3):275-279.
    PMID: 30328305 DOI: 10.17219/dmp/94656
    BACKGROUND: There is no sufficient literature on the effect of post location on endodontically treated premolar teeth with 2 roots.

    OBJECTIVES: The aim of the study was to evaluate the effect of fiber post location on fracture resistance and failure mode of endodontically treated premolars with 2 roots.

    MATERIAL AND METHODS: Fifty extracted maxillary first premolars with 2 roots were divided randomly into 5 groups. Group 1 was comprised of sound teeth, which received only metal crowns (control). Teeth from groups 2, 3, 4, and 5 were decoronated 2 mm above the cementoenamel junction (CEJ) and were endodontically treated. No post was placed in group 2 teeth. Teeth from groups 3, 4 and 5 were given a fiber post placed in the buccal canal, palatal canal, and both buccal and palatal canals, respectively. All teeth in groups 2, 3, 4, and 5 were built up with composite and full coverage metal crowns. A compressive static load was applied at an angle of 25° to the crowns with a crosshead speed of 0.5 mm/min, until fracture.

    RESULTS: One-way analysis of variance (ANOVA) showed significant differences among the groups (p = 0.002). A post hoc test showed significantly lower fracture resistance of group 4 compared to group 5 (p = 0.011). Furthermore, group 2 had significantly less fracture resistance compared to group 1 (p = 0.021) and group 5 (p = 0.002). According to Fisher's exact test, different post locations are non-significantly associated with fracture mode (p = 0.256).

    CONCLUSIONS: Fiber post location has a significant effect on fracture resistance of severely damaged, endodontically treated maxillary premolars with 2 roots. However, post placement in the palatal root is preferred, as it maintains the restorability of the tooth.

  10. Kohli S, Bhatia S, Al-Haddad A, Pulikkotil SJ, Jamayet NB
    J Prosthodont, 2022 Feb;31(2):102-114.
    PMID: 34516686 DOI: 10.1111/jopr.13433
    PURPOSE: This is a systematic review to identify the incidence of pulp necrosis and/or periapical changes among vital teeth which are used as an abutment for crown and fixed partial dentures (FPDs).

    MATERIALS AND METHODS: Two reviewers independently searched two electronic databases, PubMed and Scopus. The search was complemented from references of included studies and published reviews. Studies published in the English language through January 2021 that had assessed and documented the clinical and radiographic failure of crown or FPD in vital permanent teeth due to pulpal or periapical pathology with a follow-up of at least 12 months were selected. Data screening, data collection and extraction of data was performed. Quality of studies involved was analyzed using the Newcastle-Ottawa Quality Assessment Scale for cohort studies. Meta-analysis was done using random effects model. Publication bias was assessed using funnel plots.

    RESULTS: Electronic searches provided 10,075 records among which 20 studies were selected for systematic review and 7 studies were selected for meta-analysis. With respect to quality assessment, all the studies involved were considered as high quality as the score in scale ranged between 6 and 9 as per the Newcastle-Ottawa Quality Assessment Scale for cohort studies. The meta-analyses showed that there was no statistically significant difference in the incidence of the loss of pulp vitality or pulp necrosis through clinical and radiographic examination with the follow up period of 5 years: p < 0.001, 95% CI: 0.96-1.00, I2 = 77.84%; 10 years: p < 0.001, 95% CI: 0.88-0.95, I2 = 93.59%; 15 years: p < 0.001, 95% CI: 0.92-0.96, I2 = 94.83%; and 20 years: p < 0.001, 95% CI: 0.94-0.96, I2 = 95.01%.

    CONCLUSIONS: The meta-analysis revealed clinical and radiographic success rate ranging between 92% to 98% at different follow up periods ranging between 5 years and 20 years. Future high-quality randomized clinical controlled trials with a larger population are required to confirm the evidence as only observational studies were considered in this paper.

  11. Haddad A, Habaebi MH, Elsheikh EAA, Islam MR, Zabidi SA, Suliman FEM
    PLoS One, 2024;19(4):e0301371.
    PMID: 38557695 DOI: 10.1371/journal.pone.0301371
    To secure sensitive medical records in the healthcare clouds, this paper proposes an End-to-End Encryption (E2EE) to enhance a patient-centric blockchain-based system for electronic health record (EHR) management. The suggested system with a focus on the patient enables individuals to oversee their medical records within various involved parties by authorizing or withdrawing permission for access to their records. Utilizing the inter-planetary file system (IPFS) for record storage is chosen due to its decentralized nature and its ability to guarantee the unchangeability of records. Then an E2EE enhancement maintains the medical data integrity using dual level-Hybrid encryption: symmetric Advanced Encryption Standard (AES) and asymmetric Elliptic Curve Cryptography (ECC) cryptographic techniques. The proposed system is implemented using the Ethereum blockchain system for EHR data sharing and integration utilizing a web-based interface for the patient and all users to initiate the EHR sharing transactions over the IPFS cloud. The proposed system performance is evaluated in a working system prototype. For different file sizes between 512 KB to 100 MB, the performance metrics used to evaluate the proposed system were the time consumed for generating key, encryption, and decryption. The results demonstrate the proposed system's superiority over other cutting-edge systems and its practical ability to share secure health data in cloud environments.
  12. Al-Haddad A, Azmi NN, Penukonda R, Chia MA, Lee XW, K Anuar AF
    Aust Endod J, 2024 Nov 07.
    PMID: 39508744 DOI: 10.1111/aej.12900
    This study aimed to assess the antibiotic prescribing pattern for endodontic infections among general dental practitioners (GDPs) and endodontic specialists in Malaysia. A 22-questions survey on demographic and general information on antibiotic prescribing patterns for endodontic infection was delivered to the email addresses of general dentists and specialists via the Dental Practitifoner Information Management System database. Collected data were analysed using multivariate logistic regression tests at the significance level of 0.05. A total of 372 responses were collected. 94% of respondents were GDPs, and 6% endodontists. Clinical experience and frequency of endodontic treatment performance were the significant factors in prescribing antibiotics (p 
  13. Kohli S, Bhatia S, Banavar SR, Al-Haddad A, Kandasamy M, Qasim SSB, et al.
    Sci Rep, 2023 Mar 13;13(1):4181.
    PMID: 36914760 DOI: 10.1038/s41598-023-31125-6
    To formulate a dental bleaching agent with strawberry extract that has potent bleaching properties and antimicrobial efficacy. Enamel specimens (3 × 3 × 2 mm3) were prepared. Quaternary Ammonium Silane (CaC2 enriched) was homogenized with fresh strawberries: Group 1: supernatant strawberry (10 g) extract 
  14. Hamidi H, Sharifi Haddad A, Wisdom Otumudia E, Rafati R, Mohammadian E, Azdarpour A, et al.
    Ultrasonics, 2021 Feb;110:106288.
    PMID: 33142226 DOI: 10.1016/j.ultras.2020.106288
    Ultrasound technique is an inexpensive and ecofriendly technology commonly used in oil and gas industry to improve oil recovery and its applications have been successfully tested in both laboratory and field scales. In this technique, high-power ultrasonic waves are utilized downhole to improve oil recovery and reduce formation damage in near wellbore region that causes a reduction in hydrocarbon production rate due to the penetration of mud, scale deposition, etc. In most of the cases, barriers for the oil flow to the wellbore are effectively removed by using the ultrasound technique and the effect of improved oil recovery may last up to several months. The aim of this paper is to provide an overview of recent laboratory, field and mathematical studies to serve as reference for future extensive examination of ultrasound assisted improved oil recovery. As an added value to this field of study, research gaps and opportunities based on the review of recent works were identified and factors that needs to be considered to improve the outcome of future studies were recommended.
  15. Hatipoğlu FP, Hatipoğlu Ö, Taha N, Lehmann AP, Aldhelai TA, Madfa AA, et al.
    Int J Paediatr Dent, 2023 Sep;33(5):521-534.
    PMID: 37350350 DOI: 10.1111/ipd.13101
    BACKGROUND: Regenerative endodontics (RET) refers to biologically based procedures that aim to restore damaged tooth structures and reinstate the pulp-dentine complex to its normal physiological state.

    AIM: The purpose of this study was to examine the attitudes and practices of endodontists and paediatric dentists regarding RET.

    DESIGN: A survey was conducted among endodontists and paediatric dentists from 13 countries. A number of factors were evaluated, including frequency of RET application, followed guidelines, disinfection techniques, intracanal medication type, scaffold type, preferred coronal seal material, and follow-up period.

    RESULTS: Among the 1394 respondents, 853 (61.2%) and 541 (38.8%) were endodontists and paediatric dentists, respectively. Almost half (43%) of participants have not performed RET yet. The American Association of Endodontics guideline (47.3%) was selected as the primary source for the clinical protocol. The most frequently selected irrigant solution was 1.5%-3% NaOCl at the first (26.1%) and second (13.6%) sessions. A blood clot (68.7%) and MTA (61.9%) were the most frequently selected scaffold type and coronal barrier. Most participants preferred a 6-month follow-up period.

    CONCLUSION: According to this survey, deviations exist from current RET guidelines regarding all aspects evaluated. Standardizing clinical protocols and adhering to available guidelines would help to ensure more predictable outcomes.

  16. Kermansaravi M, Omar I, Mahawar K, Shahabi S, Bashir A, Haddad A, et al.
    Obes Surg, 2021 Dec;31(12):5303-5311.
    PMID: 34617207 DOI: 10.1007/s11695-021-05724-z
    BACKGROUND: Fasting during Ramadan is one of the five pillars of the Muslim faith. Despite the positive effects of fasting on health, there are no guidelines or clear recommendations regarding fasting after metabolic/bariatric surgery (MBS). The current study reports the result of a modified Delphi consensus among expert metabolic/bariatric surgeons with experience in managing patients who fast after MBS.

    METHODS: A committee of 61 well-known metabolic and bariatric surgeons from 24 countries was created to participate in the Delphi consensus. The committee voted on 45 statements regarding recommendations and controversies around fasting after MBS. An agreement/disagreement ≥ of 70.0% was regarded as consensus.

    RESULTS: The experts reached a consensus on 40 out of 45 statements after two rounds of voting. One hundred percent of the experts believed that fasting needs special nutritional support in patients who underwent MBS. The decision regarding fasting must be coordinated among the surgeon, the nutritionist and the patient. At any time after MBS, 96.7% advised stopping fasting in the presence of persistent symptoms of intolerance. Seventy percent of the experts recommended delaying fasting after MBS for 6 to 12 months after combined and malabsorptive procedures according to the patient's situation and surgeon's experience, and 90.1% felt that proton pump inhibitors should be continued in patients who start fasting less than 6 months after MBS. There was consensus that fasting may help in weight loss, improvement/remission of non-alcoholic fatty liver disease, dyslipidemia, hypertension and type 2 diabetes mellitus among 88.5%, 90.2%, 88.5%, 85.2% and 85.2% of experts, respectively.

    CONCLUSION: Experts voted and reached a consensus on 40 statements covering various aspects of fasting after MBS.

  17. Kermansaravi M, Chiappetta S, Shikora SA, Musella M, Kow L, Aarts E, et al.
    Obes Surg, 2024 Jul 24.
    PMID: 39046625 DOI: 10.1007/s11695-024-07395-y
    PURPOSE: With the global epidemic of obesity, the importance of metabolic and bariatric surgery (MBS) is greater than ever before. Performing these surgeries requires academic training and the completion of a dedicated fellowship training program. This study aimed to develop guidelines based on expert consensus using a modified Delphi method to create the criteria for metabolic and bariatric surgeons that must be mastered before obtaining privileges to perform MBS.

    METHODS: Eighty-nine recognized MBS surgeons from 42 countries participated in the Modified Delphi consensus to vote on 30 statements in two rounds. An agreement/disagreement among ≥ 70.0% of the experts was regarded to indicate a consensus.

    RESULTS: Consensus was reached on 29 out of 30 statements. Most experts agreed that before getting privileges to perform MBS, surgeons must hold a general surgery degree and complete or have completed a dedicated fellowship training program. The experts agreed that the learning curves for the various operative procedures are approximately 25-50 operations for the LSG, 50-75 for the OAGB, and 75-100 for the RYGB. 93.1% of experts agreed that MBS surgeons should diligently record patients' data in their National or Global database.

    CONCLUSION: MBS surgeons should have a degree in general surgery and have been enrolled in a dedicated fellowship training program with a structured curriculum. The learning curve of MBS procedures is procedure dependent. MBS surgeons must demonstrate proficiency in managing postoperative complications, collaborate within a multidisciplinary team, commit to a minimum 2-year patient follow-up, and actively engage in national and international MBS societies.

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