Displaying publications 1 - 20 of 43 in total

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  1. Fulltext Psychoses associated with thyrotoxicosis: a retrospective study of twenty cases
    Tan CK
    Med J Malaysia, 1985 Sep;40(3):247-51.
    PMID: 3842721
    A total of 23 patients with psychoses associated with thyrotoxicosis were admitted to the psychiatric unit of a University Hospital over a 13-year period, of which 20 patients were included in this retrospective study. It was found that a parallel relationship between thyrotoxicosis and psychosis appears to exist in six patients, while in the remaining 14 patients, the course of the two disease processes were largely independent of each other. Paranoid delusions and auditory hallucinations were the most prominent psychiatric symptoms. Depression was commonly seen even in patients who were not having an affective illness. In four patients, a mixed schizo-affective psychosis was seen, suggesting that the diagnostic distinction between the affective and schizophrenic reactions are often blurred in psychosis associated with thyrotoxicosis.
  2. Violent, homicidal and excited patients
    Tan CK
    Family Practitioner, 1981;4(1):12-16.
  3. The hypochondriacal patient
    Tan CK
    Family Practitioner, 1979;3(6):40-44.
  4. Fulltext An unusual localised reaction associated with vancomycin therapy
    Tan CK, Huang YQ, Yap KB
    Med J Malaysia, 2013 Oct;68(5):443-4.
    PMID: 24632878
    Vancomycin has been documented to cause various adverse cutaneous reactions. We present a case report of a man, who developed a large localized erythematous plaque in his forearm following parenteral vancomycin therapy. We believe this to be the first reported case of such cutaneous reaction associated with parenteral vancomycin therapy.
  5. Fulltext Remedial education in specific reading retardation
    Tan CK, Malhotra KK, Woon TH
    Med J Malaysia, 1980 Mar;34(3):273-8.
    PMID: 7412667
    The concept of specific reading retardation was discussed, and compared with other terms used as synonymous with it viz. dyslexia and minimal brain dysfunction. It was suggested that specific reading retardation may be a more suitable term to use. The feature's of specific reading retardation, the evaluation of reading disability and management in terms of supportive psychotherapy, environmental manipulation and remedial education was described, using a case-report. of a 13-year old boy with such a disorder as an example.
    Study site: Psychiatric clinic, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia
  6. Simvastatin-loaded lyophilized wafers as a potential dressing for chronic wounds
    Rezvanian M, Tan CK, Ng SF
    Drug Dev Ind Pharm, 2016 Dec;42(12):2055-2062.
    PMID: 27237190
    Wafers are an established drug delivery system for application to suppurating wounds. They can absorb wound exudates and are converted into a gel, offering a moist environment that is vital for wound healing. Simvastatin-loaded lyophilized wafers were developed using sodium carboxymethyl cellulose (CMC) and methyl cellulose (MC) and evaluated for their potential in the management of chronic wounds. Simvastatin (SIM) was chosen as the model drug since it is known to accelerate wound healing by promoting angiogenesis and lymphangiogenesis. Pre-formulation studies were carried out with CMC, MC, and a mixture of CMC and MC. Wafers obtained from aqueous gels of 3% CMC and blend of CMC-MC in the % weight ratio of 2:1 and 1.5:1.5 were selected for further analysis. The formulated wafers were characterized by microscopic examination, texture analysis, hydration test, rheological studies, FTIR spectroscopy, water vapor transmission and drug release test. Among the selected formulations, simvastatin-loaded CMC-MC (2:1) wafers exhibited the most desired characteristics for wound dressing application, such as good flexibility, hardness, sponginess, and viscosity. It showed a sustained drug release, which is desirable in wound healing, and was more appropriate for suppurating wounds. In conclusion, simvastatin-loaded CMC-MC (2:1) wafers showing potential for wound dressing applications were successfully developed.
  7. Fulltext Effect of tiger milk mushroom (Lignosus rhinocerus) supplementation on respiratory health, immunity and antioxidant status: an open-label prospective study
    Tan ESS, Leo TK, Tan CK
    Sci Rep, 2021 06 03;11(1):11781.
    PMID: 34083710 DOI: 10.1038/s41598-021-91256-6
    Tiger milk mushroom (TMM; Lignosus rhinocerus) have been used for a long time by indigenous communities in South East Asia regions as traditional medicine for different ailments, including respiratory disorders. The beneficial effects of TMM have been proven through in vivo and in vitro models, but these effects have yet to be validated in a clinical study. In this study, the beneficial effects of TMM supplementation were investigated in 50 voluntary participants. Participants were required to take 300 mg of TMM twice daily for three months. Level of interleukin 1β (IL-1β), interleukin 8 (IL-8), immunoglobulin A (IgA), total antioxidant capacity, malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHdG), pulmonary function and respiratory symptoms were assessed during baseline and monthly follow-up visits. Results demonstrated that supplementation of TMM significantly (p 
  8. Role of dietary supplements in the continuous battle against COVID-19
    Zaman R, Ravichandran V, Tan CK
    Phytother Res, 2024 Feb;38(2):1071-1088.
    PMID: 38168043 DOI: 10.1002/ptr.8096
    A sudden outbreak of the COVID-19 pandemic was a big blow to the world community on every level. Created by a novel coronavirus, SARS-CoV-2, which was previously unknown to the human immune system. The expert opinion almost immediately united on the fact that the most effective way of fighting the pandemic would be by building immunity artificially via a mass immunization program. However, it took about a year for the approval of the first vaccine against COVID-19. In the meantime, a big part of the general population started adapting nutritious diet plans and dietary supplements to boost natural immunity as a potential prophylactic strategy against SARS-CoV-2 infection. Whether they originate from mainstream medicine, such as synthetic supplements, or traditional herbal remedies in the form of single or poly-herbs, these supplements may comprise various components that exhibit immunomodulatory, anti-inflammatory, antioxidant, and antimicrobial characteristics. There is a substantial body of predictions and expert opinions suggesting that enhancing one's diet with dietary supplements containing additional nutrients and bioactive compounds like vitamins, minerals, amino acids, fatty acids, phytochemicals, and probiotics can enhance the immune system's ability to develop resistance against COVID-19, although none of them have any conclusive evidence nor officially recommended by World Health Organization (WHO). The current review critically acclaims the gap between public perception-based preference and real evidence-based study to weigh the actual benefit of dietary supplements in relation to COVID-19 prevention and management.
  9. Seasonal variability of chlorophyll-a and oceanographic conditions in Sabah waters in relation to Asian monsoon--a remote sensing study
    Abdul-Hadi A, Mansor S, Pradhan B, Tan CK
    Environ Monit Assess, 2013 May;185(5):3977-91.
    PMID: 22930185 DOI: 10.1007/s10661-012-2843-2
    A study was conducted to investigate the influence of Asian monsoon on chlorophyll-a (Chl-a) content in Sabah waters and to identify the related oceanographic conditions that caused phytoplankton blooms at the eastern and western coasts of Sabah, Malaysia. A series of remote sensing measurements including surface Chl-a, sea surface temperature, sea surface height anomaly, wind speed, wind stress curl, and Ekman pumping were analyzed to study the oceanographic conditions that lead to large-scale nutrients enrichment in the surface layer. The results showed that the Chl-a content increased at the northwest coast from December to April due to strong northeasterly wind and coastal upwelling in Kota Kinabalu water. The southwest coast (Labuan water) maintained high concentrations throughout the year due to the effect of Padas River discharge during the rainy season and the changing direction of Baram River plume during the northeast monsoon (NEM). However, with the continuous supply of nutrients from the upwelling area, the high Chl-a batches were maintained at the offshore water off Labuan for a longer time during NEM. On the other side, the northeast coast illustrated a high Chl-a in Sandakan water during NEM, whereas the northern tip off Kudat did not show a pronounced change throughout the year. The southeast coast (Tawau water) was highly influenced by the direction of the surface water transport between the Sulu and Sulawesi Seas and the prevailing surface currents. The study demonstrates the presence of seasonal phytoplankton blooms in Sabah waters which will aid in forecasting the possible biological response and could further assist in marine resource managements.
  10. Feasibility study of biodiesel production using lipids of Hermetia illucens larva fed with organic waste
    Leong SY, Kutty SR, Malakahmad A, Tan CK
    Waste Manag, 2016 Jan;47(Pt A):84-90.
    PMID: 25872864 DOI: 10.1016/j.wasman.2015.03.030
    Hermetia illucens larvae by nature are a decomposer which fed on organic wastes. This study explores the potential of producing biodiesel using lipids from H. illucens larvae. Three types of organic wastes (sewage sludge, fruit waste and palm decanter cake from oil palm mill) were selected based on considerable generation and disposal concern in the area of study as well as lack of investigations as feed for Hermetia illucens larvae in current literatures. Growth rate of the larvae was determined with studying the changes in the biomass per day. H. illucens larvae fed with fruit waste and palm decanter cake have shown growth rates of 0.52±0.02 and 0.23±0.09 g d(-1), respectively. No positive sign of growth were observed in the larvae fed with treated sewage sludge (-0.04±0.01 g d(-1)). Biodiesel as fatty acid methyl ester (FAME) was synthesized by transesterification of the larvae lipid using sulphuric acid as catalyst in methanol. FAME produced was ascertained using ATR-FTIR spectroscopy and GC-MS. The main compositions of fatty acid were found to be C12:0, C16:0 and C18:1n9c. Fatty acid composition of C12:0 fed with fruit waste, sewage sludge and palm decanter was found to be most abundant in the larvae lipid. The amount of C12:0 obtained was 76.13%, 58.31% and 48.06%, respectively. In addition, fatty acid of C16:0 was attained at 16.48% and 25.48% fed with sewage sludge and palm decanter, respectively. Based on the findings, FAME derived from larvae lipids is feasible to be used for biodiesel production.
  11. Strong family history of nasopharyngeal carcinoma (NPC) in Bidayuh, a local native group in Sarawak, Malaysia
    Yeo GG, Beh SP, Tan CK, Pei Jye V
    Ann Oncol, 2018 Nov;29 Suppl 9:ix98-ix99.
    PMID: 32178213 DOI: 10.1093/annonc/mdy438.017
  12. Nasopharyngeal carcinoma in children and adolescent: A 10-year review in Sarawak General Hospital, Malaysia
    Mohd Naseri NI, Lee RY, Nagaswara U, Tan CK, Pei Jye V
    Ann Oncol, 2018 Nov;29 Suppl 9:ix97.
    PMID: 32178210 DOI: 10.1093/annonc/mdy438.011
  13. Fulltext DCM2Net: an improved face recognition model for panoramic stereoscopic videos
    Zhang D, Tan WH, Wei Y, Tan CK
    Front Artif Intell, 2024;7:1295554.
    PMID: 38978998 DOI: 10.3389/frai.2024.1295554
    The panoramic stereo video has brought a new visual experience for the audience with its immersion and stereo effect. In panoramic stereo video, the face is an important element. However, the face image in panoramic stereo video has varying degrees of deformation. This brings new challenges to face recognition. Therefore, this paper proposes a face recognition model DCM2Net (Deformable Convolution MobileFaceNet) for panoramic stereo video. The model mainly integrates the feature information between channels during feature fusion, redistributes the information between channels in the deeper part of the network, and fully uses the information between different channels for feature extraction. This paper also built a panoramic stereo video live system, using the DCM2Net model to recognize the face in panoramic stereo video, and the recognition results are displayed in the video. After experiments on different datasets, the results show that our model has better results on popular datasets and panoramic datasets.
  14. Development of semi-quantitative urinary sodium test strip
    Lai JS, Tan CK, Yusoff K, Cheah SC
    Biotechnol Appl Biochem, 2023 Apr;70(2):603-612.
    PMID: 35830743 DOI: 10.1002/bab.2383
    Excessive salt consumption has been associated with greater risk of hypertension. Therefore, monitoring of dietary sodium consumption should be prioritized. As sodium is mainly excreted through urine, 24-h urine sample can be used to estimate individual sodium intake. Thus, a simple and inexpensive semi-quantitative urinary sodium detection test strip was developed based on the enzymatic reaction between β-galactosidase and chlorophenol red-β-d-galactopyranoside. When tested, color formation was distinguished at 0 M (chartreuse yellow), 0.05 M (sunflower), 0.1-0.15 M (mango tango), and 0.2-0.25 M (persimmon) sodium. Analysis from ImageJ showed a linear result (r2  > 0.9), low SD, and significant increase in magenta difference (p 2 days in adverse storage conditions (laboratory conditions, ∼80% relative humidity, 40°C, and direct light exposure) when stored in test strip bottles, and even shorter when exposed to the environment. The presence of urinary potassium, urea, and glucose did not affect test strip performance. Test strip produced comparable results to flame photometry with <15% variation when tested on overnight, random spot, and 24-h urine samples. Overall, the developed test strip can be used to enzymatically semi-quantify 0.05-0.25 M sodium.
  15. Fulltext Effects of 1-methylcyclopropene and modified atmosphere packaging on the antioxidant capacity in pepper "Kulai" during low-temperature storage
    Tan CK, Ali ZM, Ismail I, Zainal Z
    ScientificWorldJournal, 2012;2012:474801.
    PMID: 22919322 DOI: 10.1100/2012/474801
    The objective of the present study was to simultaneously evaluate the effect of a postharvest treatment on the pepper's antioxidant content and its ability to retain its economical value during the postharvest period. The fruits were pretreated by modified atmosphere packaging (MAP) with or without treatment with 1-methylcyclopropene (1-MCP) before cold storage at 10°C. Changes in the levels of non-enzymatic antioxidants, including the total phenolic, ascorbic acid levels and the total glutathione level, as well as enzymatic antioxidants, including ascorbate peroxidase (APX), glutathione reductase (GR), and catalase (CAT), were determined. Both treatments successfully extended the shelf life of the fruit for up to 25 days, and a high level of antioxidant capacity was maintained throughout the storage period. However, 1-MCP treatment maintained the high antioxidant capacity for a longer period of time. The 1-MCP-treated peppers maintained high levels of phenolic content, a high reduced glutathione (GSH)/oxidised glutathione (GSSG) ratio, decreased levels of ascorbic acid and CAT activity, and increased levels of APX and GR compared with the peppers that were not treated with 1-MCP. The overall results suggested that a combination of 1-MCP and MAP was the most effective treatment for extending shelf life while retaining the nutritional benefits.
  16. A high-dimensional, multi-transceiver channel state information dataset for enhanced human activity recognition
    Wong WE, Wong AH, Peh WQ, Tan CK
    Data Brief, 2024 Aug;55:110673.
    PMID: 39049967 DOI: 10.1016/j.dib.2024.110673
    Human Activity Recognition (HAR) has emerged as a critical research area due to its extensive applications in various real-world domains. Numerous CSI-based datasets have been established to support the development and evaluation of advanced HAR algorithms. However, existing CSI-based HAR datasets are frequently limited by a dearth of complexity and diversity in the activities represented, hindering the design of robust HAR models. These limitations typically manifest as a narrow focus on a limited range of activities or the exclusion of factors influencing real-world CSI measurements. Consequently, the scarcity of diverse training data can impede the development of efficient HAR systems. To address the limitations of existing datasets, this paper introduces a novel dataset that captures spatial diversity through multiple transceiver orientations over a high dimensional space encompassing a large number of subcarriers. The dataset incorporates a wider range of real-world factors including extensive activity range, a spectrum of human movements (encompassing both micro-and macro-movements), variations in body composition, and diverse environmental conditions (noise and interference). The experiment is performed in a controlled laboratory environment with dimensions of 5 m (width) × 8 m (length) × 3 m (height) to capture CSI measurements for various human activities. Four ESP32-S3-DevKitC-1 devices, configured as transceiver pairs with unique Media Access Control (MAC) addresses, collect CSI data according to the Wi-Fi IEEE 802.11n standard. Mounted on tripods at a height of 1.5 m, the transmitter devices (powered by external power banks) positioned at north and east send multiple Wi-Fi beacons to their respective receivers (connected to laptops via USB for data collection) located at south and west. To capture multi-perspective CSI data, all six participants sequentially performed designated activities while standing in the centre of the tripod arrangement for 5 s per sample. The system collected approximately 300-450 packets per sample for approximately 1200 samples per activity, capturing CSI information across the 166 subcarriers employed in the Wi-Fi IEEE 802.11n standard. By leveraging the richness of this dataset, HAR researchers can develop more robust and generalizable CSI-based HAR models. Compared to traditional HAR approaches, these CSI-based models hold the promise of significantly enhanced accuracy and robustness when deployed in real-world scenarios. This stems from their ability to capture the nuanced dynamics of human movement through the analysis of wireless channel characteristic from different spatial variations (utilizing two-diagonal ESP32 transceivers configuration) with higher degree of dimensionality (166 subcarriers).
  17. Ceramides and Skin Health: New Insights
    Yong TL, Zaman R, Rehman N, Tan CK
    Exp Dermatol, 2025 Feb;34(2):e70042.
    PMID: 39912256 DOI: 10.1111/exd.70042
    Ceramide has transitioned from an incidental discovery to a vital element in skincare, becoming a thoroughly studied compound in the quest to treat skin conditions. Creating a moisture barrier, preserving hydration, regulating pH, controlling inflammation, and enhancing skin functions and appearance are among its established benefits. It is often used medically to repair skin barrier defects, as observed in inflammatory skin conditions like atopic dermatitis (AD) and dry skin types. Furthermore, ceramide and its metabolites are commonly used as predictors before disease manifestation and for prognostication processes, thus can be used as biomarker for clinical diagnosis as well. In the last couple of decades, momentum was also seen in the pre-clinical studies involving anti-cancer and nanotechnology field, whereby ceramide was also used as a drug, a carrier, or even adjunct formulation to increase efficacy of treatment such as chemotherapy. Approaches to increase ceramide levels include directly replenishing lost ceramides with natural extracts, synthetic pseudo-ceramides, or ceramide-like analogues, as well as using supplements that stimulate the body's natural ceramide production. Although ceramide is a well-known treatment in skincare and for common skin conditions like AD and psoriasis, its development and related pharmacology for severe skin conditions, such as skin cancer, remain in pre-clinical stages. Hence, the purpose of this research is to explore the role of ceramide in skin health and its application in common skin diseases.
  18. Medium-term (5-year) comparison of the functional outcomes of combined anterior cruciate ligament and posterolateral corner reconstruction compared with isolated anterior cruciate ligament reconstruction
    Cartwright-Terry M, Yates J, Tan CK, Pengas IP, Banks JV, McNicholas MJ
    Arthroscopy, 2014 Jul;30(7):811-7.
    PMID: 24794571 DOI: 10.1016/j.arthro.2014.02.039
    To present a 5-year comparison of the functional outcomes of combined anterior cruciate ligament (ACL) and posterolateral corner (PLC) reconstruction with those of isolated ACL reconstruction.
  19. Oral rhinosporidiosis in Malaysia
    Ramanathan K, Ungku Dato OA, Kannan Kutty M, Dutt AK, Balasegaram M, Singh H, et al.
    Dent J Malaysia Singapore, 1969 May;9(1):27-39.
    PMID: 5258332
  20. Fulltext Comparative study of gut microbiota in wild and captive Malaysian Mahseer (Tor tambroides)
    Tan CK, Natrah I, Suyub IB, Edward MJ, Kaman N, Samsudin AA
    Microbiologyopen, 2019 05;8(5):e00734.
    PMID: 30353678 DOI: 10.1002/mbo3.734
    AIMS: The aim of this study was to identify and compare the gut microbial community of wild and captive Tor tambroides through 16S rDNA metagenetic sequencing followed by functions prediction.

    METHODS AND RESULTS: The library of 16S rDNA V3-V4 hypervariable regions of gut microbiota was amplified and sequenced using Illumina MiSeq. The sequencing data were analyzed using Quantitative Insights into Microbial Ecology (QIIME) pipeline and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). The most abundant bacterial phyla in both wild and captive T. tambroides were Firmicutes, Proteobacteria, Fusobacteria and Bacteroidetes. Cetobacterium spp., Peptostreptococcaceae family, Bacteroides spp., Phosphate solubilizing bacteria PSB-M-3, and Vibrio spp. were five most abundant OTU in wild T. tambroides as compared to Cetobacterium spp., Citrobacter spp., Aeromonadaceae family, Peptostreptococcaceae family and Turicibacter spp. in captive T. tambroides.

    CONCLUSION: In this study, the specimens of the wild T. tambroides contain more diverse gut microbiota than of the captive ones. The results suggested that Cetobacterium spp. is one of the core microbiota in guts of T. tambroides. Besides, high abundant Bacteroides spp., Citrobacter spp., Turicibacter spp., and Bacillus spp. may provide important functions in T. tambroides guts.

    SIGNIFICANCE AND IMPACT OF THE STUDY: The results of this study provide significant information of T. tambroides gut microbiota for further understanding of their physiological functions including growth and disease resistance.

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