Displaying publications 1 - 20 of 69 in total

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  1. Bera H, Gaini C, Kumar S, Sarkar S, Boddupalli S, Ippagunta SR
    Mater Sci Eng C Mater Biol Appl, 2016 Oct 01;67:170-181.
    PMID: 27287111 DOI: 10.1016/j.msec.2016.05.016
    Novel alginate-fenugreek gum (FG) gel membrane coated hydroxypropylmethylcellulose (HPMC) based matrix tablets were developed for intragastric quetiapine fumarate (QF) delivery by combining floating and swelling mechanisms. The effects of polymer blend ratios [HPMC K4M:HPMC E15] and citric acid contents on time taken for 50% drug release (t50%, min) and drug release at 8h (Q8h, %) were studied to optimize the core tablets by 3(2) factorial design. The optimized tablets (F-O) exhibited t50% of 247.67±3.51min and Q8h of 71.11±0.32% with minimum errors in prediction. The optimized tablets were coated with Ca(+2) ions crosslinked alginate-FG gel membrane by diffusion-controlled interfacial complexation technique. The biopolymeric-coated optimized matrices exhibited superior buoyancy, preferred swelling characteristics and slower drug release rate. The drug release profiles of the QF-loaded uncoated and coated optimized matrices were best fitted in Korsmeyer-Peppas model with anomalous diffusion driven mechanism. The uncoated and coated tablets containing QF were also characterized for drug-excipients compatibility, thermal behaviour and surface morphology by FTIR, DSC and SEM analyses, respectively. Thus, the newly developed alginate-FG gel membrane coated HPMC matrices are appropriate for intragastric delivery of QF over a prolonged period of time with greater therapeutic benefits.
    Matched MeSH terms: Gingiva/chemistry*
  2. Nik-Azis NM, Razali M, Goh V, Ahmad Shuhaimi NN, Mohd Nazrin NAS
    J Clin Periodontol, 2023 Jan;50(1):80-89.
    PMID: 36089895 DOI: 10.1111/jcpe.13723
    AIM: Assessment of the thickness of gingival tissues using the probe visibility test is regarded as the method of choice during routine examinations. However, the probe visibility test has not been validated for patients with gingival pigmentation and its accuracy in populations with physiological gingival pigmentation is yet unknown. This study aims to evaluate different methods for the clinical assessment of gingival thickness in participants with varying levels of gingival pigmentation.

    MATERIALS AND METHODS: Buccal mucosa of the maxillary right central incisor teeth of 171 participants was evaluated using four methods, which were direct measurements using calliper, transgingival probing method using an endodontic probe, and probe visibility method using Colorvue biotype probe (CBP) and UNC-15 probe. The pigmentation of the gingiva was assessed using the Dummett-Gupta oral pigmentation lesion index.

    RESULTS: The average gingival thickness of the selected population was 1.22 ± 0.38 mm with a distribution of 70% thick and 30% thin gingiva. Transgingival and calliper methods showed good agreement and significant correlation (r = 0.229; p = .003). Visual assessment using CBP and UNC-15 probe showed poor agreement with the direct measurement methods. Gingival pigmentation significantly affected the probe visibility assessment, reducing the visibility of both the CBP (odds ratio [OR] = 4.00; 95% confidence interval [CI], 1.83-8.74) and UNC-15 probe (OR = 1.84; 95% CI, 1.05-3.23) while controlling for thickness of the gingiva.

    CONCLUSION: The probe visibility method using either CBP or the UNC-15 probe is affected by the degree of gingival pigmentation. Direct measurements using either a calliper or transgingival probing are recommended as methods to measure the gingival thickness in populations with gingival pigmentation.

    Matched MeSH terms: Gingiva*; Gingival Diseases*
  3. Abduljabbar T, Vohra F, Akram Z, Ghani SMA, Al-Hamoudi N, Javed F
    J. Photochem. Photobiol. B, Biol., 2017 Aug;173:353-359.
    PMID: 28641206 DOI: 10.1016/j.jphotobiol.2017.06.016
    BACKGROUND: Oral pigmentation, especially in the gingiva poses esthetic problems. Laser therapy has been widely used for cosmetic therapy in dentistry. The aim of the present study was to systematically review the efficacy of surgical laser therapy (SLT) in the management of oral pigmented lesions (OPL).

    MATERIALS AND METHODS: The addressed focused question was "Is SLT effective in the management of OPL?" Databases (MEDLINE via PubMed; EMBASE; Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) were searched from 1970 up to and including February 2017.

    RESULTS: Ten studies were included. The reported number of OPL ranged between 8 and 140. Oral pigmented sites included, gingiva, buccal and labial mucosa, alveolar mucosa and lips. Lasers used in the studies included Q-switched alexandrite, Neodymium-doped yttrium aluminium garnet, diode, Erbium: yttrium aluminium garnet and carbon dioxide laser. Laser wavelength, power output and number of irradiations were 635-10,600nm, 1-10W and 1 to 9 times, respectively. The follow up period ranged from 6 to 24months. All studies reported SLT to be effective in the treatment of OPL. In five studies, recurrence of OPL occurred which ranged from 21.4% to 45%.

    CONCLUSIONS: Lasers are effective in the management of OPL including physiologic gingival pigmentation, smokers' melanosis and pigmentation in Laugier-Hunziker syndrome. Different laser types (CO2, Er:YAG and Diode) showed comparable outcomes in the treatment of OPL.

    Matched MeSH terms: Gingiva/metabolism; Gingiva/radiation effects*
  4. Loh KY, Kew ST
    Aust Fam Physician, 2007 Nov;36(11):941.
    PMID: 18050541
    Matched MeSH terms: Gingiva/physiopathology*
  5. Alhabashneh R, Alomari S, Khaleel B, Qinawi H, Alzaubi M
    J Esthet Restor Dent, 2021 04;33(3):531-537.
    PMID: 33174355 DOI: 10.1111/jerd.12680
    The objective of this study was to assess the efficacy of Hyaluronic Acid (HA) on interdental papilla (IDP) loss in the esthetic zone. Twenty one subjects (14 females and 7 males) from those referred for treatment of IDP loss at Periodontics postgraduate clinics at the Jordan University of Science and Technology. A total of 86 interdental sites (58 sites in the maxillary jaw and 28 sites in the mandibular jaw) were treated and followed up. A 0.2 ml of Hyaluronic acid was injected in each receded IDP site and injections were repeated after 21 days. Papilla sites were evaluated and statistically analyzed. At the 3 week interval the mean reduction of black triangle (BT) height was 0.17 mm (8% reduction) (P-value <0.001), at the 3 month interval there was a mean reduction of BT height of 0.83 mm (39% reduction) (P-value <0.001). At 6 months however, the reduction in BT height was 0.62 mm (29% reduction) (P-value <0.001). Within the limitations of this study, it can be concluded that the use of commercially available HA gel for the treatment of interdental papillae loss may have promising results over the first 6 months after injection. The maximum improvement in black triangles was at 3 months after injection with a reduction of improvement between 3 and 6 months. Clinical Relevance Helping clinician to take evidence based decision while considering Hyaluronic acid injection as a short term nonsurgical treatment modality for interdental papilla loss.
    Matched MeSH terms: Gingiva*
  6. Nettemu SK, Nettem S, Singh VP, William SS, Gunasekaran SS, Krisnan M, et al.
    Int J Implant Dent, 2021 06 10;7(1):77.
    PMID: 34109477 DOI: 10.1186/s40729-021-00315-0
    AIM: This study was to evaluate the association between peri-implant bleeding on probing in peri-implant diseases and its association with multilevel factors (site specific factors, implant factors, and patient level factors).

    METHODOLOGY: A cross-sectional study involved consented adult patients with ≥ 1 dental implant. Two calibrated operators examined the patients. BoP was outcome variable and peri-implant gingival biotype was principal predictor variable. The effects of site, implant, and patient level factors on BoP were assessed using a multilevel logistic regression model.

    RESULTS: Eighty patients for a total of 119 implants and 714 sites were included in the study. Bleeding on probing was observed in 42 implants (35.29%) with a significant higher risk observed in presence of gingival recession, thin peri-implant gingival biotype, duration of implant placement, smokers, and male patients.

    CONCLUSION: Peri-implant bleeding on probing was associated with site specific, implant, and patient level factors.

    Matched MeSH terms: Gingiva*; Gingival Recession*
  7. Ngeow WC, Chai WL
    Clin Anat, 2021 May;34(4):512-521.
    PMID: 32020669 DOI: 10.1002/ca.23577
    The mandibular canal is nowadays acknowledged as a major trunk with multiple smaller branches running roughly parallel to it. Most of these accessory canals contain branches of the inferior alveolar neurovascular bundle that supplies the dentition, jawbone, and soft tissue around the gingiva and lower lip. This article reviews the prevalence, classification and morphometric measurements of the retromolar canal and its aperture. A retromolar canal is a bifid variation of the mandibular canal that divides from above this main canal, and travels anterosuperiorly within the bone to exit via a single foramen or multiple foramina into the retromolar fossa. This foramen, termed the retromolar foramen, allows accessory branches of the inferior alveolar neurovascular bundles to supply tissues at the retromolar trigone. Clinically, it is of the utmost importance to determine the exact location of the mandibular canal and to identify its retromolar accessory branches when surgery in the posterior mandible is to be performed.
    Matched MeSH terms: Gingiva
  8. Lee YH, Baharuddin NA, Chan SW, Rahman MT, Bartold PM, Sockalingam S, et al.
    Clin Oral Investig, 2021 Mar;25(3):1441-1450.
    PMID: 32656595 DOI: 10.1007/s00784-020-03452-9
    OBJECTIVES: It has been proposed that citrullination and carbamylation occur in the inflamed periodontium and could be the plausible mechanisms for the generation of antigens involved in the development and progression of RA. The purpose of this study was to determine the presence and location of citrullinated and carbamylated proteins in the gingival tissues and compare their abundance in periodontitis (PD) patients with or without RA.

    MATERIALS AND METHODS: Gingival tissue samples of healthy (n = 5), PD with RA (n = 5) and PD without RA (n = 5) were collected. Specimens were formalin fixed, paraffin embedded and sectioned at 4 μm. The tissue sections were analysed for the presence of citrullinated and carbamylated proteins by immunohistochemistry. Semi-quantitative analysis was performed to quantify and compare the protein abundance between groups.

    RESULTS: The number of cells containing citrullinated and carbamylated proteins with higher intensity was markedly increased in gingival tissues from PD with or without RA in comparison with healthy controls.

    CONCLUSION: Inflamed gingival tissue is a potential source of citrullinated and carbamylated proteins other than synovial tissues. The extent to which the local accumulation of these proteins contributes to the pathogenesis of RA needs further elucidation.

    CLINICAL RELEVANCE: If PD is a potential source of post-translationally modified proteins, untreated PD should not be taken lightly in the context of RA. Hence, addressing gingival inflammation should be viewed as an important preventive measure in the general population not only for the progression of periodontal disease but also reducing the risk of developing extra-oral comorbidities.

    Matched MeSH terms: Gingiva
  9. Ngeow, W.C., Shanmuhasuntharam, P.
    Ann Dent, 1997;4(1):-.
    MyJurnal
    Surgery done around gingival margin may eventually result in loss of attachment and recession of the gingiva. Root hypersensitivity is another possible complication when coupled with overzealous tooth brushing by the patients. This paper presents an alternative method to remove a lesion located at the lateral cervical third of a root. Its advantage is that the gingival margin is kept intact.
    Matched MeSH terms: Gingiva
  10. Naomi R, Ardhani R, Hafiyyah OA, Fauzi MB
    Polymers (Basel), 2020 Sep 13;12(9).
    PMID: 32933133 DOI: 10.3390/polym12092081
    Collagen (Col) is a naturally available material and is widely used in the tissue engineering and medical field owing to its high biocompatibility and malleability. Promising results on the use of Col were observed in the periodontal application and many attempts have been carried out to inculcate Col for gingival recession (GR). Col is found to be an excellent provisional bioscaffold for the current treatment in GR. Therefore, the aim of this paper is to scrutinize an overview of the reported Col effect focusing on in vitro, in vivo, and clinical trials in GR application. A comprehensive literature search was performed using EBSCOhost, Science Direct, Springer Link, and Medline & Ovid databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) collagen OR scaffold OR hybrid scaffold OR biomaterial AND (2) gingiva recession OR tissue regeneration OR dental tissue OR healing mechanism OR gingiva. Only articles published from 2015 onwards were selected for further analysis. This review includes the physicochemical properties of Col scaffold and the outcome for GR. The comprehensive literature search retrieved a total of 3077 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 15 articles were chosen for further review. The results from these articles indicated that Col promoted gingival tissue regeneration for GR healing. Therefore, this systematic review recapitulated that Col enhances regeneration of gingival tissue either through a slow or rapid process with no sign of cytotoxicity or adverse effect.
    Matched MeSH terms: Gingiva; Gingival Recession
  11. Mohd Zambri M.M., Wan Nurazreena W.H.
    Ann Dent, 2018;25(1):1-10.
    MyJurnal
    This report aimed to describe an effective biomechanics to control the upper incisors inclination during the
    correction of gummy smile with bimaxillary proclinations. A 14-year-old female presented with a Class II
    division I incisor relationship complicated with bimaxillary proclination on a Class 2 skeletal base. The lips
    were incompetent, showing 7 mm of upper incisors at rest and 5mm maxillary gingival display on smiling
    with normal upper lip length. Treatment involved extraction of all first permanent premolars followed by
    upper and lower fixed appliances. Intrusion of the upper incisors with controlled labial crown torque was
    accomplished with mini-implant anchorage placed bilaterally on the infrazygomatic crests with the retraction
    forces above the centre of resistance using 0.019x0.025-in stainless steel archwire in 0.022-in slot. The
    0.019x0.025-in stainless steel archwire in 0.022-in slot provided the vertical play to favour lingual crown
    tipping despite having forces above the centre of resistance for concurrent anterior segment intrusion.
    Matched MeSH terms: Gingiva
  12. Ong, A.H.
    Ann Dent, 1997;4(1):-.
    MyJurnal
    The palatal root of the first permanent molar is the most commonly deflected root into the maxillary sinus during extraction. A rational approach to the surgical removal of a root from the antrum is important. Some surgeons prefer the alveolar approach while others prefer the Caldwell-Luc operation. A case is presented where the palatal root tip of the left upper first molar was removed from the maxillary sinus by the Caldwell-Luc approach with simultaneous closure of the oro-antral fistula resulting from dental extraction. A fibreoptic light probe was used. The advantages and disadvantages as well as how to avoid the common complications of this surgical technique are discussed. A good result was achieved with successful removal of the root and no loss of sensibility of the teeth and/or gum for this case.
    Matched MeSH terms: Gingiva
  13. Norhidayah, Khamiza
    Malaysian Dental Journal, 2008;29(2):154-157.
    MyJurnal
    Abscess of the periodontium is a localized purulent inflammation of the periodontal tissues1. It has been classified into three categories which are gingival abscess, periodontal abscess and pericoronal abscess. A periodontal abscess can be defined as a localized purulent infection affecting the tissues surrounding a periodontal pocket that can lead to the destruction of supporting structures4 including tortuous periodontal pockets, furcation involvement, and intrabony defects. The lesion may be acute or chronic abscess. A localized acute abscess may progress to a chronic abscess if the pus drains through a fistula into the outer gingival surface or into the periodontal pocket. (Copied from article).
    Matched MeSH terms: Gingiva; Gingival Diseases
  14. Chopra A, Sivaraman K, Thomas BS
    Gerodontology, 2017 Jun;34(2):280-283.
    PMID: 27435832 DOI: 10.1111/ger.12246
    OBJECTIVE: The aim of the article is to highlight the distinguishing features of secondary varicella gingival infection in an older women.

    BACKGROUND: Herpes zoster is an acute sporadic, painful viral infection in older people caused by the reactivation of the latent varicella zoster virus. Herpes zoster affecting the gingiva without any dermal lesions is a rare pathological condition that mimics many intraoral vesiculobullous lesions. The ambiguous nature of this condition creates a diagnostic dilemma.

    MATERIALS AND METHODS: A 58-year-old woman presented with an acute, unilateral and persistent burning sensation and pain in the gingiva with desqaumating vesicullobulous lesion.

    RESULTS: The women was diagnosed with secondary varicella zoster infection.

    CONCLUSION: Herpes zoster of the gingiva could manifest as painful desquamative vesicular lesions, pulpal or other painful neuralgic condition in older individuals which need careful diagnosis before formulating appropiate treatment plan.

    Matched MeSH terms: Gingiva
  15. Habilla, C., Sim, S.Y., Nor Aziah, Cheng, L.H.
    MyJurnal
    In this study, acid-thinned starch was blended with konjac glucomannan or psyllium husk powder at a concentration of 3% w/w (starch basis). The blends were characterized by pasting analysis and rheological
    properties evaluation. Jelly candy was made from the blends and textural characteristics were studied. Pasting analysis showed that both gums were found to significantly increase some of the pasting parameters, such as peak viscosity, trough, breakdown, final viscosity and setback values. From the frequency sweep, it was found that addition of konjac glucomanan or psyllium husk powder increased the storage modulus (G’) and loss modulus (G’’) values, with psyllium added sample showing more prominent effect than konjac added ones, when compared to the control samples. All samples were found to demonstrate thixotropic flow behaviour. Jelly candy texture profile analysis revealed that konjac glucomannan or psyllium husk powder addition, although decreasing chewability, but rendered the jelly candy less sticky.
    Matched MeSH terms: Gingiva
  16. Tengku Kamalden, T.A., Nurliza, K., Haris, A.R.
    JUMMEC, 2008;11(1):30-32.
    MyJurnal
    The presenting signs of acute leukaemia occur as a result of bone marrow failure and organ infiltration. Increased bleeding tendencies are seen on the skin, gums and mucosal lining. Bleeding in the posterior segment of the eye, namely the retina and vitreous, may occur, but do not usually cause any visual disturbances. This case demonstrates visual loss as a result of premacular subhyaloid haemorrhage in acute leukaemia.
    Matched MeSH terms: Gingiva
  17. Shaju P Jacob, Sonia Nath
    MyJurnal
    Preclinical drug testing is an important area in new drug development where animals are used. An ideal animal model for this is one which is simple, reliable and can be extrapolated to humans. Topical drugs for inflammation are conventionally tested on the skin of animals after induction of inflammation. A gingival model would be simple as inflammation can be induced naturally by the action of plaque. Rats are a popular animal model for testing drugs as well as to study various diseases of the periodontium. Periodontal disease including gingival inflammation develops in
    rats in relation to indigenous plaque or experimentally induced bacterial products. A number of features of rats ranging from anatomy, histology and response to bacterial insult can be seen mirrored to a great extent in humans. There is a lot similarity in the development and resolution of inflammation as well as the gingival wound healing of rats and humans. This paper tries to explore the feasibility of using the rat gingival model for preclinical testing of drugs acting on or influencing inflammation and concludes by identifying potential areas of research using this model. The addition of such a simple and inexpensive model for preclinical testing of drugs will be welcomed by the drug developers.
    Matched MeSH terms: Gingiva
  18. Sim, S.Y., Noor Aziah, A.A., Teng, T.T., Cheng, L.H.
    MyJurnal
    The effects of food gums addition on wheat dough freeze-thaw and frozen storage stability were studied. Thermal and dynamic mechanical properties of frozen wheat dough without yeast addition were
    determined by means of Differential Scanning Calorimetry (DSC) and Dynamic Mechanical Analysis (DMA).
    DSC results revealed that food gums showed the ability to increase freeze-thaw stability in frozen-stored
    samples wherein lower difference in melting enthalpy between first and second freeze-thaw cycle was shown. Based on DMA results, in general, difference between Tg’ and storage temperature (- 18°C) of dough became smaller upon addition of food gums. This may have a practical implication whereby the unfrozen phase could be better protected against physical degradation.
    Matched MeSH terms: Gingiva
  19. Menon BS, Teh KH
    N Engl J Med, 2021 Feb 25;384(8):744.
    PMID: 33626603 DOI: 10.1056/NEJMicm2026082
    Matched MeSH terms: Gingiva/drug effects; Gingiva/pathology*
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