Displaying publications 1 - 20 of 59 in total

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  1. Visayaragawan N, Selvarajah N, Apparau H, Kamaru Ambu V
    Med J Malaysia, 2017 08;72(4):248-249.
    PMID: 28889139 MyJurnal
    The diagnostic challenge of Bohring-Opitz Syndrome, a rare genetic disorder has haunted clinicians for ages. Our patient was born at term via caesarean-section with a birth weight of 1.95 kilograms. She had mild laryngomalacia, gastroesophageal reflux disease and seizures. Physical signs included microcephaly, hemangioma, low set ears, cleft palate, micrognatia and the typical BOS posture. Chromosomal analysis showed 46 xx -Bohring-Opitz Syndrome overlapped with C- syndrome. Goal-directed holistic care with integration of parent/carer training was started very early. She succumbed to a Respiratory- Syncitial-Virus and Pseudomonas pneumonia complicated with sepsis at the age of two years and 11 months.
    Matched MeSH terms: Intellectual Disability/complications; Intellectual Disability/diagnosis; Intellectual Disability/genetics*; Intellectual Disability/therapy
  2. Sardharwalla IB, Lingam S, Harvey DR
    Arch Dis Child, 1988 Jun;63(6):672-3.
    PMID: 3389904
    Matched MeSH terms: Intellectual Disability/diagnosis; Intellectual Disability/prevention & control*
  3. Yip MY, Yong HS, Dhaliwal SS
    Med J Malaysia, 1978 Jun;32(4):316-20.
    PMID: 732631
    Matched MeSH terms: Intellectual Disability/genetics
  4. George R, Hoi Sen Y, Lim G, Boo LJ
    Med J Malaysia, 1975 Dec;30(2):83-7.
    PMID: 1228386
    Matched MeSH terms: Intellectual Disability/diagnosis*; Intellectual Disability/epidemiology; Intellectual Disability/rehabilitation
  5. Azimah Hussain, Poole C
    To evaluate the correlation of the intragranular textures on the physical properties of coarse aggregates, four aggregates samples consisting of three granitoid sources and one limestone have been studied. The role played by intragranular textures (mineral assembladge, grain size and grain boundaries) in influencing the physical properties are potentially significant to the fact that such textural variation may complicate the aggregate strength. This study indicates that the aggregates exhibited variation in textural habits. The granitoid aggregates, which is rich with silicate composition has typical heterogranular textures of porphyritic and equigranular grain structures. Whereas the limestone aggregate comprises of bioclast and peloid allochems cemented by micrite and spar. The granitoid aggregates showed better dispersed characters and had extremely interlocking crystal boundaries which have more physical strength compared to a carbonate aggregate.
    Matched MeSH terms: Intellectual Disability
  6. Vignaendra V, Raju L, Lee C, Ghee T
    PMID: 1051827
    Matched MeSH terms: Intellectual Disability/complications
  7. Pang NT, Masiran R
    BMJ Case Rep, 2017 Mar 08;2017.
    PMID: 28275020 DOI: 10.1136/bcr-2016-218738
    A young man presented with high libido for 3 years, associated with preoccupation with sexual thoughts combined with his pursuit of pornographic materials. He had strong psychological cravings for and had spent large amount of money on sex, resulting in a dispute with his family. There were no mood or psychotic symptoms. Medical history revealed recent diagnosis of gonococcal urethritis. Cognitive assessment showed subtle deficiencies in reasoning and executive functions. There was occasional use of alcohol. Sexual addiction with comorbid mild intellectual disability was diagnosed, and pharmacological as well as psychological management were started.
    Matched MeSH terms: Intellectual Disability/complications*
  8. Hao Y, Razman R
    Front Public Health, 2023;11:1056191.
    PMID: 38026269 DOI: 10.3389/fpubh.2023.1056191
    BACKGROUND: Physical education (PE) class is an excellent way to improve moderate-to-vigorous intensity physical activity (MVPA). Increasing number of research has explored the children's PA based on movement during PE classes, but data for children with intellectual disability (ID) is still lacking.

    PURPOSE: The purpose of this study was to investigate the current status of MVPA levels of children with ID during PE classes in China, as well as differences of MVPA levels according to gender and grade.

    METHODS: Accelerometers were used to record MVPA levels of fifty-three children with severe ID from 9 to 16 years of age (mean age: 12.60 ± 1.66 years) during standard PE classes.

    RESULTS: The mean time spent in MVPA during PE classes was 8.00 ± 2.10 min, meaning only 22.88% of PE class time was spent in MVPA. As grade levels progresses, time spent in MVPA during PE classes tended to decrease; the fourth-grade children tended to spend more time in MVPA during PE classes compared with the fifth-grade and the sixth-grade (9.15 vs. 7.61 vs. 7.25 min, all p 

    Matched MeSH terms: Intellectual Disability*
  9. Che Aziz Ali, Kamal Roslan Mohamed
    Sains Malaysiana, 1996;25(4):47-68.
    The Kodiang Formation which outcrops in Kodiang and Alor Setar areas has been well studied and documented. Various geological aspects of the limestone formation have been reported in detail including its stratigraphy, sequence startigraphy, sedimentology and paleontology. Diagenetic aspect of this rock formation, however, had not been specifically discussed before. The Kodiang limestone has undergone a complicated diagenetic history which started immediately after the sediments were laid down on the sea bed. Various diagenetic products have been identified including, early marine cement, meteoric cement, and deeper subsurface cement. The diagenetic features identified are as follows; Fibrous calcite cement, sparry and poikilotopic calcites, calcite overgrowth, dolomite, silica cements and evaporites. Close examination at outcrops shows that dolomite occurs at several levels in the sequence. Their systematic occurrences can be correlated across the area. Petrographic studies show that dolomite occurs in several modes as stratified dolomite and as non-stratified dolomite. The two dolomite groups are attributed to two phases of dolomitizations. The stratified dolomites are interpreted to have been formed early in the limestone diagenetic history. The non-stratified dolomite type is, however, attributed to dolomitization during deep burial under the control of deeper subsurface physico-chemical conditions.
    Batu Kapur Kodiang yang tersingkap di Kodiang dan Alor Setar telah banyak dikaji dan didokumentasikan. Berbagai aspek geologi formasi batu kapur ini telah dilaporkan termasuk stratigrafi, startigrafi jujukan, sedimentologi dan paleontologi. Walau bagaimanapun aspek diagenesis formasi batuan ini tidak pernah dibincangkan secara khusus. Batu kapur Kodiang ini telah melalui sejarah diagenesis yang rumit yang bermula sebaik saja sedimen dimendapkan di atas permukaan dasar laut. Berbagai hasil diagenesis telah dikenal pasti termasuk penyimenan samudera awal, penyimenan meterorik dan penyimenan di bawah permukaan yang lebih dalam. Secara asas fitur-fitur yang dikenalpasti adalah seperti berikut; simen kalsit berserat, kalsit spar dan poikilotopik, tumbuhlampau kalsit, dolomit, simen silika dan evaporit. Pemeriksaan rapi pada singkapan menunjukkan dolomit hadir pada beberapa aras di dalam jujukan. Kehadirannya secara bersistematik boleh dikorelasikan pada setiap singkapan. Kajian petrografi menunjukkan dolomit wujud dalam berbagai mod yang boleh diklaskan sebagai dolomit berstrata dan dolomit tidak berstrata. Dua klas ini boleh dikaitkan dengan dua fasa pendolomitan. Dolomit berstrata ditafsirkan telah terbentuk awal di dalam sejarah diagenesis batu kapur. Dolomit tidak berstrata pula dikaitkan dengan pendolomitan semasa timbusan dalam di bawah keadaan fiziko-kimia bawah permukaan.
    Matched MeSH terms: Intellectual Disability
  10. MyJurnal
    This paper is interested in exploring the interrelatedness of some accompanying policy changes and
    initiatives in the selected Asian countries as well as reviewing the Malaysian National Food Security Policy. Actions taken in response to the food crisis in the selected Asian countries have worked out well and produced promising outcomes from a combination of availability, accessibility, utilization, and stability aspects in food security. Malaysia weighted more on availability aspect in food security by introducing more short- and longterm policy measures for boosting paddy and rice production, particularly in Sabah and Sarawak under the National Food Security Policy. However, much of the unhappiness and disequilibrium in the local paddy and rice market were created due to irrational extensive intervention of the Miller Subsidy and Beras Nasional programmes in the nation. Many of the policy measures targeted at area expansion and productivity but it was suggested that the dominant path to achieve the targeted self-sufficiency level is through research and development at specialized and committed paddy and rice research centre. Trade oriented self-reliance approach that strategized with multiple and diversified sources of rice import was tipped to be superior of current selfsufficiency approach.
    Matched MeSH terms: Intellectual Disability
  11. Stein Z, Durkin M, Belmont L
    Ann N Y Acad Sci, 1986;477:8-21.
    PMID: 3468840
    In this paper we first present methods and preliminary results of pilot surveys of "serious" mental retardation (IQ less than or equal to 55); the surveys included screening and diagnostic components and were carried out in the less-developed world. Next we discuss two problems raised by these surveys: one is the diagnosis of a case and its clinical dimensions, and the other is the interpretation of prevalence. In the next section we illustrate epidemiological approaches to the analysis of such data, in particular their relevance to prevention. Lastly, we propose that the two-stage survey approach developed in the course of the pilot work can provide a valuable basis for planning and prevention, if certain key conditions can be met.
    Matched MeSH terms: Intellectual Disability/etiology; Intellectual Disability/epidemiology*
  12. Paul FM
    Med J Malaysia, 1982 Dec;37(4):357-61.
    PMID: 6300621
    Consideration. is gzven to the recognition and prevention of carious types of mental retardation due to hazards of environmental origin. Observations are presented on congenital syphilis, congenital toxoplasmosis, congenital rubella, Singapore kernicterus, Japanese B encephalitis, and tuberculous meningitis. Appropriate preventiue measures have resulted in a significant reduction in Singapore of these conditions, and hence in a decreased frequency of environmentally determined mental retardation. and related disabilities.
    Matched MeSH terms: Intellectual Disability/etiology*; Intellectual Disability/prevention & control
  13. Tsuchida N, Nakashima M, Miyauchi A, Yoshitomi S, Kimizu T, Ganesan V, et al.
    Clin Genet, 2018 02;93(2):266-274.
    PMID: 28556953 DOI: 10.1111/cge.13061
    The seizure threshold 2 (SZT2) gene encodes a large, highly conserved protein that is associated with epileptogenesis. In mice, Szt2 is abundantly expressed in the central nervous system. Recently, biallelic SZT2 mutations were found in 7 patients (from 5 families) presenting with epileptic encephalopathy with dysmorphic features and/or non-syndromic intellectual disabilities. In this study, we identified by whole-exome sequencing compound heterozygous SZT2 mutations in 3 patients with early-onset epileptic encephalopathies. Six novel SZT2 mutations were found, including 3 truncating, 1 splice site and 2 missense mutations. The splice-site mutation resulted in skipping of exon 20 and was associated with a premature stop codon. All individuals presented with seizures, severe developmental delay and intellectual disabilities with high variability. Brain MRIs revealed a characteristic thick and short corpus callosum or a persistent cavum septum pellucidum in each of the 2 cases. Interestingly, in the third case, born to consanguineous parents, had unexpected compound heterozygous missense mutations. She showed microcephaly despite the other case and previous ones presenting with macrocephaly, suggesting that SZT2 mutations might affect head size.
    Matched MeSH terms: Intellectual Disability/genetics*; Intellectual Disability/pathology
  14. Nakashima M, Tohyama J, Nakagawa E, Watanabe Y, Siew CG, Kwong CS, et al.
    J Hum Genet, 2019 Apr;64(4):313-322.
    PMID: 30655572 DOI: 10.1038/s10038-018-0559-z
    Casein kinase 2 (CK2) is a serine threonine kinase ubiquitously expressed in eukaryotic cells and involved in various cellular processes. In recent studies, de novo variants in CSNK2A1 and CSNK2B, which encode the subunits of CK2, have been identified in individuals with intellectual disability syndrome. In this study, we describe four patients with neurodevelopmental disorders possessing de novo variants in CSNK2A1 or CSNK2B. Using whole-exome sequencing, we detected two de novo variants in CSNK2A1 in two unrelated Japanese patients, a novel variant c.571C>T, p.(Arg191*) and a recurrent variant c.593A>G, p.(Lys198Arg), and two novel de novo variants in CSNK2B in Japanese and Malaysian patients, c.494A>G, p.(His165Arg) and c.533_534insGT, p.(Pro179Tyrfs*49), respectively. All four patients showed mild to profound intellectual disabilities, developmental delays, and various types of seizures. This and previous studies have found a total of 20 CSNK2A1 variants in 28 individuals with syndromic intellectual disability. The hotspot variant c.593A>G, p.(Lys198Arg) was found in eight of 28 patients. Meanwhile, only five CSNK2B variants were identified in five individuals with neurodevelopmental disorders. We reviewed the previous literature to verify the phenotypic spectrum of CSNK2A1- and CSNK2B-related syndromes.
    Matched MeSH terms: Intellectual Disability/genetics; Intellectual Disability/physiopathology
  15. Khalid Z, Fisal N, Rozaini M
    Sensors (Basel), 2014;14(12):24046-97.
    PMID: 25615737 DOI: 10.3390/s141224046
    Wireless Sensor Network (WSN) is leading to a new paradigm of Internet of Everything (IoE). WSNs have a wide range of applications but are usually deployed in a particular application. However, the future of WSNs lies in the aggregation and allocation of resources, serving diverse applications. WSN virtualization by the middleware is an emerging concept that enables aggregation of multiple independent heterogeneous devices, networks, radios and software platforms; and enhancing application development. WSN virtualization, middleware can further be categorized into sensor virtualization and network virtualization. Middleware for WSN virtualization poses several challenges like efficient decoupling of networks, devices and software. In this paper efforts have been put forward to bring an overview of the previous and current middleware designs for WSN virtualization, the design goals, software architectures, abstracted services, testbeds and programming techniques. Furthermore, the paper also presents the proposed model, challenges and future opportunities for further research in the middleware designs for WSN virtualization.
    Matched MeSH terms: Intellectual Disability
  16. Tan AP
    Med J Malaysia, 2013 Dec;68(6):482-9.
    PMID: 24632922
    Down syndrome (Trisomy 21) is the most common chromosomal abnormality among liveborn infants. It is the most frequent form of intellectual disability caused by a microscopically demonstrable chromosomal aberration. Management requires a multidisciplinary approach to the ongoing evaluation and monitoring for associated congenital anomalies and acquired disorders.Trisomy 21 is characterized by a variety of dysmorphic features, congenital anomalies and associated medical conditions. Knowledge of these associated conditions are important for clinicians involved in the management of these patients. Appropriate radiologic imaging with prompt, accurate interpretation plays an important role in the diagnosis and management of these diseases. The primary goal of this pictorial review is to unravel the radiological findings of these associated conditions.
    Matched MeSH terms: Intellectual Disability
  17. Najwa Hanim Md Rosli, Badi’ah Yahya, Abdul Kadir Abu Bakar
    MyJurnal
    Objectives: This paper aims to discuss the issue related to the application of temporary insanity plea through a case report of a man who was earlier certified as mentally sound following a murder and suicide attempt. Methods: We report a man who committed murder and attempted suicide 7 years ago, had a psychiatric certification of not having mental illness and recently requested for a second psychiatric assessment. The factors taken into consideration in arriving at the final diagnosis are discussed. Results:The man was found to have brief psychotic disorder precipitated by psychological blow and sleep deprivation with underlying undiagnosed borderline mental retardation.Conclusion: In assessing patient with
    temporary insanity plea, various areas in the history need to be explored deeply with thorough investigations to be done in order to arrive at a fair conclusion for the patient’s and victim’s sake.
    Matched MeSH terms: Intellectual Disability
  18. Ek Zakuan Kalil, Tan, Susan M.K., Loh, Sit Fong, Norazlin Kamal Nor, Suzaily Wahab
    ASEAN Journal of Psychiatry, 2010;11(2):216-219.
    MyJurnal
    Objective: This case report highlights males as victims of sexual abuse, ascertain the factors that are associated with male sexual abuse and outline problems in management of sexual abuse with the presence of co morbidities. Methods: We report a case of sexual abuse in a 14 year old boy who has borderline mental retardation and ADHD. Results: The victim was
    traumatized due to the abuse. The perpetrator was not charged due to lack of evidence of the abuse and stigma. Conclusion: Sexual abuse that occurs in males can be influenced by multiple factors such as the presence of comorbidities. Strong awareness must be present in caregivers to prevent abuse in this population and to take appropriate and early action to effect the necessary intervention.
    Matched MeSH terms: Intellectual Disability
  19. Lim, Kuang Kuay, Chan, Ying Ying, Ahmad Ali Zainuddin, Teh, Chien Huey, Rusidah Selamat, Kee, Chee Cheong, et al.
    Int J Public Health Res, 2013;3(1):198-203.
    MyJurnal
    Iodine deficiency is still prevalent worldwide and it is the main cause of goiter, thyroid dysfunction and mental retardation. The aim of the study was to determine the iodine status and goiter prevalence among the school children in Terengganu. The representative sample consists of 1163 primary school children aged 8-10 years old randomly selected from urban and rural schools in Terengganu using stratified systematic random sampling technique. Urinary iodine levels in spot urine were determined by in house modified micro-method while goiter assessment was carried out by palpation of thyroid gland. The status of iodine deficiency was determined by the median urinary iodine concentrations (UIC) and total goiter prevalence (TGP) in accordance with the WHO criteria. The result showed the median [inter-quartile range (IQR)] urinary iodine concentrations was 78.7µg/L (50.1µg/L -120.0µg/L) indicating the iodine intake was slightly lower than recommended range of 100 µg/L. The rural school children had a significantly lower Iodine levels (median UIC=72.4µg/L, IQR=46.7µg/L -113.0µg/L) than the urban school children (median UIC=87.7µg/L, IQR=54.5 µg/L - 127.5µg/L). The total goiter prevalence (TGP) was 5.7%. The prevalence of goiter was significantly higher in rural (TGP=6.9%) compared to urban areas (TGP=3.6%). The study revealed that school children in Terengganu showed mild iodine deficiency and the condition is more pronounced in children from rural areas. The findings emphasize the importance of intervention implementation, universal salt iodization to ensure sufficient intake of iodine among the Terengganu school children.
    Matched MeSH terms: Intellectual Disability
  20. Vaithilingam, R.D., Mahmood, R.
    Ann Dent, 2009;16(1):37-42.
    MyJurnal
    The presence of macroglossia, a tendency towards poor cooperation and the inability to adapt to compl~te dental prostheses due to motor and mental deficiencies makes the oral rehabilitation of Down Syndrome patients difficult. This article reports on the use of mini implant supported overdenture to rehabilitate a Down Syndrome patient who had difficulty adapting to his new mandibular complete denture. The patient's ability to cooperate during treatment as well as the maintenance of an optimal oral hygiene practice enabled mini-implants to be inserted and maintained 20 months post insertion as evidenced by clinical and radiological findings. To the author's knowledge, this is the first reporting of a successful mini implant supported overdenture in a Down Syndrome patient.
    Matched MeSH terms: Intellectual Disability
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