Displaying publications 1 - 20 of 372 in total

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  1. Management of lymphoma: current approach
    Ng SC
    Family Physician, 1991;3:16-19.
    Matched MeSH terms: Lymphoma
  2. Eosinophilic myocarditis mimicking acute coronary syndrome in a young man with T-lymphoblastic lymphoma and hypereosinophilia
    Raffali MAA, Boon Cong B, Muhammad SF, Che Hassan HH
    BMJ Case Rep, 2023 Sep 25;16(9).
    PMID: 37748814 DOI: 10.1136/bcr-2023-255396
    A man in his 20s with underlying chemorefractory primary T-lymphoblastic lymphoma and hypereosinophilia developed acute chest pain in the ward after readmission for disease progression. ECG showed widespread ST depression and serum troponin was markedly elevated. Transthoracic echocardiography showed diffused thrombus deposition with preserved ejection fraction consistent with eosinophilic myocarditis. The patient ultimately succumbed to the disease, after complications with severe hospital-acquired pneumonia.
    Matched MeSH terms: Lymphoma, Non-Hodgkin*; Precursor Cell Lymphoblastic Leukemia-Lymphoma*; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*
  3. An interesting case of lymphosarcoma
    MAYCOCK H
    Med J Malaya, 1956 Mar;10(3):246-50.
    PMID: 13347455
    Matched MeSH terms: Lymphoma*; Lymphoma, Non-Hodgkin*
  4. Hodgkin's disease
    Webster JS
    Journal of the Malaya Branch of the British Medical Association, 1938;2:12-8.
    Matched MeSH terms: Lymphoma
  5. Fulltext Primary bone lymphoma: report of a case with multifocal skeletal involvement
    Rahmat K, Wastie M, Abdullah B
    Biomed Imaging Interv J, 2007 Oct;3(4):e52.
    PMID: 21614300 MyJurnal DOI: 10.2349/biij.3.4.e52
    Primary bone lymphoma is an uncommon tumour accounting for approximately 4-5% of extra nodal lymphoma and less than 1% of all Non-Hodgkin's lymphoma. The radiographic appearance of primary bone lymphoma is variable. As lesions frequently resemble other disease processes namely chronic osteomyelitis and metastases, further imaging evaluation and histopathological examination allow early identification for appropriate treatment. The authors present a case of anaplastic large cell lymphoma of bone presenting with multifocal osseus involvement.
    Matched MeSH terms: Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic
  6. Fulltext Acquired immunodeficiency syndrome presenting as childhood non-Hodgkin's lymphoma
    Lee WS, Chan TL, Koh MT, Ariffin WA, Lin HP
    Singapore Med J, 2001 Nov;42(11):530-3.
    PMID: 11876380
    Two children with non-Hodgkin's lymphoma (NHL) as the presenting illness of acquired immunodeficiency syndrome (AIDS) are described. There was a delay in diagnosing the underlying AIDS in both cases. In the first case, an 18-month-old boy with stage IV, high-grade,T-cell NHL, the diagnosis of underlying AIDS was suspected only when he developed recurrent and profound opportunistic infection during chemotherapy. The second case, an eight-month-old female infant presented initially with hepatosplenomegaly and thrombocytopenia of undetermined cause. She had progressive abdominal distension and swelling of her right eye one year later due to high grade B-cell NHL. She was later found to be sero-positive for HIV during pre-chemotherapy screening. As the prevalence of HIV infection continues to increase, HIV infection should be considered in the differential diagnoses of childhood hepatosplenomegaly and thrombocytopenia, and as a possible underlying cause of childhood cancer, especially NHL.
    Matched MeSH terms: Lymphoma, Non-Hodgkin/etiology*; Lymphoma, B-Cell/etiology*; Lymphoma, T-Cell/etiology*; Lymphoma, AIDS-Related/etiology*
  7. Lymphoma: an introduction into historical background, classification schemes, aetiology, geographical variation and epidemiological trend
    Peh SC, Poppema S
    Malays J Pathol, 2001 Dec;23(2):49-63.
    PMID: 12166593
    Matched MeSH terms: Lymphoma/classification*; Lymphoma/history; Lymphoma/epidemiology; Lymphoma/virology*; Lymphoma, Non-Hodgkin/classification
  8. Waldeyer ring lymphoma: a case series
    Teh CS, Jayalakshmi P, Chong SY
    Ear Nose Throat J, 2014 Sep;93(9):E22-5.
    PMID: 25255354
    We encountered a patient with a tongue base lymphoma that we initially diagnosed as a lingual tonsil in view of its benign appearance. We established the correct diagnosis of Waldeyer ring lymphoma by histology. This case led us to conduct a study of all cases of Waldeyer ring lymphoma that had been treated at our center during a 10-year period. We retrospectively examined our case records and found 35 such cases. From this group, we excluded 5 cases because of incomplete data. Thus our final study group was made up of 30 patients-14 males and 16 females, aged 14 to 76 years (mean: 51.6; median 54). The primary presenting signs and symptoms were dysphagia (n = 17 [57%]), a neck mass (n = 7 [23%]), nasal symptoms (n = 5 [17%]), and pain (n = 1 [3%]). Only 4 patients (13%) had B symptoms. A total of 20 patients (67%) presented with tonsillar involvement, 8 (27%) with nasopharyngeal involvement, 1 (3%) with tongue base lymphoma, and 1 with anterior tongue involvement. Most patients (77%) presented at an early stage. Histologically, 25 patients (83%) had high-grade diffuse large B-cell lymphoma, 4 (13%) had T-cell lymphoblastic lymphoma, and 1 (3%) had follicular lymphoma. Twenty-one patients (70%) were treated with chemotherapy, 4 (13%) received adjuvant chemotherapy with either radiotherapy or surgery, 3 (10%) resorted to other forms of treatment (primarily traditional remedies), and 2 (7%) declined treatment altogether. There were 14 patients (47%) alive at the end of the study period.
    Matched MeSH terms: Lymphoma/diagnosis*; Lymphoma/pathology; Lymphoma, Follicular/diagnosis; Lymphoma, Follicular/pathology; Lymphoma, T-Cell/diagnosis; Lymphoma, T-Cell/pathology; Lymphoma, Large B-Cell, Diffuse/diagnosis; Lymphoma, Large B-Cell, Diffuse/pathology
  9. Fulltext Clinical Characteristics and Treatment Outcome of Gastrointestinal Non-Hodgkin's Lymphoma
    Praveen S, Ho CC, Fadilah S, Sagap I
    Med J Malaysia, 2010 Jun;65(2):98-100.
    PMID: 23756789
    Primary gastrointestinal (GIT) lymphoma constitutes only 5 - 10% of all gastrointestinal tumours. The optimal therapy for these lymphomas is poorly defined and still controversial. We present our experience in the treatment and outcome of primary GIT lymphomas in UKM Medical Center, Malaysia. A retrospective review of all patients with primary GIT lymphoma from the year 2002 until 2007 was done. Our series has shown that primary GIT lymphoma is a rare disease as it comprises only 6.5% of all lymphomas treated in this institution. We had a female predominance of this disease with a large majority at an advanced stage of the disease. There was equal distribution involving stomach, small and large intestines. The incidence of primary GIT lymphomas was 6.5% with a female predominance. The majority had advanced diseases (stage III and IV) with equal distribution involving the stomach, small and large intestines. The most common histological variant was diffuse large B cell lymphoma (66%). Most (83%) patients with intestinal lymphoma had surgical resection and adjuvant chemotherapy. All patients with gastric lymphomas had chemotherapy alone. The mortality rate was 22% predominantly in younger patients with aggressive histology subtypes and advanced disease.
    Matched MeSH terms: Lymphoma, Non-Hodgkin*; Lymphoma, Large B-Cell, Diffuse
  10. Fulltext Primary Burkitt lymphoma of the ovary
    Ng SP, Leong CF, Nurismah MI, Shahila T, Jamil MA
    Med J Malaysia, 2006 Aug;61(3):363-5.
    PMID: 17240592 MyJurnal
    A 20 year-old woman presented with features of a twisted ovarian cyst and had an emergency laparotomy Intraoperative findings revealed bilateral, solid ovarian tumors and a left oophorectomy with biopsy of the contralateral ovary performed. Histopathology report confirmed Burkitt lymphoma of ovary. There was no other evidence of lymphoma elsewhere. The primary Burkitt lymphoma of the ovaries was successfully managed with six courses of highly toxic chemotherapy (Berlin-Frankfurt- Munster 1986 protocol). The patient has remained disease free for the last 36 months.
    Matched MeSH terms: Burkitt Lymphoma/pathology*; Burkitt Lymphoma/surgery
  11. Fulltext Fundamentals of the management of non-Hodgkin lymphoma
    Fadilah SA
    Med J Malaysia, 2009 Dec;64(4):333-9; quiz 340.
    PMID: 20954564 MyJurnal
    The incidence of Non-Hodgkin's lymphomas (NHL) is rising worldwide and if not adequately treated carries a high mortality rate. The pattern and frequency of NHL vary in different populations and geographical regions. It has considerable biologic and clinical heterogeneity and a definitive diagnosis can be made only after histopathogical examination. The histology and the extent of the lymphoma are the major determinants of optimal therapeutic regimen and treatment outcome. Additionally, the overall treatment strategies should be tailored according to medical status and preference of the patient. A holistic approach provided by a multi-disciplinary team of health care professionals is the cornerstone of ensuring successful treatment outcome. Importantly, therapy should be expedited and where possible performed in experienced centers. Patients achieving remission would require long-term monitoring for disease recurrence and late effects of cytotoxic chemotherapy and radiotherapy. Hence, clinicians should have a fundamental understanding in the biology and the principles of treatment of NHL. This review provides an evidence-based and systematic approach in designing therapeutic strategies for individual patients with newly diagnosed and relapsed NHL focusing on the common types of NHL with particular reference to the current practice within the local settings. The role of standard and novel therapeutic modalities in treatment will be summarized.
    Matched MeSH terms: Lymphoma, Non-Hodgkin/diagnosis; Lymphoma, Non-Hodgkin/etiology; Lymphoma, Non-Hodgkin/therapy*
  12. The spectrum of lymphoma in Malaysia: a histopathological study utilizing immunophenotyping
    Mancer K
    Malays J Pathol, 1990 Dec;12(2):77-88.
    PMID: 2102968
    A retrospective study was made to determine relative incidence of lymphoma subtypes in Malaysia. High grade non-Hodgkin's lymphoma was found to be common. Low grade non-Hodgkin's lymphoma and Hodgkin's disease were relatively rare in this Malaysian series. Non-Hodgkin's lymphoma of B-cell immunophenotype was four times as common as that of T-cell lineage. There was a high incidence of primary extranodal non-Hodgkin's lymphoma.
    Matched MeSH terms: Lymphoma/classification; Lymphoma/epidemiology*; Lymphoma/pathology
  13. Burkitt's lymphoma--long-term remission in a Malay girl
    Ramanathan K, Singh B
    Dent J Malaysia Singapore, 1971 Oct;11(2):7-11.
    PMID: 5290958
    Matched MeSH terms: Burkitt Lymphoma
  14. Host ethnicity influences non-Hodgkin's lymphoma subtype frequency and Epstein-Barr virus association rate: the experience of a multi-ethnic patient population in Malaysia
    Peh SC
    Histopathology, 2001 May;38(5):458-65.
    PMID: 11422484
    AIMS: The pattern of malignant lymphoma is known to vary in different populations. This study aims to elucidate the effect of ethnicity on subtype frequency of non-Hodgkin's lymphoma and EBV association rate.

    METHODS AND RESULTS: A total of 232 reconfirmed lymphoma cases in Malaysian patients were retrieved from the archives in the Department of Pathology, University Hospital, Kuala Lumpur. There were 24 (10%) Hodgkin's and 208 (90%) non-Hodgkin's lymphomas, 173 of the latter were in adult group (aged > or = 15 years). The ethnic composition were 41 Malays, 107 Chinese, 21 Indians and four none of the above. A male : female ratio of 2.4 : 1 was observed. Complete immunohistochemical studies in 158 cases revealed 36 (23%) T-cell, 121 (76%) B-cell and one (1%) null-cell phenotype. Seventy-five percent of the T-cell lymphomas were peripheral T/NK-cell types. Among the classifiable lesions, low-grade/indolent lymphomas constituted 17%: 2% were the lymphocytic subtype and 10% were follicular lymphomas. Approximately one-third of the follicular lymphomas occurred in Indian patients. The largest group of high-grade lymphoma was diffuse large B-cell type (46%), followed by peripheral T/NK-cell (18%). A predominance of NK/T-cell lymphomas occurred in Chinese (5/7), and all were EBV associated. Burkitt's lymphoma accounted for 5% (eight cases), all were Chinese males, with a 38% EBV-association rate. The frequency of EBV-associated B-cell lymphoma is three times more common in Chinese than Malays. The EBV positivity rate among lymphomas in ethnic Malay, Chinese and Indian patients was 5%, 15% and 22%, respectively, and in T- and B-cell lymphomas was 36% and 7%, respectively.

    CONCLUSIONS: This Malaysian series reveals differences in the subtype frequencies of non-Hodgkin's lymphomas and EBV association rate amongst patients of various ethnic groups residing in the same environment.

    Matched MeSH terms: Lymphoma, Non-Hodgkin/ethnology*; Lymphoma, Non-Hodgkin/virology; Lymphoma, B-Cell/ethnology; Lymphoma, B-Cell/metabolism; Lymphoma, B-Cell/virology; Lymphoma, T-Cell/ethnology; Lymphoma, T-Cell/metabolism; Lymphoma, T-Cell/virology
  15. Fulltext A rare case of primary extranodal laryngeal non hodgkin lymphoma
    Mark P., Najihah Hanim A., Eshamsol Kamar O., Suhaila A., Irfan M.
    International Medical Journal Malaysia, 2018;17(3):85-88.
    MyJurnal
    Lymphoma is generally a nodal disease and arises from lymphoid tissues or organs. Extranodal lymphoma accounts for almost a third of malignant lymphomas. Squamous cell carcinoma accounts for 90 % of laryngeal carcinoma, while extranodal Non Hodgkin Lymphoma (NHL) attributes only less than 1% of laryngeal neoplasms. Less than 100 of such cases been reported in literature since 1952. As to our best knowledge, no such case was ever reported in our country. We report a case of a 58-year-old gentleman who presented the typical history of laryngeal malignancy however the pathology turned out to be as NHLof Diffuse Large B-cell subtype.
    Matched MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin
  16. Fulltext The protective effects of antigen-specific IgY on pyocyanin-treated human lymphoma Raji cells
    Susilowati H, Artanto S, Yulianto HDK, Sosroseno W, Hutomo S
    F1000Res, 2019;8:1008.
    PMID: 32025288 DOI: 10.12688/f1000research.19327.2
    Background: Pyocyanin (PCN), a highly pathogenic pigment produced by Pseudomonas aeruginosa, induces caspase 3-dependent human B cell (Raji cells) death. The aim of the present study, therefore, was to assess whether antigen-specific IgY antibodies may be protective on PCN-induced Raji cell death. Methods: Chickens were subcutaneously immunized with Freund's complete adjuvant containing PCN, and then given two boosted immunizations.  Anti-PCN IgY antibodies were purified from egg yolk and detected using an agar gel precipitation test (AGPT) and ELISA. Protective effects of antigen-specific IgY on Raji cells were tested using a cell viability assay. Results: AGPT results showed the formation of strong immune complex precipitates, whilst ELISA further confirmed the presence of IgY antibodies specific to PCN at significant concentration. Further experiments showed that anti-PCN IgY antibodies significantly increased PCN-treated Raji cell viability in a dose-dependent fashion (p<0.05). Conclusions: The results of the present study suggest that anti-PCN IgY antibodies may be protective on PCN-induced Raji cell death.
    Matched MeSH terms: Lymphoma*
  17. Immunophenotyping of peroxidase-negative acute leukaemias using immunoalkaline phosphatase (APAAP) method
    Cheong SK, Lim YC, Ainoon O, Hamidah NH
    Malays J Pathol, 1991 Dec;13(2):119-21.
    PMID: 1823093
    Immunophenotyping of acute leukaemias has become an important diagnostic tool in haematology laboratories as it is now well recognised that the presence of certain surface markers has prognostic significance. In 1988, we experimented with the alkaline phosphatase anti-alkaline phosphatase (APAAP) method for immunophenotyping of leukaemic cells in our laboratory. 48 cases of peroxidase-negative acute leukaemias were studied. Our study showed that 2 peroxidase-negative cases carried myeloid surface markers, 44% were negative for the markers studied and 5% were unclassified due to technical problems. We concluded that the APAAP method is a useful technique for demonstrating cell markers in leukaemic cells as the reaction is reddish and usually intense. We failed to demonstrate surface markers in 44% of the cases probably because of the choice of a limited panel of monoclonal antibodies.
    Matched MeSH terms: Burkitt Lymphoma/classification*; Leukemia-Lymphoma, Adult T-Cell/classification*; Precursor Cell Lymphoblastic Leukemia-Lymphoma/classification*
  18. Extramedullary CD20-positive B-lymphoblastic lymphoma in a 5-year-old child: A diagnostic challenge
    Abdul Jalil D, Raja Sabudin RZA, Tang YL, Masir N
    Malays J Pathol, 2020 Aug;42(2):273-276.
    PMID: 32860381
    INTRODUCTION: Lymphoblastic leukaemia/lymphoma may present as an isolated extramedullary mass, which includes the musculoskeletal region involvement with normal or near-normal blood counts. The tumour may be in the form of B or T-lymphoblastic leukaemia/lymphoma. The clinical features and histological morphology of extramedullary B-lymphoblastic lymphoma (B-LBL) may mimic mature B-cell neoplasms, thus posing a diagnostic challenge. Arriving at the right diagnosis is crucial because these two diseases differ in their prognosis and management. A high index of suspicion is therefore important so as not to miss the correct diagnosis. The diagnosis may be overlooked because the clinical presentation may not be typical of B-LBL or the blood counts do not show any abnormalities. In this report, we highlight one such case where the diagnosis of B-LBL was missed because of its atypical presentation.
    Matched MeSH terms: Lymphoma, B-Cell/diagnosis; Lymphoma, B-Cell/pathology; Lymphoma, T-Cell/diagnosis; Lymphoma, T-Cell/pathology
  19. The expression of Bcl-2 by proliferating cells varies in different categories of B-cell lymphoma
    Masir N, Jones M, Lee AM, Goff LK, Clear AJ, Lister A, et al.
    Histopathology, 2010 Apr;56(5):617-26.
    PMID: 20459572 DOI: 10.1111/j.1365-2559.2010.03524.x
    To investigate the relationship between Bcl-2 protein expression and cell proliferation at single-cell level in B-cell lymphomas using double-labelling techniques.
    Matched MeSH terms: Lymphoma, Follicular/metabolism; Lymphoma, Follicular/pathology; Lymphoma, B-Cell/metabolism*; Lymphoma, B-Cell/pathology; Lymphoma, Large B-Cell, Diffuse/metabolism; Lymphoma, Large B-Cell, Diffuse/pathology; Lymphoma, B-Cell, Marginal Zone/metabolism; Lymphoma, B-Cell, Marginal Zone/pathology; Lymphoma, Mantle-Cell/metabolism; Lymphoma, Mantle-Cell/pathology
  20. Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia
    Lee YP, Yoon SE, Song Y, Kim SJ, Yoon DH, Chen TY, et al.
    Int J Hematol, 2021 Sep;114(3):355-362.
    PMID: 34302593 DOI: 10.1007/s12185-021-03179-7
    Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs. As part of a prospective registry study of peripheral T-cell lymphoma (PTCL) conducted across Asia, including Korea, China, Taiwan, Singapore, Malaysia, and Indonesia, subgroup analysis was performed for patients with CTCLs. Among 486 patients with PTCL, 37 with CTCL (7.6%) were identified between April 2016 and February 2019. Primary cutaneous ALK-negative anaplastic large cell lymphoma (ALCL, 35.1%) was the most common subtype. With a median follow-up period of 32.1 months, median progression-free survival (PFS) was 53.5 months (95% CI 0.0-122.5), and overall survival was not reached. 14 patients (48.2%) underwent subsequent treatment after the first relapse, but the response rate was 20% with a PFS of 2.2 months (95% CI 0.3-4.0). Six patients received autologous stem cell transplantation (auto-SCT). However, auto-SCT did not result in better outcomes. Additional studies are needed on standard care treatment of advanced or refractory and relapsed CTCLs.
    Matched MeSH terms: Lymphoma, T-Cell, Cutaneous/diagnosis; Lymphoma, T-Cell, Cutaneous/etiology; Lymphoma, T-Cell, Cutaneous/epidemiology*; Lymphoma, T-Cell, Cutaneous/therapy; Lymphoma, T-Cell, Peripheral/diagnosis; Lymphoma, T-Cell, Peripheral/etiology; Lymphoma, T-Cell, Peripheral/epidemiology; Lymphoma, T-Cell, Peripheral/therapy
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