Browse publications by year: 2011

  1. Abdul Kadir NB, Bifulco A
    Soc Psychiatry Psychiatr Epidemiol, 2011 Sep;46(9):853-62.
    PMID: 20556355 DOI: 10.1007/s00127-010-0249-4
    INTRODUCTION: The experiences of married and single mothers were compared in an investigation of psychosocial vulnerability, stress and depression in a community-based study of Moslem mothers in Malaysia. For the first time, a model of vulnerability-provoking agent originally developed by Brown et al. in the UK was tested in a Malaysian context.

    METHODS: A cross-sectional study was carried out in the district of Johor Bahru, Malaysia. Of the 1,200 women approached from membership of community associations, 1,002 (84%) completed the questionnaires. Severe life events Recent Life Events Questionnaire (Brugha and Cragg in Acta Psychiatr Scand 82:77-81, 1990) and psychosocial vulnerability (VDQ) (Moran et al. in Br J Clin Psychol 40:411-427, 2001) were used to measure vulnerability factors. Depression was measured by the General Health Questionnaire (GHQ-30) (Havenaar et al. in Soc Psychiatry Psychiatr Epidemiol 43:209-215, 2008).

    RESULTS: Single mothers had significantly higher rates of depression than those married (60.5 vs. 39.5%), as well as higher rates of severe life events and Negative Elements in Close Relationships (lack of support and conflict with children). However, married mothers had greater Negative Evaluation of Self. The two vulnerability factors were correlated to each other and to severe life events and social adversity. Logistic regression showed an interaction between severe life events in the material and relationship domains and joint vulnerability for depression outcome. The results are discussed in relation to the low recognition of psychosocial risks for depression in single mothers in Malaysia, as well as lack of appropriate services.

    MeSH terms: Adult; Cross-Sectional Studies; Depression/ethnology; Depression/psychology*; Divorce/psychology*; Female; Humans; Islam/psychology; Life Change Events; Malaysia/ethnology; Middle Aged; Mothers/psychology*; Surveys and Questionnaires; Single Parent/psychology*; Spouses/ethnology; Spouses/psychology*; Vulnerable Populations/ethnology; Vulnerable Populations/psychology
  2. Abdulla R, Chan ES, Ravindra P
    Crit Rev Biotechnol, 2011 Mar;31(1):53-64.
    PMID: 20572796 DOI: 10.3109/07388551.2010.487185
    The fuel crisis and environmental concerns, mainly due to global warming, have led researchers to consider the importance of biofuels such as biodiesel. Vegetable oils, which are too viscous to be used directly in engines, are converted into their corresponding methyl or ethyl esters by a process called transesterification. With the recent debates on "food versus fuel," non-edible oils, such as Jatropha curcas, are emerging as one of the main contenders for biodiesel production. Much research is still needed to explore and realize the full potential of a green fuel from J. curcas. Upcoming projects and plantations of Jatropha in countries such as India, Malaysia, and Indonesia suggest a promising future for this plant as a potential biodiesel feedstock. Many of the drawbacks associated with chemical catalysts can be overcome by using lipases for enzymatic transesterification. The high cost of lipases can be overcome, to a certain extent, by immobilization techniques. This article reviews the importance of the J. curcas plant and describes existing research conducted on Jatropha biodiesel production. The article highlights areas where further research is required and relevance of designing an immobilized lipase for biodiesel production is discussed.
    MeSH terms: Biotechnology/methods*; Catalysis; Esterification; Lipase/metabolism; Plant Oils/chemistry; Jatropha/metabolism*; Jatropha/chemistry; Biofuels*
  3. Rashid RA, Heidary F, Hussein A, Hitam WH, Rashid RA, Ghani ZA, et al.
    Burns, 2011 Feb;37(1):170-3.
    PMID: 20576358 DOI: 10.1016/j.burns.2010.05.019
    This study aims to describe the epidemiology of ocular burns and related injuries due to fireworks during the Aidil Fitri celebration on the East Coast of the Peninsular Malaysia. A prospective analysis of all patients with ocular burns and related injuries due to fireworks attended three tertiary hospitals in East Coast of Peninsular Malaysia during Aidil Fitri, which was from 10 September to 17 October 2008. We observed the demographic and injury characteristics, extent of the injuries and presenting visual symptoms. Thirty patients with 34 eyes with ocular burns and related injuries were identified. Patients ranged between 2 and 43 years of age. 70.00% of the patients were 12 years old and below. Of the 30 patients, 29 (96.67%) were male and the left eye was affected in 14 (46.70%). Thermal injuries accounted for 60.0% of the injuries whereas 40.0% were due to exploding firework. Burns to the eyelid and cornea (35.29%) were the most common injuries noted. Fifteen patients (50%) were bystanders whilst a majority of patients (96.67%) had no eye protection. At presentation, 15 (44.12%) eyes had a visual acuity of 6/6 to 6/9 in the injured eyes, while 3 out of 34 eyes (8.82%) had vision acuity 6/60 or worse. In conclusion, fireworks cause serious preventable ocular burns and related injuries especially in children who are the most affected age group. It affects mainly eyelid and anterior segment structures which result in moderate visual loss on presentation. Health education, public awareness and tighter legislation are essential preventive measures to limit the effect of fireworks to the public.
    MeSH terms: Adolescent; Adult; Blast Injuries/epidemiology*; Child; Child, Preschool; Explosions*; Eye Burns/etiology*; Eye Burns/epidemiology*; Female; Holidays; Humans; Malaysia/epidemiology; Male; Prospective Studies; Recreation; Visual Acuity; Incidence; Age Distribution; Sex Distribution; Young Adult
  4. Muhamad H, Ismail BS, Sameni M, Mat N
    Environ Monit Assess, 2011 May;176(1-4):43-50.
    PMID: 20582739 DOI: 10.1007/s10661-010-1565-6
    The adsorption equilibrium time and effects of pH and concentration of (14)C-labeled paraquat (1,1(')-dimethyl-4,4(')-bipyridylium dichloride) in two types of Malaysian soil were investigated. The soils used in the study were clay loam and clay soils from rice fields. Equilibrium studies of paraquat in a soil and pesticide solution were conducted. Adsorption equilibrium time was achieved within 2 h for both soil types. The amount of (14)C-labeled paraquat adsorbed onto glass surfaces increased with increasing shaking time and remained constant after 10 h. It was found that paraquat adsorbed by the two soils was very similar: 51.73 (clay loam) and 51.59 μ g g(-1) (clay) at 1 μ g/ml. The adsorption of paraquat onto both types of soil was higher at high pH, and adsorption decreased with decreasing pH. At pH 11, the amounts of (14)C-labeled paraquat adsorbed onto the clay loam and clay soil samples were 4.08 and 4.05 μ g g(-1), respectively, whereas at pH 2, the amounts adsorbed were 3.72 and 3.57 μ g g(-1), respectively. Results also suggested that paraquat sorption by soil is concentration dependent.
    MeSH terms: Adsorption; Agriculture*; Hydrogen-Ion Concentration; Paraquat/analysis*; Paraquat/chemistry*; Soil Pollutants/analysis*; Soil Pollutants/chemistry*
  5. Zyoud SH, Awang R, Sulaiman SA, Al-Jabi SW
    Fundam Clin Pharmacol, 2011 Jun;25(3):405-10.
    PMID: 20584210 DOI: 10.1111/j.1472-8206.2010.00831.x
    Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after acetaminophen overdose and to determine which clinical findings are most predictive of headache among these patients. This is a retrospective cohort study of hospital admissions for acute acetaminophen overdose that was conducted over a period of 4 years from January 1, 2005 to December 31, 2008. Demographic data, clinical characteristics, and predictors of headache were analyzed. spss 15 was used for data analysis. Two-hundred and fifty-five patients were studied; their mean age was 23.1 ± 1.6; 83.9% of them were women and 14.9% had a headache during hospitalization. Headache among patients was significantly associated with IV-NAC administration (P = 0.001), intentional ingestion of drug (P = 0.04), acetaminophen concentration above 'possible toxicity' treatment line (P = 0.04), a high acetaminophen concentration (P = 0.04), and a long hospital stay (P = 0.03). Multiple logistic regression showed a significant risk factor for headache in patients administered IV-NAC (P = 0.04). We recorded a high frequency of headache in patients with acute acetaminophen overdose in our geographical area. This study suggests that among those patients, the use of IV-NAC is associated with an increased risk of headache.
    MeSH terms: Acetaminophen/poisoning*; Acetylcysteine/administration & dosage*; Acetylcysteine/adverse effects*; Antidotes/administration & dosage; Antidotes/adverse effects; Female; Headache/chemically induced*; Hospitalization; Humans; Infusions, Intravenous; Male; Retrospective Studies; Risk Factors; Cohort Studies; Young Adult; Drug Overdose/drug therapy*
  6. Kanaheswari Y
    J Trop Pediatr, 2011 Apr;57(2):141.
    PMID: 20584719 DOI: 10.1093/tropej/fmq051
    MeSH terms: Adaptation, Physiological; Adolescent; Child; Female; Humans; Health Knowledge, Attitudes, Practice*; Malaysia; Male; Parent-Child Relations; Parents/psychology*; Surveys and Questionnaires; Urban Population; Nocturnal Enuresis/ethnology*; Nocturnal Enuresis/psychology
  7. Soong TK, Koh A, Subrayan V, Loo AV
    Graefes Arch Clin Exp Ophthalmol, 2011 Dec;249(12):1755-60.
    PMID: 20607549 DOI: 10.1007/s00417-010-1444-4
    PURPOSE: To describe the epidemiology of ocular injuries presenting to the University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.

    DESIGN: Prospective analysis of all ocular trauma injuries presenting to the Department of Ophthalmology in UMMC from 1 January 2008 to 31 December 2008.

    PARTICIPANTS: A total of 603 eyes of 546 patients were recruited for the study.

    METHODS: All patients presenting to the department with ocular trauma injuries were assessed by an ophthalmologist. Data on the type and source of injury, demographic profile of the patients, and clinical presentation were documented using a uniform and validated datasheet.

    RESULTS: Among eye injury cases, 481 patients (88.1%) were male, with a male-to-female ratio of 7.4:1. Of the patients, 412 (75.5%) were Malaysian while the remaining 134 (24.5%) were of non-Malaysian nationality. The average age was 31.5 years (range 1-81 years). A total of 238 injured eyes (43.6%) were work-related. The common sources of eye trauma include the use of high-powered tools (30.8%), motor vehicle accident (23.1%), and domestic accidents (17.7%). Only six patients (2.5%) reported to having used eye protective device (EPD) at time of their work-related injuries.

    CONCLUSIONS: A major cause of preventable ocular injuries in Malaysia was work-related trauma. Ocular injuries can be reduced by the use of eye protection devices and the implementation of appropriate preventive strategies to address each risk factor. Effective training is an integral part of occupational safety and health, which should be made mandatory at the workplace. In addition, there should be a continual assessment of safety and health issues at the workplace. A long-term database of all ocular injuries in Malaysia is recommended, to aid research on a larger scale and the development of new preventive strategies for ocular injuries.

    MeSH terms: Academic Medical Centers/statistics & numerical data; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Eye Injuries/epidemiology*; Female; Humans; Infant; Malaysia/epidemiology; Male; Middle Aged; Population Surveillance*; Prospective Studies; Young Adult
  8. Hassan Y, Al-Jabi SW, Aziz NA, Looi I, Zyoud SH
    Fundam Clin Pharmacol, 2011 Jun;25(3):388-94.
    PMID: 20608996 DOI: 10.1111/j.1472-8206.2010.00846.x
    Statins can reduce the risk of stroke in at-risk populations and improve survival after acute ischemic stroke (AIS) among patients with previous statin use. This study aimed to investigate the impact of statin use before AIS onset on in-hospital mortality and identify the factors related to in-hospital mortality among patients with and without previous statin use. A retrospective cohort study of all patients with AIS attending hospital from June 1, 2008 to December 31, 2008. Data were collected from medical records including demographic information, diagnostic information, risk factors, previous statin use, and vital discharge status. Chi-square, Fisher's exact tests, student's t-test, and Mann-Whitney U test, whatever appropriate, were used to test the significance between the variables, and multiple logistic regression was used to identify factors associated with in-hospital mortality. Altogether, 386 patients with AIS were studied, of which 113 (29.3%) had a documented previous statin use. A total of 62 (16.1%) patients with AIS died in hospital. In-hospital mortality was significantly lower among previous statin users (P = 0.013). The presence of atrial fibrillation (AF) increased in-hospital mortality among patients with or without previous statin use. The independent predictors for in-hospital mortality among AIS patients without previous statin use were the presence of diabetes mellitus (P = 0.047), AF (P = 0.045), and renal impairment (P < 0.001). The prophylactic administration of statins significantly reduces post-AIS in-hospital mortality. Furthermore, the identification of predictors of in-hospital mortality might reduce death rates and enhance the application of specific therapeutic and management strategies to patients at a high risk of dying.
    MeSH terms: Atrial Fibrillation/complications; Atrial Fibrillation/mortality; Brain Ischemia/complications; Brain Ischemia/drug therapy; Brain Ischemia/prevention & control*; Diabetes Mellitus/mortality; Female; Humans; Malaysia/epidemiology; Male; Middle Aged; Retrospective Studies; Risk Factors; Cohort Studies; Chi-Square Distribution; Logistic Models; Hospital Mortality*; Statistics, Nonparametric; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use*; Stroke/complications; Stroke/drug therapy; Stroke/prevention & control*; Diabetes Complications/mortality; Renal Insufficiency/complications; Renal Insufficiency/mortality
  9. Zyoud SH, Awang R, Sulaiman SA, Al-Jabi SW
    Hum Exp Toxicol, 2011 Jul;30(7):550-9.
    PMID: 20630911 DOI: 10.1177/0960327110377647
    Acetaminophen is one of the most commonly encountered medications in self-poisoning, with a high rate of morbidity. The prevalence and characteristics of acetaminophen intoxication associated with long hospital stay in patients are not well defined.
    MeSH terms: Acetaminophen/antagonists & inhibitors; Acetaminophen/poisoning*; Acetylcysteine/administration & dosage; Acetylcysteine/therapeutic use; Antidotes/administration & dosage; Antidotes/therapeutic use; Costs and Cost Analysis; Female; Humans; Injections, Intravenous; Length of Stay/statistics & numerical data*; Male; Time Factors; Analgesics, Non-Narcotic/poisoning*; Young Adult; Drug Overdose/drug therapy; Drug Overdose/economics*
  10. Nemati K, Abu Bakar NK, Abas MR, Sobhanzadeh E, Low KH
    Environ Monit Assess, 2011 May;176(1-4):313-20.
    PMID: 20632089 DOI: 10.1007/s10661-010-1584-3
    A study was carried out to investigate the fractionation of Cd, Cr, Cu, Fe, Mn, Pb, and Zn in shrimp aquaculture sludge from Selangor, Malaysia, using original (unmodified) and modified four-steps BCR (European Community Bureau of Reference, now known as the Standards Measurements and Testing Program) sequential extraction scheme. Step 2 of the unmodified BCR procedure (subsequently called Method A) involves treatment with 0.1 M hydroxylammonium chloride at pH 2, whereas 0.5 M hydroxylammonium chloride at pH 1.5 was used in the modified BCR procedure (subsequently called Method B). Metal analyses were carried out by flame atomic absorption spectrometry. A pseudo-total aqua-regia digest of BCR CRM 701 has also been undertaken for quality assurance purposes. The recovery of Method A for all metals studied ranges from 96.14% to 105.26%, while the recovery for Method B ranges from 95.94% to 122.40%. Our results reveal that Method A underestimated the proportion of metals bound to the easily reducible fraction except for copper. Therefore, the potential mobility of these elements is higher than others. Thus, to use this sludge as a fertilizer we have to first find a remediation for reduction of heavy metal contamination.
    MeSH terms: Animals; Cadmium/isolation & purification; Cadmium/chemistry; Chromium/isolation & purification; Chromium/chemistry; Copper/isolation & purification; Copper/chemistry; Crustacea*; Environmental Monitoring; Chemical Fractionation/methods*; Iron/isolation & purification; Iron/chemistry; Lead/isolation & purification; Lead/chemistry; Malaysia; Manganese/isolation & purification; Manganese/chemistry; Sewage/chemistry*; Zinc/isolation & purification; Zinc/chemistry; Aquaculture*; Metals, Heavy/isolation & purification*; Metals, Heavy/chemistry
  11. Thu TV, Loh TC, Foo HL, Yaakub H, Bejo MH
    Trop Anim Health Prod, 2011 Jan;43(1):69-75.
    PMID: 20632092 DOI: 10.1007/s11250-010-9655-6
    A study was carried out to investigate the effects of feeding liquid metabolite combinations produced by Lactobacillus plantarum strains on growth performance, diarrhoea incidence, faecal pH, microfloral counts, short-chain fatty acids (SCFA) and intestinal villus height and crypt depth of postweaning piglets. A total of 120 piglets (26 days old) were randomly assigned evenly into five treatment groups treated with same basal diet: (1) -ve control (free antibiotic); (2) + ve control (0.03% of chlortetracycline); (3) Com 1 (0.3% metabolite of TL1, RG11 and RI11 strains); (4) Com 2 (0.3% metabolite of TL1, RG14 and RS5 strains); (5) Com 3 (0.3% metabolite of RG11, RG14 and RI11 strains). After 5 weeks, the average daily feed intake was not significantly different (P > 0.05) among the treatments and feed conversion ratio was the highest (P 
    MeSH terms: Animals; Animal Husbandry/methods*; Diarrhea/prevention & control; Diarrhea/veterinary*; Fatty Acids, Volatile/analysis; Feces/microbiology; Feces/chemistry; Hydrogen-Ion Concentration; Intestinal Mucosa/ultrastructure*; Malaysia; Microvilli/ultrastructure; Swine; Swine Diseases/prevention & control*; Linear Models; Dietary Supplements*; Sus scrofa/anatomy & histology; Sus scrofa/growth & development*; Lactobacillus plantarum/chemistry*; Mice
  12. Yusof MI, Hassan E, Abdullah S
    Surg Radiol Anat, 2011 Mar;33(2):109-15.
    PMID: 20658232 DOI: 10.1007/s00276-010-0704-7
    Posterior translation of the spinal cord occurs passively following laminoplasty with the presence lordotic spine and availability of a space for the spinal cord to shift. This study is to predict the distance of posterior spinal cord migration after expansive laminoplasty at different cervical levels based on measurement of posterior translation of the spinal cord in normal cervical morphometry.
    MeSH terms: Adult; Aged; Cervical Vertebrae/pathology*; Cervical Vertebrae/surgery*; Female; Humans; Image Interpretation, Computer-Assisted; Laminectomy*; Magnetic Resonance Imaging/methods*; Male; Middle Aged; Spinal Cord/pathology*; Spinal Cord/surgery*; Decompression, Surgical/methods*
  13. Jusoh S, Shaharuddin B, Wan Hitam WH
    Clin Exp Ophthalmol, 2011 Jan;39(1):15-22.
    PMID: 20659136 DOI: 10.1111/j.1442-9071.2010.02385.x
    This study aims to assess the optic disc characteristics in healthy adult Malays and to correlate them with age, gender and refractive errors.
    MeSH terms: Adult; Cross-Sectional Studies; Female; Humans; Lasers; Malaysia; Male; Ophthalmoscopy; Optic Disk/anatomy & histology*; Reference Values; Refractive Errors/diagnosis; Refractive Errors/ethnology; Asian Continental Ancestry Group*; Young Adult
  14. Teh CH, Abdulghani M, Morita H, Shiro M, Hussin AH, Chan KL
    Planta Med, 2011 Jan;77(2):128-32.
    PMID: 20665368 DOI: 10.1055/s-0030-1250159
    13 α,21-Dihydroeurycomanone (1), a known quassinoid of Eurycoma longifolia Jack was recrystallized from chloroform into a novel crystal structure in space group P2 (1). Its X-ray data were compared with those of eurycomanone ( 2). Following intraperioneal injections at similar doses of 2.44 µmol/kg/day for 3 consecutive days, 2 displayed comparable potency with tamoxifen but was more potent than 1 in the anti-estrogenic effect against 17 α-ethynylestradiol (EE)-induced uterotrophy of immature rats.
    MeSH terms: Animals; Estrogen Antagonists/isolation & purification; Estrogen Antagonists/pharmacology*; Estrogen Antagonists/therapeutic use; Estrogen Antagonists/chemistry*; Ethinyl Estradiol/pharmacology; Female; Molecular Conformation; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Plant Extracts/therapeutic use; Plant Extracts/chemistry; Plants, Medicinal/chemistry; Tamoxifen/pharmacology; Tamoxifen/therapeutic use; Uterus/drug effects; Crystallography, X-Ray; Plant Roots/chemistry; Eurycoma/chemistry*; Quassins/isolation & purification; Quassins/pharmacology*; Quassins/therapeutic use; Quassins/chemistry*; Rats
  15. Hsum YW, Yew WT, Hong PL, Soo KK, Hoon LS, Chieng YC, et al.
    Planta Med, 2011 Jan;77(2):152-7.
    PMID: 20669087 DOI: 10.1055/s-0030-1250203
    Chronic inflammation is one of the predisposing factors for neoplastic transformation. Targeting inflammation through suppression of the pro-inflammatory pathway by dietary phytochemicals provides an important strategy for cancer prevention. Maslinic acid is a novel natural triterpenoid known to inhibit proliferation and induce apoptosis in some tumor cell lines. Although maslinic acid has cytotoxic and pro-apoptotic effects on cancer cells, the underlying mechanisms of its effects on the inflammatory pathway have yet to be elucidated. It has been reported that abnormal expression of pro-inflammatory enzyme cyclooxygenase-2 (COX-2) causes promotion of cellular proliferation, suppression of apoptosis, enhancement of angiogenesis and invasiveness. In the present study, the suppressive effect of maslinic acid on COX-2 expression and the binding activity of upstream transcription factors NF- κB and AP-1, which are known to regulate COX-2 transcriptional activation, were assessed using Raji cells. The anti-inflammatory action of maslinic acid was benchmarked against oleanolic acid and other standard drugs. Western blot analysis and electrophoretic mobility shift assay (EMSA) were employed to analyze COX-2 expression as well as NF- κB and AP-1 binding activity. Our results showed that maslinic acid suppresses COX-2 expression in a concentration-dependent manner. Likewise, the constitutive nuclear NF- κB (p65) activity as well as phorbol 12-myristate 13-acetate (PMA)- and sodium N-butyrate (SnB)-induced AP-1 binding activity in Raji cells were significantly reduced following treatment with maslinic acid. Since maslinic acid suppresses COX-2 expression in Raji cells at concentrations that also lowered the NF- κB (p65) and AP-1 binding activity, it is possible that the suppression of COX-2 by this natural triterpenoid might be achieved, at least in part, via the NF- κB and AP-1 signaling pathways.
    MeSH terms: Anti-Inflammatory Agents/pharmacology; Humans; Lymphoma/metabolism; Lymphoma/pathology; Lymphoma/prevention & control; Oleanolic Acid/pharmacology; Triterpenes/pharmacology*; Triterpenes/chemistry; Signal Transduction; Gene Expression/drug effects; NF-kappa B/drug effects*; NF-kappa B/metabolism; Anticarcinogenic Agents/pharmacology*; Transcription Factor AP-1/drug effects*; Transcription Factor AP-1/metabolism; Electrophoretic Mobility Shift Assay; Cell Line, Tumor; Cell Proliferation/drug effects; Cyclooxygenase 2/drug effects*; Cyclooxygenase 2/metabolism
  16. Siar CH, Toh CG, Romanos G, Ng KH
    Clin Oral Implants Res, 2011 Jan;22(1):113-20.
    PMID: 20678135 DOI: 10.1111/j.1600-0501.2010.01970.x
    collagenous and noncollagenous membranes have been investigated in many animal systems but their effects in the macaque model are unknown.
    MeSH terms: Animals; Biotransformation; Cellulose/metabolism; Collagen/metabolism; Foreign-Body Reaction; Gelatin/metabolism; Macaca fascicularis; Male; Membranes, Artificial*; Neovascularization, Physiologic; Implants, Experimental; Absorbable Implants*; Subcutaneous Tissue
  17. Wong LP, Sam IC
    J Behav Med, 2011 Feb;34(1):23-31.
    PMID: 20680674 DOI: 10.1007/s10865-010-9283-7
    In the setting of the new A(H1N1) outbreak, the study was conducted to assess: (1) fear of the A(H1N1) pandemic; (2) risk avoidance behavior; (3) health-protective behavior; and (4) psychosocial impact in the ethnically diverse population of Malaysia. A cross-sectional, computer-assisted telephone interview was conducted between July 11 and September 12, 2009. A total of 1,050 respondents were interviewed. Fear about the pandemic was high, with 73.2% of respondents reporting themselves as Slightly fearful/Fearful. High risk avoidance and health protective behavior were reported, with 78.0 and 99.0% reporting at least one avoidance and protective behavior respectively. Knowledge was a significant predictor for practice of healthprotective behavior across the three ethnic groups. Level of fear was significantly correlated with number of protective and avoidance behaviors. The study highlights the need for provision of accurate information that increases risk avoidance and health protective behaviors, while at the same time decreases fear or panic in the general public.
    MeSH terms: Adolescent; Adult; Aged; Cross-Sectional Studies; Disease Outbreaks*; Fear; Female; Humans; Influenza, Human/ethnology; Influenza, Human/prevention & control*; Influenza, Human/psychology*; Health Knowledge, Attitudes, Practice*; Malaysia/epidemiology; Male; Middle Aged; Socioeconomic Factors; Multivariate Analysis; Linear Models; Influenza A Virus, H1N1 Subtype*
  18. Ng ST, Tengku-Aizan H, Tey NP
    Asia Pac J Public Health, 2011 Jul;23(4):470-84.
    PMID: 20685663 DOI: 10.1177/1010539510374751
    This article investigates the influence of perceived health status on the daily activity participation of older Malaysians. Data from the Survey on Perceptions of Needs and Problems of the Elderly, which was conducted in 1999, were used. The negative binomial regression results show that older persons with good perceived health status reported more varieties of daily activity participation, especially among the uneducated and those with below-average self-esteem. The multinomial logistic regression model suggests that older persons with good perceived health status tended to engage daily in paid work only or with leisure activities, whereas those perceived to have poor health were more likely to engage in leisure activities only or leisure and family role activities. Promotion of a healthy lifestyle at a younger age encourages every person to monitor and take responsibility for their own health, which is a necessary strategy to ensure active participation at an older age, and thus improve their well-being.
    MeSH terms: Activities of Daily Living*; Aged; Aged, 80 and over; Female; Health Status*; Health Surveys; Humans; Interviews as Topic; Malaysia; Male; Middle Aged; Self Concept; Logistic Models; Self Efficacy*
  19. Edwards DP, Larsen TH, Docherty TD, Ansell FA, Hsu WW, Derhé MA, et al.
    Proc Biol Sci, 2011 Jan 7;278(1702):82-90.
    PMID: 20685713 DOI: 10.1098/rspb.2010.1062
    Southeast Asia is a hotspot of imperiled biodiversity, owing to extensive logging and forest conversion to oil palm agriculture. The degraded forests that remain after multiple rounds of intensive logging are often assumed to be of little conservation value; consequently, there has been no concerted effort to prevent them from being converted to oil palm. However, no study has quantified the biodiversity of repeatedly logged forests. We compare the species richness and composition of birds and dung beetles within unlogged (primary), once-logged and twice-logged forests in Sabah, Borneo. Logging had little effect on the overall richness of birds. Dung beetle richness declined following once-logging but did not decline further after twice-logging. The species composition of bird and dung beetle communities was altered, particularly after the second logging rotation, but globally imperiled bird species (IUCN Red List) did not decline further after twice-logging. Remarkably, over 75 per cent of bird and dung beetle species found in unlogged forest persisted within twice-logged forest. Although twice-logged forests have less biological value than primary and once-logged forests, they clearly provide important habitat for numerous bird and dung beetle species. Preventing these degraded forests from being converted to oil palm should be a priority of policy-makers and conservationists.
    MeSH terms: Animals; Beetles/physiology*; Birds/physiology*; Borneo; Conservation of Natural Resources/methods*; Population Dynamics; Species Specificity; Trees*; Forestry/methods; Ecosystem*; Biodiversity*
  20. Wong SW, Tiong KH, Kong WY, Yue YC, Chua CH, Lim JY, et al.
    Breast Cancer Res Treat, 2011 Jul;128(2):301-13.
    PMID: 20686837 DOI: 10.1007/s10549-010-1055-0
    Recent gene expression profiling studies have identified five breast cancer subtypes, of which the basal-like subtype is the most aggressive. Basal-like breast cancer poses serious clinical challenges as there are currently no targeted therapies available to treat it. Although there is increasing evidence that these tumors possess specific sensitivity to cisplatin, its success is often compromised due to its dose-limiting nephrotoxicity and the development of drug resistance. To overcome this limitation, our goal was to maximize the benefits associated with cisplatin therapy through drug combination strategies. Using a validated kinase inhibitor library, we showed that inhibition of the mTOR, TGFβRI, NFκB, PI3K/AKT, and MAPK pathways sensitized basal-like MDA-MB-468 cells to cisplatin treatment. Further analysis demonstrated that the combination of the mTOR inhibitor rapamycin and cisplatin generated significant drug synergism in basal-like MDA-MB-468, MDA-MB-231, and HCC1937 cells but not in luminal-like T47D or MCF-7 cells. We further showed that the synergistic effect of rapamycin plus cisplatin on basal-like breast cancer cells was mediated through the induction of p73. Depletion of endogenous p73 in basal-like cells abolished these synergistic effects. In conclusion, combination therapy with mTOR inhibitors and cisplatin may be a useful therapeutic strategy in the treatment of basal-like breast cancers.
    MeSH terms: Antineoplastic Combined Chemotherapy Protocols/pharmacology*; Breast Neoplasms/drug therapy*; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Carcinoma, Basal Cell/drug therapy*; Carcinoma, Basal Cell/genetics; Carcinoma, Basal Cell/metabolism; Cisplatin/administration & dosage; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism*; Drug Synergism; Humans; Nuclear Proteins/antagonists & inhibitors; Nuclear Proteins/genetics; Nuclear Proteins/metabolism*; RNA, Messenger/genetics; Blotting, Western; NF-kappa B/genetics; NF-kappa B/metabolism; Apoptosis; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Receptors, Transforming Growth Factor beta/genetics; Receptors, Transforming Growth Factor beta/metabolism; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Sirolimus/administration & dosage; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins/antagonists & inhibitors; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism*; RNA, Small Interfering/genetics; Cell Line, Tumor; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism; Cell Proliferation/drug effects*; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; TOR Serine-Threonine Kinases/genetics; TOR Serine-Threonine Kinases/metabolism
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