Browse publications by year: 2017

  1. Gani P, Mohamed Sunar N, Matias-Peralta H, Abdul Latiff AA, Mohamad Fuzi SF
    Prep Biochem Biotechnol, 2017 Apr 21;47(4):333-341.
    PMID: 27737612 DOI: 10.1080/10826068.2016.1244686
    Microalga biomass has been recognized as a sustainable bio-product to replace terrestrial biomass in biofuel production. The microalga industry has high operating costs, specifically on harvesting and biomass recovery. Therefore, the development of an efficient harvesting method is crucial to the minimization of production cost. A statistical analysis through response surface methodology was used to investigate the optimization of harvesting efficiency using alum and chitosan as a coagulant. Growth rate and biomass productivity were also determined. This research revealed that the harvesting efficiency using alum was 99.3%, with optimum dosage and pH of 177.74 mg L(-1) and 8.24, respectively. Chitosan achieved 94.2% biomass recovery at an optimal dosage of 169.95 mg L(-1) at pH of 12. Moreover, Botryococcus sp. achieved the maximum growth of 0.7551 µmax d(-1), with an average total biomass productivity of 9.81 mg L(-1) d(-1) in domestic wastewater. Overall, this study shows that both alum and chitosan coagulants have great potential for efficient microalgal biomass recovery. It suggests that domestic wastewater as a potential growth medium for the large-scale production of microalga biomass.
  2. Baker PR, Francis DP, Mohd Hairi NN, Othman S, Choo WY
    Age Ageing, 2017 05 01;46(3):346-348.
    PMID: 27737827 DOI: 10.1093/ageing/afw186
    There is evidence that elder abuse is a significant public health problem that is destined to grow as population age. Countries are considering how best to act and this requires an understanding of the complex causal mechanisms contributing to its occurrence and the identification of effective interventions which can potentially make a difference. Previously, a high quality synthesis of evidence for policy and practice has been missing. In this paper, we describe a new Cochrane review of interventions to prevent the occurrence or reoccurrence of elder abuse. Overall, the quality of the evidence available for decision making is very low and there is little to guide practice. Amongst the interventions, there is some evidence that teaching coping skills to family carers of persons with dementia might make the situation better. We argue that poor quality and wasteful research needs to be avoided, and front-line agencies be supported in undertaking comparative evaluation of their services.
    MeSH terms: Aged; Animals; Antioxidants; Elder Abuse*; Humans; Longevity; Male; NF-E2-Related Factor 2; Mice; Glycoside Hydrolase Inhibitors*
  3. Tan MM, Chan CKY, Reidpath DD
    J Public Health (Oxf), 2017 Dec 01;39(4):e179-e185.
    PMID: 27738128 DOI: 10.1093/pubmed/fdw109
    Background: Socioeconomic status (SES) is a strong predictor of health, and individuals with higher SES generally have better health than those with lower SES. One of the pathways that SES influences health is through health behaviors, such as dietary intake, and a higher SES has been associated with a better diet. The purpose of this study was to determine whether there was a social gradient in dietary habits among the Seventh-Day Adventists, a group of conservative Christians, where healthy eating is part of the doctrinal teaching.

    Methods: Data from a survey of 574 Adventists residing in West Malaysia, aged 18-80 years, were analyzed. Dietary habits were measured using the Nutrition subscale of Health Promoting Lifestyle Profile II.

    Results: Education and income were significantly associated with dietary habits before and after controlling for demographics. There was a gradient of association; a higher level of education and higher income were associated with better dietary habits. However, only education remained significantly associated with dietary habits when the other two socioeconomic variables were included. Employment was not significantly associated with dietary habits before or after controlling for demographic variables and the other two sociodemographic variables.

    Conclusions: This study showed that education is the strongest predictor of healthy diet, and a social gradient in dietary habits still exists even among health-conscious population.

  4. Schiess N, Rao A, Mohanraj A, Wiener CM
    Acad Psychiatry, 2017 08;41(4):551-555.
    PMID: 27738999 DOI: 10.1007/s40596-016-0616-x
    MeSH terms: Education, Medical/methods*; Humans; Malaysia; Neurology/education*; Psychiatry/education*; Students, Medical/psychology*; Social Stigma
  5. Wang XQ, Wang GH, Zhu ZR, Tang QY, Hu Y, Qiao F, et al.
    Pest Manag Sci, 2017 Jun;73(6):1277-1286.
    PMID: 27739189 DOI: 10.1002/ps.4459
    BACKGROUND: Spiders are effective biological control agents in rice ecosystems, but the comparative study of predations among main spider species under field conditions has not been fully explored owing to a lack of practical methodology. In this study, more than 6000 spiders of dominant species were collected from subtropical rice ecosystems to compare their predations on Sogatella furcifera (Horváth) (white-backed planthopper, WBPH) using DNA-based gut content analysis.

    RESULTS: The positive rates for all spider taxa were closely related to prey densities, as well as their behaviors and niches. The relationships of positive rates to prey planthopper densities for Pardosa pseudoannulata (Böes. et Str.), Coleosoma octomaculata (Böes. et Str.), Tetragnatha maxillosa Thorell and Ummeliata insecticeps (Böes. et Str.) under field conditions could be described using saturated response curves. Quantitative comparisons of predations among the four spider species confirmed that P. pseudoannulata and C. octomaculata were more rapacious than U. insecticeps and T. maxillosa under field conditions. A comparison of ratio of spiders to WBPH and positive rates between fields revealed that biological control by spiders could be effectively integrated with variety resistance.

    CONCLUSION: Generalist spiders could follow up WBPH population timely, and assemblages of spiders coupled with variety resistance could effectively suppress WBPH population. © 2016 Society of Chemical Industry.

    MeSH terms: Animals; China; Predatory Behavior; Oryza*; Spiders/classification; Spiders/physiology*; Sequence Analysis, DNA; Ecosystem; Real-Time Polymerase Chain Reaction; Biological Control Agents
  6. Hasan H, Davids K, Chow JY, Kerr G
    Eur J Sport Sci, 2017 Apr;17(3):294-302.
    PMID: 27739339 DOI: 10.1080/17461391.2016.1241829
    This study investigated effects of wearing compression garments and textured insoles on modes of movement organisation emerging during performance of lower limb interceptive actions in association football. Participants were six skilled (age = 15.67 ± 0.74 years) and six less-skilled (age = 15.17 ± 1.1 years) football players. All participants performed 20 instep kicks with maximum velocity in four randomly organised insoles and socks conditions, (a) Smooth Socks with Smooth Insoles (SSSI); (b) Smooth Socks with Textured Insoles (SSTI); (c) Compression Socks with Smooth Insoles (CSSI); and (d), Compression Socks with Textured Insoles (CSTI). Results showed that, when wearing textured and compression materials (CSSI condition), less-skilled participants displayed significantly greater hip extension and flexion towards the ball contact phase, indicating larger ranges of motion in the kicking limb than in other conditions. Less-skilled participants also demonstrated greater variability in knee-ankle intralimb (angle-angle plots) coordination modes in the CSTI condition. Findings suggested that use of textured and compression materials increased attunement to somatosensory information from lower limb movement, to regulate performance of dynamic interceptive actions like kicking, especially in less-skilled individuals.
    MeSH terms: Adolescent; Biomechanical Phenomena; Foot/physiology*; Humans; Male; Random Allocation; Soccer/physiology*; Cohort Studies; Range of Motion, Articular/physiology; Stockings, Compression*; Athletic Performance/physiology*; Feedback, Sensory/physiology*; Athletes/statistics & numerical data
  7. Krishna LS, Yuzir A, Yuvaraja G, Ashokkumar V
    Int J Phytoremediation, 2017 May 04;19(5):431-438.
    PMID: 27739901 DOI: 10.1080/15226514.2016.1244161
    The feasibility for the removal of Acid Blue25 (AB25) by Bengal gram fruit shell (BGFS), an agricultural by-product, has been investigated as an alternative for high-cost adsorbents. The impact of various experimental parameters such as dose, different dye concentration, solution pH, and temperature on the removal of Acid Blue25 (AB25) has been studied under the batch mode of operation. pH is a significant impact on the sorption of AB25 onto BGFS. The maximum removal of AB25 was achieved at a pH of 2 (83.84%). The optimum dose of biosorbent was selected as 200 mg for the removal of AB25 onto BGFS. Kinetic studies reveal that equilibrium reached within 180 minutes. Biosorption kinetics has been described by Lagergren equation and biosorption isotherms by classical Langmuir and Freundlich models. Equilibrium data were found to fit well with the Langmuir and Freundlich models, and the maximum monolayer biosorption capacity was 29.41 mg g(-1) of AB25 onto BGFS. The kinetic studies indicated that the pseudo-second-order (PSO) model fitted the experimental data well. In addition, thermodynamic parameters have been calculated. The biosorption process was spontaneous and exothermic in nature with negative values of ΔG° (-1.6031 to -0.1089 kJ mol(-1)) and ΔH° (-16.7920 kJ mol(-1)). The negative ΔG° indicates the feasibility of physical biosorption process. The results indicate that BGFS could be used as an eco-friendly and cost-effective biosorbent for the removal of AB25 from aqueous solution.
    MeSH terms: Adsorption; Anthraquinones/metabolism*; Biodegradation, Environmental; Coloring Agents/metabolism*; Fruit/chemistry; Water Pollutants, Chemical/metabolism*; Biomass; Cicer/metabolism*
  8. Shaharuddin B, Ahmad S, Md Latar N, Ali S, Meeson A
    Stem Cells Transl Med, 2017 03;6(3):761-766.
    PMID: 28297580 DOI: 10.5966/sctm.2016-0175
    Limbal stem cell (LSC) deficiency is a visually debilitating condition caused by abnormal maintenance of LSCs. It is treated by transplantation of donor-derived limbal epithelial cells (LECs), the success of which depends on the presence and quality of LSCs within the transplant. Understanding the immunobiological responses of these cells within the transplants could improve cell engraftment and survival. However, human corneal rings used as a source of LSCs are not always readily available for research purposes. As an alternative, we hypothesized that a human telomerase-immortalized corneal epithelial cell (HTCEC) line could be used as a model for studying LSC immunobiology. HTCEC constitutively expressed human leukocyte antigen (HLA) class I but not class II molecules. However, when stimulated by interferon-γ, HTCECs then expressed HLA class II antigens. Some HTCECs were also migratory in response to CXCL12 and expressed stem cell markers, Nanog, Oct4, and Sox2. In addition because both HTCECs and LECs contain side population (SP) cells, which are an enriched LSC population, we used these SP cells to show that some HTCEC SP cells coexpressed ABCG2 and ABCB5. HTCEC SP and non-side population (NSP) cells also expressed CXCR4, but the SP cells expressed higher levels. Both were capable of colony formation, but the NSP colonies were smaller and contained fewer cells. In addition, HTCECs expressed ΔNp63α. These results suggest the HTCEC line is a useful model for further understanding LSC biology by using an in vitro approach without reliance on a supply of human tissue. Stem Cells Translational Medicine 2017;6:761-766.
    MeSH terms: Animals; Cell Line; Cell Line, Transformed; Chemotaxis; Colony-Forming Units Assay; Epithelial Cells/cytology; Epithelial Cells/metabolism; Histocompatibility Testing; HLA Antigens/metabolism; Humans; Models, Biological*; Stem Cells/cytology*; Stem Cells/metabolism; Biomarkers/metabolism; 3T3 Cells; Limbus Corneae/cytology*; Limbus Corneae/immunology*; Telomerase/metabolism; Epithelium, Corneal/cytology*; Receptors, CXCR4/metabolism; Mice; Side-Population Cells/cytology
  9. Ali SM, Siddiqui R, Ong SK, Shah MR, Anwar A, Heard PJ, et al.
    Appl Microbiol Biotechnol, 2017 Jan;101(1):253-286.
    PMID: 27743045 DOI: 10.1007/s00253-016-7872-2
    Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents. We hypothesized that animals living in polluted environments are potential sources of antimicrobials. Under polluted milieus, organisms such as cockroaches encounter different types of microbes, including superbugs. Such creatures survive the onslaught of superbugs and are able to ward off disease by producing antimicrobial substances. Here, we characterized antibacterial properties in extracts of various body organs of cockroaches (Periplaneta americana) and showed potent antibacterial activity in crude brain extract against methicillin-resistant Staphylococcus aureus and neuropathogenic Escherichia coli K1. The size-exclusion spin columns revealed that the active compound(s) are less than 10 kDa in molecular mass. Using cytotoxicity assays, it was observed that pre-treatment of bacteria with lysates inhibited bacteria-mediated host cell cytotoxicity. Using spectra obtained with LC-MS on Agilent 1290 infinity liquid chromatograph, coupled with an Agilent 6460 triple quadruple mass spectrometer, tissues lysates were analysed. Among hundreds of compounds, only a few homologous compounds were identified that contained the isoquinoline group, chromene derivatives, thiazine groups, imidazoles, pyrrole-containing analogs, sulfonamides, furanones, and flavanones and known to possess broad-spectrum antimicrobial properties and anti-inflammatory, anti-tumour, and analgesic properties. Further identification, characterization, and functional studies using individual compounds can act as a breakthrough in developing novel therapeutics against various pathogens including superbugs.
    MeSH terms: Animals; Animal Structures/chemistry; Anti-Bacterial Agents/isolation & purification*; Anti-Bacterial Agents/chemistry; Cell Extracts/chemistry*; Chromatography, Liquid; Cockroaches/chemistry*; Escherichia coli/drug effects; Molecular Weight; Mass Spectrometry; Staphylococcus aureus/drug effects
  10. Zainuddin A, Chua KH, Tan JK, Jaafar F, Makpol S
    J Physiol Biochem, 2017 Feb;73(1):59-65.
    PMID: 27743340 DOI: 10.1007/s13105-016-0524-2
    Human diploid fibroblasts (HDFs) proliferation in culture has been used as a model of aging at the cellular level. Growth arrest is one of the most important mechanisms responsible for replicative senescence. Recent researches have been focusing on the function of vitamin E in modulating cellular signaling and gene expression. Therefore, the aim of this study was to elucidate the effect of palm γ-tocotrienol (vitamin E) in modulating cellular aging through p16INK4a pathway in HDF cells. Primary culture of senescent HDFs was incubated with 70 μM of palm γ-tocotrienol for 24 hours. Silencing of p16INK4a was carried out by siRNA transfection. RNA was extracted from the different treatment groups and gene expression analysis was carried out by real-time reverse transcription polymerase chain reaction. Proteins that were regulated by p16INK4a were determined by western blot technique. The finding of this study showed that p16INK4a mRNA was overexpressed in senescent HDFs, and hypophosphorylated-pRb and cyclin D1 protein expressions were increased (p 
    MeSH terms: Cell Cycle; Cells, Cultured; Child; Chromans/metabolism*; Fibroblasts/cytology; Fibroblasts/enzymology; Fibroblasts/metabolism*; Gene Expression Regulation; Humans; Male; Phosphorylation; Protein Processing, Post-Translational; Vitamin E/analogs & derivatives*; Vitamin E/metabolism; Signal Transduction; Down-Regulation*; Cell Aging*; Cyclin D1/antagonists & inhibitors*; Cyclin D1/genetics; Cyclin D1/metabolism; Cyclin-Dependent Kinase Inhibitor p16/antagonists & inhibitors*; Cyclin-Dependent Kinase Inhibitor p16/genetics; Cyclin-Dependent Kinase Inhibitor p16/metabolism; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligases/antagonists & inhibitors*; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Cell Proliferation; Foreskin/cytology; Retinoblastoma Binding Proteins/antagonists & inhibitors*; Retinoblastoma Binding Proteins/genetics; Retinoblastoma Binding Proteins/metabolism
  11. Al-Namnam NM, Nambiar P, Shanmuhasuntharam P, Harris M
    Aust Dent J, 2017 Jun;62(2):228-232.
    PMID: 27743399 DOI: 10.1111/adj.12472
    Dengue is a mosquito transmitted flaviviral infection which can give rise to severe haemorrhage (dengue haemorrhagic fever) and with capillary leakage induces hypovolaemic shock (dengue shock syndrome). Although dengue symptoms and complications have been known for many decades, there has only been one documented case of osteonecrosis of the maxilla which was treated by excision of the necrotic bone. In this case of dengue infection, extensive maxillary osteonecrosis and minimal root resorption appeared to follow factitious injury with a toothpick but resolved with non-surgical management.
    MeSH terms: Adult; Dengue/complications*; Geography; Humans; Male; Maxilla/pathology; Maxilla/virology; Osteonecrosis/complications*; Osteonecrosis/virology; Risk Factors; Root Resorption*; Yemen; Severe Dengue/complications*
  12. Kelly AM, Keijzers G, Klim S, Graham CA, Craig S, Kuan WS, et al.
    Acad Emerg Med, 2017 Mar;24(3):328-336.
    PMID: 27743490 DOI: 10.1111/acem.13118
    OBJECTIVES: The objective was to describe the epidemiology of dyspnea presenting to emergency departments (EDs) in the Asia-Pacific region, to understand how it is investigated and treated and its outcome.

    METHODS: Prospective interrupted time series cohort study conducted at three time points in EDs in Australia, New Zealand, Singapore, Hong Kong, and Malaysia of adult patients presenting to the ED with dyspnea as a main symptom. Data were collected over three 72-hour periods and included demographics, comorbidities, mode of arrival, usual medications, prehospital treatment, initial assessment, ED investigations, treatment in the ED, ED diagnosis, disposition from ED, in-hospital outcome, and final hospital diagnosis. The primary outcomes of interest are the epidemiology, investigation, treatment, and outcome of patients presenting to ED with dyspnea.

    RESULTS: A total of 3,044 patients were studied. Patients with dyspnea made up 5.2% (3,105/60,059, 95% confidence interval [CI] = 5.0% to 5.4%) of ED presentations, 11.4% of ward admissions (1,956/17,184, 95% CI = 10.9% to 11.9%), and 19.9% of intensive care unit (ICU) admissions (104/523, 95% CI = 16.7% to 23.5%). The most common diagnoses were lower respiratory tract infection (20.2%), heart failure (14.9%), chronic obstructive pulmonary disease (13.6%), and asthma (12.7%). Hospital ward admission was required for 64% of patients (95% CI = 62% to 66%) with 3.3% (95% CI = 2.8% to 4.1%) requiring ICU admission. In-hospital mortality was 6% (95% CI = 5.0% to 7.2%).

    CONCLUSION: Dyspnea is a common symptom in ED patients contributing substantially to ED, hospital, and ICU workload. It is also associated with significant mortality. There are a wide variety of causes however chronic disease accounts for a large proportion.

    MeSH terms: Aged; Aged, 80 and over; Australia; Dyspnea/diagnosis; Dyspnea/epidemiology*; Emergency Service, Hospital/statistics & numerical data*; Female; Hong Kong/epidemiology; Hospitalization/statistics & numerical data*; Humans; Middle Aged; New Zealand/epidemiology; Prospective Studies; Risk; Singapore/epidemiology; Cohort Studies; Comorbidity; Hospital Mortality
  13. Kwan MK, Chiu CK, Chan CY
    Eur Spine J, 2017 Jan;26(1):155-161.
    PMID: 27734195 DOI: 10.1007/s00586-016-4803-y
    PURPOSE: To assess the pattern of intra-operative blood loss at various surgical stages comparing between single and two surgeons.

    METHODS: Lenke 1 and 2 adolescent idiopathic scoliosis (AIS) patients who underwent instrumented posterior spinal fusion (PSF) surgery from two centres between June 2014 and December 2015 were prospectively recruited into this study. The patients were grouped into Group 1 (single surgeon) and Group 2 (two surgeons). One to one matching using 'prospective propensity score-matched cohort patient sampling method' was done. The surgery was divided into six stages: stage 1-exposure, stage 2-screw insertion, stage 3-release, stage 4-correction, stage 5-corticotomies and bone grafting and stage 6-closure.

    RESULTS: A total of 116 patients were recruited. Of 86 patients who were operated by the two surgeons, 30 patients were matched with 30 patients that were operated by a single surgeon. Operation duration was significantly longer in Group 1 (257.3 ± 51.4 min) compared to Group 2 (164.0 ± 25.7 min). The total blood loss was significantly higher in Group 1 (1254.7 ± 521.5 mL) compared to Group 2 (893.7 ± 518.4 mL). Total blood loss/level fused was significantly higher in Group 1 (117.5 ± 42.8 mL/level) compared to Group 2 (82.6 ± 39.4 mL/level). Group 1 had significantly higher blood loss and blood loss/level fused for stages 1, 2 and 3. Group 2 had lower incidence of allogenic blood transfusion.

    CONCLUSIONS: In PSF surgery for AIS patients, two-surgeon strategy was associated with shorter operation duration, lesser blood loss and lower incidence of allogenic blood transfusion.

    MeSH terms: Adolescent; Blood Transfusion/statistics & numerical data; Female; Humans; Male; Prospective Studies; Scoliosis/surgery*; Spinal Fusion*; Blood Loss, Surgical/statistics & numerical data*; Matched-Pair Analysis; Propensity Score; Operative Time; Surgeons/statistics & numerical data*
  14. Hakeem KR, Sabir M, Ozturk M, Akhtar MS, Ibrahim FH
    Rev Environ Contam Toxicol, 2017;242:183-217.
    PMID: 27734212 DOI: 10.1007/398_2016_11
    Increased use of nitrogenous (N) fertilizers in agriculture has significantly altered the global N-cycle because they release nitrogenous gases of environmental concerns. The emission of nitrous oxide (N2O) contributes to the global greenhouse gas accumulation and the stratospheric ozone depletion. In addition, it causes nitrate leaching problem deteriorating ground water quality. The nitrate toxicity has been reported in a number of studies showing the health hazards like methemoglobinemia in infants and is a potent cause of cancer. Despite these evident negative environmental as well as health impacts, consumption of N fertilizer cannot be reduced in view of the food security for the teeming growing world population. Various agronomic and genetic modifications have been practiced to tackle this problem. Some agronomic techniques adopted include split application of N, use of slow-release fertilizers, nitrification inhibitors and encouraging the use of organic manure over chemical fertilizers. As a matter of fact, the use of chemical means to remediate nitrate from the environment is very difficult and costly. Particularly, removal of nitrate from water is difficult task because it is chemically non-reactive in dilute aqueous solutions. Hence, the use of biological means for nitrate remediation offers a promising strategy to minimize the ill effects of nitrates and nitrites. One of the important goals to reduce N-fertilizer application can be effectively achieved by choosing N-efficient genotypes. This will ensure the optimum uptake of applied N in a balanced manner and exploring the molecular mechanisms for their uptake as well as metabolism in assimilatory pathways. The objectives of this paper are to evaluate the interrelations which exist in the terrestrial ecosystems between the plant type and characteristics of nutrient uptake and analyze the global consumption and demand for fertilizer nitrogen in relation to cereal production, evaluate the various methods used to determine nitrogen use efficincy (NUE), determine NUE for the major cereals grown across large agroclimatic regions, determine the key factors that control NUE, and finally analyze various strategies available to improve the use efficiency of fertilizer nitrogen.
    MeSH terms: Agriculture; Fertilizers; Nitrates/toxicity*; Nitrogen Oxides/toxicity*; Environmental Restoration and Remediation*
  15. Bathrellos GD, Skilodimou HD, Chousianitis K, Youssef AM, Pradhan B
    Sci Total Environ, 2017 Jan 01;575:119-134.
    PMID: 27736696 DOI: 10.1016/j.scitotenv.2016.10.025
    Preparation of natural hazards maps are vital and essential for urban development. The main scope of this study is to synthesize natural hazard maps in a single multi-hazard map and thus to identify suitable areas for the urban development. The study area is the drainage basin of Xerias stream (Northeastern Peloponnesus, Greece) that has frequently suffered damages from landslides, floods and earthquakes. Landslide, flood and seismic hazard assessment maps were separately generated and further combined by applying the Analytical Hierarchy Process (AHP) and utilizing a Geographical Information System (GIS) to produce a multi-hazard map. This map represents the potential suitability map for urban development in the study area and was evaluated by means of uncertainty analysis. The outcome revealed that the most suitable areas are distributed in the southern part of the study area, where the landslide, flood and seismic hazards are at low and very low level. The uncertainty analysis shows small differences on the spatial distribution of the suitability zones. The produced suitability map for urban development proves a satisfactory agreement between the suitability zones and the landslide and flood phenomena that have affected the study area. Finally, 40% of the existing urban pattern boundaries and 60% of the current road network are located within the limits of low and very low suitability zones.
    MeSH terms: Body Fluids; Environmental Monitoring; Greece; Urban Renewal; Uncertainty; Geographic Information Systems; Rivers; Physical Phenomena; Earthquakes; Floods; Landslides
  16. Abd Hamid H, Mutazah R, Yusoff MM, Abd Karim NA, Abdull Razis AF
    Food Chem Toxicol, 2017 Oct;108(Pt B):451-457.
    PMID: 27725206 DOI: 10.1016/j.fct.2016.10.004
    Rhodomyrtus tomentosa (Aiton) Hassk. has a wide spectrum of pharmacological effects and has been used to treat wounds, colic diarrhoea, heartburns, abscesses and gynaecopathy. The potential antiproliferative activities of R. tomentosa extracts from different solvents were evaluated in vitro on HepG2, MCF-7 and HT 29 cell lines while antioxidant activity was monitored by radical scavenging assay (DPPH), copper reducing antioxidant capacity (CUPRAC) and β-carotene bleaching assay. Extracts from R. tomentosa show the viability of the cells in concentration-dependent manner. According to the IC50 obtained, the ethyl acetate extracts showed significant antiproliferative activity on HepG2 (IC50 11.47 ± 0.280 μg/mL), MCF-7 (IC50 2.68 ± 0.529 μg/mL) and HT 29 (IC50 16.18 ± 0.538 μg/mL) after 72 h of treatment. Bioassay guided fractionation of the ethyl acetate extract led to the isolation of lupeol. Methanol extracts show significant antioxidant activities in DPPH (EC50 110.25 ± 0.005 μg/ml), CUPRAC (EC50 53.84 ± 0.004) and β-carotene bleaching (EC50 58.62 ± 0.001) due to the presence of high total flavonoid and total phenolic content which were 110.822 ± 0.017 mg butylated hydroxytoluene (BHT)/g and 190.467 ± 0.009 mg gallic acid (GAE)/g respectively. Taken together, the results extracts show the R. tomentosa as a potential source of antioxidant and antiproliferative efficacy.
    MeSH terms: Antineoplastic Agents, Phytogenic/pharmacokinetics*; Antioxidants/pharmacology*; Cell Survival/drug effects*; Humans; Plant Extracts/pharmacology*; Plant Extracts/chemistry; Solvents/chemistry*; Inhibitory Concentration 50; Myrtaceae/chemistry*; Cell Line, Tumor
  17. Sathasivam HP, Ismail S, Ahmad AR, Basri NN, Muhamad H, Mohd Tahir NF, et al.
    PMID: 27727102 DOI: 10.1016/j.oooo.2016.08.005
    This study was performed to obtain the clinicodemographic data regarding patients with trigeminal neuralgia (TN) treated at oral-maxillofacial medicine clinics, as there is a paucity of such information in the Asian setting.
  18. Brand JS, Hedayati E, Bhoo-Pathy N, Bergh J, Hall P, Humphreys K, et al.
    Cancer, 2017 02 01;123(3):468-475.
    PMID: 27727456 DOI: 10.1002/cncr.30364
    BACKGROUND: Venous thromboembolism (VTE) is a serious complication of cancer and its treatment. The current study assessed the risk and clinical predictors of VTE in breast cancer patients by time since diagnosis.

    METHODS: This Swedish population-based study included 8338 breast cancer patients diagnosed from 2001 to 2008 in the Stockholm-Gotland region with complete follow-up until 2012. Their incidence of VTE was compared with the incidence among 39,013 age-matched reference individuals from the general population. Cox and flexible parametric models were used to examine associations with patient, tumor, and treatment characteristics, accounting for time-dependent effects.

    RESULTS: Over a median follow-up of 7.2 years, 426 breast cancer patients experienced a VTE event (cumulative incidence, 5.1%). The VTE incidence was 3-fold increased (hazard ratio [HR], 3.28; 95% confidence interval [CI], 2.87-3.74) in comparison with the incidence in the general population and was highest 6 months after diagnosis (HR, 8.62; 95% CI, 6.56-11.33) with a sustained increase in risk thereafter (HR at 5 years, 2.19; 95% CI, 1.80-2.67). Independent predictors of VTE included the following: older age, being overweight, preexisting VTE, comorbid disease, tumor size > 40 mm, progesterone receptor (PR)-negative status, more than 4 affected lymph nodes, and receipt of chemo- and endocrine therapy. The impact of chemotherapy was limited to early-onset VTE, whereas comorbid disease and PR-negative status were more strongly associated with late-onset events.

    CONCLUSIONS: This study confirms the long-term risk of VTE in breast cancer patients and identifies a comprehensive set of clinical risk predictors. Temporal associations with patient, tumor, and treatment characteristics provide insight into the time-dependent etiology of VTE. Cancer 2017;123:468-475. © 2016 American Cancer Society.

    MeSH terms: Adult; Age Factors; Aged; Breast Neoplasms/complications*; Breast Neoplasms/drug therapy*; Breast Neoplasms/pathology; Female; Humans; Middle Aged; Risk Factors; Sweden; Time Factors; Cohort Studies; Proportional Hazards Models; Venous Thromboembolism/etiology; Venous Thromboembolism/pathology*
  19. Hamidi H, Sharifi Haddad A, Mohammadian E, Rafati R, Azdarpour A, Ghahri P, et al.
    Ultrason Sonochem, 2017 Mar;35(Pt A):243-250.
    PMID: 27720591 DOI: 10.1016/j.ultsonch.2016.09.026
    CO2flooding process as a common enhanced oil recovery method may suffer from interface instability due to fingering and gravity override, therefore, in this study a method to improve the performance of CO2flooding through an integrated ultraosund-CO2flooding process is presented. Ultrasonic waves can deliver energy from a generator to oil and affect its properties such as internal energy and viscosity. Thus, a series of CO2flooding experiments in the presence of ultrasonic waves were performed for controlled and uncontrolled temperature conditions. Results indicate that oil recovery was improved by using ultrasound-assisted CO2flooding compared to conventional CO2flooding. However, the changes were more pronounced for uncontrolled temperature conditions of ultrasound-assisted CO2flooding. It was found that ultrasonic waves create a more stable interface between displacing and displaced fluids that could be due to the reductions in viscosity, capillary pressure and interfacial tension. In addition, higher CO2injection rates, increases the recovery factor in all the experiments which highlights the importance of injection rate as another factor on reduction of the fingering effects and improvement of the sweep efficiency.
  20. Liao WC, Angsuwatcharakon P, Isayama H, Dhir V, Devereaux B, Khor CJ, et al.
    Gastrointest Endosc, 2017 Feb;85(2):295-304.
    PMID: 27720741 DOI: 10.1016/j.gie.2016.09.037
    MeSH terms: Cholangiopancreatography, Endoscopic Retrograde/adverse effects; Cholangiopancreatography, Endoscopic Retrograde/methods*; Humans; Pancreatitis/etiology; Pancreatitis/prevention & control; Postoperative Complications/etiology; Postoperative Complications/prevention & control; Stents; Sphincterotomy, Endoscopic/methods*; Endosonography/instrumentation*
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