Browse publications by year: 2017

  1. Wan Mazlina Md Saad, Mohd Khairul Amran Mohammad, Muhamad Idham Mohamed, Hairil Rashmizal Abdul Razak
    MyJurnal
    This animal modelling study aimed to investigate the effects of LDR exposure on cellular ROS production,
    oxidative DNA damage, and alteration of cellular ultrastructure and apoptosis-related protein expressions.
    Ten male ICR mice were randomly divided into two groups consisting of control (Cx) and radiation
    (Rx) groups. On day 29 of post-acclimatisation, mice underwent total body irradiation with 100 µGy
    X-ray. Liver and lung tissues were assessed for the levels of cellular ROS production and Apurinic/
    Apyrimidinic sites generation. Ultrastructural alteration was detected using TEM, alteration of p53,
    Bax, and Bcl-2 expressions was determined by western blotting. Results showed that exposure to LDR
    significantly increased the levels of cellular ROS and AP sites in mice. Ultrastructure of the nucleus in
    Rx showed nuclear blebbing and structural changes in morphology that indicate cell death. Meanwhile,
    p53, Bax, and Bcl-2 proteins increased in expressions and altered the balance of Bax/Bcl-2 ratio. These
    findings may postulate that LDR exposure may enhance oxidative DNA damage and alter expression
    of apoptosis-related proteins.
  2. Nik Norziehana Che Isa, Yusairie Mohd, Mohammad Hafizudden Mohd Zaki, Sharifah Aminah Syed Mohamad
    MyJurnal
    Non antimicrobial touch surface materials such as stainless steel can act as a medium for transmitting
    microbes, leading to the increase of hospital-acquired infections and antibiotic-resistant microbes.
    Copper can be used to replace the current non-antimicrobial touch surfaces, however, the high cost of
    solid copper hampers copper from being the ideal choice. Therefore, stainless steel touch surfaces coated
    with copper can become the option for a low cost yet effective alternative. In this study, electrodeposition
    technique was used to coat copper on 304 stainless steel surface using 0.01 M CuSO4 solution, at pH 1.
    The electrodeposition process was done using chronoamperometry by applying –0.25 V vs. Ag/AgCl for
    15 min. Morphological observation revealed that 304 stainless steel surface was uniformly coated with
    compact and dense copper. EDAX analysis showed the composition of copper of 98.9 wt. %, ranging
    in diameter from 60-90 nm grain size. Thickness of the coating was approximately 105.8 nm. The
    antibacterial property of copper coating was analysed by both Gram negative E. coli and Gram positive
    S. aureus. Results indicated that copper coating has excellent antibacterial behaviour in destroying both
    bacteria. E. coli was more sensitive to the biocidal action of the copper coating of which 100 % reduction
    was observed within 5 min of exposure. As for S. aureus, a 100% reduction was achieved only after 10
    min of exposure.
  3. Muhammad Shukri Senwan, Muhd Fauzi Safia, Zainon Mohd Noor, Zaidah Zainal Ariffin
    MyJurnal
    Aspergillus sp. is an extremely resilient species that can be found everywhere in the environment and
    is present abundantly in water and soil. The defining characteristic of Aspergillus sp. is their extensive
    hyphal network which enable them to survive anywhere, even in very harsh conditions. This study was
    carried out to isolate the filamentous fungi from peat soil of animal agricultural farm and characterise
    them based on their morphological and molecular characteristics. Growth rate of each isolated fungi was
    also evaluated in order to determine the period of maturity for each fungi. Soil samples were collected,
    weighed and then dissolved in sterile distilled water. The samples were serially diluted and spread
    onto potato dextrose agar (PDA) for isolation. Different isolated colonies that were morphologically
    different from each plate was purified and sub-cultured onto new media for macroscopic and microscopic
    identifications. For molecular identification, a conventional technique was used in genomic DNA
    extraction of filamentous fungi due to their thick cell wall and presence of surface proteins protecting the
    fungus. These characteristics make it difficult to harvest the genomic DNA. Polymerase chain reaction
    (PCR) was carried out using internal transcribed spacer primers; ITS1 (forward) and ITS4 (reverse).
    The morphological identification and molecular
    technique showed that majority of these isolated
    fungi are Aspergillus sp.
  4. Siti Noratiqah Mohamad Deros, Arnis Asmat, Shattri Mansor
    MyJurnal
    Temporal distribution of forecasted wind speed is important to assess wind capacity for wind-related
    technology purposes. Regional wind energy estimation needs the development of wind pattern to monitor
    and forecast temporal wind behaviour. Temporal wind in Malaysia mainly depends on monsoonal factor
    that circulates yearly and each monsoon derives distinct character of wind. This paper aims to develop a
    model of wind speed pattern from historical wind speed data. Then, the model was used to forecast 5-years
    seasonal wind speed and identify temporal distribution. Wind speed model development and forecast
    was performed by identifying the best combination of wind speed seasonal component using Seasonal
    Auto-regressive and Moving Average (SARIMA) model. Thus, three distribution models, Lognormal,
    Weibull and Gamma models, were exploited to further observe consistency using Kolmogorov-Smirnov
    goodness-of-fit test. The best fit model to represent seasonal wind distribution in each monsoon season
    at Pulau Langkawi, Malaysia, is Log-normal distribution (0.04679-0.108).
  5. Safura Ramli, Evana Kamarudin, Mazura Bahar
    MyJurnal
    After ABO, Rhesus (Rh) is the second most clinically important blood group regarding transfusion
    and pregnancy induced alloimmunisation. RhD DEL is a subtype of variant RhD, which is difficult to
    determine in a routine blood bank, since it expresses an extremely low level of D antigens. Serologically,
    it can only be detected via adsorption-elution test. To date, there have been limited data available on the
    Rhd DEL phenotype in Malaysia. Thus, this study was carried out to detect DEL phenotype among RhD
    negative donors in Malaysia. A total of 43 RhD-negative blood samples were collected from National
    Blood Centre, Malaysia. Rh phenotype for each sample was tested, followed by adsorption elution
    technique. Then, identification of DEL carrying RHD1227A allele was performed via SSP-PCR. Rhphenotype
    identified were ccee (79.07%), Ccee (13.95%), 4.65% of ccEe phenotype and only 2.33% of
    CCee phenotype. One (2.3%) out of the 43 samples was identified as DEL phenotype carrying RHD1227A
    allele when tested using SSP-PCR, but none was identified from adsorption-elution. A larger sample
    size is recommended to determine the exact prevalence of DEL phenotype, as well as specificity and
    sensitivity between SSP-PCR as compared with the traditional adsorption elution technique.
  6. Bajuri, F., Mazlan, N., Ishak, M.R.
    MyJurnal
    Kenaf natural fibre is used as a sustainable form of material to reinforce polymeric composite. However, natural fibres usually do not perform as well as synthetic fibres. Silica nanoparticle is a material with high surface area and its high interfacial interaction with the matrix results in its improvement. In this research, silica nanoparticles were introduced into epoxy resin as a filler material to improve the mechanical properties of the kenaf-reinforced epoxy. They were dispersed into the epoxy using a homogeniser at 3000 rpm for 10 minutes. The composites were fabricated by spreading the silica filled epoxy evenly onto the kenaf mat before hot pressing the resin wet kenaf mat. The results show for flexural properties, composites with higher fibre and silica volume content generally had better properties with specimen 601 (60 vol% kenaf and1 vol% silica) having the highest strength at 68.9 MPa. Compressive properties were erratic with specimen 201 (20 vol% kenaf and 1 vol% silica) having the highest strength at 53.6 MPa.
    MeSH terms: Dental Materials; Epoxy Resins; Polymers; Silicon Dioxide; Hibiscus; Nanoparticles
  7. Zuber, M., Hisham, M.S.B., Nasir, N.A.M., Basri, A.A., Khader, S.M.A.
    MyJurnal
    This paper is a Computational Fluid Dynamics (CFD) study of the performance of a jet engine annular
    combustor that was subjected to various loading conditions. The aim is to comprehend the effect of
    various genuine working conditions on ignition and emission performance. The numerical models utilized for fuel ignition is the feasible k-ω model for turbulent stream, species transport (aviation fuel and air) with eddy-dissipation reaction modelling and pollution model for nitrogen oxides (NOX) emission. The results obtained confirm the findings described in the literature.
  8. Fitri, A., Hashim, R., Motamedi, S.
    MyJurnal
    This study simulates the nearshore current characteristics at Carey Island by using MIKE 21 Hydrodynamic FM. The model simulations are calibrated and validated against measured conditions by adjusting the values of bed resistant over the stipulated computation domain. To evaluate the accuracy of the simulation results, three statistical parameters, namely RMSE, R Squared, and Thiel’s inequality coefficients are calculated to compare the observed and simulated results. The results indicate that the current speeds during the spring tide are approximately between 0 m/s and 0.64 m/s which come from Northwest to southeast direction. A good agreement between observed and simulated values of current speeds, current direction and water level with R squared of approximately 0.92 to 0.95 are obtained. Results suggest that the bed resistant is an important parameter in the hydrodynamic simulation using MIKE 21 Hydrodynamic FM.
  9. Hayder A. Alrazen, Ahmad, K.A.
    MyJurnal
    Diesel engines produce high emissions of nitrogen oxide, smoke and particulate matter. The challenge is to reduce exhaust emissions but without making changing their mechanical configuration. This paper is an overview of the effect of natural gas on the diesel engine emissions. Literature review suggests that engine load, air-fuel ratio, and engine speed play a key role in reducing the pollutants in the diesel engine emissions with natural gas enrichment. It is found that increasing the percentage of natural gas (CNG) will affect emissions. Nitrogen oxide (NOx) is decreased and increased at part loads and high loads respectively when adding CNG. The reduction in carbon dioxide (CO2), particulate matter (PM) and smoke are observed when adding CNG. However, carbon monoxide (CO) and unburned hydrocarbon (HC) are increased when CNG is added.
    MeSH terms: Vehicle Emissions; Carbon Dioxide; Carbon Monoxide; Hydrocarbons; Nitric Oxide; Nitrogen Oxides; Smoke; Particulate Matter; Natural Gas
  10. Torabi Asr, M., Masoumi, M.M., Mustapha, F.
    MyJurnal
    Pre-stressing is a concept used in many engineering structures. In this study prestressing in the form of axial compression stress is proposed in the blade structure of H-Darrieus wind turbine. The study draws a structural comparison between reference and prestressed configurations of turbine rotor with respect to their dynamic vibrational response. Rotordynamics calculations provided by ANSYS Mechanical is used to investigate the effects of turbine rotation on the dynamic response of the system. Rotation speed ranging between 0 to 150 rad/s was examined to cover the whole operating range of commercial instances. The modal analysis ends up with first six mode shapes of both rotor configurations. As a result, the displacement of the proposed configurations reduced effectively. Apparent variations in Campbell diagrams of both cases indicate that prestressed configuration has its resonant frequencies far away from turbine operation speeds and thus remarkably higher safety factor against whirling and probable following failures.
    MeSH terms: Probability; Rotation; Wind; Data Compression; Physical Phenomena
  11. Chong SE, Mohamad Zaini RH, Suraiya S, Lee KT, Lim JA
    Malar J, 2017 01 03;16(1):2.
    PMID: 28049485 DOI: 10.1186/s12936-016-1666-y
    BACKGROUND: Dengue and malaria are two common, mosquito-borne infections, which may lead to mortality if not managed properly. Concurrent infections of dengue and malaria are rare due to the different habitats of its vectors and activities of different carrier mosquitoes. The first case reported was in 2005. Since then, several concurrent infections have been reported between the dengue virus (DENV) and the malaria protozoans, Plasmodium falciparum and Plasmodium vivax. Symptoms of each infection may be masked by a simultaneous second infection, resulting in late treatment and severe complications. Plasmodium knowlesi is also a common cause of malaria in Malaysia with one of the highest rates of mortality. This report is one of the earliest in literature of concomitant infection between DENV and P. knowlesi in which a delay in diagnosis had placed a patient in a life-threatening situation.

    CASE PRESENTATION: A 59-year old man staying near the Belum-Temengor rainforest at the Malaysia-Thailand border was admitted with fever for 6 days, with respiratory distress. His non-structural protein 1 antigen and Anti-DENV Immunoglobulin M tests were positive. He was treated for severe dengue with compensated shock. Treating the dengue had so distracted the clinicians that a blood film for the malaria parasite was not done. Despite aggressive supportive treatment in the intensive care unit (ICU), the patient had unresolved acidosis as well as multi-organ failure involving respiratory, renal, liver, and haematological systems. It was due to the presentation of shivering in the ICU, that a blood film was done on the second day that revealed the presence of P. knowlesi with a parasite count of 520,000/μL. The patient was subsequently treated with artesunate-doxycycline and made a good recovery after nine days in ICU.

    CONCLUSIONS: This case contributes to the body of literature on co-infection between DENV and P. knowlesi and highlights the clinical consequences, which can be severe. Awareness should be raised among health-care workers on the possibility of dengue-malaria co-infection in this region. Further research is required to determine the real incidence and risk of co-infection in order to improve the management of acute febrile illness.

    MeSH terms: Antimalarials/administration & dosage; Dengue/complications*; Dengue/diagnosis*; Dengue/pathology; Dengue Virus/isolation & purification*; Doxycycline/administration & dosage; Humans; Malaria/complications*; Malaria/diagnosis*; Malaria/pathology; Malaysia; Male; Middle Aged; Thailand; Plasmodium knowlesi/isolation & purification*; Treatment Outcome; Artemisinins/administration & dosage; Coinfection/diagnosis*; Coinfection/pathology
  12. Teow SY, Yap HY, Peh SC
    J Pathog, 2017;2017:7349268.
    PMID: 29464124 DOI: 10.1155/2017/7349268
    Epstein-Barr virus (EBV) is a pathogen that infects more than 90% of global human population. EBV primarily targets B-lymphocytes and epithelial cells while some of them infect monocyte/macrophage, T-lymphocytes, and dendritic cells (DCs). EBV infection does not cause death by itself but the infection has been persistently associated with certain type of cancers such as nasopharyngeal carcinoma (NPC), Burkitt's lymphoma (BL), and Hodgkin's lymphoma (HL). Recent findings have shown promise on targeting EBV proteins for cancer therapy by immunotherapeutic approach. Some studies have also shown the success of adopting EBV-based therapeutic vaccines for the prevention of EBV-associated cancer particularly on NPC. In-depth investigations are in progress to refine the current therapeutic and vaccination strategies. In present review, we discuss the highly potential EBV targets for NPC immunotherapy and therapeutic vaccine development as well as addressing the underlying challenges in the process of bringing the therapy and vaccination from the bench to bedside.
  13. Mohd Azahar NMZ, Krishnapillai ADS, Zaini NH, Yusoff K
    Heart Asia, 2017;9(2):e010864.
    PMID: 29467830 DOI: 10.1136/heartasia-2016-010864
    Objective: Despite various efforts, hypertension remains poorly controlled, thus allowing cardiovascular disease (CVD) to impact the health burden worldwide. Patients' perception of risk may contribute to this scenario. The present study aims to assess the level of risk perception among individuals with hypertension in rural Malaysia.

    Methods: This is a community-based study conducted among adults between 2010 and 2011 among a rural population in Raub, Pahang, Malaysia. Blood pressure was measured after 5 min of rest. Measurement was done twice and the average was recorded. Cardiovascular risk perception score (CvRPS) was derived using the Modified Risk and Health Behavior Questionnaire. Higher CvRPS indicates the respondent perceives a poorer prognostic outlook.

    Results: A total of 383 respondents who have hypertension participated in this study. The mean age of respondents was 62±10.6 years; men 63.1±9.6 years, women 61.2±11.1 years (p>0.05). Among hypertensives, those who were not on medication had significantly lower CvRPS compared with those who were on medications (115.9±22.1vs 120.9±23.5, p=0.036); those who were not aware of their hypertensive status had significantly lower CvRPS compared with respondents who were aware about their hypertension (116.7±22.5vs 121.7±21.3, p=0.029) and those with uncontrolled hypertension had significantly lower CvRPS compared with those whose blood pressure was controlled (118.2±22.2vs 128.8±25.8, p=0.009).

    Conclusions: Our study shows that respondents who were not on medications, unaware of their hypertension status and those who had uncontrolled hypertension tended to underestimate (lower CvRPS) their risk for CVD. Improving their CvPRS through a concerted health education may lead to better therapeutic behaviour and outcomes.

  14. Kan KW, Sylves P, Nik-Ahmad-Zuky NL, Shatriah I
    Cureus, 2017 Dec 13;9(12):e1942.
    PMID: 29468098 DOI: 10.7759/cureus.1942
    Dengue fever is common in the tropics and its clinical manifestations and complications are well-known. However, dengue-related ocular complications are rare. Here we present a postpartum female who complained of bilateral central scotoma, at five days after the clinical diagnosis of dengue fever. The ocular examination was suggestive of dengue maculopathy and foveolitis. She was treated with a combination of intravenous methylprednisolone and immunoglobulin. The final visual recovery was good.
    MeSH terms: Dengue; Eye; Female; Head; Immunoglobulins; Methylprednisolone; Retinal Diseases; Scotoma; Postpartum Period
  15. Sahu PS, Lim YAL, Mahmud R, Somanath SD, Tan CT, Ramachandran CP
    Asian Pac J Trop Med, 2017 Apr;10(4):332-340.
    PMID: 28552103 DOI: 10.1016/j.apjtm.2017.03.024
    Seizures due to neurocysticercosis (NCC) is a neglected human-to-human transmitted disorder and an emerging problem worldwide. A substantial portion of recent onset seizures is known to be attributed to NCC in Taenia solium (T. solium) endemic areas where populations which neither raise pigs nor eat pig meat are also at risk. High prevalence of NCC causing epilepsy has been reported in the underdeveloped areas of Southeast Asia (SEA) however, only fragmentary information on its incidence is available in countries like Malaysia. In Malaysia T. solium infection was previously thought to be infrequent due to Muslim population majority and the religious prohibition of consuming pork, but it is not totally absent. There is an evident lack of knowledge and awareness of the actual burden, routes of transmission, and the impact of NCC in this region. The problem is assumed to be more prevalent particularly in cities because of the frequent inflow of possibly T. solium infected individuals or carriers among those who migrate from neighboring endemic countries to Malaysia. The issue of imported cases that are likely to be emerging in Malaysia is highlighted here. An accurate quantification of regional burdens of epilepsy due to NCC in Malaysia is warranted considering the disease emergence in its neighboring countries. It is suggested that the importance of NCC be recognized through quantification of its burden, and also to collect epidemiological data for its subsequent elimination in line of World Health Organization's mission for control of cysticercosis as a neglected tropical disease. In this review the need as well as a strategy for neuro-care center screening of epilepsy cases, and various issues with possible explanations are discussed. It is also proposed that NCC be declared as a reportable disease which is one of the eradicable public health problems in SEA.
    MeSH terms: Red Meat; Animals; Asia, Southeastern; Cities; Cysticercosis; Epilepsy; Humans; Islam; Malaysia; Public Health; Seizures; Swine; Taeniasis; Incidence; Prevalence; Neurocysticercosis; Sus scrofa; Taenia solium
  16. Hosadurga R, Shanti T, Hegde S, Kashyap RS, Arunkumar SM
    J Indian Soc Periodontol, 2017;21(4):315-325.
    PMID: 29456307 DOI: 10.4103/jisp.jisp_139_17
    BACKGROUND: In developing nations like India awareness and education about dental implants as a treatment modality is still scanty.

    AIM: The study was conducted to determine the awareness, knowledge, and attitude of patients toward dental implants as a treatment modality among the general population and to assess the influence of personality characteristics on accepting dental implants as a treatment modality in general and as well as treatment group.

    MATERIALS AND METHODS: A structured questionnaire-based survey was conducted on 500 randomly selected participants attending the outpatient department. The study was conducted in 2 parts. In the first part of the study, level of awareness, knowledge, and attitude was assessed. In the second part of the study, interactive educational sessions using audiovisual aids were conducted following which a retest was conducted. The participants who agreed to undergo implant treatment were followed up to assess their change in attitude towards dental implants posttreatment. Thus pain, anxiety, functional, and esthetic benefits were measured using visual analog scale. They were further followed up for 1 year to reassess awareness, knowledge, and attitude towards dental implants.

    RESULTS: A total of 450 individuals completed the questionnaires. Only 106 individuals agreed to participate in the educational sessions and 83 individuals took the retest. Out of these, only 39 individuals chose implants as a treatment option. A significant improvement in the level of information, subjective and objective need for information, was noted after 1 year.

    CONCLUSION: In this study, a severe deficit in level of information, subjective and objective need for information towards, dental implants as a treatment modality was noted. In the treatment group, a significant improvement in perception of dental implant as a treatment modality suggests that professionally imparted knowledge can bring about a change in the attitude.

  17. Hammad MA, Tangiisuran B, Kharshid AM, Abdul-Aziz N, Hassan Y, Aziz NA, et al.
    J Pharm Bioallied Sci, 2017 Oct-Dec;9(4):221-228.
    PMID: 29456372 DOI: 10.4103/jpbs.JPBS_26_17
    Context: The literature of drug-drug interaction (DDI)-related uncontrolled causality, and preventability of DDI-induced UCG (HbA1c >7%) in outpatients glycemia (UCG) among outpatients with Type 2 diabetes mellitus is still limited.
    Aims: The aim of this study is to identify the prevalence, mechanism, severity, with Type 2 diabetes.
    Settings and Design: A cross-sectional study was conducted in Penang General Hospital.
    Methods: A computerized system for DDI checking was used to assess the severity and mechanism of DDIs. Drug interaction probability scale was used to evaluate the likelihood of DDIs. Preventability of DDIs has been determined by the instrument of Hallas. The UCG prevalence related to DDIs was further assessed.
    Statistical Analysis Used: SPSS 21.00 was used in this study.
    Results: From 425 outpatients with HbA1c% test, their mean age was 58.7 ± 12.8 years. Only 225 (52.9%) cases had controlled glycemia while 200 (47.1%) cases with UCG. They had multiple comorbidities, with a mean number of 3.8 ± 2.2/patient and often prescribed with multiple medications, with a mean number of 6.33 ± 4.67/patient. It has been detected that 86 DDIs causing UCG in 46 patients (23%) with range of (1 - 4) DDIs per patient. Drugs with DDI-induced UCG were as follows: diuretics (79%), salbutamol (9.2%), cortisones (5.8%), and others (6%). The majority of these DDIs were categorized as possible (77.9%) and preventable (37%).
    Conclusion: Nearly one-quarter of UCG was induced by DDIs; most of these DDIs are possible, and more than one-third are preventable. It was concluded that thiazide diuretics have the highest prevalence of DDI-related UCG.
    Study site: Endocrine clinic, Hospital Pulau Pinang, Malaysia
    MeSH terms: Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2*; Drug Interactions*; Hospitals, General; Humans; Hyperglycemia*; Malaysia; Outpatient Clinics, Hospital
  18. Ramatillah DL, Syed Sulaiman SA, Khan AH, Meng OL
    J Pharm Bioallied Sci, 2017 Oct-Dec;9(4):229-238.
    PMID: 29456373 DOI: 10.4103/jpbs.JPBS_191_17
    Background: Quality of life is one of the parameters to check the improvement of hemodialysis treatment among hemodialysed patients. Those patients will be dealing with this treatment in long term if this treatment is the only way for them to replace their kidney function and this thing will affect their quality of life.
    Objective: To evaluate the quality of life patients on hemodialysis using kidney disease quality of life-short term 24 (KDQoL-SF24) Malaysian Version.
    Materials and Methods: Cohort observational study was conducted in this study. The study included 78 hemodialysed patients in HD center Penang, Malaysia.
    Results: There were 9 components which had the lower of the mean and standard deviation (SD) than the standard form; work status (15.01 ± 35.57), cognitive function (75.66 ± 13.75), quality of life social interaction (76.32 ± 16.11), sleep (55.86 ± 15.30), social support (59.61 ± 22.08), patient satisfaction (43.24 ± 15.32), physical functioning (50.06 ± 42.81), general health (29.62 ± 25.56), and role emotional (54.27 ± 49.92). In this HD center, the group of patient's age who had the lower mean ± SD from the KDQoL-SF Manual Standard were the first and the sixth groups of patient's age (≤20 and 61-70).
    Conclusion: The study conducted in HD center, Penang, Malaysia showed that the scoring of work status, cognitive function, quality of social interaction, sleep, social support, patient satisfaction, physical functioning, general health, and role emotional were low than standard form.
    MeSH terms: Cognition; Emotions; Renal Dialysis; Humans; Interpersonal Relations; Kidney Diseases; Kidneys, Artificial; Malaysia; Quality of Life; Cohort Studies; Patient Satisfaction
  19. Ariffin NM, Islahudin F, Makmor-Bakry M, Kumolosasi E, Hamid MHA
    J Pharm Bioallied Sci, 2017 Oct-Dec;9(4):239-245.
    PMID: 29456374 DOI: 10.4103/jpbs.JPBS_48_17
    Introduction: Primaquine is vital for the management of liver-stagePlasmodium vivaxandPlasmodium ovalemalaria. However, primaquine effectiveness is dependent on various factors and differs between populations. Therefore, this study was conducted to identify factors that affect the length of stay and relapse during primaquine combination treatment in malaria-infected patients in the local setting.

    Materials and Methods: A retrospective study on the use of primaquine combination amongP. vivaxandP. ovaleinfected patients in Selangor, Malaysia within a 5-year period from 2011 to 2015 was obtained from the National Malaria Case Registry, Malaysia. Data collected were patient characteristics (age, gender, nationality, glucose-6-phosphate dehydrogenase, pregnancy); disease characteristics (survival, past malaria infection, parasite type, presence of gametocyte, parasite count, week onset, severity, transmission type); and treatment characteristics (type of antimalarial, treatment completion). Outcome measures were length of stay and relapse during a 1-year follow-up.

    Results: A total of 635 patients were included in the study. Based on a multivariate logistic regression analysis, the significant predictors for length of stay were gender (P= 0.009) and indigenous transmission (P< 0.001). Male patients had a shorter length of stay than females by 0.868 days (P= 0.009), and indigenous transmission took 1.82 days more compared to nonindigenous transmission (P< 0.001). Predictors for relapse were indigenous transmission of malaria (P= 0.019), which was 15.83 times more likely to relapse than nonindigenous transmission (P< 0.01).

    Conclusions: This study reveals that the effectiveness of primaquine was clinically associated with gender and indigenous transmission. To that end, vigilant monitoring of primaquine use is required to reduce relapse and future transmission.
    MeSH terms: Animals; Antimalarials; Ethnic Groups; Female; Follow-Up Studies; Glucosephosphate Dehydrogenase; Humans; Length of Stay; Liver; Malaria; Malaysia; Male; Parasites; Pregnancy; Primaquine; Recurrence; Registries; Retrospective Studies; Logistic Models; Outcome Assessment (Health Care)
  20. Shakeel S, Nesar S, Rahim N, Iffat W, Ahmed HF, Rizvi M, et al.
    J Pharm Bioallied Sci, 2017 Oct-Dec;9(4):266-271.
    PMID: 29456378 DOI: 10.4103/jpbs.JPBS_327_16
    Aims: Despite an increased popularity of print and electronic media applications, there is a paucity of data reflecting doctors' opinions regarding efficient utilization of these resources for the betterment of public health. Hence, this study aimed to investigate the perception of physicians toward the effect of electronic and print media on the health status of patients.
    Setting and Design: The current research is a cross-sectional study conducted from January 2015 to July 2015. The study population comprised physicians rendering their services in different hospitals of Karachi, Pakistan, selected by the nonprobability convenience sampling technique. In this study, 500 questionnaires were distributed through email or direct correspondence.
    Methods and Materials: Physicians' perception toward the impact of electronic and print media on the health status of patients was assessed with a 20-item questionnaire. Different demographic characteristics, such as age, gender, institution, position, and experience of respondents, were recorded. Quantitative data were analyzed with the use of Statistical Package for Social Sciences, version 20.0 (SPSS, Chicago, IL). The association of the demographic characteristics of the responses of physicians was determined by one-way ANOVA using 0.05 level of significance.
    Results: In this study, 254 physicians provided consent to show their responses for research purposes. A response rate of 50.8% was obtained. Nearly one-third of the respondents negated that patients get health benefit using electronic and print media. The majority did not consider electronic and print media as lifestyle-modifying factors. Physicians thought that patients particularly do not rely on mass media for acquiring health information and consider healthcare professionals as unswerving information resource.
    Conclusions: Mass media can be productive resources to augment awareness among patients, although physicians seem unconvinced about the extended usage of print/electronic media.
    MeSH terms: Analysis of Variance; Attitude; Awareness; Chicago; Cross-Sectional Studies; Health Status; Humans; Informed Consent; Life Style; Mass Media; Pakistan; Perception; Physicians; Public Health; Surveys and Questionnaires; Social Sciences; Electronic Mail
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