Browse publications by year: 2021

  1. Jayashree S, Reza MNH, Malarvizhi CAN, Mohiuddin M
    Heliyon, 2021 Aug;7(8):e07753.
    PMID: 34430741 DOI: 10.1016/j.heliyon.2021.e07753
    Background: The current level of industrialization has generated many challenges worldwide, including ecological hazards, climate change, and the overuse of non-renewable natural resources, thereby creating an increasing demand for achieving the goal of the Triple Bottom Line (TBL). In this regard, Industry 4.0 can be used as a crunch point to contribute to the production process that can help achieve sustainable development.

    Purpose: While the Malaysian government proposed the "Industry4ward" approach to enhance technological adoption, there is scarce empirical evidence in the literature that validates SMEs for Industry 4.0. Using Dynamic Capability View (DCV), this study proposes a framework that includes core determinants like top management commitment, supply chain integration, and IT infrastructure, that can significantly influence Industry 4.0 implementation toward achieving TBL sustainability.

    Design/methodology/approach: Employing simple random sampling, the study adopted a quantitative approach based on 199 useable respondent's feedback collected through a survey questionnaire of 900 employees from Malaysian SMEs. The statistical analysis was performed using Structural Equation Modeling (Partial Least Square, SmartPLS 3.3.2).

    Findings: The results show that top management and IT infrastructure significantly impact Industry 4.0 implementation and sustainability. In contrast, the analysis also demonstrates that supply chain integration is insignificant to Industry 4.0 implementation in SMEs. The findings also indicate that the relationship between the determinants of Industry 4.0 and TBL sustainability can be mediated by the "effective implementation" of Industry 4.0.

    Recommendations: The study highlights the practical consequences of the role and use of the determinants in Industry 4.0 implementation. Its findings help managers and policy-makers to optimize value creation to achieve sustainable development goals.

    Limitations and future research: Focusing only on Malaysian manufacturing SMEs may restrict the generalization of the study; thus, a benchmarking analysis from other industrial settings is encouraged. The questionnaire-based survey is a further limitation of the study.

  2. Mohammed HA, Sulaiman GM, Anwar SS, Tawfeeq AT, Khan RA, Mohammed SAA, et al.
    Nanomedicine (Lond), 2021 09;16(22):1937-1961.
    PMID: 34431317 DOI: 10.2217/nnm-2021-0070
    Aims: To evaluate the anti breast-cancer activity, biocompatibility and toxicity of poly(d,l)-lactic-co-glycolic acid (PLGA)-encapsulated quercetin nanoparticles (Q-PLGA-NPs). Materials & methods: Quercetin was nano-encapsulated by an emulsion-diffusion process, and the nanoparticles were fully characterized through Fourier transform infrared spectroscopy, x-ray diffractions, FESEM and zeta-sizer analysis. Activity against CAL51 and MCF7 cell lines were assessed by DNA fragmentation assays, fluorescence microscopy, and acridine-orange, and propidium-iodide double-stainings. Biocompatibility towards red blood cells and toxicity towards mice were also explored. Results: The Q-PLGA-NPs exhibited apoptotic activity against the cell lines. The murine in vivo studies showed no significant alterations in the liver and kidney's functional biomarkers, and no apparent abnormalities, or tissue damages were observed in the histological images of the liver, spleen, lungs, heart and kidneys. Conclusion: The study established the preliminary in vitro efficacy and in vivo safety of Q-PLGA-NPs as a potential anti-breast cancer formulation.
    MeSH terms: Animals; Humans; Neoplasms*; Quercetin/pharmacology; Gene Expression; Apoptosis; Lactic Acid; Mice; Nanoparticles*; MCF-7 Cells
  3. Wang MC, Freaney PM, Perak AM, Greenland P, Lloyd-Jones DM, Grobman WA, et al.
    J Am Heart Assoc, 2021 09 07;10(17):e020717.
    PMID: 34431359 DOI: 10.1161/JAHA.120.020717
    Background The prevalence of obesity in the population has increased in parallel with increasing rates of adverse pregnancy outcomes (APOs). Quantifying contemporary trends in prepregnancy obesity and associations with interrelated APOs (preterm birth, low birth weight, and pregnancy-associated hypertension) together and individually can inform prevention strategies to optimize cardiometabolic health in women and offspring. Methods and Results We performed a serial, cross-sectional study using National Center for Health Statistics birth certificate data including women aged 15 to 44 years with live singleton births between 2013 and 2018, stratified by race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, and non-Hispanic Asian). We quantified the annual prevalence of prepregnancy obesity (body mass index ≥30.0 kg/m2; body mass index ≥27.5 kg/m2 if non-Hispanic Asian). We then estimated adjusted associations using multivariable logistic regression (odds ratios and population attributable fractions) for obesity-related APOs compared with normal body mass index (18.5-24.9 kg/m2; 18.5-22.9 kg/m2 if non-Hispanic Asian). Among 20 139 891 women, the prevalence of prepregnancy obesity increased between 2013 and 2018: non-Hispanic White (21.6%-24.8%), non-Hispanic Black (32.5%-36.2%), Hispanic (26.0%-30.5%), and non-Hispanic Asian (15.3%-18.6%) women (P-trend 
    MeSH terms: Cross-Sectional Studies; Female; Hispanic Americans; Humans; Infant, Newborn; Pregnancy; Pregnancy Outcome/epidemiology; United States/epidemiology
  4. Wang VV, Chang CY, Radhakrishnan AP
    Rev Soc Bras Med Trop, 2021;54:e02962021.
    PMID: 34431947 DOI: 10.1590/0037-8682-0296-2021
    MeSH terms: Aspergillus; Humans
  5. Chang CY
    Rev Soc Bras Med Trop, 2021;54:e03342021.
    PMID: 34431951 DOI: 10.1590/0037-8682-0334-2021
    MeSH terms: Acquired Immunodeficiency Syndrome*; HIV; Humans; Mycobacterium avium
  6. Younas M, Zou H, Laraib T, Abbas W, Akhtar MW, Aslam MN, et al.
    PLoS One, 2021;16(8):e0256450.
    PMID: 34432836 DOI: 10.1371/journal.pone.0256450
    Food production and waste recycling are the two major issues faced globally with rapidly increasing population. Recycling organic wastes to crop amendments could be a possible solution to these issues. Earthworms transfer organic waste to compost, which is used to grow crops and increase crop productivity. This study assessed the impact of vermicompost produced from the residues of six desert plant species, i.e., (Ziziphus mauritiana, Aerva javanica, Calligonum comosum, Sacchrum benghalens, Calligonum polygonoides and Prosopis cineraria) combined with farmyard manure (5 t ha-1) on growth, yield and photosynthetic activity of maize crop. Earthworm species Eisenia fetida (Savigny, 1826) was used to prepare vermicomposting of all tested plant species. The desert species were collected from natural habitats, chopped, dried, mixed with FYM and then earthworms were released to prepare the vermicompost. The earthworms were excluded twenty days after release and resultant was considered as compost and used in the experiment. Results revealed that application of P. cineraria vermicompost resulted in the highest plant height (75.33 cm), stem diameter (22.66 mm), cob length (17.66 cm), number of grains/cob (374.67), 1000-grain weight (260.41 g) and grains yield (3.20 t/ha). Application of P. cineraria vermicompost resulted in the highest uptake of macronutrients, i.e., N (91.01%), P (22.07%), K (80.41%), micronutrients, i.e., Fe (19.07 ppm), Zn (40.05 ppm), and phenolic contents (150). Application of P. cineraria vermicompost also resulted in the highest quantum photosynthetic yield (0.42 mole C/mole of photon), chlorophyll florescence (355.18 moles of photon m-2s-1) and electron transport rate (310.18 micro mole m-2s-1). It is concluded that vermicomposting has the potential to improve growth and yield of maize crop. Particularly, application of vermicompost obtained from P. cineraria can be used to improve the growth and yield of maize crop. Nonetheless, field trials are necessary for a wide scale recommendation.
  7. Mohd Romlay MR, Mohd Ibrahim A, Toha SF, De Wilde P, Venkat I
    PLoS One, 2021;16(8):e0256665.
    PMID: 34432855 DOI: 10.1371/journal.pone.0256665
    Low-end LiDAR sensor provides an alternative for depth measurement and object recognition for lightweight devices. However due to low computing capacity, complicated algorithms are incompatible to be performed on the device, with sparse information further limits the feature available for extraction. Therefore, a classification method which could receive sparse input, while providing ample leverage for the classification process to accurately differentiate objects within limited computing capability is required. To achieve reliable feature extraction from a sparse LiDAR point cloud, this paper proposes a novel Clustered Extraction and Centroid Based Clustered Extraction Method (CE-CBCE) method for feature extraction followed by a convolutional neural network (CNN) object classifier. The integration of the CE-CBCE and CNN methods enable us to utilize lightweight actuated LiDAR input and provides low computing means of classification while maintaining accurate detection. Based on genuine LiDAR data, the final result shows reliable accuracy of 97% through the method proposed.
    MeSH terms: Algorithms*; Humans; Lasers*; Robotics; Software; Cluster Analysis
  8. Dayana Priyadharshini S, Suresh Babu P, Manikandan S, Subbaiya R, Govarthanan M, Karmegam N
    Environ Pollut, 2021 Aug 17;290:117989.
    PMID: 34433126 DOI: 10.1016/j.envpol.2021.117989
    Surface and water bodies in many parts of the world are affected due to eutrophication, contamination and depletion. The approach of wastewater treatment using algae for eliminating nutrients and other pollutants from domestic wastewater is growing interest among the researchers. However, sustainable treatment of the wastewater is considered to be important in establishing more effective nutrient and pollutant reduction using algal systems. In comparison to the conventional method of remediation, there are opportunities to commercially viable businesses interest with phycoremediation, thus by achieving cost reductions and renewable bioenergy options. Phycoremediation is an intriguing stage for treating wastewater since it provides tertiary bio-treatment while producing potentially valuable biomass that may be used for a variety of applications. Furthermore, the phycoremediation provides the ability to remove heavy metals as well as harmful organic substances, without producing secondary contamination. In this review, the role of microalgae in treating different wastewaters and the process parameters affecting the treatment and future scope of research have been discussed. Though several algae are employed for wastewater treatment, species of the genera Chlamydomonas, Chlorella, and Scenedesmus are extensively utilized. Interestingly, there is a vast scope for employing algal species with high flocculation capacity and adsorption mechanisms for the elimination of microplastics. In addition, the algal biomass generated during phycoremediation has been found to possess high protein and lipid contents, promising their exploitation in biofuel, food and animal feed industries.
  9. Haricharan PB, Voruganti S, Kotha A, Shivanna MM, Gandhi B, Suresh N
    Eur J Dent, 2021 Aug 25.
    PMID: 34433220 DOI: 10.1055/s-0041-1731925
    OBJECTIVES:  This clinical trial compared the efficacy of atraumatic restorative treatment (ART) sealants against resin-based sealants in terms of their retention and fissure caries preventive benefits over a period of 24 months among a section of school children in the Southern Indian state of Telangana.

    MATERIALS AND METHODS:  A split mouth clinical trial employed 198 children, who received these sealants on their lower permanent first molars. Retention was assessed 6 monthly and caries annually STATISTICAL ANALYSIS:  Chi-square tests were utilized to analyze the retention rate and the incidence of dental caries between the two groups. Kaplan-Meier survival analysis plotted the cumulative survival percentage of partially, and fully retained sealants and the survival of dentin carious free pits and fissures among both the groups. A linear binary logistical regression analysis calculated the odds ratio.

    RESULTS:  A statistical significant difference was observed in the retention rate between these sealants at every follow-up stage. The cumulative survival percentage of ART and resin sealants was calculated to be 30.9 and 37.5% by the end of 2 years. The Kaplan-Meier analysis showed no significant difference with regard to the survival of dentin carious free pits and fissures. The odds ratio for this trial was 0.747 (95% confidence interval: 0.493-1.13) CONCLUSION:  Resin sealants fared better than ART sealants in the field of retention. However, no significant differences were observed with regard to fissure caries prevention by the end of the study period.

  10. Tan, Jin Rong, Dayang Azzyati Awang Dahlan
    JUMMEC, 2021;24(1):91-97.
    MyJurnal
    Introduction: Ureteric obstruction commonly presents as a urological emergency requiring urgent intervention with urinary diversion. Double J stenting (DJS) is the preferred option to relieve ureteric tract obstruction in our centre.

    Objective: Our study aims to determine the feasibility and outcomes of DJS by general surgeons and medical officers in a hospital without a resident urologist and to identify the possible predictive factors for successful DJS.

    Methods: This is a clinical audit of all patients scheduled for DJS in Hospital Bintulu, Sarawak, from January 2017 to March 2020. A total of 57 patients were included. Socio-demographic data and factors predicting success rate, i.e., level of ureteric obstruction and its causes (intrinsic or extrinsic), diagnosis, size and nature of stone(s), degree of hydronephrosis and pre-operative renal profile, were collected. Success rate and postoperative outcomes for all successful cases were evaluated. Bivariate statistical analyses were used to investigate the association of predictive factors with the success rate of DJS.

    Results: Double J stenting was successful in 63.2% (36 cases) of our total samples of 57 cases. Out of 36 successful cases, 82.1% of the cases were able to return to baseline renal profile within 14 days and 83.3% did not develop fever within 3 days post-operative. The post-operative mean length of stay was 3.16 days and post-operative day 1 mean pain score was 0.72. Causes of obstruction by intrinsic factors, urolithiasis, pre-operative normal serum creatinine (
  11. Pal, Bikramjit, Chong, Sook Vui, Thein, Aung Win, Tay, Ava Gwak Mui, Soe, Htoo Htoo Kyaw, Pal, Sudipta
    JUMMEC, 2021;24(1):83-90.
    MyJurnal
    Introduction: Medical simulation is a technique that allows interactive and immersive activity by recreating all or part of a clinical experience without exposing the patients to the antecedent risks. High-fidelity patient simulation-based teaching is an innovative and efficient method to address increasing student enrolment, faculty shortages and restricted clinical sites.

    Objective: To assess the effectiveness of high-fidelity patient simulation (HFPS) as compared to video-assisted lecture-based teaching method (VALB) among undergraduate medical students.

    Methods: The study was a Randomized Controlled Trial which involved 56 final year undergraduate medical students. The effectiveness of teaching based on HFPS (intervention group) and VALB (control group), on acquisition of knowledge, was assessed by multiple choice questions (MCQs) in the first and fourth week. Similarly, the skills competency was assessed by objective structured clinical examination (OSCE) in the second and fourth week. Mean and standard deviation (SD) for total score of knowledge and skills assessments were used as outcome measures. P value < 0.05 was considered to be statistically significant.

    Results: In both groups, students had significant higher mean MCQ scores at Post-tests. The intervention group had higher mean change score of MCQ marks than the control group but the difference was not statistically significant. In both the first and second skills assessments, mean OSCE scores for intervention group were higher than control group but this difference was not statistically significant.

    Conclusion: There was significant gain in knowledge in both methods of teaching but did not reach statistical difference in terms of skills enhancement in the intervention group as compared to the control group.
  12. Bouzaboul, Mounir, Abidli, Zakaria, Amri, Abdeslam, Rabea, Ziri, Ahami, Ahmed Omar Touhami
    JUMMEC, 2021;24(1):76-82.
    MyJurnal
    Introduction: Attention is one of many cognitive functions; it plays a central role in the learning process. For this reason, our study aims to determine the impact of attentional abilities on academic performance among middle school learners in Middle Atlas of Morocco.

    Methods: Data were collected from a sample of 137 middle school learners. For the assessment of attentional abilities, we performed the Trail Making Test (TMT) to estimate mental flexibility. Evaluation of selective attention was done through the Stroop Test and the measurement of sustained attention was achieved via the d2-R test.

    Results: Our results revealed that the attentional abilities of learners in our samples are positively correlated with their academic performance and vice versa.

    Conclusion: At the end of this study, it is important to establish a thorough diagnosis of attentional disorders to identify learners with attention problems in order to implement a remedial program so as to avoid the detrimental effects of these disorders on the academic performance of learners.
  13. Nik Nadirah Nik Azis, Samihah Abdul Karim, Mariam Mohamad, Nadia Mohd Mustafah
    JUMMEC, 2021;24(1):70-75.
    MyJurnal
    Objective: The aim of this study was to investigate scuba diving induced exercise response in novice divers as required in open water scuba diving certification.

    Methods: Maximal cardiopulmonary exercise test (CPET) was performed in 30 novice divers before and within 24 hours after a standard scuba diving open water certification diving protocol of four open water dives.

    Results: A significant increase in maximal oxygen consumption (VO2max) in mL·kg-1·min-1 after scuba diving training [25.84 (6.0) vs. 27.04 (7.0)] (p
  14. Sundus, Ahlam, Tan, Maw Pin, Sellappans, Renukha
    JUMMEC, 2021;24(1):63-69.
    MyJurnal
    Introduction: The population of Malaysia is ageing rapidly. Due to the relatively greater incidence of noncommunicable diseases among older adults, polypharmacy is highly prevalent in this population. This polypharmacy along with other age-related factors increases the risk of drug-related problems to several folds. Currently, no study in Malaysia or even Asia has determined the type and nature of drug-related problems among non-institutionalised older adults. Therefore, this study aims to highlight common drug-related problems among community-dwelling older persons (≥ 65 years) with polypharmacy.

    Materials and Methods: A cross-sectional exploratory study was carried out where in-depth home medication reviews were carried out by two pharmacists. Participants were recruited from geriatric and fall clinics of the University of Malaya Medical Centre located in the urban area of the Federal Territory of Malaysia. The total numbers of drug-related problems were classified using the Pharmaceutical Care Network Europe (PCNE) classification V9.0. Recommendations and referral letters were provided based on the pharmaceutical care issues identified.

    Results: Thirty participants were recruited, among whom 178 drug-related problems were identified with a median value of six [range 1-11] drug-related problems per participant. The majority of problems were related to the effectiveness of prescribed treatment (69.1 %), followed by the possibility of adverse effects (28.7 %).

    Conclusion: Home medication review identifies numerous medication-related issues and allows for patient education and detailed counselling in an informal and patient-friendly manner. Future studies to determine the longitudinal effect of home medication review on patient outcome, cost implications, and overall healthcare utilization are now indicated.
  15. Noraida Md Idrus, Siti Mistima Maat
    MyJurnal
    Healthy competition in the field of education makes every individual strive to improve their abilities and competencies in terms of knowledge, skills and values related to mathematics. Mathematics as an important communication tool in the pursuit of the progress of the Industrial Revolution 4.0 era requires a community that is fluent and literate in mathematics. The main focus is to produce a generation of leaders who are analytical, critical and logical thinking urging the education sector to identify issues and shortcomings of self-efficacy related to mathematics from the grassroots level. The purpose of this study is to make a systematic literature review on the components of self-efficacy and its inclusion in mathematics education research. Two research questions that are emphasised are the components of self-efficacy and how self-efficacy is studied in empirical research in mathematics education. This study uses the PRISMA Model. Two search engines are used, namely the Education Resources Information Center (ERIC) and Google Scholar. Out of the 152 articles identified, a total of 20 articles were accepted that met the purpose of the study. Based on the analysis conducted, there are 4 components of self-efficacy that have been identified, namely mathematical self-efficacy, technological self-efficacy, academic self-efficacy and teaching self-efficacy. The findings also show that the majority of self-efficacy studies are conducted quantitatively compared to qualitatively. The main research lines observed were the level of self-efficacy, the relationship between self-efficacy and other relevant variables, and the development of self-efficacy. Although many previous studies have been conducted in the Asian continent, the number of studies that emphasise self-efficacy in the Malaysian environment is still considered small. Therefore, the results of this study are expected to provide a deep understanding so that such studies can be implemented in the context of education in Malaysia.
  16. Muhammad Raqib Mohd Sofian, Azman Azwan Azmawati
    MyJurnal
    Malaysia has previously experienced various incidents and issues involving race and religion and it has caused problems in terms of relations between races and religions. Issues involving religion and race often involve Islam, which is also the official religion of Malaysia. Islam is often a sensitive subject because it is often used as a tool to maintain the hegemony and status quo by the government in the context of Malaysia. In 2013, a non-governmental organization known as " COMANGO" submitted several demands involving human rights in Malaysia to the United Nations (UN) at the Universal Periodic Assessment (UPR). COMANGO was said to have made several demands that challenged the position of Islam and Malays in Malaysia and also promoting free sex. This issue has received widespread coverage in the Malaysian press; especially the mainstream press and it is seen as an issue that can benefit the government to strengthen their power by playing this issue to the general public. Therefore, this article aims to examine the messages delivered by the mainstream press on this issue, specifically Utusan Malaysia and The Star. The findings of the study show that the two newspapers provide almost the same coverage with little differences. Utusan Malaysia is seen as strongly opposing to COMANGO demands and elevates the UMNO party as a party that really fight for Islam while The Star, although seen as giving COMANGO more opportunities to express their stance, is seen to be cautious in their reporting on the issue
  17. Romzi Ationg, Mohd. Sohaimi Esa, Mohd Azri Ibrahim, Jualang Azlan Gansau, Andreas Totu, Irma Wani Othman
    MyJurnal
    This paper presents an analysis on the resurgence of multiethnic political ideology in Sabah through the slogan of ‘Sabah for Sabahan’. It is found that after several decades of dealing with racial issues, Sabah is increasingly understanding the fact that politicizing ethnic differences will only lead to destruction. This situation was found to be an effect on the use of the slogan "Sabah for Sabahan". Therefore, the slogan should be considered as one of the important factors in the process of development or the resurgence of multi-ethnic political ideology in Sabah. In other words, this paper has shown that changes in political characteristics in a society characterized by diversity can be done through the creation and widespread use of specific political slogans that are very significant with the current needs and needs of the population in an administrative unit such as village, city and country
  18. M. Kaviza
    MyJurnal
    Kajian berbentuk korelasi ini bertujuan untuk menentukan sama ada terdapat hubungan antara penggunaan aplikasi Google Classroom dari aspek pengetahuan, kemahiran dan sikap terhadap pencapaian dalam pembelajaran sejarah. Seramai 114 orang murid Tingkatan Empat yang dipilih berdasarkan teknik persampelan rawak mudah terlibat dalam kajian ini. Instrumen kajian ini merupakan soal selidik dan ujian pencapaian. Data kajian ini dianalisis secara statistik inferensi iaitu ujian Korelasi Pearson dan ujian Regresi Pelbagai melalui perisian IBM SPSS. Dapatan kajian ini menunjukkan bahawa terdapat hubungan linear positif yang sederhana tinggi secara signifikan antara min penggunaan aplikasi Google Classroom iaitu pengetahuan, kemahiran dan sikap terhadap pencapaian dalam pembelajaran sejarah. Selain itu, pengetahuan, kemahiran dan sikap dalam penggunaan aplikasi Google Classroom dilaporkan merupakan pembolehubah-pembolehubah peramal dan telah menyumbang sebanyak 27 peratus varians terhadap pencapaian dalam pembelajaran sejarah dalam kajian ini. Implikasi kajian ini telah memaparkan sumber maklumat kepada para guru sejarah untuk melaksanakan proses pembelajaran dan pemudahcaraan melalui penggunaan aplikasi Google Classroom dengan berkesan kerana aplikasi Google Classroom didapati mempengaruhi peningkatan pencapaian dalam pembelajaran sejarah dalam kalangan murid.
  19. Dzulkarnain AAA, Salamat S, Shahrudin FA, Jamal FN, Zakaria MN
    J Audiol Otol, 2021 Oct;25(4):199-208.
    PMID: 34425654 DOI: 10.7874/jao.2021.00248
    BACKGROUND AND OBJECTIVES: No known studies have investigated the influence of stimulus polarity on the Auditory Brainstem Response (ABR) elicited from level-specific (LS) chirp. This study is important as it provides a better understanding of the stimulus polarity selection for ABR elicited from LS chirp stimulus. We explored the influence of stimulus polarity on the ABR from LS chirp compared to the ABR from click at 80 dBnHL in normal-hearing adults.

    SUBJECTS AND PURPOSE: Nineteen adults with normal hearing participated. The ABRs were acquired using click and LS chirp stimuli using three stimulus polarities (rarefaction, condensation, and alternating) at 80 dBnHL. The ABRs were tested only on the right ear at a stimulus rate of 33.33 Hz. The ABR test was stopped when the recording reached the residual noise level of 0.04 µV. The ABRs amplitudes, absolute latencies, inter-peak latencies (IPLs), and the recorded number of averages were statistically compared among ABRs at different stimulus polarities and stimuli combinations.

    RESULTS: Rarefaction polarity had the largest ABR amplitudes and SNRs compared with other stimulus polarities in both stimuli. There were marginal differences in the absolute latencies and IPLs among stimulus polarities. No significant difference in the number of averages required to reach the stopping criteria was found.

    CONCLUSIONS: Stimulus polarities have a significant influence on the ABR to LS chirp. Rarefaction polarity is recommended for clinical use because of its larger ABR peak I, III, and V amplitudes than those of the other stimulus polarities.

  20. Mokhtar M, Rismayuddin NAR, Mat Yassim AS, Ahmad H, Abdul Wahab R, Dashper S, et al.
    Biofouling, 2021 08;37(7):767-776.
    PMID: 34425729 DOI: 10.1080/08927014.2021.1967334
    Candida albicans causes candidiasis, particularly in immunocompromised patients. Streptococcus salivarius K12 (K12) is a probiotic isolated from a healthy oral cavity. The study aimed to determine the effect of K12 on C. albicans aggregation, biofilm formation and dimorphism. C. albicans ATCC MYA-4901, acquired immunodeficiency syndrome (AIDS) isolate (ALC2), and oral cancer isolate (ALC3) and K12 were used in the study. All C. albicans strains and K12 were grown in yeast peptone dextrose agar and brain heart infusion agar, respectively, prior to aggregation, biofilm and dimorphism assays. Auto-aggregation of C. albicans MYA-4901 and ALC2 was categorised as high, while the co-aggregation of the strains was low in the presence of K12. C. albicans total cell count decreased significantly when co-cultured with K12 compared with monocultured C. albicans biofilm (p 
    MeSH terms: Candida albicans; Candidiasis*; Humans; Sex Characteristics; Biofilms; Streptococcus salivarius*
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