PATIENT CONCERNS: The patients had limited bone height and proximity to the IAN, making traditional implant techniques challenging. Concerns included the risk of nerve damage and difficulties in achieving optimal implant placement due to anatomical constraints.
DIAGNOSES: Both patients had severe bone resorption and insufficient bone height in the posterior mandible, with concerns about IAN positioning. The first patient had grade III mobility in tooth #46 with a periapical infection, while the second had bilateral posterior mandibular pain and grade III mobility in tooth #47.
INTERVENTIONS: Implants were placed using DNS, allowing precise planning and real-time guidance during surgery. Based on cone beam computed tomography, preoperative planning assessed bone height and IAN proximity. DNS ensured accurate implant placement, avoiding nerve interference, while bone grafts and growth factors were applied for healing.
OUTCOMES: Both cases showed successful implant placement without complications like nerve damage or implant misplacement. Follow-up cone beam computed tomography scans confirmed well-positioned implants, with minimal bone resorption in the first case over 2 years and stable conditions in the second case after 6 months.
LESSONS: This series highlights DNS's effectiveness in improving implant accuracy and reducing nerve injury risks, suggesting its value in complex dental implant surgeries.
METHODS: Ethnic Malay and Indian IRD patients were consecutively enrolled from retina clinics in Singapore and Malaysia. Phenotypic and genetic data were reviewed.
RESULTS: A total of 100 unrelated individuals (Malay: n = 46, Indian: n = 54) were enrolled. Sixteen distinct IRD phenotypes were identified, with nonsyndromic retinitis pigmentosa (RP) comprising 46% of all cases. Stargardt disease and cone-rod dystrophy accounted for 20% and 11% of cases, respectively. Exome sequencing yielded genotypes in 64.3% of Malay and 68.9% of Indian cases. Variants in ABCA4 were the most common cause of IRD overall. Recurrent variants were identified in ABCA4, GUCY2D, PRPH2, and TULP1 for Malays, and in ABCA4 and MFSD8 (CLN7) for Indians. Homozygosity was more frequent among Indians than Malays (58.1% vs. 19.2%; p = 0.003).
CONCLUSIONS: This study demonstrated diverse phenotypic and genotypic outcomes in Malay and Indian populations of Singapore and Malaysia, with distinct differences between them. Homozygosity was common among ethnic Indian IRD cases, explaining phenotypic diversity. These findings inform the identification of regionally relevant IRDs for developing targeted therapies in Malay and Indian patients from Southeast Asia.
METHODS: Data from the Gulf Cardiogenic Shock (Gulf-CS) registry-a multicenter registry of CS-AMI patients from six Gulf countries-were analyzed to compare in-hospital and long-term outcomes for patients with and without RVD. RVD was defined by echocardiographic criteria: TAPSE <17 mm, S' wave <12 cm/s, and TAPSE/PASP ratio < 0.34. Multivariable logistic and Cox regression models were used to identify in-hospital and follow-up mortality predictors.
RESULTS: Among 1,513 CS-AMI patients, RVD was independently associated with higher in-hospital mortality (55.87% vs. 42.89%, p < 0.001) and lower survival at 6, 12, 18, and 24 months (58%, 35%, 18%, and 6% vs. 73%, 53%, 38%, and 30%; p < 0.001). Predictors of in-hospital mortality included advanced SCAI shock stage, cardiac arrest, age, NSTEMI, number of vessels affected, and elevated creatinine, while follow-up mortality was associated with advanced SCAI stage, reduced LVEF, elevated BUN, history of CABG and comorbidities including COPD and prior CVA.
CONCLUSION: RVD is a significant independent predictor of both in-hospital and long-term mortality in CS-AMI, highlighting the need for early RVD assessment and specific interventions. This study's findings support the integration of RV-focused management strategies to improve survival outcomes in this high-risk population.
METHODS: This cross-sectional study involved stratified sampling of participants from the four Gaza districts in Palestine. Individuals aged 18 years or older completed the Arab Ocular Surface Disease Index (Arab-OSDI) questionnaire and the Perceived Stress Scale (PSS-10) to assess stress levels.
RESULTS: A total of 426 participants (238 males and 188 females) completed the Arabic versions of the OSDI and PSS-10 questionnaires. The mean Arab-OSDI score was 21, with 40.6 % of participants scoring ≥23, the threshold for moderate to severe DED symptoms. Participants with moderate or high perceived stress levels had significantly higher mean Arab-OSDI scores than individuals with low stress levels (p = 0.029). Logistic regression analysis identified age over 50 years, and the high PSS as significant factors associated with Arab-OSDI scores ≥13 (p
METHODS: Data were collected and analysed over three months from January 2023 using an ontology-based information extraction system (Semantic Hub). The system identified patient "stories" and extracted themes from online posts from January 2013 to March 2023, focusing on Korea and Taiwan by filtering the geographic location of users, the language used, and the local online platforms. Extracted texts were structured into knowledge graphs and analysed descriptively.
RESULTS: The patient voice was identified in 133,857 messages (9,620 patients) from the Naver online platform in Korea and included internet chat forums focused on macular degeneration. The most important factors for AMD treatments were effectiveness (1,632/3,401 mentions; 48%), price and access to insurance (33%), tolerability (10%) and doctor and clinic recommendations (9%). Treatment burden associated with intravitreal injection of vascular endothelial growth factor inhibitors related to tolerability (254/942 mentions; 27%), financial burden (20%), hospital selection (18%) and emotional burden (14%). In Taiwan, 444 messages were identified from Facebook, YouTube and Instagram. The success of treatment was judged by improvements in visual acuity (20/121 mentions; 16.5%), effect on oedema (10.7%), less distortion (9.1%) and inhibition of angiogenesis (5.8%). Tolerability concerns were rarely mentioned (26/440 mentions; 5.9%).
CONCLUSIONS: Digital Listening using Semantic-NLP can provide real-world insights from large amounts of internet data quickly and with low human labour cost. This allows healthcare companies to respond to the unmet needs of patients for effective and safe treatment and improved patient quality of life throughout the product lifecycle.
METHODS: Accordingly, 254 male athletes (Mean age = 23.1 ± 5.4 years) voluntarily participated in the study. This study was designed with the relational survey model, one of the quantitative research models. Athletic Mental Energy Scale and Dispositional Flow State Scale-2 were used as data collection tools. After confirming the validity and reliability of the scales, the data were analyzed. In this study, blank data were first evaluated to check the suitability of the analysis and assumptions. After the structure of the scales was verified, firstly, when the skewness kurtosis values for the normality test were examined, it was deter-mined that the data were suitable for normal distribution as the values were between - 1.5 and + 1.5 and the Q-Q graph did not show deviations from the distribution. In this context, Pearson Correlation Analysis was used to determine the relationship between athletic mental energy and flow state, and structural equation modeling (SEM) analysis was used to determine the determinant role of mental energy. Mental energy significantly predicted the flow state (β = 0.81, p
METHODS: Gene expression profiles of DN patients were obtained from GEO datasets (GSE30122 and GSE30528) and analyzed for differentially expressed genes (DEGs) using the limma package. Gene set variation analysis (GSVA) was conducted to assess lipid metabolism pathways, while Mendelian randomization (MR) and Pearson correlation evaluated the association between DEGs and adipokines. Immune cell infiltration was analyzed using the IOBR R package (MCP-counter and xCell methods), followed by MR analysis of DN-related immune responses. Celastrol target genes were identified using the SEA database.
RESULTS: A total of 70 intersecting DEGs were identified. GSVA revealed that brown and beige adipocyte differentiation pathways were downregulated, while adipocyte-related pathways were upregulated in DN (p
OBJECTIVE: To evaluate the risk of EDs and its associated factors among medical students in the Middle East and North Africa (MENA) region.
METHODS: A web-based cross-sectional study was conducted among medical students in the MENA region during the months of June and July 2024. The primary data collection instrument was a comprehensive questionnaire that contained the Eating Attitudes Test (EAT-26) and sociodemographic and clinical features and designed using Google Forms and distributed via social media platforms.
RESULTS: The total number of participants was 5061. The mean age in our population was 22.58 ± 3.27. Our population's average EAT-26 score was 13.87 ± 10.7, with ranges varying from 0 to 72. Based on their EAT-26 scores being 20 or above, 1254 people (24.8%) were deemed to be at risk of EDs. Among the participants, 8% were underweight. The multivariable logistic regression model revealed several eating disorder risk factors such as T1DM, schizophrenia, autism, female gender, IBD, and daily exposure to thin body ideal. Regular sports practice and weight satisfaction were protective factors.
CONCLUSION: There exists a higher prevalence of individuals at risk for the development of EDs in the MENA region especially females, students with comorbidities, and those having conflictual relationships with their parents. Regular sports practice and weight satisfaction are protective factors.