Chemopreventive effects of a curcumin-like diarylpentanoid [2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro

Lee KH 1 , Abas F 2 , Mohamed Alitheen NB 1 , Shaari K 2 , Lajis NH 2 , Israf DA 2 Show all authors , Syahida A 1

Affiliations 

  • 1 Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Kuala Lumpur, Selangor, Malaysia
  • 2 Institute of Bioscience, Universiti Putra Malaysia, Kuala Lumpur, Selangor, Malaysia
Int J Rheum Dis, 2015 Jul;18(6):616-27.
PMID: 24832356 DOI: 10.1111/1756-185X.12341

Abstract

Synovial fibroblast has emerged as a potential cellular target in progressive joint destruction in rheumatoid arthritis development. In this study, BDMC33 (2,6-bis[2,5-dimethoxybenzylidene]cyclohexanone), a curcumin analogue with enhanced anti-inflammatory activity has been synthesized and the potency of BDMC33 on molecular and cellular basis of synovial fibroblasts (SF) were evaluated in vitro.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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