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Associations of glycemia and lipid levels in pregnancy with dyslipidemia 10-14 years later: The HAPO follow-up study

Lowe LP 1 , Perak AM 2 , Kuang A 1 , Lloyd-Jones DM 1 , Sacks DA 3 , Deerochanawong C 4 Show all authors , Maresh M 5 , Ma RC 6 , Lowe WL 1 , Metzger BE 1 , Scholtens DM 1 , HAPO and HAPO Follow-Up Study Cooperative Research Groups

Affiliations 

  • 1 Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  • 2 Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA. Electronic address: amarma@luriechildrens.org
  • 3 Kaiser Permanente of Southern California, Pasadena, CA, USA
  • 4 Rajavithi Hospital, Bangkok, Thailand
  • 5 Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
  • 6 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Diabetes Res Clin Pract, 2022 Mar;185:109790.
PMID: 35192911 DOI: 10.1016/j.diabres.2022.109790

Abstract

AIMS: To examine associations of pregnancy glycemia with future dyslipidemia.

METHODS: We analyzed data from Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study participants. We examined associations of gestational diabetes (GDM), sum of fasting, 1-hour, and 2-hour glucose z-scores after 75-g load, insulin sensitivity, and lipid levels at 24-32 weeks' gestation with dyslipidemia 10-14 years postpartum.

RESULTS: Among 4,693 women, 14.3% had GDM. At follow-up, mean (SD) age was 41.7 (5.7) years, 32.3% had total cholesterol (TC) ≥ 5.17, 27.2% had HDL cholesterol 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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