Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest

Ng KB; Bustamam A; Sukari MA; Abdelwahab SI; Mohan S; Buckle MJ; Kamalidehghan B; Nadzri NM; Anasamy T; A Hadi AH; Rahman HS

doi:10.1186/1472-6882-13-41

Fulltext

Induction of selective cytotoxicity and apoptosis in human T4-lymphoblastoid cell line (CEMss) by boesenbergin a isolated from boesenbergia rotunda rhizomes involves mitochondrial pathway, activation of caspase 3 and G2/M phase cell cycle arrest

Ng KB ¹ , Bustamam A , Sukari MA , Abdelwahab SI , Mohan S , Buckle MJ Show all authors , Kamalidehghan B , Nadzri NM , Anasamy T , A Hadi AH , Rahman HS

Affiliations

¹ UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

BMC Complement Altern Med, 2013;13:41.

PMID: 23432947 DOI: 10.1186/1472-6882-13-41

Abstract

Boesenbergia rotunda (Roxb.) Schlecht (family zingiberaceae) is a rhizomatous herb that is distributed from north-eastern India to south-east Asia, especially in Indonesia, Thailand and Malaysia. Previous research has shown that the crude extract of this plant has cytotoxic properties. The current study examines the cytotoxic properties of boesenbergin A isolated from Boesenbergia rotunda.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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