Synergistic cytotoxic effects of combined δ-tocotrienol and jerantinine B on human brain and colon cancers

Abubakar IB 1 , Lim KH 2 , Kam TS 3 , Loh HS 4

Affiliations 

  • 1 School of Biosciences, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address: khyx2ibr@nottingham.edu.my
  • 2 School of Pharmacy, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address: Kuanhon.Lim@nottingham.edu.my
  • 3 Department of Chemistry, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Malaysia. Electronic address: tskam@um.edu.my
  • 4 School of Biosciences, Faculty of Science, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia; Biotechnology Research Centre, The University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Electronic address: Sandy.Loh@nottingham.edu.my
J Ethnopharmacol, 2016 May 26;184:107-18.
PMID: 26947901 DOI: 10.1016/j.jep.2016.03.004

Abstract

The genus Tabernaemontana has widespread distribution throughout tropical and subtropical parts of the world, i.e. Africa, Asia and America which has long been used for treatments of different disease conditions including tumours, wounds, syphilis, stomach ache and headache. Some Tabernaemontana species are used for treatment of piles, spleen and abdominal tumours in India. In particular, the leaf of Tabernaemontana corymbosa is used for treatment of tumours in Bangladesh. Parts of the plant or whole plants are used as decoctions, steam bath, powder and ointments.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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