In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis

Chong HZ; Yeap SK; Rahmat A; Akim AM; Alitheen NB; Othman F; Gwendoline-Ee CL

doi:10.1186/1472-6882-12-134

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In vitro evaluation of Pandanus amaryllifolius ethanol extract for induction of cell death on non-hormone dependent human breast adenocarcinoma MDA-MB-231 cell via apoptosis

Chong HZ ¹ , Yeap SK , Rahmat A , Akim AM , Alitheen NB , Othman F Show all authors , Gwendoline-Ee CL

Affiliations

¹ Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

BMC Complement Altern Med, 2012;12:134.

PMID: 22909149 DOI: 10.1186/1472-6882-12-134

Abstract

Our previous study had shown that P. amaryllifolius was able to selectively inhibit cell proliferation of hormone independent breast cancer cell line MDA-MB-231. To understand the mode of killing and mechanism of action for P. amaryllifolius, the ethanol extract was evaluated for their alteration of cell cycle progression, PS externalization, DNA fragmentation and expression of anti/pro-apoptotic related protein.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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