Application of SELDI-TOF in N-glycopeptides profiling of the urine from patients with endometrial, ovarian and cervical cancer

Mu AK 1 , Lim BK 2 , Aminudin N 1 , Hashim OH 3 , Shuib AS 1

Affiliations 

  • 1 a Department of Cell and Molecular Biology , University Putra Malaysia , Serdang , Selangor , Malaysia
  • 2 b Department of Obstetrics and Gynaecology
  • 3 c Department of Molecular Medicine , and
Arch Physiol Biochem, 2016 Jul;122(3):111-6.
PMID: 26849673 DOI: 10.3109/13813455.2016.1151441

Abstract

Endometrial (ECa), ovarian (OCa) and cervical (CCa) cancers are among 10 of the most common cancers affecting women worldwide. Cancers are known to cause some proteins to be differentially glycosylated or aberrantly excreted in the urine, which can be used as biomarkers. Since ECa, OCa and CCa are difficult to diagnose at the early stage, the aim of the present study was to identify a panel of new biomarkers for early detection of the cancers using surface-enhanced laser desorption/ionization-time-of-flight (SELDI-TOF) technology. Identification of early biomarkers that are specific and efficient can increase the survival rate of the patients.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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