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Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo

Al-Henhena N 1 , Khalifa SA 2 , Ying RP 1 , Ismail S 3 , Hamadi R 4 , Shawter AN 1 Show all authors , Idris AM 5 , Azizan A 5 , Al-Wajeeh NS 1 , Abdulla MA 6 , El-Seedi HR 7

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 Department of Experimental Hematology, Karolinska University Hospital, SE-141 86, Stockholm, Sweden
  • 3 Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Department of Biochemistry, Faculty of Medicine, Sana'a University, Sana'a, Yemen
  • 5 Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 6 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. ammeen@um.edu.my
  • 7 Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia. hesham@um.edu.my
BMC Complement Altern Med, 2015;15(1):419.
PMID: 26608653 DOI: 10.1186/s12906-015-0926-7

Abstract

With cancer being one of the major causes of death around the world, studies are ongoing to find new chemotherapeutic leads. There are common mechanisms for colorectal cancer (CRC) formation. Several are connected with oxidative stress-induced cell apoptosis and others are related to imbalanced homeostasis or intake of drugs/toxins. Plants that have been used for decades in folk and traditional medicine have been accepted as one of the commonest sources of discovered natural agents of cancer chemotherapy and chemoprevention. The aim was to study the antioxidant and chemopreventive effects of Strobilanthes crispus on colorectal cancer formation.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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