Fulltext

Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats

Hajrezaie M 1 , Hassandarvish P 2 , Moghadamtousi SZ 3 , Gwaram NS 4 , Golbabapour S 1 , Najihussien A 2 Show all authors , Almagrami AA 2 , Zahedifard M 1 , Rouhollahi E 2 , Karimian H 5 , Fani S 5 , Kamalidehghan B 5 , Majid NA 3 , Ali HM 4 , Abdulla MA 2

Affiliations 

  • 1 Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia
  • 5 Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
PLoS One, 2014;9(3):e91246.
PMID: 24618844 DOI: 10.1371/journal.pone.0091246

Abstract

Based on the potential of Schiff base compounds to act as sources for the development of cancer chemotherapeutic agents, this in vivo study was performed to investigate the inhibitory properties of the synthetic Schiff base compound Cu(BrHAP)2 on colonic aberrant crypt foci (ACF).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications