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Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia

Fornace KM 1 , Nuin NA 2 , Betson M 3 , Grigg MJ 4 , William T 5 , Anstey NM 4 Show all authors , Yeo TW 4 , Cox J 1 , Ying LT 2 , Drakeley CJ 1

Affiliations 

  • 1 London School of Hygiene and Tropical Medicine
  • 2 Biotechnology Research Institute, Universiti Sabah Malaysia
  • 3 Royal Veterinary College, London, United Kingdom
  • 4 Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Menzies School of Health Research, Darwin, Australia
  • 5 Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit Sabah Department of Health, Clinical Research Centre Jesselton Medical Centre, Kota Kinabalu, Malaysia
J Infect Dis, 2016 Mar 01;213(5):784-7.
PMID: 26433222 DOI: 10.1093/infdis/jiv475

Abstract

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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