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Venom-gland transcriptome and venom proteome of the Malaysian king cobra (Ophiophagus hannah)

Tan CH 1 , Tan KY 2 , Fung SY 3 , Tan NH 4

Affiliations 

  • 1 Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. tanchoohock@gmail.com
  • 2 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. kytan_kae@yahoo.com
  • 3 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. fungshinyee@gmail.com
  • 4 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. tanngethong@yahoo.com.sg
BMC Genomics, 2015;16:687.
PMID: 26358635 DOI: 10.1186/s12864-015-1828-2

Abstract

The king cobra (Ophiophagus hannah) is widely distributed throughout many parts of Asia. This study aims to investigate the complexity of Malaysian Ophiophagus hannah (MOh) venom for a better understanding of king cobra venom variation and its envenoming pathophysiology. The venom gland transcriptome was investigated using the Illumina HiSeq™ platform, while the venom proteome was profiled by 1D-SDS-PAGE-nano-ESI-LCMS/MS.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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