Obesity is a main public health problem predisposes many to the obesity-related health problems worldwide. Malaysia was ranked as sixth in Asia with high prevalence of obesity by the World Health Organisation in 2010. It is multifactorial origin and depends on many internal and external interactions; between human beings and the environment. In this review article, the focus will be on the example of chemical obesogens that present silently in the daily diet, pharmaceutical or industrial compounds that predispose people to obesity through altering and disrupting normal bodily metabolic processes