Objective: This preliminary investigation intended to evaluate the healthrelated quality of life (HRQoL) profile of HIV/AIDS family caregivers residing in Kuala Terengganu, Malaysia and to explore the psychometric properties of the Malay Caregiver Quality of Life (MCQoL) questionnaire in this sample. Methods: A convenient sample of family caregivers of HIV/AIDS patients who were aware of the diagnosis was enrolled. They were recruited from the Infectious Disease Clinic, Hospital Sultanah Nur Zahirah, Terengganu. Data was analysed using SPSS16 employing descriptive and non-parametric statistical methods. Results: Thirty respondents consented participation [median age = 43.0 years (range 19.0-81.0); female = 63.3%, married = 70.0%; ≤ primary school qualification = 46.7%; self-employed = 66.7% and rural residents = 56.7%]. Across all patients, the highest domain score was for Disruptiveness (median = 3.3; range 1.4-4.0) while Burden was the lowest (median = 2.3; range 1.0-3.6). As expected, males reported significantly better Financial Concerns and Burden (p