Strobilanthes crispus (S. crispus) is an herbal medicine plant which is native to countries from Madagascar to Indonesia. The plants contained high amount of mineral content and vitamin C, B1 and B2. This plant are used in medicinal and to treat a variety of ailments in the various traditional systems of medicine. Phytochemical investigations have revealed that the plant contain polyphenols, flavonoids, catechins, alkaloids, caffeine, tannins, compounds known to possess multiple health beneficial effects. Preclinical studies have shown that the plant possess antioxidant, free radical scavenging, anticancer, antidiabetic, antimicrobial, wound healing and antiulcerogenic activities. This review presents the comprehensive overview of phytochemical constituents, pharmacological and toxicological properties of S. crispus and to provide preliminary information for future research and for commercial exploitation.