Fulltext

Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Moskal A 1 , Freisling H 1 , Byrnes G 1 , Assi N 1 , Fahey MT 2 , Jenab M 1 Show all authors , Ferrari P 1 , Tjønneland A 3 , Petersen KE 3 , Dahm CC 4 , Hansen CP 4 , Affret A 5 , Boutron-Ruault MC 5 , Cadeau C 5 , Kühn T 6 , Katzke V 6 , Iqbal K 7 , Boeing H 7 , Trichopoulou A 8 , Bamia C 8 , Naska A 8 , Masala G 9 , de Magistris MS 10 , Sieri S 11 , Tumino R 12 , Sacerdote C 13 , Peeters PH 14 , Bueno-de-Mesquita BH 15 , Engeset D 16 , Licaj I 17 , Skeie G 17 , Ardanaz E 18 , Buckland G 19 , Castaño JM 20 , Quirós JR 21 , Amiano P 20 , Molina-Portillo E 20 , Winkvist A 22 , Myte R 23 , Ericson U 24 , Sonestedt E 24 , Perez-Cornago A 25 , Wareham N 26 , Khaw KT 27 , Huybrechts I 1 , Tsilidis KK 28 , Ward H 29 , Gunter MJ 1 , Slimani N 1

Affiliations 

  • 1 International Agency for Research on Cancer (IARC-WHO), 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France
  • 2 Department of Statistics, Data Science and Epidemiology, Swinburne University of Technology, Hawthorn, Melbourne, VIC 3122, Australia
  • 3 Danish Cancer Society Research Center, Unit of Diet, Genes and Environment, Strandboulevarden 49, Copenhagen DK-2100, Denmark
  • 4 Section for Epidemiology, Department of Public Health, Aarhus University, Bartholins Alle 2, Aarhus C DK-8000, Denmark
  • 5 Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM UMRS 1018, Villejuif F-94805, France
  • 6 Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany
  • 7 Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, Nuthetal 14558, Germany
  • 8 Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece
  • 9 Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Ponte Nuovo Palazzina 28A 'Mario Fiori', Via delle Oblate 4, Florence 50141, Italy
  • 10 Department of Clinical and Experimental Medicine, Federico II University, via Pansini 5, 80131 Naples, Italy
  • 11 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian, 1, Milano 20133, Italy
  • 12 Cancer Registry and Histopathology Unit, 'Civic-M.P.Arezzo' Hospital, ASP, Via Dante No. 109, Ragusa 97100, Italy
  • 13 Unit of Cancer Epidemiology, University of Turin, Via Santena 7, Turin 10126, Italy
  • 14 Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispost Str. 6.131, PO Box 85500, Utrecht 3508 GA The Netherlands
  • 15 Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and The Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands
  • 16 The Norwegian Food Safety Authority, Head Office, Postboks 383, 2381 Brumunddal, Norway
  • 17 Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø N-9037, Norway
  • 18 Navarra Public Health Institute, c/Leyre 15, Pamplona 31003, Pamplona, Spain
  • 19 Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, Avda Gran Via 199-203, 08908 Barcelona, Spain
  • 20 CIBER, Epidemiology and Public Health (CIBERESP), Melchor Fernández Almagro, 3-5, Madrid 28029, Spain
  • 21 Public Health Directorate, Asturias, Ciriaco Miguel Vigil St 9, Oviedo 33006, Spain
  • 22 Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, PO Box 459, 40530 Gothenburg, Sweden
  • 23 Department of Radiation Sciences, Oncology, Umeå University, SE-901 87 Umeå, Sweden
  • 24 Department of Clinical Sciences Malmö, Lund University, Box 117, SE-221 00 Lund, Sweden
  • 25 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Oxford OX3 7LF, UK
  • 26 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Box 285, CB2 0QQ Cambridge, UK
  • 27 Clinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0SP, UK
  • 28 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, University Campus, Ionnina 45110, Greece
  • 29 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, Cambridge
Br J Cancer, 2016 Nov 22;115(11):1430-1440.
PMID: 27764841 DOI: 10.1038/bjc.2016.334

Abstract

BACKGROUND: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

METHODS: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.

RESULTS: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.

CONCLUSIONS: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications