Fulltext

Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Zamora-Ros R 1 , Barupal DK 1 , Rothwell JA 1 , Jenab M 1 , Fedirko V 2 , Romieu I 1 Show all authors , Aleksandrova K 3 , Overvad K 4 , Kyrø C 5 , Tjønneland A 5 , Affret A 6 , His M 6 , Boutron-Ruault MC 6 , Katzke V 7 , Kühn T 7 , Boeing H 3 , Trichopoulou A 8 , Naska A 8 , Kritikou M 8 , Saieva C 9 , Agnoli C 10 , Santucci de Magistris M 11 , Tumino R 12 , Fasanelli F 13 , Weiderpass E 14 , Skeie G 14 , Merino S 15 , Jakszyn P 16 , Sánchez MJ 17 , Dorronsoro M 18 , Navarro C 18 , Ardanaz E 18 , Sonestedt E 19 , Ericson U 19 , Maria Nilsson L 20 , Bodén S 21 , Bueno-de-Mesquita HB 22 , Peeters PH 23 , Perez-Cornago A 24 , Wareham NJ 25 , Khaw KT 26 , Freisling H 1 , Cross AJ 23 , Riboli E 23 , Scalbert A 1

Affiliations 

  • 1 Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC-WHO), Lyon, France
  • 2 Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA
  • 3 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
  • 4 Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark
  • 5 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 6 Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France
  • 7 Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
  • 8 Hellenic Health Foundation, Athens, Greece
  • 9 Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy
  • 10 Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • 11 Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
  • 12 Cancer Registry and Histopathology Unit, "Civic M.P. Arezzo" Hospital, ASP, Ragusa, Italy
  • 13 Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
  • 14 Department of Community Medicine, Faculty of Health Sciences, UiT The Artic University of Tromsø, Tromsø, Norway
  • 15 Public Health Directorate, Asturias, Spain
  • 16 Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
  • 17 Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs, Granada Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain
  • 18 CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
  • 19 Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
  • 20 Nutritional Research and Arcum, Arctic Research Centre at Umeå University, Umeå, Sweden
  • 21 Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden
  • 22 Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
  • 23 School of Public Health, Imperial College London, London, United Kingdom
  • 24 Cancer Epidemiology Unit, University of Oxford, United Kingdom
  • 25 MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
  • 26 Department of Public Health and Primary Care, University of Cambridge, United Kingdom
Int J Cancer, 2017 Apr 15;140(8):1836-1844.
PMID: 28006847 DOI: 10.1002/ijc.30582

Abstract

Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications