Affiliations 

  • 1 Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Serdang 43400, Selangor, Malaysia. muhusma@gmail.com
  • 2 Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA), Serdang 43400, Selangor, Malaysia. mzobir@upm.edu.my
  • 3 Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Serdang 43400, Selangor, Malaysia. sharida.fakurazi@gmail.com
  • 4 Department of Cell & Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Serdang 43400, Selangor, Malaysia. masjaffri@upm.edu.my
  • 5 Centre for Diagnostic and Nuclear Imaging, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia. ahmadsaadff@gmail.com
Nanomaterials (Basel), 2017 Aug 31;7(9).
PMID: 28858229 DOI: 10.3390/nano7090244

Abstract

We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO₃)₃ as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines (HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have a promising dual diagnostic and therapeutic features to further develop a better future for clinical remedy for cancer treatment.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.