Affiliations 

  • 1 International Medical University, 57000 Bukit Jalil, Kuala Lumpur, Malaysia. sidney_ong@yahoo.co.uk
  • 2 Hospital Tuanku Ja'afar, Seremban, Negeri Sembilan, Malaysia
Med J Malaysia, 2017 10;72(5):311-313.
PMID: 29197889 MyJurnal

Abstract

Acute necrotising encephalopathy of childhood (ANEC) is an uncommon disease with characteristic clinical and imaging findings. We present two cases of ANEC secondary to Respiratory Syncytial Virus (RSV) and mycoplasma infections. An eight-month-old boy presented with features of gastroenteritis but soon developed multiple episodes of seizures. Blood and CSF cultures were negative but nasopharyngeal aspirate immunofluorescence was positive for RSV. A nine-year-old girl presented with abnormal behaviour following two days of prodromal symptoms. Her serological markers implicated mycoplasma (IgM titre 1: 640). CT brain of both patients showed bilateral symmetrical thalamic hypodensities, while MRI revealed more extensive white matter involvements.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.